Synergistic suppression of autoimmune arthritis through concurrent treatment with tolerogenic DC and MSC

Scientific Reports

Volumn 7, Issue , 2017, Pages

  Li, Rong ^a,b   Zhang, Yujuan ^a,b   Zheng, Xiufen ^c   Peng, Shanshan ^a,b   Yuan, Keng ^a,b   Zhang, Xusheng ^c   Min, Weiping ^a,b,c  

^a NANCHANG UNIVERSITY   (China)

^b Jiangxi Provincial Key Laboratory of Immunotherapy   (China)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

RELB PROTEIN, MOUSE; TRANSCRIPTION FACTOR RELB;

ANIMAL; BAGG ALBINO MOUSE; CELL TRANSPLANTATION; DBA MOUSE; DENDRITIC CELL; DISEASE MODEL; GENE SILENCING; GENETICS; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTHERAPY; MESENCHYMAL STROMA CELL; PHYSIOLOGY; PROCEDURES; RHEUMATOID ARTHRITIS; TREATMENT OUTCOME;

ANIMALS; ARTHRITIS, RHEUMATOID; CELL TRANSPLANTATION; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; GENE SILENCING; IMMUNOSUPPRESSION; IMMUNOTHERAPY; MESENCHYMAL STROMAL CELLS; MICE, INBRED BALB C; MICE, INBRED DBA; TRANSCRIPTION FACTOR RELB; TREATMENT OUTCOME;

EID: 85013862591     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep43188     Document Type: Article

References (32)

1. McInnes, I. B., Buckley, C. D., Isaacs, J. D. Cytokines in rheumatoid arthritis-shaping the immunological landscape. Nat Rev Rheumatol 12, 63-68, doi: 10.1038/nrrheum. 2015. 171 (2015).
2. Li, R., et al. Gene silencing of IL-12 in dendritic cells inhibits autoimmune arthritis. J Transl Med 10, 19, doi: 10.1186/1479-5876-10-19 (2012).
3. Popov, I., et al. Preventing autoimmune arthritis using antigen-specific immature dendritic cells: a novel tolerogenic vaccine. Arthritis Res Ther 8, R141, doi: 10.1186/ar2031 (2006).
4. Lebre, M. C., Tak, P. P. Dendritic cells in rheumatoid arthritis: Which subset should be used as a tool to induce tolerance Human Immunol 70, 321-4, doi: 10.1016/j. humimm. 2009. 02. 006 (2009)
5. Ahmed, M. S., Bae, Y. S. Dendritic Cell-based Immunotherapy for Rheumatoid Arthritis: from Bench to Bedside. Immune Netw 16, 44-51, doi: 10.4110/in. 2016. 16. 1. 44 (2016).
6. Anderson, A. E., et al. Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4+ T-cells partly via TGF-beta1. Clin Exp Immunol, doi: 10.1111/cei. 12870 (2016).
7. Brooke, G., et al. Therapeutic applications of mesenchymal stromal cells. Semin Cell Dev Biol 18, 846-858, doi: 10.1016/j. semcdb. 2007. 09. 012 (2007).
8. Djouad, F., Bouffi, C., Ghannam, S., Noel, D., Jorgensen, C. Mesenchymal stem cells: innovative therapeutic tools for rheumatic diseases. Nat Rev Rheumatol 5, 392-399, doi: 10.1038/nrrheum. 2009. 104 (2009).
9. Leong, D. J., Sun, H. B. Mesenchymal stem cells in tendon repair and regeneration: basic understanding and translational challenges. Ann N Y Acad Sci, doi: 10.1111/nyas. 13262 (2016).
10. Ng, J., et al. Immunomodulatory Properties of Induced Pluripotent Stem Cell-Derived Mesenchymal Cells. J Cell Biochem 117, 2844-2853, doi: 10.1002/jcb. 25596 (2016).
11. Kunwar, S., Dahal, K., Sharma, S. Anti-IL-17 therapy in treatment of rheumatoid arthritis: a systematic literature review and metaanalysis of randomized controlled trials. Rheumatol Int 36, 1065-1075, doi: 10.1007/s00296 (2016).
12. Bhattaram, P., Chandrasekharan, U. The joint synovium: A critical determinant of articular cartilage fate in inflammatory joint diseases. Semin Cell Dev Biol, doi: 10.1016/j. semcdb. 2016. 05. 009 (2016).
13. Brand, D. D., Kang, A. H., Rosloniec, E. F. The mouse model of collagen-induced arthritis. Methods Mol Med 102, 295-312, doi: 10.1385/1-59259-805-6:295 (2004).
14. Mauri, C., Feldmann, M., Williams, R. O. Down-regulation of Th1-mediated pathology in experimental arthritis by stimulation of the Th2 arm of the immune response. Arthritis Rheum 48, 839-845, doi: 10.1002/art. 10832 (2003).
15. Le Blanc, K., Ringden, O. Immunomodulation by mesenchymal stem cells and clinical experience. J Intern Med 262, 509-525, doi: 10.1111/j. 1365-2796. 2007. 01844. x (2007).
16. Sany, J. Intravenous immunoglobulin therapy for rheumatic diseases. Curr Opin Rheumatol 6, 305-310, doi: 10.1038/nrrheum. 2011. 61 (1994).
17. Min, W. P., et al. Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance. J Immunol 170, 1304-1312, doi: 10.4049/jimmunol. 170. 3. 1304 (2003).
18. Yang, J., et al. LF15-0195 generates tolerogenic dendritic cells by suppression of NF-kappaB signaling through inhibition of IKK activity. J Leukoc Biol 74, 438-447, doi: 10.1189/jlb. 1102582 (2003).
19. Lechler, R., Ng, W. F., Steinman, R. M. Dendritic cells in transplantation-friend or foe Immunity 14, 357-368, doi: 10.1016/S1074-7613(01)00116-9 (2001).
20. Steinman, R. M., Hawiger, D., Nussenzweig, M. C. Tolerogenic dendritic cells. Annu Rev Immunol 21, 685-711, doi: 10.1146/annurev. immunol. 21. 120601. 141040 (2003).
21. Matsue, H., et al. Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells. Nat Med 5, 930-937, doi: 10.1038/11375 (1999).
22. Zheng, X., et al. RNAi-mediated CD40-CD154 interruption promotes tolerance in autoimmune arthritis. Arthritis Res Ther 12, R13, doi: 10.1186/ar2914 (2010).
23. Chen, L., Tredget, E. E., Wu, P. Y., Wu, Y. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 3, e1886, doi: 10.1371/journal. pone. 0001886 (2008).
24. Seki, T., et al. Visualization of RelB expression and activation at the single-cell level during dendritic cell maturation in Relb-Venus knock-in mice. J Biochem 158, 485-495, doi: 10.1093/jb/mvv064 (2015).
25. Min, W. P., et al. Dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survival. J Immunol 164, 161-167, doi: 10.4049/jimmunol. 164. 1. 161 (2000).
26. Li, M., et al. Immune modulation and tolerance induction by RelB-silenced dendritic cells through RNA interference. J Immunol 178, 5480-5487, doi: 10.4049/jimmunol. 178. 9. 5480 (2007).
27. Zhou, K., et al. Transplantation of human bone marrow mesenchymal stem cell ameliorates the autoimmune pathogenesis in MRL/lpr mice. Cell Mol Immunol 5, 417-424, doi: 10.1038/cmi. 2008. 52 (2008).
28. Parekkadan, B., Tilles, A. W., Yarmush, M. L. Bone marrow-derived mesenchymal stem cells ameliorate autoimmune enteropathy independently of regulatory T cells. Stem Cells 26, 1913-1919, doi: 10.1634/stemcells. 2007-0790 (2008).
29. Boumaza, I., et al. Autologous bone marrow-derived rat mesenchymal stem cells promote PDX-1 and insulin expression in the islets, alter T cell cytokine pattern and preserve regulatory T cells in the periphery and induce sustained normoglycemia. J Autoimmun, doi: 10.1016/j. jaut. 2008. 10. 004 (2008).
30. Elbashir, S. M., Harborth, J., Weber, K., Tuschl, T. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 26, 199-213, doi:10. 1016/S1046-2023(02)00023-3 (2002).
31. Chamberlain, G., Fox, J., Ashton, B., Middleton, J. Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25, 2739-2749, doi: 10.1634/stemcells. 2007-0197 (2007).
32. Tasso, R., Pennesi, G. When stem cells meet immunoregulation. Int Immunopharmacol 9, 596-598, doi: 10.1016/j. intimp. 2009. 01. 014 (2009).