The impact of vaporized nanoemulsions on ultrasound-mediated ablation

Journal of Therapeutic Ultrasound

Volumn 1, Issue 1, 2013, Pages

  Zhang, Peng ^a   Kopechek, Jonathan A ^a   Porter, Tyrone M ^a  

^a Boston University   (United States)

Author keywords

High intensity focused ultrasound; Phase shift nanoemulsions; Polyacrylamide hydrogels; Thermal ablation; Vaporized perfluorocarbon droplets

Indexed keywords

ALBUMIN; PERFLUOROPENTANE; POLYACRYLAMIDE GEL;

ARTICLE; CALIBRATION; EXCITATION; HIGH INTENSITY FOCUSED ULTRASOUND; HIGH-ENERGY SHOCK WAVE; IMAGE PROCESSING; MICROBUBBLE; NANOEMULSION; POLYMERIZATION; PRIORITY JOURNAL; SOUND INTENSITY; TEMPERATURE; VISION;

EID: 85013746062     PISSN: None     EISSN: 20505736     Source Type: Journal    
DOI: 10.1186/2050-5736-1-2     Document Type: Article

References (57)

1. Hynynen K, Darkazanli A, Unger E, Schenck JF: MRI-guided noninvasive ultrasound surgery. Med Phys. 1993, 20: 107-15. 10.1118/1.597093.
2. Illing RO, Kennedy JE, Wu F, ter Haar GR, Protheroe AS, Friend PJ, Gleeson FV, Cranston DW, Phillips RR, Middleton MR: The safety and feasibility of extracorporeal high-intensity focused ultrasound (HIFU) for the treatment of liver and kidney tumours in a Western population. Br J Cancer. 2005, 93: 890-5. 10.1038/sj.bjc.6602803.
3. Kennedy JE: High-intensity focused ultrasound in the treatment of solid tumours. Nat Rev Cancer. 2005, 5: 321-7. 10.1038/nrc1591.
4. Wu F, Wang ZB, Zhu H, Chen WZ, Zou JZ, Bai J, Li KQ, Jin CB, Xie FL, Su HB: Extracorporeal high intensity focused ultrasound treatment for patients with breast cancer. Breast Cancer Res Treat. 2005, 92: 51-60. 10.1007/s10549-004-5778-7.
5. ter Haar G, Coussios C: High intensity focused ultrasound: past, present and future. Int J Hyperthermia. 2007, 23: 85-7. 10.1080/02656730601185924.
6. Mikami K, Murakami T, Okada A, Osuga K, Tomoda K, Nakamura H: Magnetic resonance imaging-guided focused ultrasound ablation of uterine fibroids: early clinical experience. Radiat Med. 2008, 26: 198-205. 10.1007/s11604-007-0215-6.
7. Wu F, Wang ZB, Chen WZ, Bai J, Zhu H, Qiao TY: Preliminary experience using high intensity focused ultrasound for the treatment of patients with advanced stage renal malignancy. J Urol. 2003, 170: 2237-40. 10.1097/01.ju.0000097123.34790.70.
8. Kennedy JE, Wu F, ter Haar GR, Gleeson FV, Phillips RR, Middleton MR, Cranston D: High-intensity focused ultrasound for the treatment of liver tumours. Ultrasonics. 2004, 42: 931-5. 10.1016/j.ultras.2004.01.089.
9. Wu F, Wang ZB, Chen WZ, Wang W, Gui Y, Zhang M, Zheng G, Zhou Y, Xu G, Li M, Zhang C, Ye H, Feng R: Extracorporeal high intensity focused ultrasound ablation in the treatment of 1,038 patients with solid carcinomas in China: an overview. Ultrason Sonochem. 2004, 11: 149-54. 10.1016/j.ultsonch.2004.01.011.
10. Hynynen K: The threshold for thermally significant cavitation in dog's thigh muscle in vivo. Ultrasound Med Biol. 1991, 17: 157-69. 10.1016/0301-5629(91)90123-E.
11. Holt RG, Roy RA: Measurements of bubble-enhanced heating from focused, MHz-frequency ultrasound in a tissue-mimicking material. Ultrasound Med Biol. 2001, 27: 1399-412. 10.1016/S0301-5629(01)00438-0.
12. Sokka SD, King R, Hynynen K: MRI-guided gas bubble enhanced ultrasound heating in in vivo rabbit thigh. Phys Med Biol. 2003, 48: 223-41. 10.1088/0031-9155/48/2/306.
13. Melodelima D, Chapelon JY, Theillere Y, Cathignol D: Combination of thermal and cavitation effects to generate deep lesions with an endocavitary applicator using a plane transducer: ex vivo studies. Ultrasound Med Biol. 2004, 30: 103-11. 10.1016/j.ultrasmedbio.2003.09.005.
14. Umemura S, Kawabata K, Sasaki K: In vivo acceleration of ultrasonic tissue heating by microbubble agent. IEEE Trans Ultrason Ferroelectr Freq Control. 2005, 52: 1690-8.
15. Coussios CC, Roy RA: Applications of acoustics and cavitation to noninvasive therapy and drug delivery. Annu Rev Fluid Mech. 2008, 40: 395-420. 10.1146/annurev.fluid.40.111406.102116.
16. Farny CH, Holt RG, Roy RA: Temporal and spatial detection of HIFU-induced inertial and hot-vapor cavitation with a diagnostic ultrasound system. Ultrasound Med Biol. 2009, 35: 603-15. 10.1016/j.ultrasmedbio.2008.09.025.
17. Farny CH, Glynn Holt R, Roy RA: The correlation between bubble-enhanced HIFU heating and cavitation power. IEEE Trans Biomed Eng. 2010, 57: 175-84.
18. Church CC: Spontaneous homogeneous nucleation, inertial cavitation and the safety of diagnostic ultrasound. Ultrasound Med Biol. 2002, 28: 1349-64. 10.1016/S0301-5629(02)00579-3.
19. Xu Z, Fowlkes JB, Ludomirsky A, Cain CA: Investigation of intensity thresholds for ultrasound tissue erosion. Ultrasound Med Biol. 2005, 31: 1673-82. 10.1016/j.ultrasmedbio.2005.07.016.
20. Canney MS, Khokhlova VA, Bessonova OV, Bailey MR, Crum LA: Shock-induced heating and millisecond boiling in gels and tissue due to high intensity focused ultrasound. Ultrasound Med Biol. 2010, 36: 250-67. 10.1016/j.ultrasmedbio.2009.09.010.
21. Khokhlova VA, Bailey MR, Reed JA, Cunitz BW, Kaczkowski PJ, Crum LA: Effects of nonlinear propagation, cavitation, and boiling in lesion formation by high intensity focused ultrasound in a gel phantom. J Acoust Soc Am. 2006, 119: 1834-48. 10.1121/1.2161440.
22. Khokhlova TD, Canney MS, Lee D, Marro KI, Crum LA, Khokhlova VA, Bailey MR: Magnetic resonance imaging of boiling induced by high intensity focused ultrasound. J Acoust Soc Am. 2009, 125: 2420-31. 10.1121/1.3081393.
23. Tung YS, Liu HL, Wu CC, Ju KC, Chen WS, Lin WL: Contrast-agent-enhanced ultrasound thermal ablation. Ultrasound Med Biol. 2006, 32: 1103-10. 10.1016/j.ultrasmedbio.2006.04.005.
24. Luo W, Zhou X, Ren X, Zheng M, Zhang J, He G: Enhancing effects of SonoVue, a microbubble sonographic contrast agent, on high-intensity focused ultrasound ablation in rabbit livers in vivo. J Ultrasound Med. 2007, 26: 469-76.
25. Luo W, Zhou X, He G, Li Q, Zheng X, Fan Z, Liu Q, Yu M, Han Z, Zhang J, Qian Y: Ablation of high intensity focused ultrasound combined with SonoVue on rabbit VX2 liver tumors: assessment with conventional gray-scale US, conventional color/power Doppler US, contrast-enhanced color Doppler US, and contrast-enhanced pulse-inversion harmonic US. Ann Surg Oncol. 2008, 15: 2943-53. 10.1245/s10434-008-0032-x.
26. Porter TM, Smith DA, Holland CK: Acoustic techniques for assessing the Optison destruction threshold. J Ultrasound Med. 2006, 25: 1519-29.
27. Ferrara K, Pollard R, Borden M: Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery. Annu Rev Biomed Eng. 2007, 9: 415-47. 10.1146/annurev.bioeng.8.061505.095852.
28. Farny CH, Wu TM, Holt RG, Murray TW, Roy RA: Nucleating cavitation from laser-illuminated nano-particles. Acoust Res Lett Onl. 2005, 6: 138-43. 10.1121/1.1897823.
29. Zhang P, Porter T: An in vitro study of a phase-shift nanoemulsion: a potential nucleation agent for bubble-enhanced HIFU tumor ablation. Ultrasound Med Biol. 2010, 36: 1856-66. 10.1016/j.ultrasmedbio.2010.07.001.
30. Sheeran PS, Luois S, Dayton PA, Matsunaga TO: Formulation and acoustic studies of a new phase-shift agent for diagnostic and therapeutic ultrasound. Langmuir. 2011, 27: 10412-20. 10.1021/la2013705.
31. Rapoport NY, Kennedy AM, Shea JE, Scaife CL, Nam KH: Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles. J Control Release. 2009, 138: 268-76. 10.1016/j.jconrel.2009.05.026.
32. Clasohm LY, Vakarelski IU, Dagastine RR, Chan DY, Stevens GW, Grieser F: Anomalous pH dependent stability behavior of surfactant-free nonpolar oil drops in aqueous electrolyte solutions. Langmuir. 2007, 23: 9335-40. 10.1021/la701568r.
33. Antoine C: Tensions des vapeurs; nouvelle relation entre les tensions et les temperatures. Comptes Rendus des Seances de l'Academie des Sci. 1888, 107: 681-4.
34. Yaws CL, Yang HC: To estimate vapor pressure easily: Antoine coefficients relate vapor pressure to temperature for almost 700 major organic compounds. Hydrocarb Process. 1989, 68: 65-8.
35. Kripfgans OD, Fowlkes JB, Miller DL, Eldevik OP, Carson PL: Acoustic droplet vaporization for therapeutic and diagnostic applications. Ultrasound Med Biol. 2000, 26: 1177-89. 10.1016/S0301-5629(00)00262-3.
36. Gahn G, Ackerman RH, Candia MR, Barrett KM, Lev MH, Huang AY: Dodecafluoropentane ultrasonic contrast enhancement in carotid diagnosis: preliminary results. J Ultrasound Med. 1999, 18: 101-8.
37. Maeda H, Wu J, Sawa T, Matsumura Y, Hori K: Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release. 2000, 65: 271-84. 10.1016/S0168-3659(99)00248-5.
38. Torchilin VP: Multifunctional nanocarriers. Adv Drug Deliv Rev. 2006, 58: 1532-55. 10.1016/j.addr.2006.09.009.
39. Lafon C, Zderic V, Noble ML, Yuen JC, Kaczkowski PJ, Sapozhnikov OA, Chavrier F, Crum LA, Vaezy S: Gel phantom for use in high-intensity focused ultrasound dosimetry. Ultrasound Med Biol. 2005, 31: 1383-9. 10.1016/j.ultrasmedbio.2005.06.004.
40. Maruvada S, Harris GR, Herman BA, King RL: Acoustic power calibration of high-intensity focused ultrasound transducers using a radiation force technique. J Acoust Soc Am. 2007, 121: 1434-9. 10.1121/1.2431332.
41. Lo AH, Kripfgans OD, Carson PL, Rothman ED, Fowlkes JB: Acoustic droplet vaporization threshold: effects of pulse duration and contrast agent. IEEE Trans Ultrason Ferroelectr Freq Control. 2007, 54: 933-46.
42. Morris H, Rivens I, Shaw A, Haar GT: Investigation of the viscous heating artefact arising from the use of thermocouples in a focused ultrasound field. Phys Med Biol. 2008, 53: 4759-76. 10.1088/0031-9155/53/17/020.
43. Lai P, McLaughlan JR, Draudt AB, Murray TW, Cleveland RO, Roy RA: Real-time monitoring of high-intensity focused ultrasound lesion formation using acousto-optic sensing. Ultrasound Med Biol. 2011, 37: 239-52. 10.1016/j.ultrasmedbio.2010.11.004.
44. Sheeran PS, Wong VP, Luois S, McFarland RJ, Ross WD, Feingold S, Matsunaga TO, Dayton PA: Decafluorobutane as a phase-change contrast agent for low-energy extravascular ultrasonic imaging. Ultrasound Med Biol. 2011, 37: 1518-30. 10.1016/j.ultrasmedbio.2011.05.021.
45. Kyriakou Z, Corral-Baques MI, Amat A, Coussios CC: HIFU-induced cavitation and heating in ex vivo porcine subcutaneous fat. Ultrasound Med Biol. 2011, 37: 568-79. 10.1016/j.ultrasmedbio.2011.01.001.
46. Yoshioka H: Surface modification of haemoglobin-containing liposomes with polyethylene glycol prevents liposome aggregation in blood plasma. Biomaterials. 1991, 12: 861-4. 10.1016/0142-9612(91)90075-L.
47. Johnsson M, Edwards K: Phase behavior and aggregate structure in mixtures of dioleoylphosphatidylethanolamine and poly(ethylene glycol)-lipids. Biophys J. 2001, 80: 313-23. 10.1016/S0006-3495(01)76016-X.
48. Klibanov AL, Maruyama K, Torchilin VP, Huang L: Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett. 1990, 268: 235-7. 10.1016/0014-5793(90)81016-H.
49. Litzinger DC, Buiting AM, van Rooijen N, Huang L: Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes. Biochim Biophys Acta. 1994, 1190: 99-107. 10.1016/0005-2736(94)90038-8.
50. Allen TM, Hansen C, Martin F, Redemann C, Yau-Young A: Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo. Biochim Biophys Acta. 1991, 1066: 29-36. 10.1016/0005-2736(91)90246-5.
51. Gabizon A, Shmeeda H, Barenholz Y: Pharmacokinetics of pegylated liposomal Doxorubicin: review of animal and human studies. Clin Pharmacokinet. 2003, 42: 419-36. 10.2165/00003088-200342050-00002.
52. Lafon C, Murillo-Rincon A, Goldenstedt C, Chapelon JY, Mithieux F, Owen NR, Cathignol D: Feasibility of using ultrasound contrast agents to increase the size of thermal lesions induced by non-focused transducers: in vitro demonstration in tissue mimicking phantom. Ultrasonics. 2009, 49: 172-8. 10.1016/j.ultras.2008.07.013.
53. Luo W, Zhou X, Yu M, He G, Zheng X, Li Q, Liu Q, Han Z, Zhang J, Qian Y: Ablation of high-intensity focused ultrasound assisted with SonoVue on Rabbit VX2 liver tumors: sequential findings with histopathology, immunohistochemistry, and enzyme histochemistry. Ann Surg Oncol. 2009, 16: 2359-68. 10.1245/s10434-009-0419-3.
54. Kaneko Y, Maruyama T, Takegami K, Watanabe T, Mitsui H, Hanajiri K, Nagawa H, Matsumoto Y: Use of a microbubble agent to increase the effects of high intensity focused ultrasound on liver tissue. Eur Radiol. 2005, 15: 1415-20. 10.1007/s00330-005-2663-7.
55. Bailey MR, Couret LN, Sapozhnikov OA, Khokhlova VA, ter Haar G, Vaezy S, Shi X, Martin R, Crum LA: Use of overpressure to assess the role of bubbles in focused ultrasound lesion shape in vitro. Ultrasound Med Biol. 2001, 27: 695-708. 10.1016/S0301-5629(01)00342-8.
56. McLaughlan J, Rivens I, Leighton T, Ter Haar G: A study of bubble activity generated in ex vivo tissue by high intensity focused ultrasound. Ultrasound Med Biol. 2010, 36: 1327-44. 10.1016/j.ultrasmedbio.2010.05.011.
57. Meaney PM, Cahill MD, ter Haar GR: The intensity dependence of lesion position shift during focused ultrasound surgery. Ultrasound Med Biol. 2000, 26: 441-50. 10.1016/S0301-5629(99)00161-1.