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Volumn , Issue , 2013, Pages 193-208

Bio-complexity: Challenging reductionism

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EID: 85013709333     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-4998-0_12     Document Type: Chapter
Times cited : (22)

References (44)
  • 2
    • 54849148600 scopus 로고    scopus 로고
    • The conflict between complex systems and reductionism
    • Heng HH. The conflict between complex systems and reductionism. JAMA. 2008;300:1580-1.
    • (2008) JAMA , vol.300 , pp. 1580-1581
    • Heng, H.H.1
  • 6
    • 68449086236 scopus 로고    scopus 로고
    • Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    • The International Schizophrenia Consortium. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature. 2009;460:748-52.
    • (2009) Nature , vol.4 , Issue.60 , pp. 748-752
  • 8
    • 77958102017 scopus 로고    scopus 로고
    • Missing heritability and stochastic genome alterations
    • Heng HH. Missing heritability and stochastic genome alterations. Nat Rev Genet. 2010;11:813.
    • (2010) Nat Rev Genet , vol.11 , pp. 813
    • Heng, H.H.1
  • 11
    • 68249134187 scopus 로고    scopus 로고
    • How much is life worth: Cetuximab, non-small cell lung cancer, and a $440 billion question
    • Fojo T, Grady C. How much is life worth: cetuximab, non-small cell lung cancer, and a $440 billion question. J Natl Cancer Inst. 2009;101:1044-8.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 1044-1048
    • Fojo, T.1    Grady, C.2
  • 12
    • 34047151849 scopus 로고    scopus 로고
    • The disconnection between tumor response and survival
    • Mittra I. The disconnection between tumor response and survival. Nat Clin Pract Oncol. 2007;4:203.
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 203
    • Mittra, I.1
  • 13
    • 77957984508 scopus 로고    scopus 로고
    • Genetic and epigenetic heterogeneity in cancer: The ultimate challenge for drug therapy
    • Heng HH, Liu G, Stevens JB, Bremer SW, Ye KJ, Ye CJ. Genetic and epigenetic heterogeneity in cancer: the ultimate challenge for drug therapy. Curr Drug Targets. 2010;11:1304-16.
    • (2010) Curr Drug Targets , vol.11 , pp. 1304-1316
    • Heng, H.H.1    Liu, G.2    Stevens, J.B.3    Bremer, S.W.4    Ye, K.J.5    Ye, C.J.6
  • 14
    • 4043075127 scopus 로고    scopus 로고
    • Cancer prevention strategies that address the evolutionary dynamics of neoplastic cells: Simulating benign cell boosters and selection for chemosensitivity
    • Maley CC, Reid BJ, Forrest S. Cancer prevention strategies that address the evolutionary dynamics of neoplastic cells: simulating benign cell boosters and selection for chemosensitivity. Cancer Epidemiol Biomarkers Prev. 2004;13:1375-84.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 1375-1384
    • Maley, C.C.1    Reid, B.J.2    Forrest, S.3
  • 16
    • 33947393565 scopus 로고    scopus 로고
    • Mapping the cancer genome. Pinpointing the genes involved in cancer will help chart a new course across the complex landscape of human malignancies
    • Collins FS, Barker AD. Mapping the cancer genome. Pinpointing the genes involved in cancer will help chart a new course across the complex landscape of human malignancies. Sci Am. 2007;296:50-7.
    • (2007) Sci Am , vol.296 , pp. 50-57
    • Collins, F.S.1    Barker, A.D.2
  • 17
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med. 2004;10:789-99.
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 18
    • 34547641984 scopus 로고    scopus 로고
    • Cancer genome sequencing: The challenges ahead
    • Heng HH. Cancer genome sequencing: The challenges ahead. BioEssays. 2007;29:783-94.
    • (2007) BioEssays , vol.29 , pp. 783-794
    • Heng, H.H.1
  • 19
    • 35748947286 scopus 로고    scopus 로고
    • Systems and complexity thinking in general practice: Part 1 - clinical application
    • Sturmberg JP. Systems and complexity thinking in general practice: part 1 - clinical application. Aust Fam Physician. 2007;36:170-3.
    • (2007) Aust Fam Physician , vol.36 , pp. 170-173
    • Sturmberg, J.P.1
  • 20
    • 66449129067 scopus 로고    scopus 로고
    • The genome-centric concept: Resynthesis of evolutionary theory
    • Heng HH. The genome-centric concept: resynthesis of evolutionary theory. Bioessays. 2009;31:512-25.
    • (2009) Bioessays , vol.31 , pp. 512-525
    • Heng, H.H.1
  • 24
  • 25
    • 72549104482 scopus 로고    scopus 로고
    • Heterogeneity is not always noise lessons from improvement
    • Davidoff F. Heterogeneity is not always noise lessons from improvement. JAMA. 2009;302:2580-6.
    • (2009) JAMA , vol.302 , pp. 2580-2586
    • Davidoff, F.1
  • 26
    • 0021242388 scopus 로고
    • Tumor heterogeneity
    • Heppner GH. Tumor heterogeneity. Cancer Res. 1984; 44:2259-65.
    • (1984) Cancer Res , vol.44 , pp. 2259-2265
    • Heppner, G.H.1
  • 27
    • 79951481957 scopus 로고    scopus 로고
    • Initial impact of the sequencing of the human genome
    • Lander ES. Initial impact of the sequencing of the human genome. Nature. 2011; 470:187-97.
    • (2011) Nature , vol.470 , pp. 187-197
    • Lander, E.S.1
  • 31
    • 34547614739 scopus 로고    scopus 로고
    • Elimination of altered karyotypes by sexual reproduction preserves species identity
    • Heng HH. Elimination of altered karyotypes by sexual reproduction preserves species identity. Genome. 2007; 50: 517-524.
    • (2007) Genome , vol.50 , pp. 517-524
    • Heng, H.H.1
  • 32
    • 61549083373 scopus 로고    scopus 로고
    • The evolution of meiosis from mitosis
    • Wilkins and Holliday. The evolution of meiosis from mitosis. Genetics. 2009; 181: 2-12.
    • (2009) Genetics , vol.181 , pp. 2-12
  • 33
    • 70450284334 scopus 로고    scopus 로고
    • Origin and maintenance of sex: The evolutionary joys of self sex
    • Gorelick R and Carpione. J. Origin and maintenance of sex: the evolutionary joys of self sex. Biol. J. Soc. 2009; 98: 707-728.
    • (2009) Biol. J. Soc , vol.98 , pp. 707-728
    • Gorelick, R.1    Carpione, J.2
  • 34
    • 79953304054 scopus 로고    scopus 로고
    • Sex reduces genetic variation: A multidisciplinary review
    • Gorelick R and Heng HH. Sex reduces genetic variation: a multidisciplinary review. 2011; Evolution. 64: 1088-1098.
    • (2011) Evolution , vol.64 , pp. 1088-1098
    • Gorelick, R.1    Heng, H.H.2
  • 35
    • 85028888704 scopus 로고    scopus 로고
    • Preface: Back to the future
    • (in press)
    • Heng HH. Preface: Back to the future. Cytogenet Genome Res 2012; (in press).
    • (2012) Cytogenet Genome Res
    • Heng, H.H.1
  • 40
    • 61449171881 scopus 로고    scopus 로고
    • 2009 Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient
    • Amariglio N, Hirshberg A, Scheithauer BW, Cohen Y, Loewenthal R, et al. 2009 Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient. PLoS Med 2009; 6: e1000029.
    • (2009) PLoS Med , vol.6 , pp. e1000029
    • Amariglio, N.1    Hirshberg, A.2    Scheithauer, B.W.3    Cohen, Y.4    Loewenthal, R.5
  • 43
    • 79951633793 scopus 로고    scopus 로고
    • Ten questions for evolutionary studies of diseases vulnerability
    • 2011
    • Nesse RM. Ten questions for evolutionary studies of diseases vulnerability. 2011; Evolutionary Applications 4:264-277, 2011
    • (2011) Evolutionary Applications , vol.4 , pp. 264-277
    • Nesse, R.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.