Spine stereotactic radiosurgery with concurrent tyrosine kinase inhibitors for metastatic renal cell carcinoma

Journal of Neurosurgery: Spine

Volumn 25, Issue 6, 2016, Pages 766-774

  Miller, Jacob A ^a   Balagamwala, Ehsan H ^a   Angelov, Lilyana ^a,b   Suh, John H ^a,b   Rini, Brian ^a   Garcia, Jorge A ^a   Ahluwalia, Manmeet ^a,b   Chao, Samuel T ^a,b  

^a TAUSSIG CANCER INSTITUTE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Oncology; Renal cell carcinoma; Spine radiosurgery; Tyrosine kinase inhibitors

Indexed keywords

AXITINIB; BEVACIZUMAB; EVEROLIMUS; PAZOPANIB; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; SUNITINIB; TEMSIROLIMUS; ANTINEOPLASTIC AGENT; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE;

ADULT; AGED; ARTICLE; CANCER CONTROL; CANCER PROGNOSIS; COHORT ANALYSIS; CONE BEAM COMPUTED TOMOGRAPHY; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEMALE; FOLLOW UP; HUMAN; HYPOFRACTIONATED RADIOTHERAPY; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; POSTOPERATIVE PAIN; RADIOTHERAPY DOSAGE; RENAL CELL CARCINOMA; RETROSPECTIVE STUDY; SPINAL CORD METASTASIS; SPINE FRACTURE; SPINE SURGERY; STEREOTACTIC RADIOSURGERY; SYSTEMIC THERAPY; WHOLE BRAIN RADIOTHERAPY; ADVERSE EFFECTS; ANTAGONISTS AND INHIBITORS; CARCINOMA, RENAL CELL; DRUG EFFECTS; KIDNEY NEOPLASMS; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PATHOLOGY; PROCEDURES; RADIOSURGERY; SECONDARY; SPINAL NEOPLASMS; SPINE; SURGERY; TREATMENT FAILURE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; CARCINOMA, RENAL CELL; COMBINED MODALITY THERAPY; FEMALE; HUMANS; KIDNEY NEOPLASMS; MALE; MIDDLE AGED; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; RADIOSURGERY; RETROSPECTIVE STUDIES; SPINAL NEOPLASMS; SPINE; TREATMENT FAILURE;

EID: 85013697350     PISSN: 15475654     EISSN: 15475646     Source Type: Journal    
DOI: 10.3171/2016.4.SPINE16229     Document Type: Article

References (30)

1. Ahluwalia MS, Chao ST, Parsons MW, Suh JH, Wang D, Mikkelsen T, et al: Phase II trial of sunitinib as adjuvant therapy after stereotactic radiosurgery in patients with 1-3 newly diagnosed brain metastases. J Neurooncol 124:485-491, 2015
2. Azad A, Maddison C, Stewart J: Radiation recall dermatitis induced by pazopanib. Onkologie 36:674-676, 2013
3. Balagamwala EH, Angelov L, Koyfman SA, Suh JH, Reddy CA, Djemil T, et al: Single-fraction stereotactic body radiotherapy for spinal metastases from renal cell carcinoma. J Neurosurg Spine 17:556-564, 2012
4. Balagamwala EH, Chao ST, Suh JH: Principles of radiobiology of stereotactic radiosurgery and clinical applications in the central nervous system. Technol Cancer Res Treat 11:3-13, 2012
5. Basille D, Andrejak M, Bentayeb H, Kanaan M, Fournier C, Lecuyer E, et al: Bronchial fistula associated with sunitinib in a patient previously treated with radiation therapy. Ann Pharmacother 44:383-386, 2010
6. Chang EL, Shiu AS, Mendel E, Mathews LA, Mahajan A, Allen PK, et al: Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. J Neurosurg Spine 7:151-160, 2007
7. Cox BW, Jackson A, Hunt M, Bilsky M, Yamada Y: Esophageal toxicity from high-dose, single-fraction paraspinal stereotactic radiosurgery. Int J Radiat Oncol Biol Phys 83:e661-e667, 2012
8. Inoue T, Kinoshita H, Komai Y, Kawabata T, Kawa G, Uemura Y, et al: Two cases of gastrointestinal perforation after radiotherapy in patients receiving tyrosine kinase inhibitor for advanced renal cell carcinoma. World J Surg Oncol 10:167, 2012
9. Jung DL, Balagamwala EH, Angelov L, Suh JH, Reddy CA, Djemil T, et al: Incidence and risk factors for pain flare following spine radiosurgery. Int J Radiat Oncol Biol Phys 87 Suppl:S568-S569, 2013 (Abstract)
10. Kao J, Chen CT, Tong CCL, Packer SH, Schwartz M, Chen SH, et al: Concurrent sunitinib and stereotactic body radiotherapy for patients with oligometastases: Final report of a prospective clinical trial. Target Oncol 9:145-153, 2014
11. Koyfman SA, Djemil T, Burdick MJ, Woody N, Balagamwala EH, Reddy CA, et al: Marginal recurrence requiring salvage radiotherapy after stereotactic body radiotherapy for spinal metastases. Int J Radiat Oncol Biol Phys 83:297-302, 2012
12. Lam JS, Leppert JT, Belldegrun AS, Figlin RA: Novel approaches in the therapy of metastatic renal cell carcinoma. World J Urol 23:202-212, 2005
13. Mauceri HJ, Hanna NN, Beckett MA, Gorski DH, Staba MJ, Stellato KA, et al: Combined effects of angiostatin and ionizing radiation in antitumour therapy. Nature 394:287-291, 1998
14. Motzer RJ, Bander NH, Nanus DM: Renal-cell carcinoma. N Engl J Med 335:865-875, 1996
15. Motzer RJ, Hutson TE, Cella D, Reeves J, Hawkins R, Guo J, et al: Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med 369:722-731, 2013
16. Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S, et al: Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 27:3584- 3590, 2009
17. Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, et al: Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356:115-124, 2007
18. Neri A, Lambert Y, Marrelli D, Di Mare G, Mastrogiacomo D, Corso G, et al: Gastro-pleuro-pericardial fistula following combined radiation and chemotherapy for lung metastases from renal cell carcinoma: Report of a case. Surg Today 43:1457-1460, 2013
19. Nguyen QN, Shiu AS, Rhines LD, Wang H, Allen PK, Wang XS, et al: Management of spinal metastases from renal cell carcinoma using stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys 76:1185-1192, 2010
20. Ryu S, Pugh SL, Gerszten PC, Yin FF, Timmerman RD, Hitchcock YJ, et al: RTOG 0631 Phase 2/3 study of image guided stereotactic radiosurgery for localized (1-3) spine metastases: Phase 2 results. Pract Radiat Oncol 4:76-81, 2014
21. Ryu S, Pugh SL, Gerszten PC, Yin FF, Timmerman RD, Hitchcock YJ, et al: RTOG 0631 Phase II/III study of imageguided stereotactic radiosurgery for localized (1-3) spine metastases: Phase II results. Int J Radiat Oncol Biol Phys 81:S131-S132, 2011
22. Sahgal A, Atenafu EG, Chao S, Al-Omair A, Boehling N, Balagamwala EH, et al: Vertebral compression fracture after spine stereotactic body radiotherapy: A multi-institutional analysis with a focus on radiation dose and the spinal instability neoplastic score. J Clin Oncol 31:3426-3431, 2013
23. Schueneman AJ, Himmelfarb E, Geng L, Tan J, Donnelly E, Mendel D, et al: SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer Res 63:4009-4016, 2003
24. Staehler M, Haseke N, Nuhn P, Tüllmann C, Karl A, Siebels M, et al: Simultaneous anti-angiogenic therapy and singlefraction radiosurgery in clinically relevant metastases from renal cell carcinoma. BJU Int 108:673-678, 2011
25. Straka C, Kim DWN, Timmerman RD, Pedrosa I, Jacobs C, Brugarolas J: Ablation of a site of progression with stereotactic body radiation therapy extends sunitinib treatment from 14 to 22 months. J Clin Oncol 31:e401-e403, 2013
26. Thibault I, Al-Omair A, Masucci GL, Masson-Côté L, Lochray F, Korol R, et al: Spine stereotactic body radiotherapy for renal cell cancer spinal metastases: Analysis of outcomes and risk of vertebral compression fracture. J Neurosurg Spine 21:711-718, 2014
27. Vickers MM, Al-Harbi H, Choueiri TK, Kollmannsberger C, North S, MacKenzie M, et al: Prognostic factors of survival for patients with metastatic renal cell carcinoma with brain metastases treated with targeted therapy: Results from the international metastatic renal cell carcinoma database consortium. Clin Genitourin Cancer 11:311-315, 2013
28. Wuthrick EJ, Curran WJ Jr, Camphausen K, Lin A, Glass J, Evans J, et al: A pilot study of hypofractionated stereotactic radiation therapy and sunitinib in previously irradiated patients with recurrent high-grade glioma. Int J Radiat Oncol Biol Phys 90:369-375, 2014
29. Yuasa T, Kitsukawa S, Sukegawa G, Yamamoto S, Kudo K, Miyazawa K, et al: Early onset recall pneumonitis during targeted therapy with sunitinib. BMC Cancer 13:3, 2013
30. Zhu H, Wang Z, Xu Q, Zhang Y, Zhai Y, Bai J, et al: Inhibition of STAT1 sensitizes renal cell carcinoma cells to radiotherapy and chemotherapy. Cancer Biol Ther 13:401-407, 2012