Serum uric acid level and association with cognitive impairment and dementia: systematic review and meta-analysis

Age

Volumn 38, Issue 1, 2016, Pages 1-11

  Khan, Aamir A ^a   Quinn, Terence J ^a   Hewitt, Jonathan ^b   Fan, Yuhua ^c   Dawson, Jesse ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cognition; Dementia; Meta analysis; Systematic review; Uric acid

Indexed keywords

URIC ACID;

ALZHEIMER DISEASE; CASE CONTROL STUDY; COGNITION; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; MULTIINFARCT DEMENTIA; PARKINSON DISEASE; PUBLISHING; REVIEW; SYSTEMATIC REVIEW; TIME SERIES ANALYSIS; URIC ACID BLOOD LEVEL; AGING; BLOOD; COGNITIVE DEFECT; DEMENTIA; DISEASE COURSE; META ANALYSIS; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PHYSIOLOGY;

AGING; COGNITION; COGNITIVE DYSFUNCTION; DEMENTIA; DISEASE PROGRESSION; HUMANS; NEUROPSYCHOLOGICAL TESTS; URIC ACID;

EID: 85013697123     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-016-9871-8     Document Type: Review

References (56)

1. Afsar B, Elsurer R, Covic A et al (2011) Relationship between uric acid and subtle cognitive dysfunction in chronic kidney disease. Am J Nephrol 34:49–54
2. Ahlskog JE, Uitti RJ, Low PA et al (1995) No evidence for systemic oxidant stress in Parkinson’s or Alzheimer’s disease. Mov Disord 10(5):566–573
3. Annanmaki T, Pessala-Driver A, Hokkanen L et al (2008) Uric acid associates with cognition in Parkinson’s disease. Parkinsonism Relat Disord 14:576–578
4. Annanmaki T, Pohja M, Parviainn T et al (2011) Uric acid and cognition in Parkinson’s disease: a follow-up study. Parkinsonism Relat Disord 17:333–337
5. Ascherio A, LeWitt PA, Xu K (2009) Urate as a predictor of the rate of clinical decline in Parkinson disease. Arch Neurol 66 (12)
6. Baldieras I, Santana I, Proenca MT et al (2008) Peripheral oxidative damage in mild cognitive impairment and mild Alzheimer’s disease. J Alzheimers Dis 15:117–128
7. Bowman GL, Shannon J, Frei B (2010) Uric acid as a CNS antioxidant. J Alzheimers Dis 19(4):1331–1336. doi:10.3233/JAD-2010-1330
8. Can M, Varlibas F, Guven B (2013) Ischemia modified albumin and plasma oxidative stress markers in Alzheimer’s disease. Eur Neurol 69:377–380
9. Cankurtaran M, Yesil Y, Kuyumcu ME et al (2013) Altered levels of homocysteine and serum natural antioxidants links oxidative damage to Alzheimer’s disease. J Alzheimers Dis 33(4):1051–1058. doi:10.3233/JAD-2012-121630
10. Cascalheira JF, Joao SS, Pinhancos SS (2009) Serum homocysteine: interplay with other circulating and genetic factors in association to Alzheimer’s type dementia. Clin Biochem 42:783–790
11. Cervelatti C, Cremonini E, Bosi C (2013) Systemic oxidative stress in older patients with mild cognitive impairment or late onset Alzheimer’s disease. Curr Alzheimer Res 10:000–000
12. Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G (2004) Purine-rich foods, dairy and protein intake, and the risk of gout in men. N Engl J Med 350:1093–1103
13. Cicero AF, Desideri G, Grossi G (2014) Serum uric acid and impaired cognitive function in a cohort of healthy young elderly: data from the Brisighella study. Intern Emerg Med
14. Dawson J, Walters M (2006) Uric acid and xanthine oxidase: future therapeutic targets in the prevention of cardiovascular disease? Br J Clin Pharmacol 62:633–644
15. Euser SM, Hofman A, Westendrop RGJ (2009) Serum uric acid and cognitive function and dementia. Brain 132:377–382
16. Folstein MF, Fosltein SE, McHugh PR (1975) “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3):189–198
17. Foy CJ, Passmore AP, Vahidassr MD et al (1999) Plasma chain-breaking antioxidants in Alzheimer’s disease, vascular dementia and Parkinson’s disease. Q J Med 92:39–45
18. Gackowski D, Rozalski R, Siomek A (2008) Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia. J Neurol Sci 266:57–62
19. González-Aramburu I, Sánchez-Juan P, Sierra M (2014) Serum uric acid and risk of dementia in Parkinson’s disease. Parkinsonism Relat Disord 20(6):637–639
20. Hemingway H, Croft P, Perel P (2013) Prognosis research strategy (PROGRESS) 1: a framework for researching clinical outcomes. BMJ 346:e5595
21. Higgin JPT, Altman DB, Sterne JAC (2011) Chapter 8: assessing risk of bias in included studies. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 Updated March
22. Irizarry MC, Raman R, Schwarzschild MA (2009) Plasma urate and progression of mild cognitive impairment. Neurodegener Dis 6:23–28
23. Iuliano L, Monticolo R, Straface G (2010) Vitamin E and enzymatic/oxidative stress-driven oxysterols in amnestic mild cognitive impairment subtypes and Alzheimer’s disease. J Alzheimers Dis 21:1383–1392
24. Kasa M, Bierma TJ, Waterstraat F Jr et al (1989) Routine blood chemistry screen: a diagnostic aid for Alzheimer’s disease. Neuroepidemiology 8(5):254–261
25. Kim TS, Pae CU, Yun SJ (2006) Decreased plasma antioxidants in patients with Alzheimer’s disease. Int J Geriatr Psychiatry 21:344–348
26. Li J, Dong BR, Lin P (2010) Association of cognitive function with serum uric acid level among Chinese nonagenarians and centenarians. Exp Gerontol 45(5):331–335
27. Li W, Zhao P, Zhao X-J, Li Z-K (2012) Clinic Focus 27:1508–1509
28. Madan P, Kalra OP, Agarwal S et al (2007) Cognitive impairment in chronic kidney disease. Nephrol Dial Transplant 22:440–444
29. Maesaka JK, Wolf-Klein G, Piccione JM et al (1993) Hypouricemia, abnormal renal tubular urate transport, and plasma natriuretic factor(s) in patients with Alzheimer's disease. J Am Geriatr Soc 41(5):501–506
30. Maetzler W, Stapf AK, Schulte C et al (2011) Serum and cerebrospinal fluid uric acid levels in Lewy body disorders: associations with disease occurrence and amyloid-B pathway. J Alzheimers Dis 27:119–126
31. Matsubayashi K, Matsumoto M, Kawamoto A et al (1988) Hematocrit, serum lipids and cardiovascular indices as risk factors in vascular dementia. Jpn J Geriatr 25:576–580
32. Moccia M, Piccilo M, Erro R et al (2014) I s serum uric acid related to non-motor symptoms in de-novo Parkinson’s disease patients? Parkinsonism Relat Disord 20(7):772–775. doi:10.1016/j.parkreldis.2014.03.016
33. Pan M, Gao H, Long L et al (2013) Serum uric acid in patients with Parkinson’s disease and vascular parkinsonism: a cross-sectional stud. Neuroimmunomodulation 20:19–28
34. Polidori MC, Meococci P (2002) Plasma susceptibility to free radical-induced al1tioxidant consumptiol1 and lipid peroxidation is increased in very old subjects with Alzheimer disease. J Alzheimers Dis 4(6):517–522
35. Polidori MC, Mattioli P, Aldred S (2004) Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia. Dement Geriatr Cogn Disord 18(3-4):265–270
36. Pulido R, Jimenez-Escrig A, Orensanz L et al (2005) Study of plasma antioxidant status in Alzheimer’s disease. Eur J Neurol 12:531–535
37. Qin JB, Yang MH (2009) Clin Focus 24:57–58
38. Reyes AJ (2003) Cardiovascular drugs and serum uric acid. Cardiovasc Drugs Ther 17:397–414
39. Rinaldi P, Polidori MC, Metastasio X et al (2003) Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer’s disease. Neurobiol Aging 24:915–919
40. Ruggiero Cherubini A, Lauretani F et al (2009) Uric acid and dementia in community-dwelling older persons. Dement Geriatr Cogn Disord 27:382–389
41. Schretlen DJ, Inscore AB, Vannorsdall TD et al (2007) Serum uric acid and brain ischemia in normal elderly adults. Neurology 69:1418–1423
42. Shang X, Zhang F, Meng L et al (2009) Relationship between the level of serum uric acid and alzheimer’s disease. J China Med Univ 38(5)
43. Stroup DF, Berlin JA, Morton SC et al (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA 283:2008–2012
44. Tohgi H, Abe T, Takahashi S et al (1993) The urate and xanthine concentrations in the cerebrospinal fluid in patients with vascular dementia of the Binswanger type, Alzheimer type dementia, and Parkinson’s disease. J Neural Transm 6:119–126
45. Vanorsdall TD, Jinnah HA, Gordon B, Kraut M, Schrelten D (2008) Cerebral ischemia mediates the effect of serum uric acid on cognitive function. Stroke 39:3418–3420
46. Verhaaren BF, Vernooji MW, Dehghen A et al (2013) The relation of uric acid to brain atrophy and cognition: the Rotterdam Scan Study. Neuroepidemiology 41(1):29–34. doi:10.1159/000346606
47. von Elm E, Altman DG, Egger M (2008) The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol 61(4):344–349. doi:10.1016/j.jclinepi.2007.11.008
48. Wang X, Luo W, Wang L et al (2009) Study on uric acid and the related factors associated with cognition in the patients with Parkinson’s disease. Zhonghua Yi Xue Za Zhi 89(23):1633–1635
49. Wells GA, Shea B, O’Connell D et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. Available from: URL: http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm
50. Wen S, Minfeng C, Houliang W et al (2012) Serum uric acid levels and the clinical characteristics of depression. Clin Biochem 45:49–53
51. Wikkelso C, Blomstrand C, Nordquist P (1981) Cerebrospinal fluid investigations in multi-infarct dementia and senile dementia. Acta Neurol Scand 64:1–11
52. Wu Y, Zhang D, Pang Z et al (2013) Association of serum uric acid level with muscle strength and cognitive function among Chinese aged 50–74 years. Geriatr Gerontol Int 13:672–677
53. Yoldas TK, Keklikoglu H, Zengin O et al (2010) Relation of serum uric acid level with cognitive functions and number of plaques in patients with relapsing remitting multiple sclerosis. Nöropsikiyatri Arşivi 47:333–337
54. You Z, Liu D (2012) The relationship of serum uric acid level with depression and cognitive dysfunction in elderly patients with PD. Chinese J Rehabil 27(4)
55. Yu ZF, Bruce-Keller AJ, Goodman Y, Mattson MP (1998) Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo. J Neurosci Res 53:613–625
56. Zafrilla P, Mulero J, Xandri JM et al (2006) Oxidative stress in alzheimer patients in different stages of the disease. Current I(iI,'illal Chemistr) 13:1075-1 OS]