Relationship between uric acid and subtle cognitive dysfunction in chronic kidney disease

American Journal of Nephrology

Volumn 34, Issue 1, 2011, Pages 49-54

  Afsar, Baris ^a   Elsurer, Rengin ^a   Covic, Adrian ^c   Johnson, Richard J ^d   Kanbay, Mehmet ^b,e  

^a Zonguldak State Hospital   (Turkey)

^b Kayseri Training and Research Hospital ^*  (Turkey)

^c GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^e Alparslan Mahallesi   (Turkey)

Author keywords

Chronic kidney disease; Cognitive function; Uric acid

Indexed keywords

URIC ACID;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CEREBROVASCULAR DISEASE; CHRONIC KIDNEY DISEASE; COGNITIVE DEFECT; DISEASE ASSOCIATION; EDUCATIONAL STATUS; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; PRIORITY JOURNAL; URIC ACID BLOOD LEVEL;

AGE FACTORS; AGED; CEREBROVASCULAR DISORDERS; COGNITION DISORDERS; EDUCATIONAL STATUS; FEMALE; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; PSYCHOLOGICAL TESTS; RENAL INSUFFICIENCY, CHRONIC; URIC ACID;

EID: 79958057024     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000329097     Document Type: Article

References (47)

1. Kurella M, Chertow GM, Fried LF, et al: Chronic kidney disease and cognitive impairment in the elderly: the health, aging, and body composition study. J Am Soc Nephrol 2005; 16: 2127-2133. (Pubitemid 41716444) (Pubitemid 41716444)
2. Kurella M, Yaffe K, Shlipak MG, Wenger NK and Chertow GM: Chronic kidney disease and cognitive impairment in menopausal women. Am J Kidney Dis 2005; 45: 66-76. (Pubitemid 40038046) (Pubitemid 40038046)
3. Kurella Tamura M, Wadley V, Yaffe K, et al: Kidney function and cognitive impairment in US adults: the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study. Am J Kidney Dis 2008; 52: 227-234. (Pubitemid 351978145) (Pubitemid 351978145)
4. Seliger SL, Siscovick DS, Stehman-Breen CO, et al: Moderate renal impairment and risk of dementia among older adults: the Cardiovascular Health Cognition Study. J Am Soc Nephrol 2004; 15: 1904-1911. (Pubitemid 38822071) (Pubitemid 38822071)
5. Pereira AA, Weiner DE, Scott T, Sarnak MJ: Cognitive function in dialysis patients. Am J Kidney Dis 2005; 45: 448-462. (Pubitemid 40341324) (Pubitemid 40341324)
6. Cherubini A, Lowenthal DT, Paran E, Mecocci P, Williams LS, Senin U: Hypertension and cognitive function in the elderly. Am J Ther 2007; 14: 533-554. (Pubitemid 350307691) (Pubitemid 350307691)
7. Johnson RJ, Segal MS, Srinivas T, et al: Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link? J Am Soc Nephrol 2005; 16: 1909-1919. (Pubitemid 41716421) (Pubitemid 41716421)
8. Sanchez-Lozada LG, Tapia E, Johnson RJ, Rodriguez-Iturbe B, Herrera-Acosta J: Glomerular hemodynamic changes associated with arteriolar lesions and tubulointerstitial inflammation. Kidney Int Suppl 2003; 86:S9-S14. (Pubitemid 37159621) (Pubitemid 37159621)
9. Uzu T, Kida Y, Shirahashi N, et al: Cerebral microvascular disease predicts renal failure in type 2 diabetes. J Am Soc Nephrol 2010; 21: 520-526.
10. Kanbay M, Sanchez-Lozada LG, Franco M, et al: Microvascular disease and its role in the brain and cardiovascular system: a potential role for uric acid as a cardiorenal toxin. Nephrol Dial Transplant 2011; 26: 430-437.
11. Sanchez-Lozada LG, Tapia E, Rodriguez- Iturbe B, Johnson RJ, Herrera-Acosta J: Hemodynamics of hyperuricemia. Semin Nephrol 2005; 25: 19-24. (Pubitemid 40128144) (Pubitemid 40128144)
12. Sanchez-Lozada LG, Tapia E, Santamaria J, et al: Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney rats. Kidney Int 2005; 67: 237-247. (Pubitemid 40019245) (Pubitemid 40019245)
13. Kang DH, Nakagawa T, Feng L, et al: A role for uric acid in the progression of renal disease. J Am Soc Nephrol 2002; 13: 2888-2897. (Pubitemid 35386908) (Pubitemid 35386908)
14. Mazzali M, Kanellis J, Han L, et al: Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am J Physiol 2002; 282:F991-F997. (Pubitemid 34654464) (Pubitemid 34654464)
15. Rao GN, Corson MA, Berk BC: Uric acid stimulates vascular smooth muscle cell roliferation by increasing platelet-derived growth factor A-chain expression. J Biol Chem 1991; 266: 8604-8608. (Pubitemid 21906552) (Pubitemid 21906552)
16. Watanabe S, Kang DH, Feng L, et al: Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. Hypertension 2002; 40: 355-360. (Pubitemid 35006723) (Pubitemid 35006723)
17. Wu J, Chen X, Xie Y, et al: Characteristics and risk factors of intrarenal arterial lesions in patients with IgA nephropathy. Nephrol Dial Transplant 2005; 20: 719-727. (Pubitemid 40520648) (Pubitemid 40520648)
18. Basara N, Kanbayb M, Sen N, et al: Elevated serum uric acid predicts angiographic impaired reperfusion and one-year mortality in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention. J Investig Med, in press.
19. Schretlen DJ, Inscore AB, Jinnah HA, Rao V, Gordon B, Pearlson GD: Serum uric acid and cognitive function in community-dwelling older adults. Neuropsychology 2007; 21: 136-140. (Pubitemid 46066213) (Pubitemid 46066213)
20. Schretlen DJ, Inscore AB, Vannorsdall TD, et al: Serum uric acid and brain ischemia in normal elderly adults. Neurology 2007; 69: 1418-1423. (Pubitemid 47511463) (Pubitemid 47511463)
21. Vannorsdall TD, Jinnah HA, Gordon B, Kraut M, Schretlen DJ: Cerebral ischemia mediates the effect of serum uric acid on cognitive function. Stroke 2008; 39: 3418-3420.
22. Molloy DW, Standish TI: A guide to the standardized Mini-Mental State Examination. Int Psychogeriatr 1997; 9(suppl 1):87-94, discussion 143-150. (Pubitemid 28045345) (Pubitemid 28045345)
23. Vertesi A, Lever JA, Molloy DW, et al: Standardized Mini-Mental State Examination. Use and interpretation. Can Fam Physician 2001; 47: 2018-2023. (Pubitemid 33107474) (Pubitemid 33107474)
24. Güngen C, Ertan T, Eker E, Yasar R, Engin F: Reliability and validity of the standardized Mini Mental State Examination in the diagnosis of mild dementia in the Turkish population. 2002;13:273-281 (in Turkish).
25. Kim SY, Guevara JP, Kim KM, Choi HK, Heitjan DF, Albert DA: Hyperuricemia and risk of stroke: a systematic review and metaanalysis. Arthritis Rheum 2009; 61: 885-892.
26. Grayson PC, Kim SY, Lavalley M, Choi HK: Hyperuricemia and incident hypertension: a systematic review and meta-analysis. Arthritis Care Res (Hoboken) 2011; 63: 102-110.
27. Sanchez-Lozada LG, Tapia E, Soto V, et al: Effect of febuxostat on the progression of renal disease in 5/6 nephrectomy rats with and without hyperuricemia. Nephron Physiol 2008; 108: 69-78.
28. Cherubini A, Lowenthal DT, Paran E, Mecocci P, Williams LS, Senin U: Hypertension and cognitive function in the elderly. Dis Mon 2010; 56: 106-147.
29. Kim TS, Pae CU, Yoon SJ, et al: Decreased plasma antioxidants in patients with Alzheimer's disease. Int J Geriatr Psychiatry 2006; 21: 344-348.
30. Rinaldi P, Polidori MC, Metastasio A, et al: Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease. Neurobiol Aging 2003; 24: 915-919. (Pubitemid 36962976) (Pubitemid 36962976)
31. Polidori MC, Mattioli P, Aldred S, et al: Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia. Dement Geriatr Cogn Disord 2004; 18: 265-270. (Pubitemid 39370302) (Pubitemid 39370302)
32. Irizarry MC, Raman R, Schwarzschild MA, et al: Plasma urate and progression of mild cognitive impairment. Neurodegener Dis 2009; 6: 23-28.
33. Euser SM, Hofman A, Westendorp RG, Breteler MM: Serum uric acid and cognitive function and dementia. Brain 2009; 132: 377-382.
34. Lee SM, Lee AL, Winters TJ, et al: Low serum uric acid level is a risk factor for death in incident hemodialysis patients. Am J Nephrol 2009; 29: 79-85.
35. Ames BN, Cathcart R, Schwiers E, Hochstein P: Uric acid provides an antioxidant defense in humans against oxidant- and radicalcaused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A 1981; 78: 6858-6862. (Pubitemid 12216861) (Pubitemid 12216861)
36. Becker BF, Reinholz N, Leipert B, Raschke P, Permanetter B, Gerlach E: Role of uric acid as an endogenous radical scavenger and antioxidant. Chest 1991; 100: 176S-181S.
37. Imaram W, Gersch C, Kim KM, Johnson RJ, Henderson GN, Angerhofer A: Radicals in the reaction between peroxynitrite and uric acid identified by electron spin resonance spectroscopy and liquid chromatography mass spectrometry. Free Radic Biol Med 2010; 49: 275-281.
38. Khosla UM, Zharikov S, Finch JL, et al: Hyperuricemia induces endothelial dysfunction. Kidney Int 2005; 67: 1739-1742. (Pubitemid 40577708) (Pubitemid 40577708)
39. Corry DB, Eslami P, Yamamoto K, Nyby MD, Makino H, Tuck ML: Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin- angiotensin system. J Hypertens 2008; 26: 269-275.
40. Yu MA, Sanchez-Lozada LG, Johnson RJ, Kang DH: Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction. J Hypertens 2010; 28: 1234-1242.
41. Sanchez-Lozada LG, Soto V, Tapia E, et al: Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia. Am J Physiol 2008; 295:F1134-F1141.
42. Kanellis J, Watanabe S, Li JH, et al: Uric acid stimulates monocyte chemoattractant protein- 1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension 2003; 41: 1287-1293. (Pubitemid 36706079) (Pubitemid 36706079)
43. Kang DH, Park SK, Lee IK, Johnson RJ: Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol 2005; 16: 3553-3562. (Pubitemid 46211276) (Pubitemid 46211276)
44. Siu YP, Leung KT, Tong MK, Kwan TH: Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level. Am J Kidney Dis 2006; 47: 51-59. (Pubitemid 41828266) (Pubitemid 41828266)
45. Talaat KM, El-Sheikh AR: The effect of mild hyperuricemia on urinary transforming growth factor beta and the progression of chronic kidney disease. Am J Nephrol 2007; 27: 435-440. (Pubitemid 47481999) (Pubitemid 47481999)
46. Goicoechea M, de Vinuesa SG, Verdalles U, et al: Effect of allopurinol in chronic kidney disease progression and cardiovascular risk. Clin J Am Soc Nephrol 2010; 5: 1388-1393.
47. Suliman ME, Johnson RJ, Garcia-Lopez E, et al: J-shaped mortality relationship for uric acid in CKD. Am J Kidney Dis 2006; 48: 761-771. (Pubitemid 44740052) (Pubitemid 44740052)