The effect of amiodarone on warfarin anticoagulation: a register-based nationwide cohort study involving the Swedish population

Journal of Thrombosis and Haemostasis

Volumn 15, Issue 3, 2017, Pages 446-453

  Holm, J ^a   Lindh, J D ^a   Andersson, M L ^a   Mannheimer, B ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

amiodarone; cytochrome P 450 CYP2C9; drug interactions; International normalized ratio; warfarin

Indexed keywords

AMIODARONE; WARFARIN; ANTIARRHYTHMIC AGENT; ANTICOAGULANT AGENT;

ADULT; AGED; ANTICOAGULATION; ARTICLE; COHORT ANALYSIS; DRUG DOSE COMPARISON; FEMALE; HUMAN; INTERNATIONAL NORMALIZED RATIO; MAJOR CLINICAL STUDY; MALE; MONITORING; RETROSPECTIVE STUDY; SWEDISH CITIZEN; VERY ELDERLY; BLEEDING; BLOOD CLOTTING; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG MONITORING; MIDDLE AGED; REGISTER; SWEDEN; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; AMIODARONE; ANTI-ARRHYTHMIA AGENTS; ANTICOAGULANTS; BLOOD COAGULATION; COHORT STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG MONITORING; FEMALE; HEMORRHAGE; HUMANS; INTERNATIONAL NORMALIZED RATIO; MALE; MIDDLE AGED; REGISTRIES; RETROSPECTIVE STUDIES; SWEDEN; WARFARIN; YOUNG ADULT;

EID: 85013426669     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.13614     Document Type: Article

References (25)

1. Pirmohamed M, James S, Meakin S, Green C, Scott AK, Walley TJ, Farrar K, Park BK, Breckenridge AM. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ 2004; 329: 15–9.
2. Fitzmaurice DA, Blann AD, Lip GY. Bleeding risks of antithrombotic therapy. BMJ 2002; 325: 828–31.
3. Mason JW. Amiodarone. N Engl J Med 1987; 316: 455–66.
4. Julian DG, Camm AJ, Frangin G, Janse MJ, Munoz A, Schwartz PJ, Simon P. Randomised trial of effect of amiodarone on mortality in patients with left-ventricular dysfunction after recent myocardial infarction: EMIAT. European Myocardial Infarct Amiodarone Trial Investigators. Lancet 1997; 349: 667–74.
5. McDonald MG, Au NT, Wittkowsky AK, Rettie AE. Warfarin-amiodarone drug-drug interactions: determination of [I](u)/K(I, u) for amiodarone and its plasma metabolites. Clin Pharmacol Ther 2012; 91: 709–17.
6. Heimark LD, Wienkers L, Kunze K, Gibaldi M, Eddy AC, Trager WF, O'Reilly RA, Goulart DA. The mechanism of the interaction between amiodarone and warfarin in humans. Clin Pharmacol Ther 1992; 51: 398–407.
7. O'Reilly RA, Trager WF, Rettie AE, Goulart DA. Interaction of amiodarone with racemic warfarin and its separated enantiomorphs in humans. Clin Pharmacol Ther 1987; 42: 290–4.
8. Freedman B, Potpara TS, Lip GY. Stroke prevention in atrial fibrillation. Lancet 2016; 388: 806–17.
9. Vitry AI, Roughead EE, Ramsay EN, Preiss AK, Ryan P, Gilbert AL, Caughey GE, Shakib S, Esterman A, Zhang Y, McDermott RA. Major bleeding risk associated with warfarin and co-medications in the elderly population. Pharmacoepidemiol Drug Saf 2011; 20: 1057–63.
10. Klein TE, Altman RB, Eriksson N, Gage BF, Kimmel SE, Lee MT, Limdi NA, Page D, Roden DM, Wagner MJ, Caldwell MD, Johnson JA. Estimation of the warfarin dose with clinical and pharmacogenetic data. N Engl J Med 2009; 360: 753–64.
11. Gage BF, Eby C, Johnson JA, Deych E, Rieder MJ, Ridker PM, Milligan PE, Grice G, Lenzini P, Rettie AE, Aquilante CL, Grosso L, Marsh S, Langaee T, Farnett LE, Voora D, Veenstra DL, Glynn RJ, Barrett A, McLeod HL. Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin. Clin Pharmacol Ther 2008; 84: 326–31.
12. Zhong SL, Liu Y, Yu XY, Xu D, Tan HH, Lin QX, Yang M, Lao HY, Lin SG. The influence of genetic polymorphisms and interacting drugs on initial response to warfarin in Chinese patients with heart valve replacement. Eur J Clin Pharmacol 2011; 67: 581–90.
13. Lu Y, Won KA, Nelson BJ, Qi D, Rausch DJ, Asinger RW. Characteristics of the amiodarone-warfarin interaction during long-term follow-up. Am J Health Syst Pharm 2008; 65: 947–52.
14. Sanoski CA, Bauman JL. Clinical observations with the amiodarone/warfarin interaction: dosing relationships with long-term therapy. Chest 2002; 121: 19–23.
15. Almog S, Shafran N, Halkin H, Weiss P, Farfel Z, Martinowitz U, Bank H. Mechanism of warfarin potentiation by amiodarone: dose–and concentration–dependent inhibition of warfarin elimination. Eur J Clin Pharmacol 1985; 28: 257–61.
16. Kerin NZ, Blevins RD, Goldman L, Faitel K, Rubenfire M. The incidence, magnitude, and time course of the amiodarone-warfarin interaction. Arch Intern Med 1988; 148: 1779–81.
17. Auricula. http://www.ucr.uu.se/auricula/. Accessed 1 September 2016.
18. Journalia. http://www.journalia.se/. Accessed 1 September 2016.
19. Wettermark B, Hammar N, Fored CM, Leimanis A, Otterblad Olausson P, Bergman U, Persson I, Sundstrom A, Westerholm B, Rosen M. The new Swedish Prescribed Drug Register–opportunities for pharmacoepidemiological research and experience from the first six months. Pharmacoepidemiol Drug Saf 2007; 16: 726–35.
20. Bottiger Y, Laine K, Andersson ML, Korhonen T, Molin B, Ovesjo ML, Tirkkonen T, Rane A, Gustafsson LL, Eiermann B. SFINX-a drug-drug interaction database designed for clinical decision support systems. Eur J Clin Pharmacol 2009; 65: 627–33.
21. Rosendaal FR, Cannegieter SC, van der Meer FJ, Briet E. A method to determine the optimal intensity of oral anticoagulant therapy. Thromb Haemost 1993; 69: 236–9.
22. Mannheimer B, Andersson ML, Jarnbert-Pettersson H, Lindh JD. The effect of carbamazepine on warfarin anticoagulation: a register-based nationwide cohort study involving the Swedish population. J Thromb Haemost 2016; 14: 765–71.
23. R Core team. R: A language and environment for statistical computing 2013. hiip:/www.R-project.org/. Accessed 1 May 2015.
24. Zhong SL, Yu XY, Liu Y, Xu D, Mai LP, Tan HH, Lin QX, Yang M, Lin SG. Integrating interacting drugs and genetic variations to improve the predictability of warfarin maintenance dose in Chinese patients. Pharmacogenet Genomics 2012; 22: 176–82.
25. FASS (the Swedish Physicians’ Desk Reference). http://www.fass.se/LIF/startpage, Accessed 1 September 2016.