The pool of fatty acids covalently bound to platelet proteins by thioester linkages can be altered by exogenously supplied fatty acids

Lipids

Volumn 34, Issue 1, 1999, Pages

  Muszbek, Laszlo ^b   Haramura, Gizella ^b   Cluette Brown, Joanne E ^a   Van Cott, Elizabeth M ^a   Laposata, Michael ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; OLEIC ACID; PALMITIC ACID; STEARIC ACID; THIOESTER;

ACYLATION; CONFERENCE PAPER; FATTY ACID SYNTHESIS; FATTY ACID TRANSPORT; HUMAN; LIPID ANALYSIS; LIPID COMPOSITION; PROTEIN BINDING; PROTEIN LIPID INTERACTION; THROMBOCYTE ACTIVATION;

EID: 0033042833     PISSN: 00244201     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02562334     Document Type: Conference Paper

References (18)

1. Casey, P.J. (1995) Protein Lipidation in Cell Signaling, Science 268, 221-225.
2. Milligan, G., Parenti, M., and Magee, A.I. (1995) The Dynamic Role of Palmitoylation in Signal Transduction, Trends Biochem. Sci. 20, 181-187.
3. Low, M.G. (1989) Glycosyl-Phosphatidylinositol: A Versatile Anchor for Cell Surface Proteins, FASEB J. 3, 1600-1608.
4. Low, M.G., and Saltiel, A.R. (1988) Structural and Functional Roles of Glycosyl-Phosphatidylinositol in Membranes, Science 239, 268-275.
5. Muszbek, L., and Laposata, M. (1993) Myristoylation of Proteins in Platelets Occurs Predominantly Through Thioester Linkages, J. Biol. Chem. 268, 8251-8255.
6. Muszbek, L., and Laposata, M. (1989) Covalent Modification of Platelet Proteins by Palmitate, Blood 74, 1339-1347.
7. Muszbek, L., and Laposata, M. (1993) Covalent Modification of Proteins by Arachidonate and Eicosapentaenoate in Platelets, J. Biol. Chem. 268, 18243-18248.
8. Masterson, W.J., Raper, J., Doering, T.L., Hart, G.W., and Englund, P.T. (1990) Fatty Acid Remodeling: A Novel Reaction Sequence in the Biosynthesis of Trypanosome Glycosyl Phosphatidylinositol Membrane Anchors, Cell 62, 73-80.
9. Kaufman, J.F., Krangel, M.S., and Strominger, I.L. (1984) Cysteines in the Transmembrane Region of Major Histocompatibility Complex Antigens are Fatty Acylated via Thioester Bonds, J. Biol. Chem. 259, 7230-7238.
10. Hennes, A.R., Awai, K., Hammerstrand, K., and Duboff, G.S. (1966) Carbon-14 in Carboxyl Carbon of Fatty Acids Formed by Platelets from Normal and Diabetic Subjects, Nature 210, 839-841
11. Wilcox, C.A., Hu, J.S., and Olson, N.E. (1987) Acylation of Proteins by Myristic Acid Occurs Cotranslationally, Science 238, 1275-1278
12. Buss, J.E., Solski, P.A., Schaeffer, J.P., MacDonald, M.J., and Der, C.J. (1989) Activation of the Cellular Proto-Oncogene Product p21 Ras by Addition of a Myristylation Signal, Science 243, 1600-1603.
13. Wedegaertner, P.B., Chu, D.H., Wilson, P.T., Levis, M.J., and Bourne, H.R. (1993) Palmitoylation is Required for Signaling Functions and Membrane Attachment of Gqα and Gsα, J. Biol. Chem. 268, 25001-25008.
14. 2-Adrenergic Receptor, J. Biol. Chem. 264, 7564-7569.
15. Zhang, F., Kamp, F., and Hamilton, J.A. (1996) Dissociation of Long and Very Long Chain Fatty Acids from Phospholipid Bilayers, Biochemistry 35, 16055-16060.
16. Fujimoto, T., Stroud, E., Whatley, R.E., Prescott, S.M., Muszbek, L., Laposata, M., and McEver, R.P. (1993) P-Selectin is Acylated with Palmitic Acid and Stearic Acid at Cysteine 766 Through a Thioester Linkage, J. Biol. Chem. 268, 11394-11400.
17. Zeng, F.Y., Kaphalia, B.S., Ansari, G.A.S., and Weigel, P.H. (1995) Fatty Acylation of the Rat Asialoglycoprotein Receptor, J. Biol. Chem. 270, 21382-21387.
18. Berthiaume, L., and Resh, M.D. (1995) Biochemical Characterization of a Palmitoyl Acyltransferase Activity that Palmitoylates Myristoylated Proteins, J. Biol. Chem. 270, 22399-22405.