A Glycovariant of Human CD44 is Characteristically Expressed on Human Mesenchymal Stem Cells

Stem Cells

Volumn 35, Issue 4, 2017, Pages 1080-1092

  Pachón Peña, Gisela ^a,b   Donnelly, Conor ^a,b   Ruiz Cañada, Catalina ^a,b   Katz, Adam ^c   Fernández Veledo, Sonia ^d,e   Vendrell, Joan ^d,e   Sackstein, Robert ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^d INSTITUT D INVESTIGACIÓ SANITÀRIA PERE VIRGILI IISPV   (Spain)

^e INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

E selectin ligand; Exofucosylation; Fucosyltransferase; Glycosyltransferase programmed stereosubstitution; Hematopoietic cell E L selectin ligand; Mesenchymal stem cell; Sialyl Lewis X; sLeX

Indexed keywords

5' NUCLEOTIDASE; ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ALPHA 1,3 FUCOSYLTRANSFERASE; ALPHA4 INTEGRIN; BETA1 INTEGRIN; CD146 ANTIGEN; CD34 ANTIGEN; CD36 ANTIGEN; CD45 ANTIGEN; CD62E ANTIGEN; ENDOGLIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLYCOPROTEIN; GLYCOSYLTRANSFERASE; HECA452 ANTIGEN; HERMES ANTIGEN; L SELECTIN; LYMPHOCYTE ANTIGEN; MICROSOMAL AMINOPEPTIDASE; THY 1 ANTIGEN; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; CD44 PROTEIN, HUMAN; FIBRONECTIN; HYALURONIC ACID BINDING PROTEIN; LIGAND; POLYSACCHARIDE; PROTEIN BINDING; SIALIDASE;

ADIPOSE DERIVED STEM CELL; ADULT; ANTIGEN EXPRESSION; ARTICLE; BINDING AFFINITY; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL ADHESION; CELL DIFFERENTIATION; CELL MIGRATION; CELL SURFACE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; FUCOSYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LECTIN BINDING; MESENCHYMAL STEM CELL; NORMAL HUMAN; PROTEIN PROTEIN INTERACTION; UPREGULATION; ADIPOSE TISSUE; BONE MARROW CELL; CELL LINE; CYTOLOGY; GENE EXPRESSION REGULATION; GLYCOSYLATION; IMMUNOPHENOTYPING; MESENCHYMAL STROMA CELL; METABOLISM;

ADIPOSE TISSUE; BONE MARROW CELLS; CELL ADHESION; CELL DIFFERENTIATION; CELL LINE; E-SELECTIN; FIBRONECTINS; GENE EXPRESSION REGULATION; GLYCOPROTEINS; GLYCOSYLATION; GLYCOSYLTRANSFERASES; HUMANS; HYALURONAN RECEPTORS; IMMUNOPHENOTYPING; L-SELECTIN; LIGANDS; MESENCHYMAL STROMAL CELLS; NEURAMINIDASE; POLYSACCHARIDES; PROTEIN BINDING;

EID: 85013105592     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2549     Document Type: Article

References (31)

1. Di Nicola M, Carlo-Stella, Magni M et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002;10:3838–3843.
2. Meisel R, Zibert A, Laryea M et al. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood 2004;12:4619–4621.
3. Pachón-Peña G, Yu G, Tucker A et al. Stromal stem cells from adipose tissue and bone marrow of age-matched female donors display distinct immunophenotypic profiles. J Cell Physiol 2011;3:843–851.
4. Pachón-Peña G, Serena C, Ejarque M et al. Obesity determines the immunophenotypic profile and functional characteristics of human mesenchymal stem cells from adipose tissue. Stem Cells Transl Med 2016;5:464–475.
5. Bourin P, Bunnell B, Casteilla L et al. Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: A joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT). Cytotherapy 2013;15:641–648.
6. Pires A, Mendes-Pinheiro B, Teixera F et al. Unveiling the differences of secretome of human bone marrow mesenchymal stem cells, adipose tissue-derived stem cells, and human umbilical cord perivascular cells: A proteomic analysis. Stem Cells Dev 2016;25:1073–1083.
7. Sousa B, Parreira R, Fonseca E et al. Human adult stem cells from diverse origins: An overview from multiparametric immunophenotyping to clinical applications. Cytometry A 2014;1:43–77.
8. Mizuno H, Tobita M Uysal A. Concise review: Adipose-derived stem cells as a novel tool for future regenerative medicine. Stem Cells 2012;5:804–810.
9. Melief S, Zwaginga J, Fibbe W et al. Adipose tissue-derived multipotent stromal cells have a higher immunomodulatory capacity than their bone marrow-derived counterparts. Stem Cells Transl Med 2013;2:455–463.
10. Purandare B, Teklemarian T, Zhao L et al. Temporal HLA profiling and immunomodulatory effects of human adult bone marrow- and adipose-derived mesenchymal stem cells. Regen Med 2014;1:67–79.
11. Sackstein R, Merzaban J, Cain D et al. Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone. Nat Med 2008;11:181–187.
12. Sackstein R. Glycosyltransferase-programmed stereosubstitution (GPS) to create HCELL: Engineering a roadmap for cell migration. Immunol Rev 2009;1:51–74.
13. Sackstein R. Directing stem cell trafficking via GPS. Methods Enzymol 2010;479:93–105.
14. Livak K, Schmittgen T. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)). Methods 2001;25:402–408.
15. Dykstra B, Lee J, Mortensen L et al. Glycoengineering of E-Selectin ligands by intrecellular versus extracellular fucosylation differentially affects osteotropism of human mesenchymal stem cells. Stem Cells 2016;34:2501–2511.
16. Lee JY, Buzney C, Poznansky M et al. Dynamic alterations in chemokine gradients induce transendothelial shuttling of human T cells under physiologic shear conditions. J Leukocyte Biol 2009;86:1285–1294.
17. Boyce J, Mellor E, Perkins B et al. Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions. Blood 2002;8:2890–2896.
18. Burdick M, McCaffery J, Kim Y et al. Colon carcinoma cell glycolipids, integrins, and other glycoproteins mediate adhesion to HUVECs under flow. Am J Physiol Cell Physiol 2003;4:977–987.
19. Thankamony S, Sackstein R. Enforced hematopoietic cell E-and L-selectin ligand (HCELL) expression primes transendotelial migration of human mesenchymal stem cells. Proc Natl Acad Sci USA 2011;6:2258–2263.
20. Okajima T, Fukumoto S, Miyazaki H et al. Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal-VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids. J Biol Chem 1999;17:11479–11486.
21. Sasaki K, Watanabe E, Kawashima K et al. Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection. J Biol Chem 1993;30:22782–22787.
22. Harduin-Lepers A, Vallejo-Ruiz V, Krzewinski-Recchi M et al. The human sialyltransferase family. Biochimie 2001;8:727–737.
23. Serna S, Yan S, Martin-Lomas M et al. Fucosyltransferases as synthetic tools: Glycan array based substrate selection and core fucosylation of synthetic N-glycans. J Am Chem Soc 2011;41:16495–16502.
24. de Vries T, Knegtel R, Holmes E et al. Fucosyltransferases: Structure/function studies. Glycobiology 2001;11:119R–128R.
25. Escrevente C, Machado E, Brito C et al. Different expression levels of α3/4fucosyltransferases and Lewis determinants in ovarian carcinoma tissues and cell lines. Int J Oncol 2006;29:557–566.
26. Papaioannou T, Stefanadis C. Vascular wall shear stress: basic principles and methods. Hellenic J Cardiol 2005;46:9–15.
27. Lv F, Tuan R, Cheung K et al. Concise review: The surface markers and identity of human mesenchymal stem cells. Stem Cells 2014;32:1408–1419.
28. Mondal N, Buffone A, Stolfa G et al. ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes. Blood 2015;125:687–696.
29. Merzaban J, Burdick M, Gadhoum S et al. Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells. Blood 2011;118:1774–1783.
30. Merzaban J, Imitola J, Starossom SC et al. Cell surface glycan engineering of neural stem cells augments neurotropism and improves recovery in a murine model of multiple sclerosis. Glycobiology 2015;25:1392–1409.
31. Abdi R, Moore R, Sakai S et al. HCELL expression on murine MSC licenses pancreatotropism and confer durable reversal of autoimmune diabetes in NOD mice. Stem Cells 2015;33:1523–1531.