Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood-brain barrier disruption after ischemic brain injury

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 7, 2017, Pages E1243-E1252

  Shi, Yejie ^a,b,c   Jiang, Xiaoyan ^a,c   Zhang, Lili ^b,c   Pu, Hongjian ^c   Hu, Xiaoming ^a,b,c   Zhang, Wenting ^a   Cai, Wei ^c   Gao, Yanqin ^a,c   Leak, Rehana K ^d   Keep, Richard F ^e   Bennett, Michael V L ^a,f   Chen, Jun ^a,b,c  

^a FUDAN UNIVERSITY   (China)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d DUQUESNE UNIVERSITY   (United States)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^f ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Endothelial cell; HSP27; Neuroinflammation; Stress fiber; Tight junction

Indexed keywords

HEAT SHOCK PROTEIN 27; ACTIN;

ACTIN POLYMERIZATION; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN NERVE CELL; CELL DEATH; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; ENDOTHELIUM; GENE OVEREXPRESSION; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MALE; MICROVASCULATURE; MOUSE; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; PROTEIN DOMAIN; STRESS FIBER; ANIMAL; BRAIN; C57BL MOUSE; CELL CULTURE; ENDOTHELIUM CELL; GENETICS; HUMAN; METABOLISM; MOTOR ACTIVITY; NERVE CELL; PATHOPHYSIOLOGY; POLYMERIZATION; REPERFUSION INJURY; TRANSGENE; TRANSGENIC MOUSE; VASCULARIZATION;

ACTINS; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM; HSP27 HEAT-SHOCK PROTEINS; HUMANS; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR ACTIVITY; NEURONS; POLYMERIZATION; REPERFUSION INJURY; TRANSGENES;

EID: 85013059303     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1621174114     Document Type: Article

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