Repeated cell therapy: a paradigm shift whose time has come

Circulation Research

Volumn 120, Issue 7, 2017, Pages 1072-1074

  Bolli, Roberto ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

adoptive transfer; cardiac repair; cell therapy; myocardium; regeneration; stem cells

Indexed keywords

CARDIAC STEM CELL; CELL THERAPY; CONCEPTUAL FRAMEWORK; ENGRAFTMENT; HEART INFARCTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; RETREATMENT; REVIEW; STEM CELL TRANSPLANTATION; ANIMAL; BIOLOGICAL THERAPY; HEART DISEASE; PATHOPHYSIOLOGY; PROCEDURES; REGENERATION; TRENDS;

ANIMALS; CELL- AND TISSUE-BASED THERAPY; HEART DISEASES; HUMANS; REGENERATION; STEM CELL TRANSPLANTATION;

EID: 85012918106     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.117.310710     Document Type: Review

References (13)

1. Sanganalmath SK, Bolli R, Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions. Circ Res 2013 113 810 834. doi: 10.1161/CIRCRESAHA.113.300219.
2. Keith MC, Bolli R, "String theory" of c-kit(pos) cardiac cells: a new paradigm regarding the nature of these cells that may reconcile apparently discrepant results. Circ Res 2015 116 1216 1230. doi: 10.1161/CIRCRESAHA.116.305557.
3. Fisher SA, Doree C, Mathur A, Martin-Rendon E, Meta-analysis of cell therapy trials for patients with heart failure. Circ Res 2015 116 1361 1377. doi: 10.1161/CIRCRESAHA.116.304386.
4. Gyöngyösi M, Wojakowski W, Lemarchand P, ACCRUE Investigators Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data. Circ Res 2015 116 1346 1360. doi: 10.1161/CIRCRESAHA.116.304346.
5. Sahara M, Santoro F, Chien KR, Programming and reprogramming a human heart cell. EMBO J 2015 34 710 738. doi: 10.15252/embj.201490563.
6. Gerbin KA, Murry CE, The winding road to regenerating the human heart. Cardiovasc Pathol 2015 24 133 140. doi: 10.1016/j.carpath.2015.02.004.
7. Tang XL, Li Q, Rokosh G, Sanganalmath SK, Chen N, Ou Q, Stowers H, Hunt G, Bolli R, Long-term outcome of administration of c-kit(POS) cardiac progenitor cells after acute myocardial infarction: transplanted cells do not become cardiomyocytes, but structural and functional improvement and proliferation of endogenous cells persist for at least one year. Circ Res 2016 118 1091 1105. doi: 10.1161/CIRCRESAHA.115.307647.
8. Hong KU, Guo Y, Li QH, Cao P, Al-Maqtari T, Vajravelu BN, Du J, Book MJ, Zhu X, Nong Y, Bhatnagar A, Bolli R, c-kit+ Cardiac stem cells alleviate post-myocardial infarction left ventricular dysfunction despite poor engraftment and negligible retention in the recipient heart. PLoS One 2014 9 e96725. doi: 10.1371/journal.pone.0096725.
9. Cai C, Guo Y, Teng L, Nong Y, Tan M, Book MJ, Zhu X, Wang XL, Du J, Wu WJ, Xie W, Hong KU, Li Q, Bolli R, Preconditioning human cardiac stem cells with an HO-1 inducer exerts beneficial effects after cell transplantation in the infarcted murine heart. Stem Cells 2015 33 3596 3607. doi: 10.1002/stem.2198.
10. Li QH, Guo YR, Ou QH, Wu WJ, Zhu XP, Luo L, Li J, Bolli R, Expression of heme oxygenase-1 in cardiac stem cells enhances the efficacy of cell therapy for attenuating left ventricular dysfunction and remodeling after myocardial infarction. Circulation 2012 126 A9534
11. Tokita Y, Tang XL, Li Q, Wysoczynski M, Hong KU, Nakamura S, Wu WJ, Xie W, Li D, Hunt G, Ou Q, Stowers H, Bolli R, Repeated administrations of cardiac progenitor cells are markedly more effective than a single administration: a new paradigm in cell therapy. Circ Res 2016 119 635 651. doi: 10.1161/CIRCRESAHA.116.308937.
12. Guo Y, Wysoczynski M, Non Y, Tomlin A, Zhu X, Gumpert A, Nasr M, Muthusamy S, Li H, Book M, Khan A, Hong K, Li Q, Bolli R, Repeated doses of cardiac mesenchymal cells are therapeutically superior to a single dose in mice with old myocardial infarction. Basic Res Cardiol 2017 112 18. doi: 10.1007/s00395-017-0606-5.
13. Hodgkinson CP, Bareja A, Gomez JA, Dzau VJ, Emerging concepts in paracrine mechanisms in regenerative cardiovascular medicine and biology. Circ Res 2016 118 95 107. doi: 10.1161/CIRCRESAHA.115.305373.