We can see clearly now: Optical clearing and kidney morphometrics

Current Opinion in Nephrology and Hypertension

Volumn 26, Issue 3, 2017, Pages 179-186

  Puelles, Victor G ^a,b   Moeller, Marcus J ^b   Bertram, John F ^a  

^a MONASH UNIVERSITY   (Australia)

^b RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Kidney Microanatomy; Morphometry; Optical clearing

Indexed keywords

SOLVENT; WATER;

AQUEOUS SOLUTION; CELL SPECIFICITY; EMBEDDING; GLOMERULUS; HUMAN; HYDROGEL; KIDNEY; KIDNEY TISSUE; MORPHOMETRY; PODOCYTE; PRIORITY JOURNAL; REVIEW; ANATOMY AND HISTOLOGY; ANIMAL; CELL COUNT; CYTOLOGY; DIAGNOSTIC IMAGING; MICROSCOPY; PROCEDURES; SOLUTION AND SOLUBILITY; THREE DIMENSIONAL IMAGING;

ANIMALS; CELL COUNT; HUMANS; HYDROGELS; IMAGING, THREE-DIMENSIONAL; KIDNEY; KIDNEY GLOMERULUS; MICROSCOPY; PODOCYTES; SOLUTIONS; SOLVENTS; WATER;

EID: 85012887639     PISSN: 10624821     EISSN: 14736543     Source Type: Journal    
DOI: 10.1097/MNH.0000000000000314     Document Type: Review

References (49)

1. Fenton RA, Praetorius J. Anatomy of the kidney. In: Skorecki K, Taal MW, editors. Brenner and rector's the kidney. Philadelphia: Elsevier; 2016. pp. 42-82.
2. Ricardo SD, Bertram JF, Ryan GB. Podocyte architecture in puromycin aminonucleoside-treated rats administered tungsten or allopurinol. Exp Nephrol 1995; 3:270-279.
3. Sterio DC. The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc 1984; 134 (Pt 2):127-136.
4. Bertram JF. Analyzing renal glomeruli with the new stereology. Int Rev Cytol 1995; 161:111-172.
5. Conchello JA, Lichtman JW. Optical sectioning microscopy. Nat Methods 2005; 2:920-931.
6. Mertz J. Optical sectioning microscopy with planar or structured illumination. Nat Methods 2011; 8:811-819.
7. Reynaud EG, Kržič U, Greger K, Stelzer EHK. Light sheet-based fluorescence microscopy: more dimensions, more photons, and less photodamage. HFSP J 2008; 2:266-275.
8. Lichtman JW, Conchello JA. Fluorescence microscopy. Nat Methods 2005; 2:910-919.
9. Richardson DS, Lichtman JW. Clarifying tissue clearing. Cell 2015; 162:246-257.
10. Dodt HU, Leischner U, Schierloh A, et al. Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain. Nat Methods 2007; 4:331-336.
11. Erturk A, Becker K, Jährling N, et al. Three-dimensional imaging of solventcleared organs using 3DISCO. Nat Protoc 2012; 7:1983-1995.
12. Renier N,Wu Z, Simon DJ, et al. iDISCO: a simple, rapid method toimmunolabel large tissue samples for volume imaging. Cell 2014; 159:896-910.
13. Klingberg A, Hasenberg A, Ludwig-Portugall I, et al. Fully automated evaluation of total glomerular number and capillary tuft size in nephritic kidneys using lightsheet microscopy. J Am Soc Nephrol 2016; 28:452-459.
14. Pan C, Cai R, Quacquarelli FP, et al. Shrinkage-mediated imaging of entire organs and organisms using uDISCO. Nat Methods 2016; 13:859-867.
15. Becker K, Jährling N, Saghafi S, et al. Chemical clearing and dehydration of GFP expressing mouse brains. PLoS One 2012; 7:e33916.
16. Chiang AS, Lin WY, Liu HP, et al. Insect NMDA receptors mediate juvenile hormone biosynthesis. Proc Natl Acad Sci U S A 2002; 99:37-42.
17. Hama H, Kurokawa H, Kawano H, et al. Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain. Nat Neurosci 2011; 14:1481-1488.
18. Ke MT, Fujimoto S, Imai T. SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction. Nat Neurosci 2013; 16:1154-1161.
19. Susaki EA, Tainaka K, Perrin D, et al. Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis. Cell 2014; 157:726-739.
20. Tainaka K, Kubota SI, Suyama TQ, et al. Whole-body imaging with single-cell resolution by tissue decolorization. Cell 2014; 159:911-924.
21. Chung K, Wallace J, Kim SY, et al. Structural and molecular interrogation of intact biological systems. Nature 2013; 497:332-337.
22. Yang B, Treweek JB, Kulkarni RP, et al. Single-cell phenotyping within transparent intact tissue through whole-body clearing. Cell 2014; 158:945-958.
23. Tomer R, Ye L, Hsueh B, Deisseroth K. Advanced CLARITY for rapid and highresolution imaging of intact tissues. Nat Protoc 2014; 9:1682-1697.
24. Chen F, Tillberg PW, Boyden ES. Optical imaging. Expansion microscopy. Science 2015; 347:543-548.
25. Marcussen N. Atubular glomeruli in cisplatin-induced chronic interstitial nephropathy. An experimental stereological investigation. APMIS 1990; 98:1087-1097.
26. Torres R, Velazquez H, Chang JJ, et al. Three-dimensional morphology by multiphoton microscopy with clearing in a model of cisplatin-induced CKD. J Am Soc Nephrol 2016; 27:1102-1112.
27. Olson E, Levene MJ, Torres R. Multiphoton microscopy with clearing for three dimensional histology of kidney biopsies. Biomed Opt Express 2016; 7:3089-3096.
28. Puelles VG, Bertram JF. Counting glomeruli and podocytes: rationale and methodologies. Curr Opin Nephrol Hypertens 2015; 24:224-230.
29. Puelles VG, Hoy WE, Hughson MD, et al. Glomerular number and size variability and risk for kidney disease. Curr Opin Nephrol Hypertens 2011; 20:7-15.
30. Bertram JF, Cullen-McEwen LA, Egan GF, et al. Why and how we determine nephron number. Pediatr Nephrol 2014; 29:575-580.
31. Cullen-McEwen LA, Armitage JA, Nyengaard JR, Bertram JF. Estimating nephron number in the developing kidney using the physical disector/fractionator combination. Methods Mol Biol 2012; 886:109-119.
32. Cullen-McEwen LA, Douglas-Denton RN, Bertram JF. Estimating total nephron number in the adult kidney using the physical disector/fractionator combination. Methods Mol Biol 2012; 886:333-350.
33. Puelles VG, Zimanyi MA, Samuel T, et al. Estimating individual glomerular volume in the human kidney: clinical perspectives. Nephrol Dial Transplant 2012; 27:1880-1888.
34. Beeman SC, Cullen-McEwen LA, Puelles VG, et al. MRI-based glomerular morphology and pathology in whole human kidneys. Am J Physiol Renal Physiol 2014; 306:F1381-F1390.
35. Baldelomar EJ, Charlton JR, Beeman SC, et al. Phenotyping by magnetic resonance imaging nondestructively measures glomerular number and volume distribution in mice with and without nephron reduction. Kidney Int 2016; 89:498-505.
36. Heilmann M, Neudecker S, Wolf I, et al. Quantification of glomerular number and size distribution in normal rat kidneys using magnetic resonance imaging. Nephrol Dial Transplant 2012; 27:100-107.
37. Beeman SC, Zhang M, Gubhaju L, et al. Measuring glomerular number and size in perfused kidneys using MRI. Am J Physiol Renal Physiol 2011; 300:F1454-F1457.
38. Wiggins RC. The spectrum of podocytopathies: a unifying view of glomerular diseases. Kidney Int 2007; 71:1205-1214.
39. Fukuda A, Chowdhury MA, Venkatareddy MP, et al. Growth-dependent podocyte failure causes glomerulosclerosis. J Am Soc Nephrol 2012; 23:1351-1363.
40. Wharram BL, Goyal M, Wiggins JE, et al. Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol 2005; 16:2941-2952.
41. Lemley KV, Bertram JF, Nicholas SB, White K. Estimation of glomerular podocyte number: a selection of valid methods. J Am Soc Nephrol 2013; 24:1193-1202.
42. Puelles VG, Douglas-Denton RN, Cullen-McEwen L, et al. Design-based stereological methods for estimating numbers of glomerular podocytes. Ann Anat 2014; 196:48-56.
43. Puelles VG, Douglas-Denton RN, Cullen-McEwen LA, et al. Podocyte number in children and adults: associations with glomerular size and numbers of other glomerular resident cells. J Am Soc Nephrol 2015; 26:2277-2288.
44. Puelles VG, van der Wolde JW, Schulze KE, et al. Validation of a threedimensional method for counting and sizing podocytes in whole glomeruli. J Am Soc Nephrol 2016; 27:3093-3104.
45. Wanner N, Hartleben B, Herbach N, et al. Unraveling the role of podocyte turnover in glomerular aging and injury. J Am Soc Nephrol 2014; 25:707-716.
46. Guo JK, Marlier A, Shi H, et al. Increased tubular proliferation as an adaptive response to glomerular albuminuria. J Am Soc Nephrol 2012; 23:429-437.
47. Shankland SJ. The podocyte's response to injury: role in proteinuria and glomerulosclerosis. Kidney Int 2006; 69:2131-2147.
48. Kriz W, Shirato I, Nagata M, et al. The podocyte's response to stress: the enigma of foot process effacement. Am J Physiol Renal Physiol 2013; 304:F333-F347.
49. Unnersjo-Jess D, Scott L, Blom H, Brismar H. Super-resolution stimulated emission depletion imaging of slit diaphragm proteins in optically cleared kidney tissue. Kidney Int 2016; 89:243-247.