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Volumn 61, Issue , 2017, Pages 164-172

Inverse expression of caveolin-1 and EGFR in thyroid cancer patients

Author keywords

BRAF V600E; Caveolin 1; EGFR; FNAB; Thyroid cancer

Indexed keywords

B RAF KINASE; CAVEOLIN 1; MESSENGER RNA; VASCULOTROPIN; BRAF PROTEIN, HUMAN; CAV1 PROTEIN, HUMAN; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR VIII; TUMOR MARKER;

EID: 85012305781     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2016.10.020     Document Type: Article
Times cited : (17)

References (42)
  • 1
    • 84954418538 scopus 로고    scopus 로고
    • Cancer statistics for Asian Americans, native Hawaiians, and Pacific islanders, 2016: converging incidence in males and females
    • [1] Torre, L.A., Sauer, A.M., Chen, M.S. Jr., Kagawa-Singer, M., Jemal, A., Siegel, R.L., Cancer statistics for Asian Americans, native Hawaiians, and Pacific islanders, 2016: converging incidence in males and females. CA Cancer J Clin 66 (2016), 182–202.
    • (2016) CA Cancer J Clin , vol.66 , pp. 182-202
    • Torre, L.A.1    Sauer, A.M.2    Chen, M.S.3    Kagawa-Singer, M.4    Jemal, A.5    Siegel, R.L.6
  • 2
    • 77954761901 scopus 로고    scopus 로고
    • Thyroid cancer epidemiology and prognostic variables
    • [2] Sipos, J.A., Mazzaferri, E.L., Thyroid cancer epidemiology and prognostic variables. Clin Oncol (R Coll Radiol) 22 (2010), 395–404.
    • (2010) Clin Oncol (R Coll Radiol) , vol.22 , pp. 395-404
    • Sipos, J.A.1    Mazzaferri, E.L.2
  • 3
    • 19944426526 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) is overexpressed in anaplastic thyroid cancer, and the EGFR inhibitor gefitinib inhibits the growth of anaplastic thyroid cancer
    • [3] Schiff, B.A., McMurphy, A.B.., Jasser, S.A., et al. Epidermal growth factor receptor (EGFR) is overexpressed in anaplastic thyroid cancer, and the EGFR inhibitor gefitinib inhibits the growth of anaplastic thyroid cancer. Clin Cancer Res 10 (2004), 8594–8602.
    • (2004) Clin Cancer Res , vol.10 , pp. 8594-8602
    • Schiff, B.A.1    McMurphy, A.B.2    Jasser, S.A.3
  • 4
    • 84864367360 scopus 로고    scopus 로고
    • The ERBB network: at last, cancer therapy meets systems biology
    • [4] Yarden, Y., Pines, G., The ERBB network: at last, cancer therapy meets systems biology. Nat Rev Cancer 12 (2012), 553–563.
    • (2012) Nat Rev Cancer , vol.12 , pp. 553-563
    • Yarden, Y.1    Pines, G.2
  • 5
    • 0034954124 scopus 로고    scopus 로고
    • The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy
    • [5] Pedersen, M.W., Meltorn, M., Damstrup, L., Poulsen, H.S., The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy. Ann Oncol 12 (2001), 745–760.
    • (2001) Ann Oncol , vol.12 , pp. 745-760
    • Pedersen, M.W.1    Meltorn, M.2    Damstrup, L.3    Poulsen, H.S.4
  • 6
    • 84886089551 scopus 로고    scopus 로고
    • The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered
    • [6] Gan, H.K., Cvrljevic, A.N., Johns, T.G., The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered. FEBS J 280 (2013), 5350–5370.
    • (2013) FEBS J , vol.280 , pp. 5350-5370
    • Gan, H.K.1    Cvrljevic, A.N.2    Johns, T.G.3
  • 7
    • 65549101146 scopus 로고    scopus 로고
    • Expression of EGFRvIII in thyroid carcinoma: immunohistochemical study by camel antibodies
    • [7] Omidfar, K., Moinfar, Z., Sohi, A.N., et al. Expression of EGFRvIII in thyroid carcinoma: immunohistochemical study by camel antibodies. Immunol Invest 38 (2009), 165–180.
    • (2009) Immunol Invest , vol.38 , pp. 165-180
    • Omidfar, K.1    Moinfar, Z.2    Sohi, A.N.3
  • 8
    • 84866298370 scopus 로고    scopus 로고
    • Caveolae, caveolins, cavins, and endothelial cell function: new insights
    • [8] Sowa, G., Caveolae, caveolins, cavins, and endothelial cell function: new insights. Front Physiol, 2, 2012, 120.
    • (2012) Front Physiol , vol.2 , pp. 120
    • Sowa, G.1
  • 9
    • 84857118750 scopus 로고    scopus 로고
    • The interaction between caveolin-1 and rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk
    • [9] Arpaia, E., Blaser, H., Quintela-Fandino, M., et al. The interaction between caveolin-1 and rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk. Oncogene 31 (2012), 884–896.
    • (2012) Oncogene , vol.31 , pp. 884-896
    • Arpaia, E.1    Blaser, H.2    Quintela-Fandino, M.3
  • 10
    • 0035809933 scopus 로고    scopus 로고
    • A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance
    • [10] Pol, A., Luetterforst, R., Lindsay, M., Heino, S., Ikonen, E., Parton, R.G., A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance. J Cell Biol 152 (2001), 1057–1070.
    • (2001) J Cell Biol , vol.152 , pp. 1057-1070
    • Pol, A.1    Luetterforst, R.2    Lindsay, M.3    Heino, S.4    Ikonen, E.5    Parton, R.G.6
  • 11
    • 52549127487 scopus 로고    scopus 로고
    • Caveolin-1 in tumor progression: the good, the bad and the ugly
    • [11] Goetz, J.G., Lajoie, P., Wiseman, S.M., Nabi, I.R., Caveolin-1 in tumor progression: the good, the bad and the ugly. Cancer Metastasis Rev 27 (2008), 715–735.
    • (2008) Cancer Metastasis Rev , vol.27 , pp. 715-735
    • Goetz, J.G.1    Lajoie, P.2    Wiseman, S.M.3    Nabi, I.R.4
  • 12
    • 4444382247 scopus 로고    scopus 로고
    • Papillary and follicular thyroid carcinomas show distinctly different microarray expression profiles and can be distinguished by a minimum of five genes
    • [12] Aldred, M.A., Huang, Y., Liyanarachchi, S., et al. Papillary and follicular thyroid carcinomas show distinctly different microarray expression profiles and can be distinguished by a minimum of five genes. J Clin Oncol 22 (2004), 3531–3539.
    • (2004) J Clin Oncol , vol.22 , pp. 3531-3539
    • Aldred, M.A.1    Huang, Y.2    Liyanarachchi, S.3
  • 13
    • 18344365571 scopus 로고    scopus 로고
    • Caveolin-1 overexpression is an early event in the progression of papillary carcinoma of the thyroid
    • [13] Ito, Y., Yoshida, H., Nakano, K., et al. Caveolin-1 overexpression is an early event in the progression of papillary carcinoma of the thyroid. Br J Cancer 86 (2002), 912–916.
    • (2002) Br J Cancer , vol.86 , pp. 912-916
    • Ito, Y.1    Yoshida, H.2    Nakano, K.3
  • 14
    • 0030731231 scopus 로고    scopus 로고
    • Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities
    • [14] Couet, J., Sargiacomo, M., Lisanti, M.P., Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities. J Biol Chem 272 (1997), 30429–30438.
    • (1997) J Biol Chem , vol.272 , pp. 30429-30438
    • Couet, J.1    Sargiacomo, M.2    Lisanti, M.P.3
  • 15
    • 0034677942 scopus 로고    scopus 로고
    • Epidermal growth factor–stimulated tyrosine phosphorylation of caveolin-1. Enhanced caveolin-1 tyrosine phosphorylation following aberrant epidermal growth factor receptor status
    • [15] Kim, Y.N., Wiepz, G.J., Guadarrama, A.G., Bertics, P.J., Epidermal growth factor–stimulated tyrosine phosphorylation of caveolin-1. Enhanced caveolin-1 tyrosine phosphorylation following aberrant epidermal growth factor receptor status. J Biol Chem 275 (2000), 7481–7491.
    • (2000) J Biol Chem , vol.275 , pp. 7481-7491
    • Kim, Y.N.1    Wiepz, G.J.2    Guadarrama, A.G.3    Bertics, P.J.4
  • 16
    • 84859900874 scopus 로고    scopus 로고
    • Multiparametric image analysis reveals role of Caveolin1 in endosomal progression rather than internalization of EGFR
    • [16] Schmidt-Glenewinkel, H., Reinz, E., Bulashevska, S., et al. Multiparametric image analysis reveals role of Caveolin1 in endosomal progression rather than internalization of EGFR. FEBS Lett 586 (2012), 1179–1189.
    • (2012) FEBS Lett , vol.586 , pp. 1179-1189
    • Schmidt-Glenewinkel, H.1    Reinz, E.2    Bulashevska, S.3
  • 17
    • 84960532446 scopus 로고    scopus 로고
    • Microparticle-induced activation of the vascular endothelium requires caveolin-1/caveolae
    • [17] Andrews, A.M., Rizzo, V., Microparticle-induced activation of the vascular endothelium requires caveolin-1/caveolae. PLoS One, 11, 2016, e0149272.
    • (2016) PLoS One , vol.11
    • Andrews, A.M.1    Rizzo, V.2
  • 18
    • 84978086444 scopus 로고    scopus 로고
    • C-Src/Cav1-dependent activation of the EGFR by Dsg2
    • [18] Overmiller, A.M., McGuinn, K.P., Roberts, B.J., et al. C-Src/Cav1-dependent activation of the EGFR by Dsg2. Oncotarget 7 (2016), 37536–37555.
    • (2016) Oncotarget , vol.7 , pp. 37536-37555
    • Overmiller, A.M.1    McGuinn, K.P.2    Roberts, B.J.3
  • 19
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • [19] Davies, H., Bignell, G.R., Cox, C., et al. Mutations of the BRAF gene in human cancer. Nature 417 (2002), 949–954.
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 20
    • 79953325102 scopus 로고    scopus 로고
    • Molecular analysis of thyroid tumors
    • [20] Nikiforov, Y.E., Molecular analysis of thyroid tumors. Mod Pathol 24 (2011), S34–S43.
    • (2011) Mod Pathol , vol.24 , pp. S34-S43
    • Nikiforov, Y.E.1
  • 21
    • 63149194964 scopus 로고    scopus 로고
    • (V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway
    • [21] Pratilas, C.A., Taylor, B.S., Ye, Q., et al. (V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway. Proc Natl Acad Sci U S A 106 (2009), 4519–4524.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 4519-4524
    • Pratilas, C.A.1    Taylor, B.S.2    Ye, Q.3
  • 22
    • 10744222003 scopus 로고    scopus 로고
    • BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas
    • [22] Nikiforova, M.N., Kimura, E.T., Gandhi, M., et al. BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas. J Clin Endocrinol Metab 88 (2003), 5399–5404.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5399-5404
    • Nikiforova, M.N.1    Kimura, E.T.2    Gandhi, M.3
  • 23
    • 80655147350 scopus 로고    scopus 로고
    • Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samples
    • [23] Nikiforov, Y.E., Ohori, N.P., Hodak, S.P., et al. Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samples. J Clin Endocrinol Metab 96 (2011), 3390–3397.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 3390-3397
    • Nikiforov, Y.E.1    Ohori, N.P.2    Hodak, S.P.3
  • 24
    • 84875952085 scopus 로고    scopus 로고
    • Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer
    • [24] Xing, M., Alzahrani, A.S., Carson, K.A., et al. Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer. JAMA 309 (2013), 1493–1501.
    • (2013) JAMA , vol.309 , pp. 1493-1501
    • Xing, M.1    Alzahrani, A.S.2    Carson, K.A.3
  • 25
    • 84906815246 scopus 로고    scopus 로고
    • BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence
    • [25] Xing, M., Liu, R., Liu, X., et al. BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence. J Clin Oncol 32 (2014), 2718–2726.
    • (2014) J Clin Oncol , vol.32 , pp. 2718-2726
    • Xing, M.1    Liu, R.2    Liu, X.3
  • 26
    • 77954818058 scopus 로고    scopus 로고
    • The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM
    • [26] Edge, S.B., Compton, C.C., The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 17 (2010), 1471–1474.
    • (2010) Ann Surg Oncol , vol.17 , pp. 1471-1474
    • Edge, S.B.1    Compton, C.C.2
  • 27
    • 77956571967 scopus 로고    scopus 로고
    • Correlation between the BRAF V600E mutation and tumor invasiveness in papillary thyroid carcinomas smaller than 20 millimeters: analysis of 1060 cases
    • [27] Basolo, F., Torregrossa, L., Giannini, R., et al. Correlation between the BRAF V600E mutation and tumor invasiveness in papillary thyroid carcinomas smaller than 20 millimeters: analysis of 1060 cases. J Clin Endocrinol Metab 95 (2010), 4197–4205.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 4197-4205
    • Basolo, F.1    Torregrossa, L.2    Giannini, R.3
  • 28
    • 33644586429 scopus 로고    scopus 로고
    • Detection of BRAF mutation in thyroid papillary carcinomas by mutant allele-specific PCR amplification (MASA)
    • [28] Sapio, M.R., Posca, D., Troncone, G., et al. Detection of BRAF mutation in thyroid papillary carcinomas by mutant allele-specific PCR amplification (MASA). Eur J Endocrinol 154 (2006), 341–348.
    • (2006) Eur J Endocrinol , vol.154 , pp. 341-348
    • Sapio, M.R.1    Posca, D.2    Troncone, G.3
  • 29
    • 69949123875 scopus 로고    scopus 로고
    • Robust detection of EGFR copy number changes and EGFR variant III: technical aspects and relevance for glioma diagnostics
    • [29] Jeuken, J., Sijben, A., Alenda, C., et al. Robust detection of EGFR copy number changes and EGFR variant III: technical aspects and relevance for glioma diagnostics. Brain Pathol 19 (2009), 661–671.
    • (2009) Brain Pathol , vol.19 , pp. 661-671
    • Jeuken, J.1    Sijben, A.2    Alenda, C.3
  • 30
    • 84865517604 scopus 로고    scopus 로고
    • Caveolin-1 plays a critical role in the differentiation of monocytes into macrophages
    • [30] Fu, Y., Moore, X.L., Lee, M.K., et al. Caveolin-1 plays a critical role in the differentiation of monocytes into macrophages. Arterioscler Thromb Vasc Biol 32 (2012), e117–e125.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. e117-e125
    • Fu, Y.1    Moore, X.L.2    Lee, M.K.3
  • 31
    • 84872321028 scopus 로고    scopus 로고
    • Caveolin-1 expression in thyroid neoplasia spectrum: comparison of two commercial antibodies
    • [31] Jankovic, J., Paskas, S., Marecko, I., Bozic, V., Cvejic, D., Savin, S., Caveolin-1 expression in thyroid neoplasia spectrum: comparison of two commercial antibodies. Dis Markers 33 (2012), 321–331.
    • (2012) Dis Markers , vol.33 , pp. 321-331
    • Jankovic, J.1    Paskas, S.2    Marecko, I.3    Bozic, V.4    Cvejic, D.5    Savin, S.6
  • 32
    • 84893529790 scopus 로고    scopus 로고
    • Caveolin-1 expression in papillary thyroid carcinoma: correlation with clinicopathological parameters and BRAF mutation status
    • [32] Paskas, S., Jankovic, J., Marecko, I., et al. Caveolin-1 expression in papillary thyroid carcinoma: correlation with clinicopathological parameters and BRAF mutation status. Otolaryngol Head Neck Surg 150 (2014), 201–209.
    • (2014) Otolaryngol Head Neck Surg , vol.150 , pp. 201-209
    • Paskas, S.1    Jankovic, J.2    Marecko, I.3
  • 33
    • 66549094655 scopus 로고    scopus 로고
    • Molecular markers in thyroid fine-needle aspiration biopsy: a prospective study
    • [33] Franco, C., Martinez, V., Allamand, J.P., et al. Molecular markers in thyroid fine-needle aspiration biopsy: a prospective study. Appl Immunohistochem Mol Morphol 17 (2009), 211–215.
    • (2009) Appl Immunohistochem Mol Morphol , vol.17 , pp. 211-215
    • Franco, C.1    Martinez, V.2    Allamand, J.P.3
  • 34
    • 84861898656 scopus 로고    scopus 로고
    • Use of molecular markers in samples obtained from preoperative aspiration of thyroid
    • [34] Rodrigues, H.G., de Pontes, A.A., Adan, L.F., Use of molecular markers in samples obtained from preoperative aspiration of thyroid. Endocr J 59 (2012), 417–424.
    • (2012) Endocr J , vol.59 , pp. 417-424
    • Rodrigues, H.G.1    de Pontes, A.A.2    Adan, L.F.3
  • 35
    • 84961583756 scopus 로고    scopus 로고
    • Galectin-3 and HBME-1 improve the accuracy of core biopsy in indeterminate thyroid nodules
    • [35] Trimboli, P., Guidobaldi, L., Amendola, S., et al. Galectin-3 and HBME-1 improve the accuracy of core biopsy in indeterminate thyroid nodules. Endocrine 52 (2016), 39–45.
    • (2016) Endocrine , vol.52 , pp. 39-45
    • Trimboli, P.1    Guidobaldi, L.2    Amendola, S.3
  • 36
    • 84929860349 scopus 로고    scopus 로고
    • Expression of the estrogen receptor alpha, progesterone receptor and epidermal growth factor receptor in papillary thyroid carcinoma tissues
    • [36] Chen, D., Qi, W., Zhang, P., Guan, H., Wang, L., Expression of the estrogen receptor alpha, progesterone receptor and epidermal growth factor receptor in papillary thyroid carcinoma tissues. Oncol Lett 10 (2015), 317–320.
    • (2015) Oncol Lett , vol.10 , pp. 317-320
    • Chen, D.1    Qi, W.2    Zhang, P.3    Guan, H.4    Wang, L.5
  • 37
    • 33846849604 scopus 로고    scopus 로고
    • Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A
    • [37] Yeh, M.W., Rougier, J.P., Park, J.W., et al. Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A. Endocr Relat Cancer 13 (2006), 1173–1183.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 1173-1183
    • Yeh, M.W.1    Rougier, J.P.2    Park, J.W.3
  • 38
    • 84928745211 scopus 로고    scopus 로고
    • Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer
    • [38] Zhang, L., Zhang, Y., Mehta, A., et al. Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer. Oncotarget 6 (2015), 9073–9085.
    • (2015) Oncotarget , vol.6 , pp. 9073-9085
    • Zhang, L.1    Zhang, Y.2    Mehta, A.3
  • 39
    • 79951847980 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and caveolin-1 coexpression identifies adult supratentorial ependymomas with rapid unfavorable outcomes
    • [39] Senetta, R., Miracco, C., Lanzafame, S., et al. Epidermal growth factor receptor and caveolin-1 coexpression identifies adult supratentorial ependymomas with rapid unfavorable outcomes. Neuro Oncol 13 (2011), 176–183.
    • (2011) Neuro Oncol , vol.13 , pp. 176-183
    • Senetta, R.1    Miracco, C.2    Lanzafame, S.3
  • 40
    • 84886721499 scopus 로고    scopus 로고
    • Epidermal growth factor receptor overexpression is a marker for adverse pathologic features in papillary thyroid carcinoma
    • [40] Fisher, K.E., Jani, J.C., Fisher, S.B., et al. Epidermal growth factor receptor overexpression is a marker for adverse pathologic features in papillary thyroid carcinoma. J Surg Res 185 (2013), 217–224.
    • (2013) J Surg Res , vol.185 , pp. 217-224
    • Fisher, K.E.1    Jani, J.C.2    Fisher, S.B.3
  • 41
    • 83755206271 scopus 로고    scopus 로고
    • Epidermal growth factor receptor 1 expression is upregulated in undifferentiated thyroid carcinomas in humans
    • [41] Landriscina, M., Pannone, G., Piscazzi, A., et al. Epidermal growth factor receptor 1 expression is upregulated in undifferentiated thyroid carcinomas in humans. Thyroid 21 (2011), 1227–1234.
    • (2011) Thyroid , vol.21 , pp. 1227-1234
    • Landriscina, M.1    Pannone, G.2    Piscazzi, A.3
  • 42
    • 84931568577 scopus 로고    scopus 로고
    • Overexpression of EphB4, EphrinB2, and epidermal growth factor receptor in papillary thyroid carcinoma: a pilot study
    • [42] Sharma, G.K., Dhillon, V.K., Masood, R., Maceri, D.R., Overexpression of EphB4, EphrinB2, and epidermal growth factor receptor in papillary thyroid carcinoma: a pilot study. Head Neck 37 (2015), 964–969.
    • (2015) Head Neck , vol.37 , pp. 964-969
    • Sharma, G.K.1    Dhillon, V.K.2    Masood, R.3    Maceri, D.R.4


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