Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer

Oncotarget

Volumn 6, Issue 11, 2015, Pages 9073-9085

  Zhang, Lisa ^a   Zhang, Yaqin ^b   Mehta, Amit ^a,c   Boufraqech, Myriem ^a   Davis, Sean ^a   Wang, Jing ^d   Tian, Ze ^d   Yu, Zhiya ^a   Boxer, Matthew B ^b   Kiefer, Jeffrey A ^e   Copland, John A ^f   Smallridge, Robert C ^f   Li, Zhuyin ^b   Shen, Min ^b   Kebebew, Electron ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

^d CURIS INC   (United States)

^e TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^f MAYO CLINIC   (United States)

Author keywords

Anaplastic thyroid cancer; CUDC 101; EGFR; HDAC; Quantitative high throughput screening

Indexed keywords

BETA CATENIN; CASPASE; CUDC 101; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; NERVE CELL ADHESION MOLECULE; PROTEIN P21; SURVIVIN; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; X LINKED INHIBITOR OF APOPTOSIS; 7-(4-(3-ETHYNYLPHENYLAMINO)-7-METHOXYQUINAZOLIN-6-YLOXY)-N-HYDROXYHEPTANAMIDE; ANTINEOPLASTIC AGENT; DNA; ERBB2 PROTEIN, HUMAN; HYDROXAMIC ACID; MOLECULAR LIBRARY; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; TUMOR PROTEIN;

ANAPLASTIC THYROID CANCER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER SURVIVAL; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL MIGRATION; CELL PROLIFERATION; DEACETYLATION; DRUG EFFICACY; EPITHELIAL MESENCHYMAL TRANSITION; GENE SEQUENCE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; IC50; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THYROID CANCER CELL LINE; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CARCINOMA; CELL CYCLE; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; MOLECULAR LIBRARY; MOLECULARLY TARGETED THERAPY; MUTATION; PATHOLOGY; SECONDARY; THYROID NEOPLASMS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA; CELL CYCLE; CELL LINE, TUMOR; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; HIGH-THROUGHPUT SCREENING ASSAYS; HISTONE DEACETYLASE INHIBITORS; HUMANS; HYDROXAMIC ACIDS; MICE; MOLECULAR TARGETED THERAPY; MUTATION; NEOPLASM PROTEINS; PROTEIN KINASE INHIBITORS; QUINAZOLINES; RECEPTOR, ERBB-2; SMALL MOLECULE LIBRARIES; THYROID NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84928745211     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3268     Document Type: Article

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