A childhood acute lymphoblastic leukemia genome-wide association study identifies novel sex-specific risk variants

Medicine (United States)

Volumn 95, Issue 46, 2016, Pages

  Singh, Sandeep K ^a   Lupo, Philip J ^b   Scheurer, Michael E ^c   Saxena, Anshul ^a   Kennedy, Amy E ^d   Ibrahimou, Boubakari ^a   Barbieri, Manuel Alejandro ^a   Mills, Ken I ^e   McCauley, Jacob L ^f   Okcu, Mehmet Fatih ^c   Dorak, Mehmet Tevfik ^a  

^a FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^b TEXAS CHILDREN S CANCER CENTER   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^f UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Acute lymphoblastic leukemia; Case only study; Effect modification; Expression quantitative trait loci; Gene expression regulation; Genome wide association study; Sex specific association

Indexed keywords

COX6B1 PROTEIN; ESTROGEN RECEPTOR; HLA DQA1 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; K LYSINE ACETYLTRANSFERASE 7; MICRORNA; MIR 17 92; PROTEIN; RASSF2 PROTEIN; SEX HORMONE; UNCLASSIFIED DRUG; HLA DQ ANTIGEN; HLA-DQA1 ANTIGEN; RASSF2 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENCE; ARTICLE; BINDING SITE; BONE MARROW; CAUCASIAN; CHILD; CHILDHOOD; COMPARATIVE STUDY; CONTROL; CONTROLLED STUDY; CPG ISLAND; ENHANCER REGION; EXPRESSION QUANTITATIVE TRAIT LOCUS; FEMALE; FREQUENCY; GENE EXPRESSION LEVEL; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HAPLOTYPE MAP; HORMONE DETERMINATION; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PREGNANCY; PRIORITY JOURNAL; PROMOTER REGION; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; TRANSCRIPTION INITIATION SITE; GENETIC PREDISPOSITION; GENETICS; INFANT; PRESCHOOL CHILD; RISK; TEXAS;

CHILD; CHILD, PRESCHOOL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HLA-DQ ALPHA-CHAINS; HUMANS; INFANT; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RISK; SEX FACTORS; TEXAS; TUMOR SUPPRESSOR PROTEINS;

EID: 85012005500     PISSN: 00257974     EISSN: 15365964     Source Type: Journal    
DOI: 10.1097/MD.0000000000005300     Document Type: Article

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