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Volumn 5, Issue 3, 2008, Pages

The intergenic spacer of the Drosophila Adh-Adhr dicistronic mRNA stimulates internal translation initiation

Author keywords

3 end processing; Dicistronic mRNA; IRES; Splicing; Translation

Indexed keywords

ALCOHOL DEHYDROGENASE; MESSENGER RNA; MESSENGER RNA PRECURSOR; SPACER DNA;

EID: 85011942133     PISSN: 15476286     EISSN: 15558584     Source Type: Journal    
DOI: 10.4161/rna.5.3.6676     Document Type: Article
Times cited : (6)

References (39)
  • 1
    • 0011343769 scopus 로고
    • How ribosomes select initiator regions in mRNA: Base pair formation between the 3′ terminus of 16S rRNA and the mRNA during initiation of protein synthesis in Escherichia coli
    • Steitz JA, Jakes K. How ribosomes select initiator regions in mRNA: base pair formation between the 3′ terminus of 16S rRNA and the mRNA during initiation of protein synthesis in Escherichia coli. Proc Natl Acad Sci USA 1975; 72:4734-8.
    • (1975) Proc Natl Acad Sci USA , vol.72 , pp. 4734-4738
    • Steitz, J.A.1    Jakes, K.2
  • 2
    • 0024546509 scopus 로고
    • The scanning model for translation: An update
    • Kozak M. The scanning model for translation: an update. J Cell Biol 1989; 108:229-41.
    • (1989) J Cell Biol , vol.108 , pp. 229-241
    • Kozak, M.1
  • 4
    • 13844318119 scopus 로고    scopus 로고
    • Blumenthal T. Operons in eukaryotes. Brief Funct Genomic Proteomic 2004; 3:199-211.
    • Blumenthal T. Operons in eukaryotes. Brief Funct Genomic Proteomic 2004; 3:199-211.
  • 5
    • 0029795968 scopus 로고    scopus 로고
    • The Stoned Locus Of Drosophila Melanogaster Produces a Dicistronic Transcript and Encodes 2 Distinct Polypeptides
    • Andrews J, Smith M, Merakovsky J, Coulson M, Hannan F, Kelly LE. The Stoned Locus Of Drosophila Melanogaster Produces a Dicistronic Transcript and Encodes 2 Distinct Polypeptides. Genetics 1996; 143:1699-711.
    • (1996) Genetics , vol.143 , pp. 1699-1711
    • Andrews, J.1    Smith, M.2    Merakovsky, J.3    Coulson, M.4    Hannan, F.5    Kelly, L.E.6
  • 6
    • 34249021370 scopus 로고    scopus 로고
    • Peptides encoded by short ORFs control development and define a new eukaryotic gene family
    • Galindo MI, Pueyo JI, Fouix S, Bishop SA, Couso JP. Peptides encoded by short ORFs control development and define a new eukaryotic gene family. PLoS Biol 2007; 5:106.
    • (2007) PLoS Biol , vol.5 , pp. 106
    • Galindo, M.I.1    Pueyo, J.I.2    Fouix, S.3    Bishop, S.A.4    Couso, J.P.5
  • 7
    • 33746736922 scopus 로고    scopus 로고
    • A segmentation gene in tribolium produces a polycistronic mRNA that codes for multiple conserved peptides
    • Savard J, Marques-Souza H, Aranda M, Tautz D. A segmentation gene in tribolium produces a polycistronic mRNA that codes for multiple conserved peptides. Cell 2006; 126:559-69.
    • (2006) Cell , vol.126 , pp. 559-569
    • Savard, J.1    Marques-Souza, H.2    Aranda, M.3    Tautz, D.4
  • 8
    • 0030933005 scopus 로고    scopus 로고
    • The Adh-related gene of Drosophila melanogaster is expressed as a functional dicistronic messenger RNA: Multigenic transcription in higher organisms
    • Brogna S, Ashburner M. The Adh-related gene of Drosophila melanogaster is expressed as a functional dicistronic messenger RNA: Multigenic transcription in higher organisms. EMBO J 1997; 16:2023-31.
    • (1997) EMBO J , vol.16 , pp. 2023-2031
    • Brogna, S.1    Ashburner, M.2
  • 10
    • 36049018312 scopus 로고    scopus 로고
    • Stark A, Lin MF, Kheradpour P, Pedersen JS, Parts L, Carlson JW, Crosby MA, Rasmussen MD, Roy S, Deoras AN, Ruby JG, Brennecke J, Curators HF, Project BD, Hodges E, Hinrichs AS, Caspi A, Paten B, Park SW, Han MV, Maeder ML, Polansky BJ, Robson BE, Aerts S, van Helden J, Hassan B, Gilbert DG, Eastman DA, Rice M, Weir M, Hahn MW, Park Y, Dewey CN, Pachter L, Kent WJ, Haussler D, Lai EC, Bartel DP, Hannon GJ, Kaufman TC, Eisen MB, Clark AG, Smith D, Celniker SE, Gelbart WM, Kellis M, Crosby MA, Matthews BB, Schroeder AJ, Sian Gramates L, St Pierre SE, Roark M, Wiley KL Jr, Kulathinal RJ, Zhang P, Myrick KV, Antone JV, Gelbart WM, Carlson JW, Yu C, Park S, Wan KH, Celniker SE. Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature 2007; 450:219-32.
    • Stark A, Lin MF, Kheradpour P, Pedersen JS, Parts L, Carlson JW, Crosby MA, Rasmussen MD, Roy S, Deoras AN, Ruby JG, Brennecke J, Curators HF, Project BD, Hodges E, Hinrichs AS, Caspi A, Paten B, Park SW, Han MV, Maeder ML, Polansky BJ, Robson BE, Aerts S, van Helden J, Hassan B, Gilbert DG, Eastman DA, Rice M, Weir M, Hahn MW, Park Y, Dewey CN, Pachter L, Kent WJ, Haussler D, Lai EC, Bartel DP, Hannon GJ, Kaufman TC, Eisen MB, Clark AG, Smith D, Celniker SE, Gelbart WM, Kellis M, Crosby MA, Matthews BB, Schroeder AJ, Sian Gramates L, St Pierre SE, Roark M, Wiley KL Jr, Kulathinal RJ, Zhang P, Myrick KV, Antone JV, Gelbart WM, Carlson JW, Yu C, Park S, Wan KH, Celniker SE. Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature 2007; 450:219-32.
  • 11
    • 0029437960 scopus 로고
    • Internal initiation of translation in eukaryotes: The picornavirus paradigm and beyond
    • Jackson RJ, Kaminski A. Internal initiation of translation in eukaryotes: The picornavirus paradigm and beyond. RNA 1995; 1:985-1000.
    • (1995) RNA , vol.1 , pp. 985-1000
    • Jackson, R.J.1    Kaminski, A.2
  • 12
    • 28844476749 scopus 로고    scopus 로고
    • Alternative mechanisms of initiating translation of mammalian mRNAs
    • Jackson RJ. Alternative mechanisms of initiating translation of mammalian mRNAs. Biochem Soc Trans 2005; 33:1231-41.
    • (2005) Biochem Soc Trans , vol.33 , pp. 1231-1241
    • Jackson, R.J.1
  • 13
    • 21244431682 scopus 로고    scopus 로고
    • Internal ribosome entry sites in cellular mRNAs: Mystery of their existence
    • Komar AA, Hatzoglou M. Internal ribosome entry sites in cellular mRNAs: mystery of their existence. J Biol Chem 2005; 280:23425-8.
    • (2005) J Biol Chem , vol.280 , pp. 23425-23428
    • Komar, A.A.1    Hatzoglou, M.2
  • 15
    • 23044487223 scopus 로고    scopus 로고
    • Effective translation of the second cistron in two Drosophila dicistronic transcripts is determined by the absence of in-frame AUG codons in the first cistron
    • Wall AA, Phillips AM, Kelly LE. Effective translation of the second cistron in two Drosophila dicistronic transcripts is determined by the absence of in-frame AUG codons in the first cistron. J Biol Chem 2005; 280:27670-8.
    • (2005) J Biol Chem , vol.280 , pp. 27670-27678
    • Wall, A.A.1    Phillips, A.M.2    Kelly, L.E.3
  • 16
    • 0033866762 scopus 로고    scopus 로고
    • Duplication, dicistronic transcription and subsequent evolution of the Alcohol dehydrogenase and Alcohol dehydrogenase-related genes in Drosophila
    • Betran E, Ashburner M. Duplication, dicistronic transcription and subsequent evolution of the Alcohol dehydrogenase and Alcohol dehydrogenase-related genes in Drosophila. Mol Biol Evol 2000; 17:1344-52.
    • (2000) Mol Biol Evol , vol.17 , pp. 1344-1352
    • Betran, E.1    Ashburner, M.2
  • 17
    • 0031024996 scopus 로고    scopus 로고
    • Ultrabithorax and Antennapedia 5′ untranslated regions promote developmentally regulated internal translation initiation
    • Ye X, Fong P, Iizuka N, Choate D, Cavener DR. Ultrabithorax and Antennapedia 5′ untranslated regions promote developmentally regulated internal translation initiation. Mol Cell Biol 1997; 17:1714-21.
    • (1997) Mol Cell Biol , vol.17 , pp. 1714-1721
    • Ye, X.1    Fong, P.2    Iizuka, N.3    Choate, D.4    Cavener, D.R.5
  • 18
    • 0029978413 scopus 로고    scopus 로고
    • A test for cell autonomy, based on di-cistronic messanger translation
    • Hart K, Bienz M. A test for cell autonomy, based on di-cistronic messanger translation. Development 1996; 122:747-51.
    • (1996) Development , vol.122 , pp. 747-751
    • Hart, K.1    Bienz, M.2
  • 19
    • 0028347758 scopus 로고
    • The molecular evolution of the alcohol dehydrogenase and alcohol dehydrogenase-related genes in the Drosophila melanogaster species subgroup
    • Jeffs PS, Holmes EC, Ashburner M. The molecular evolution of the alcohol dehydrogenase and alcohol dehydrogenase-related genes in the Drosophila melanogaster species subgroup. Mol Biol Evol 1994; 11:287-304.
    • (1994) Mol Biol Evol , vol.11 , pp. 287-304
    • Jeffs, P.S.1    Holmes, E.C.2    Ashburner, M.3
  • 20
    • 0035008872 scopus 로고    scopus 로고
    • New ways of initiating translation in eukaryotes?
    • Kozak M. New ways of initiating translation in eukaryotes? Mol Cell Biol 2001; 21:1899-907.
    • (2001) Mol Cell Biol , vol.21 , pp. 1899-1907
    • Kozak, M.1
  • 21
    • 33646884832 scopus 로고    scopus 로고
    • Assessing IRES activity in the HIF-1alpha and other cellular 5′ UTRs
    • Bert AG, Grepin R, Vadas MA, Goodall GJ. Assessing IRES activity in the HIF-1alpha and other cellular 5′ UTRs. RNA 2006; 12:1074-83.
    • (2006) RNA , vol.12 , pp. 1074-1083
    • Bert, A.G.1    Grepin, R.2    Vadas, M.A.3    Goodall, G.J.4
  • 23
    • 33646193306 scopus 로고    scopus 로고
    • Control of mammalian translation by mRNA structure near caps
    • Babendure JR, Babendure JL, Ding JH, Tsien RY. Control of mammalian translation by mRNA structure near caps. RNA 2006; 12:851-61.
    • (2006) RNA , vol.12 , pp. 851-861
    • Babendure, J.R.1    Babendure, J.L.2    Ding, J.H.3    Tsien, R.Y.4
  • 24
    • 0942268832 scopus 로고    scopus 로고
    • Splicing enhances translation in mammalian cells: An additional function of the exon junction complex
    • Nott A, Le Hir H, Moore MJ. Splicing enhances translation in mammalian cells: an additional function of the exon junction complex. Genes Dev 2004; 18:210-22.
    • (2004) Genes Dev , vol.18 , pp. 210-222
    • Nott, A.1    Le Hir, H.2    Moore, M.J.3
  • 25
    • 33750200773 scopus 로고    scopus 로고
    • An interaction between U2AF 65 and CF I(m) links the splicing and 3′ end processing machineries
    • Millevoi S, Loulergue C, Dettwiler S, Karaa SZ, Keller W, Antoniou M, Vagner S. An interaction between U2AF 65 and CF I(m) links the splicing and 3′ end processing machineries. EMBO J 2006; 25:4854-64.
    • (2006) EMBO J , vol.25 , pp. 4854-4864
    • Millevoi, S.1    Loulergue, C.2    Dettwiler, S.3    Karaa, S.Z.4    Keller, W.5    Antoniou, M.6    Vagner, S.7
  • 26
    • 33745944934 scopus 로고    scopus 로고
    • Direct interactions between subunits of CPSF and the U2 snRNP contribute to the coupling of pre-mRNA 3′ end processing and splicing
    • Kyburz A, Friedlein A, Langen H, Keller W. Direct interactions between subunits of CPSF and the U2 snRNP contribute to the coupling of pre-mRNA 3′ end processing and splicing. Mol Cell 2006; 23:195-205.
    • (2006) Mol Cell , vol.23 , pp. 195-205
    • Kyburz, A.1    Friedlein, A.2    Langen, H.3    Keller, W.4
  • 27
    • 0025029405 scopus 로고
    • Point Mutations In Aauaaa and the Poly(a) Addition Site - Effects On the Accuracy and Efficiency Of Cleavage and Polyadenylation In vitro
    • Sheets MD, Ogg SC, Wickens MP. Point Mutations In Aauaaa and the Poly(a) Addition Site - Effects On the Accuracy and Efficiency Of Cleavage and Polyadenylation In vitro. Nucleic Acids Research 1990; 18:5799-805.
    • (1990) Nucleic Acids Research , vol.18 , pp. 5799-5805
    • Sheets, M.D.1    Ogg, S.C.2    Wickens, M.P.3
  • 28
    • 7044249198 scopus 로고    scopus 로고
    • Internal ribosome entry site drives cap-independent translation of reaper and heat shock protein 70 mRNAs in Drosophila embryos
    • Hernandez G, Vazquez-Pianzola P, Sierra JM, Rivera-Pomar R. Internal ribosome entry site drives cap-independent translation of reaper and heat shock protein 70 mRNAs in Drosophila embryos. RNA 2004; 10:1783-97.
    • (2004) RNA , vol.10 , pp. 1783-1797
    • Hernandez, G.1    Vazquez-Pianzola, P.2    Sierra, J.M.3    Rivera-Pomar, R.4
  • 29
    • 0033229825 scopus 로고    scopus 로고
    • Translational control of dosage compensation in Drosophila by Sex-lethal: Cooperative silencing via the 5′ and 3′ UTRs of msl-2 mRNA is independent of the poly(A) tail
    • Gebauer F, Corona DF, Preiss T, Becker PB, Hentze MW. Translational control of dosage compensation in Drosophila by Sex-lethal: cooperative silencing via the 5′ and 3′ UTRs of msl-2 mRNA is independent of the poly(A) tail. EMBO J 1999; 18:6146-54.
    • (1999) EMBO J , vol.18 , pp. 6146-6154
    • Gebauer, F.1    Corona, D.F.2    Preiss, T.3    Becker, P.B.4    Hentze, M.W.5
  • 30
    • 0034672093 scopus 로고    scopus 로고
    • The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
    • Le Hir H, Izaurralde E, Maquat LE, Moore MJ. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. EMBO J 2000; 19:6860-9.
    • (2000) EMBO J , vol.19 , pp. 6860-6869
    • Le Hir, H.1    Izaurralde, E.2    Maquat, L.E.3    Moore, M.J.4
  • 31
    • 33846505055 scopus 로고    scopus 로고
    • A nucleo-cytoplasmic SR protein functions in viral IRES-mediated translation initiation
    • Bedard KM, Daijogo S, Semler BL. A nucleo-cytoplasmic SR protein functions in viral IRES-mediated translation initiation. EMBO J 2007; 26:459-67.
    • (2007) EMBO J , vol.26 , pp. 459-467
    • Bedard, K.M.1    Daijogo, S.2    Semler, B.L.3
  • 32
    • 34548535363 scopus 로고    scopus 로고
    • Cap-independent translation is required for starvation-induced differentiation in yeast
    • Gilbert WV, Zhou K, Butler TK, Doudna JA. Cap-independent translation is required for starvation-induced differentiation in yeast. Science 2007; 317:1224-7.
    • (2007) Science , vol.317 , pp. 1224-1227
    • Gilbert, W.V.1    Zhou, K.2    Butler, T.K.3    Doudna, J.A.4
  • 33
    • 7044227587 scopus 로고    scopus 로고
    • Stop codon-mediated suppression of splicing is a novel nuclear scanning mechanism not affected by elements of protein synthesis and NMD
    • Wachtel C, Li B, Sperling J, Sperling R. Stop codon-mediated suppression of splicing is a novel nuclear scanning mechanism not affected by elements of protein synthesis and NMD. RNA 2004; 10:1740-50.
    • (2004) RNA , vol.10 , pp. 1740-1750
    • Wachtel, C.1    Li, B.2    Sperling, J.3    Sperling, R.4
  • 34
    • 0035103259 scopus 로고    scopus 로고
    • The Drosophila alcohol dehydrogenase gene may have evolved independently of the functionally homologous medfly, olive fly and flesh fly genes
    • Brogna S, Benos PV, Gasperi G, Savakis C. The Drosophila alcohol dehydrogenase gene may have evolved independently of the functionally homologous medfly, olive fly and flesh fly genes. Mol Biol Evol 2001; 18:322-9.
    • (2001) Mol Biol Evol , vol.18 , pp. 322-329
    • Brogna, S.1    Benos, P.V.2    Gasperi, G.3    Savakis, C.4
  • 35
    • 0029909458 scopus 로고    scopus 로고
    • An efficient DDAB-mediated transfection of Drosophila S2 cells
    • Han K. An efficient DDAB-mediated transfection of Drosophila S2 cells. Nucleic Acids Res 1996; 24:4362-3.
    • (1996) Nucleic Acids Res , vol.24 , pp. 4362-4363
    • Han, K.1
  • 37
    • 0002440928 scopus 로고
    • Molecular cloning
    • Cold Spring Harbour, New York: Cold Spring Harbour Laboratory Press
    • Sambrook J, Fritsch EF, Maniatis T. Molecular cloning. A Laboratory Manual. Cold Spring Harbour, New York: Cold Spring Harbour Laboratory Press 1989.
    • (1989) A Laboratory Manual
    • Sambrook, J.1    Fritsch, E.F.2    Maniatis, T.3
  • 38
    • 0028921834 scopus 로고
    • Improved green fluorescence
    • Heim R, Cubitt AB, Tsien RY. Improved green fluorescence. Nature 1995; 373:663-4.
    • (1995) Nature , vol.373 , pp. 663-664
    • Heim, R.1    Cubitt, A.B.2    Tsien, R.Y.3
  • 39
    • 0003455528 scopus 로고
    • Cold Spring Harbour, New York: Cold Spring Harbour Laboratory Press
    • Ashburner M. Drosophila: a laboratory handbook. Cold Spring Harbour, New York: Cold Spring Harbour Laboratory Press 1989.
    • (1989) Drosophila: A laboratory handbook
    • Ashburner, M.1


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