In vitro selected RNA aptamer recognizing glutathione induces ROS-mediated apoptosis in the human breast cancer cell line MCF 7

RNA Biology

Volumn 8, Issue 1, 2011, Pages

  Bala, Jyoti ^a   Bhaskar, Ashima ^a   Varshney, Akhil ^a   Singh, Abhay Kumar ^b   Dey, Sharmistha ^b   Yadava, Pramod ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Apoptosis; Cancer; Glutathione; RNA aptamer; ROS; SELEX; SPR

Indexed keywords

APTAMER; CASPASE 3; GLUTATHIONE; REACTIVE OXYGEN METABOLITE; RNA DERIVATIVE;

APOPTOSIS; ARTICLE; CELL SPECIFICITY; CELL STRAIN MCF 7; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA DEGRADATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; SURFACE PLASMON RESONANCE;

EID: 85011937534     PISSN: 15476286     EISSN: 15558584     Source Type: Journal    
DOI: 10.4161/rna.V.I.14116     Document Type: Article

References (38)

1. Cox JC, Hayhurst A, Hesselberth J, Bayer TS, Georgiou G, Ellington AD. Automated selection of aptamers against protein targets translated in vitro: from gene to aptamer. Nucleic Acids Res 2002; 30:108.
2. Pendergrast PS, Marsh HN, Grate D, Healy JM, Stanton M. Nucleic acid aptamers for target validation and therapeutic applications. J Biomol Tech 2005; 16:224-34.
3. White RR, Sullenger BA, Rusconi CP. Developing aptamers into therapeutics. J Clin Invest 2000; 106:929-34.
4. Ellington AD, Szostak JW. In vitro selection of RNA molecules that bind specific ligands. Nature 1990; 346:818-22.
5. Tuerk C, Gold L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 1990; 249:505-10.
6. Meister A. On the discovery of glutathione. Trends Biochem Sci 1988; 13:185-8.
7. Viña J, Romero FJ, Saez GT, Pallardó FV. Effects of cysteine and N-acetyl cysteine on GSH content of brain of adult rats. Experientia 1983; 39:164-5. (Pubitemid 13187483)
8. Hayes JD, McLellan LI. Glutathione and glutathione-dependent enzymes represent a coordinately regulated defence against oxidative stress. Free Radic Res 1999; 31:273-300. (Pubitemid 29452854)
9. Coffey RN, Watson RW, Hegarty NJ, O'Neill A, Gibbons N, Brady HR, Fitzpatrick JM. Thiol-mediated apoptosis in prostate carcinoma cells. Cancer 2000; 88:2092-104. (Pubitemid 30233211)
10. Dusre L, Mimnaugh EG, Myers CE, Sinha BK. Potentiation of doxorubicin cytotoxicity by buthionine sulfoximine in multidrug-resistant human breast tumor cells. Cancer Res 1989; 49:511-5. (Pubitemid 19050305)
11. Buttke TM, Sandstrom PA. Oxidative stress as a mediator of apoptosis. Immunol Today 1994; 15:7-10.
12. Hug H, Enari M, Nagata S. No requirement of reactive oxygen intermediates in Fas-mediated apoptosis. FEBS Lett 1994; 351:311-3. (Pubitemid 24285323)
13. Kaplowitz N, Fernández-Checa JC, Kannan R, Garcia-Ruiz C, Ookhtens M, Yi JR. GSH transporters: Molecular characterization and role in GSH homeostasis. Biol Chem 1996; 377:267-73.
14. Ghibelli L, Coppola S, Fanelli C, Rotilio G, Civitareale P, Scovassi AI, et al. Glutathione depletion causes cytochrome c release even in the absence of cell commitment to apoptosis. FASEB J 1999; 13:2031-6. (Pubitemid 29517633)
15. Armstrong JS, Steinauer KK, Hornung B, Irish JM, Lecane P, Birrell GW, et al. Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line. Cell Death Differ 2002; 9:252-63. (Pubitemid 34223869)
16. Zuker M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 2003; 31:3406-15. (Pubitemid 37442169)
17. Bernhart SH, Hofacker IL, Will S, Gruber AR, Stadler PF. RNAalifold: improved consensus structure prediction for RNA alignments. BMC Bioinformatics 2008; 9:474.
18. Torarinsson E, Lindgreen S. WAR: Webserver for aligning structural RNAs. Nucleic Acids Res 2008; 36:79-84.
19. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26:239-57.
20. Esteve JM, Mompo J, Garcia de la Asuncion J, Sastre J, Asensi M, Boix J, et al. Oxidative damage to mitochondrial DNA and glutathione oxidation in apoptosis: studies in vivo and in vitro. FASEB J 1999; 13:1055-64. (Pubitemid 29249731)
21. Rich RL, Myszka DG. Higher-throughput, label-free, real-time molecular interaction analysis. Analytical Biochemistry 2007; 361:1-6. (Pubitemid 46026999)
22. de-los-Santos-Alvarez N, Lobo-Castañón MJ, Miranda-Ordieres AJ, Tuñón-Blanco P. SPR sensing of small molecules with modified RNA aptamers: detection of neomycin B. Biosens Bioelectron 2009; 24:2547-53.
23. Ishikawa T. The ATP-dependent glutathione S-conjugate export pump. Trends Biochem Sci 1992; 17:463-8.
24. Suzuki T, Nishio K, Tanabe S. The MRP family and anticancer drug metabolism. Curr Drug Metab 2001; 2:367-77. (Pubitemid 33133981)
25. Balendiran GK, Dabur R, Fraser D. The role of glutathione in cancer. Cell Biochem Funct 2004; 22:343-52. (Pubitemid 39518098)
26. Russo A, DeGraff W, Friedman N, Mitchell JB. Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs. Cancer Res 1986; 46:2845-8. (Pubitemid 16074292)
27. Bailey HH, Ripple G, Tutsch KD, Arzoomanian RZ, Alberti D, Feierabend C, et al. Phase I study of continuous-infusion L-S, R-buthionine sulfoximine with intravenous melphalan. J Natl Cancer Inst 1997; 89:1789-96. (Pubitemid 27516233)
28. Chen X, Carystinos GD, Batist G. Potential for selective modulation of glutathione in cancer. Chem Biol Interact 1998; 263-75. (Pubitemid 28271950)
29. Wu J. Apoptosis and angiogenesis: Two promising tumor markers in breast cancer. Anticancer Res 1996; 16:2233-9. (Pubitemid 26265571)
30. Gerschenson LE, Rotello RJ. Apoptosis: a different type of cell death. FASEB J 1992; 6:2450-5.
31. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281:1309-12. (Pubitemid 28406816)
32. Li Y, Lee HJ, Corn RM. Fabrication and characterization of RNA aptamer microarrays for the study of protein-aptamer interactions with SPR imaging. Nucleic Acids Res 2006; 3:6416-24. (Pubitemid 46019397)
33. Arnold FH, Schofield SA, Blanch HW. Analytical affinity chromatography II. Rate theory and the measurement of biological binding kinetics. J Chromatogr 1986; 355:13-27.
34. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991; 139:271-9.
35. 2 in cultured endothelial cells. Arch Biochem Biophys 1993; 302:348-55.
36. Jiwajinda S, Santisopasri V, Murakami A, Kim OK, Kim HW, Ohigashi H. Suppressive effects of edible Thai plants on superoxide and nitric oxide generation. Asian Pac J Cancer 2002; 215-23.
37. Balachandran R, ter Haar E, Yalowich JC, Welsh MJ, Grant SG, Day BW. Induction of human breast cancer cell apoptosis from G2/M preceded by stimulation into the cell cycle by Z-1,1-dichloro-2,3-diphenylcyclopropane. Biochem Pharmacol 1999; 5:97-110. (Pubitemid 29012499)
38. Jollow D, Mitchell L, Zampaglione N, Gillete J. Bromobenze induced liver necrosis: Protective role of glutathione and evidence for 3,4-bromobenzenoxide as the hepatotoxic intermediate. Pharmacol 1974; 11:151-69.