Lgl/aPKC and Crb regulate the salvador/warts/hippo pathway

Fly

Volumn 4, Issue 4, 2010, Pages 288-293

  Parsons, Linda M ^a   Grzeschik, Nicola A ^a   Allott, Melinda L ^a   Richardson, Helena E ^a,b  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

APKC; Cell polarity; Crb; Drosophila; Hippo pathway; Lgl; Tumor suppressor gene

Indexed keywords

EID: 85011936084     PISSN: 19336934     EISSN: 19336942     Source Type: Journal    
DOI: 10.4161/fly.4.4.13116     Document Type: Article

References (29)

1. Hariharan IK, Bilder D. Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila. Annu Rev Genet 2006; 40:335-361.
2. Wodarz A, Näthke I. Cell polarity in development and cancer. Nat Cell Biol 2007; 9:1016-1024.
3. Badouel C, Garg A, McNeill H. Herding Hippos: regulating growth in flies and man. Current Opinion in Cell Biology 2009; 21:837-843.
4. Grzeschik NA, Parsons L, Allott M, Harvey KF, Richardson HE. Lgl, aPKC and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr Biol 2010; 20:573-581.
5. Robinson B, Huang J, Hong Y, Moberg K. Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded. Curr Biol 2010; 20:582-590.
6. Ling C, Zheng Y, Yin F, Yu J, Huang J, Hong Y, et al. The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. PNAS 2010; 1-6.
7. Grzeschik NA, Amin N, Secombe J, Brumby AM, Richardson HE. Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye. Dev Biol 2007; 311:106-123.
8. Assémat E, Bazellières E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D. Polarity complex proteins. Biochim Biophys Acta 2008; 1778:614-630.
9. Sotillos S, Díaz-Meco MT, Caminero E, Moscat J, Campuzano S. DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. J Cell Biol 2004; 166:549-557.
10. Wodarz A, Hinz U, Engelbert M, Knust E. Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila. Cell 1995; 82:67-76.
11. Izaddoost S, Nam SC, Bhat MA, Choi HJBK. Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres. Nature 2002; 416:178-182.
12. Laprise P, Beronja S, Silva-Gagliardi N, Pellikka M, Jensen A, Mcglade C, et al. The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size. Dev Cell 2006; 11:363-374.
13. Médina E, Williams J, Klipfell E, Zarnescu D, Thomas G, Le Bivic A. Crumbs interacts with moesin and beta(Heavy)-spectrin in the apical membrane skeleton of Drosophila. J Cell Biol 2002; 158:941-951.
14. Polesello C, Huelsmann S, Brown NH, Tapon N. The Drosophila RASSF homolog antagonizes the hippo pathway. Curr Biol 2006; 16:2459-2465.
15. Genevet A, Polesello C, Blight K, Robertson F, Collinson LM, Pichaud F, et al. The Hippo pathway regulates apical-domain size independently of its growth-control function. J Cell Sci 2009; 122:2360-2370.
16. Moscat J, Diaz-Meco MT, Albert A, Campuzano S. Cell signaling and function organized by PB1 domain interactions. Mol Cell 2006; 23:631-640.
17. Atsushi Suzuki KAaSO. Protein Kinase Ci (PKCi): A PKC Isotype Essential for the Development of Multicellular Organisms. J Biochem 2003; 133:9-16.
18. Georgiou M, Marinari E, Burden J, Baum B. Cdc42, Par6 and aPKC regulate Arp2/3-mediated endocytosis to control local adherens junction stability. Curr Biol 2008; 18:1631-1638.
19. Joberty G, Petersen C, Gao L, Macara IG. The cellpolarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol 2000; 2:531-539.
20. Leibfried A, Fricke R, Morgan MJ, Bogdan S, Bellaiche Y. Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-cadherin endocytosis. Curr Biol 2008; 18:1639-1648.
21. Harris KP, Tepass U. Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis. J Cell Biol 2008; 183:1129-1143.
22. Caroline Badouel LG, Nancy Amin, Ankush Garg, Robyn Rosenfeld, Thierry Le Bihan, Helen McNeill. The FERM-domain protein expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie. Developmental Cell 2009; 16:411-420.
23. Pellikka M, Tanentzapf G, Pinto M, Smith C, McGlade CJ, Ready DF, et al. Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis. Nature 2002; 416:143-149.
24. Richardson EC, Pichaud F. Crumbs is required to achieve proper organ size control during Drosophila head development. Development 2010; 137:641-650.
25. Chen ZJ, Sun LJ. Nonproteolytic Functions of Ubiquitin in Cell Signaling. Molecular Cell 2009; 33:275-286.
26. Herranz H, Stamataki E, Feiguin F, Milán M. Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of gammasecretase activity. EMBO Rep 2006; 7:297-302.
27. Hamaratoglu F, Gajewski K, Sansores-Garcia L, Morrison C, Tao C, Halder G. The Hippo tumorsuppressor pathway regulates apical-domain size in parallel to tissue growth. J Cell Sci 2009; 122:2351-2359.
28. Grusche FA, Richardson HE, Harvey KF. Upstream regulation of the Hippo size control pathway. Current Biology 2010; 20:R574-R582.
29. Baena-Lopez LA, Iguez IR, Baonza A. The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dallylike. PNAS 2008; 105:9645-9650.