New insights into highly potent tyrosinase inhibitors based on 3-heteroarylcoumarins: Anti-melanogenesis and antioxidant activities, and computational molecular modeling studies

Bioorganic and Medicinal Chemistry

Volumn 25, Issue 5, 2017, Pages 1687-1695

  Pintus, Francesca ^a   Matos, Maria J ^b,c   Vilar, Santiago ^c,d   Hripcsak, George ^d   Varela, Carla ^e   Uriarte, Eugenio ^b,f   Santana, Lourdes ^b   Borges, Fernanda ^c   Medda, Rosaria ^a   Di Petrillo, Amalia ^a   Era, Benedetta ^a   Fais, Antonella ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c UNIVERSITY OF PORTO   (Portugal)

^d Department of Medicine   (United States)

^e UNIVERSITY OF COIMBRA   (Portugal)

^f UNIVERSIDAD AUTÓNOMA DE CHILE   (Chile)

Author keywords

3 Heteroarylcoumarins; B16F10 melanoma cells; Melanogenesis; Tyrosinase inhibitors

Indexed keywords

3 (4 BROMOTHIOPHEN 2 YL) 5,7 DIHYDROXYCOUMARIN; 3 (4 BROMOTHIOPHEN 2 YL) 6 METHOXYCOUMARIN; 3 (4 BROMOTHIOPHEN 2 YL) 7 HYDROXYCOUMARIN; 3 (4 BROMOTHIOPHEN 2 YL) 7,8 DIHYDROXYCOUMARIN; 3 (4 BROMOTHIOPHEN 2 YL) 8 HYDROXYCOUMARIN; 3 HETEROARYLCOUMARIN DERIVATIVE; 5,7 DIHYDROXY 3 (THIOPHEN 2 YL)COUMARIN; 6 HYDROXY 3 (THIOPHEN 2 YL)COUMARIN; 6 METHOXY 3 (THIOPHEN 2 YL)COUMARIN; 7 HYDROXY 3 (THIOPHEN 2 YL)COUMARIN; ANTIOXIDANT; COUMARIN DERIVATIVE; KOJIC ACID; TROLOX C; UNCLASSIFIED DRUG; ENZYME INHIBITOR; MELANIN; MONOPHENOL MONOOXYGENASE;

ABTS RADICAL SCAVENGING ASSAY; ANIMAL CELL; ANTIMELANOGENESIS ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DPPH RADICAL SCAVENGING ASSAY; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; EC50; IC50; LIMIT OF QUANTITATION; MOLECULAR DOCKING; MOLECULAR MODEL; MOUSE; NONHUMAN; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CARBON NUCLEAR MAGNETIC RESONANCE; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; TUMOR CELL LINE;

ANIMALS; ANTIOXIDANTS; CARBON-13 MAGNETIC RESONANCE SPECTROSCOPY; CELL LINE, TUMOR; ENZYME INHIBITORS; MASS SPECTROMETRY; MELANINS; MICE; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; MONOPHENOL MONOOXYGENASE; PROTON MAGNETIC RESONANCE SPECTROSCOPY;

EID: 85011876563     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2017.01.037     Document Type: Article

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