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Volumn 65, Issue 6, 2016, Pages 995-1003

The effect of colesevelam treatment on bile acid and lipid metabolism and glycemic control in healthy men

Author keywords

Bile acid; Bile acid sequestrant; Cholesterol 7a hydroxylase; Genetics; LDL cholesterol

Indexed keywords

7 ALPHA-HYDROXY-4-CHOLESTEN-3-ONE; BILE ACID; CHOLAGOGUE; CHOLEST 4 EN 3 ONE; CHOLESTEROL 7ALPHA MONOOXYGENASE; COLESEVELAM; CYP7A1 PROTEIN, HUMAN; FGF19 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR; GLUCOSE BLOOD LEVEL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; THYROID HORMONE;

EID: 85011805091     PISSN: 08628408     EISSN: 18029973     Source Type: Journal    
DOI: 10.33549/physiolres.933276     Document Type: Article
Times cited : (7)

References (31)
  • 1
    • 0025728697 scopus 로고
    • The plasma level of 7 alpha-hydroxy-4-cholesten-3-one reflects the activity of hepatic cholesterol 7 alpha-hydroxylase in man
    • AXELSON M, BJORKHEM I, REIHNER E, EINARSSON K: The plasma level of 7 alpha-hydroxy-4-cholesten-3-one reflects the activity of hepatic cholesterol 7 alpha-hydroxylase in man. FEBS Lett 284: 216-218, 1991.
    • (1991) FEBS Lett , vol.284 , pp. 216-218
    • Axelson, M.1    Bjorkhem, I.2    Reihner, E.3    Einarsson, K.4
  • 2
    • 77957960122 scopus 로고    scopus 로고
    • Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism
    • BRUFAU G, STELLAARD F, PRADO K, BLOKS VW, JONKERS E, BOVERHOF R, KUIPERS F, MURPHY EJ: Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism. Hepatology 52: 1455-1464, 2010.
    • (2010) Hepatology , vol.52 , pp. 1455-1464
    • Brufau, G.1    Stellaard, F.2    Prado, K.3    Bloks, V.W.4    Jonkers, E.5    Boverhof, R.6    Kuipers, F.7    Murphy, E.J.8
  • 3
    • 70349430938 scopus 로고    scopus 로고
    • Bile acids: Regulation of synthesis
    • CHIANG JY: Bile acids: regulation of synthesis. J Lipid Res 50: 1955-1966, 2009.
    • (2009) J Lipid Res , vol.50 , pp. 1955-1966
    • Chiang, J.Y.1
  • 4
    • 84891710536 scopus 로고    scopus 로고
    • Bile acid metabolism and signaling
    • CHIANG JY: Bile acid metabolism and signaling. Compr Physiol 3: 1191-1212, 2013.
    • (2013) Compr Physiol , vol.3 , pp. 1191-1212
    • Chiang, J.Y.1
  • 5
    • 84880133958 scopus 로고    scopus 로고
    • Ezetimibe and bile acid sequestrants: Impact on lipoprotein metabolism and beyond
    • COUTURE P, LAMARCHE B: Ezetimibe and bile acid sequestrants: impact on lipoprotein metabolism and beyond. Curr Opin Lipidol 24: 227-232, 2013.
    • (2013) Curr Opin Lipidol , vol.24 , pp. 227-232
    • Couture, P.1    Lamarche, B.2
  • 6
    • 0032848728 scopus 로고    scopus 로고
    • Association of the A-204C polymorphism in the cholesterol 7alpha-hydroxylase gene with variations in plasma low density lipoprotein cholesterol levels in the Framingham Offspring Study
    • COUTURE P, OTVOS JD, CUPPLES LA, WILSON PW, SCHAEFER EJ, ORDOVAS JM: Association of the A-204C polymorphism in the cholesterol 7alpha-hydroxylase gene with variations in plasma low density lipoprotein cholesterol levels in the Framingham Offspring Study. J Lipid Res 40: 1883-1889, 1999.
    • (1999) J Lipid Res , vol.40 , pp. 1883-1889
    • Couture, P.1    Otvos, J.D.2    Cupples, L.A.3    Wilson, P.W.4    Schaefer, E.J.5    Ordovas, J.M.6
  • 9
    • 4444278680 scopus 로고    scopus 로고
    • CYP7A1 A-278C polymorphism affects the response of plasma lipids after dietary cholesterol or cafestol interventions in humans
    • HOFMAN MK, WEGGEMANS RM, ZOCK PL, SCHOUTEN EG, KATAN MB, PRINCEN HM: CYP7A1 A-278C polymorphism affects the response of plasma lipids after dietary cholesterol or cafestol interventions in humans. J Nutr 134: 2200-2204, 2004.
    • (2004) J Nutr , vol.134 , pp. 2200-2204
    • Hofman, M.K.1    Weggemans, R.M.2    Zock, P.L.3    Schouten, E.G.4    Katan, M.B.5    Princen, H.M.6
  • 10
    • 0037841595 scopus 로고    scopus 로고
    • Polymorphisms in CYP-7A1, not APOE, influence the change in plasma lipids in response to population dietary change in an 8 year follow-up; results from the Czech MONICA study
    • HUBACEK JA, PITHA J, SKODOVA Z, POLEDNE R, LANSKA V, WATERWORTH DM, HUMPHRIES SE, TALMUD PJ: Polymorphisms in CYP-7A1, not APOE, influence the change in plasma lipids in response to population dietary change in an 8 year follow-up; results from the Czech MONICA study. Clin Biochem 36: 263-267, 2003.
    • (2003) Clin Biochem , vol.36 , pp. 263-267
    • Hubacek, J.A.1    Pitha, J.2    Skodova, Z.3    Poledne, R.4    Lanska, V.5    Waterworth, D.M.6    Humphries, S.E.7    Talmud, P.J.8
  • 11
    • 33645098531 scopus 로고    scopus 로고
    • Clinical utility of bile acid sequestrants in the treatment of dyslipidemia: A scientific review
    • INSULL W JR: Clinical utility of bile acid sequestrants in the treatment of dyslipidemia: a scientific review. South Med J 99: 257-273, 2006.
    • (2006) South Med J , vol.99 , pp. 257-273
    • Insull, W.Jr.1
  • 12
    • 3242736602 scopus 로고    scopus 로고
    • Interactions between common genetic polymorphisms in ABCG5/G8 and CYP7A1 on LDL cholesterol-lowering response to atorvastatin
    • KAJINAMI K, BROUSSEAU ME, ORDOVAS JM, SCHAEFER EJ: Interactions between common genetic polymorphisms in ABCG5/G8 and CYP7A1 on LDL cholesterol-lowering response to atorvastatin. Atherosclerosis 175: 287-293, 2004.
    • (2004) Atherosclerosis , vol.175 , pp. 287-293
    • Kajinami, K.1    Brousseau, M.E.2    Ordovas, J.M.3    Schaefer, E.J.4
  • 13
    • 22744439625 scopus 로고    scopus 로고
    • A promoter polymorphism in cholesterol 7alpha-hydroxylase interacts with apolipoprotein E genotype in the LDL-lowering response to atorvastatin
    • KAJINAMI K, BROUSSEAU ME, ORDOVAS JM, SCHAEFER EJ: A promoter polymorphism in cholesterol 7alpha-hydroxylase interacts with apolipoprotein E genotype in the LDL-lowering response to atorvastatin. Atherosclerosis 180: 407-415, 2005.
    • (2005) Atherosclerosis , vol.180 , pp. 407-415
    • Kajinami, K.1    Brousseau, M.E.2    Ordovas, J.M.3    Schaefer, E.J.4
  • 14
    • 8444245966 scopus 로고    scopus 로고
    • The A-204C polymorphism in the cholesterol 7alpha-hydroxylase (CYP7A1) gene determines the cholesterolemia responsiveness to a high-fat diet
    • KOVAR J, SUCHANEK P, HUBACEK JA, POLEDNE R: The A-204C polymorphism in the cholesterol 7alpha-hydroxylase (CYP7A1) gene determines the cholesterolemia responsiveness to a high-fat diet. Physiol Res 53: 565-568, 2004.
    • (2004) Physiol Res , vol.53 , pp. 565-568
    • Kovar, J.1    Suchanek, P.2    Hubacek, J.A.3    Poledne, R.4
  • 15
    • 44849122588 scopus 로고    scopus 로고
    • Improved HPLC analysis of serum 7alpha-hydroxycholest-4-en-3-one, a marker of bile acid malabsorption
    • LENICEK M, JUKLOVA M, ZELENKA J, KOVAR J, LUKAS M, BORTLIK M, VITEK L: Improved HPLC analysis of serum 7alpha-hydroxycholest-4-en-3-one, a marker of bile acid malabsorption. Clin Chem 54: 1087-1088, 2008a.
    • (2008) Clin Chem , vol.54 , pp. 1087-1088
    • Lenicek, M.1    Juklova, M.2    Zelenka, J.3    Kovar, J.4    Lukas, M.5    Bortlik, M.6    Vitek, L.7
  • 16
    • 59649088924 scopus 로고    scopus 로고
    • CYP7A1 promoter polymorphism -203A>C affects bile salt synthesis rate in patients after ileal resection
    • LENICEK M, KOMAREK V, ZIMOLOVA M, KOVAR J, JIRSA M, LUKAS M, VITEK L: CYP7A1 promoter polymorphism -203A>C affects bile salt synthesis rate in patients after ileal resection. J Lipid Res 49: 2664-2667, 2008b.
    • (2008) J Lipid Res , vol.49 , pp. 2664-2667
    • Lenicek, M.1    Komarek, V.2    Zimolova, M.3    Kovar, J.4    Jirsa, M.5    Lukas, M.6    Vitek, L.7
  • 17
    • 0003309654 scopus 로고
    • I. Reduction in incidence of coronary heart disease
    • LRC-CPPT - Lipid Research Clinics Coronary Primary Prevention Trial Results: I. Reduction in incidence of coronary heart disease. JAMA 251: 351-364, 1984a.
    • (1984) JAMA , vol.251 , pp. 351-364
  • 18
    • 0003309652 scopus 로고
    • II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering
    • LRC-CPPT - Lipid Research Clinics Coronary Primary Prevention Trial Results: II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA 251: 365-374, 1984b.
    • (1984) JAMA , vol.251 , pp. 365-374
  • 19
    • 84911468361 scopus 로고    scopus 로고
    • Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures
    • LIU J, LU H, LU YF, LEI X, CUI JY, ELLIS E, STROM SC, KLAASSEN CD: Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicol Sci 141: 538-546, 2014.
    • (2014) Toxicol Sci , vol.141 , pp. 538-546
    • Liu, J.1    Lu, H.2    Lu, Y.F.3    Lei, X.4    Cui, J.Y.5    Ellis, E.6    Strom, S.C.7    Klaassen, C.D.8
  • 20
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • MATTHEWS DR, HOSKER JP, RUDENSKI AS, NAYLOR BA, TREACHER DF, TURNER RC: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419, 1985.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 22
    • 41149144697 scopus 로고    scopus 로고
    • Novel potent and selective bile acid derivatives as TGR5 agonists: Biological screening, structure-activity relationships, and molecular modeling studies
    • SATO H, MACCHIARULO A, THOMAS C, GIOIELLO A, UNE M, HOFMANN AF, SALADIN R, SCHOONJANS K, PELLICCIARI R, AUWERX J: Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem 51: 1831-1841, 2008.
    • (2008) J Med Chem , vol.51 , pp. 1831-1841
    • Sato, H.1    Macchiarulo, A.2    Thomas, C.3    Gioiello, A.4    Une, M.5    Hofmann, A.F.6    Saladin, R.7    Schoonjans, K.8    Pellicciari, R.9    Auwerx, J.10
  • 23
    • 0029666109 scopus 로고    scopus 로고
    • Serum concentrations of 7alpha-hydroxy-4-cholesten-3-one reflect bile acid synthesis in humans
    • SAUTER G, BERR F, BEUERS U, FISCHER S, PAUMGARTNER G: Serum concentrations of 7alpha-hydroxy-4-cholesten-3-one reflect bile acid synthesis in humans. Hepatology 24: 123-126, 1996.
    • (1996) Hepatology , vol.24 , pp. 123-126
    • Sauter, G.1    Berr, F.2    Beuers, U.3    Fischer, S.4    Paumgartner, G.5
  • 24
    • 85139005247 scopus 로고
    • Bile acids
    • LAWSON AM (ed.), Walter de Gruyter, Berlin and New York
    • SETCHELL KDR, LAWSON AM: Bile acids. In: Mass Spectrometry. LAWSON AM (ed.), Walter de Gruyter, Berlin and New York, 1989, pp 53-125.
    • (1989) Mass Spectrometry , pp. 53-125
    • Setchell, K.D.R.1    Lawson, A.M.2
  • 25
    • 84975784398 scopus 로고    scopus 로고
    • The role of bile acids in metabolic regulation
    • VÍTEK L, HALUZÍK M: The role of bile acids in metabolic regulation. J Endocrinol 228: R85-R96, 2016.
    • (2016) J Endocrinol , vol.228 , pp. R85-R96
    • Vítek, L.1    Haluzík, M.2
  • 27
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • WANG H, CHEN J, HOLLISTER K, SOWERS LC, FORMAN BM: Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 3: 543-553, 1999.
    • (1999) Mol Cell , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 28
    • 0032520266 scopus 로고    scopus 로고
    • Linkage between cholesterol 7alpha-hydroxylase and high plasma low-density lipoprotein cholesterol concentrations
    • WANG J, FREEMAN DJ, GRUNDY SM, LEVINE DM, GUERRA R, COHEN JC: Linkage between cholesterol 7alpha-hydroxylase and high plasma low-density lipoprotein cholesterol concentrations. J Clin Invest 101: 1283-1291, 1998.
    • (1998) J Clin Invest , vol.101 , pp. 1283-1291
    • Wang, J.1    Freeman, D.J.2    Grundy, S.M.3    Levine, D.M.4    Guerra, R.5    Cohen, J.C.6
  • 31
    • 33947120281 scopus 로고    scopus 로고
    • Results of the glucose-lowering effect of WelChol study (GLOWS): A randomized, double-blind, placebo-controlled pilot study evaluating the effect of colesevelam hydrochloride on glycemic control in subjects with type 2 diabetes
    • ZIEVE FJ, KALIN MF, SCHWARTZ SL, JONES MR, BAILEY WL: Results of the glucose-lowering effect of WelChol study (GLOWS): a randomized, double-blind, placebo-controlled pilot study evaluating the effect of colesevelam hydrochloride on glycemic control in subjects with type 2 diabetes. Clin Ther 29: 74-83, 2007.
    • (2007) Clin Ther , vol.29 , pp. 74-83
    • Zieve, F.J.1    Kalin, M.F.2    Schwartz, S.L.3    Jones, M.R.4    Bailey, W.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.