Identification of an itaconic acid degrading pathway in itaconic acid producing Aspergillus terreus

Applied Microbiology and Biotechnology

Volumn 100, Issue 17, 2016, Pages 7541-7548

  Chen, Mei ^a   Huang, Xuenian ^a,b   Zhong, Chengwei ^a,b   Li, Jianjun ^a,c   Lu, Xuefeng ^a  

^a QINGDAO INSTITUTE OF BIOENERGY AND BIOPROCESS TECHNOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c INSTITUTE OF PROCESS ENGINEERING   (China)

Author keywords

Aspergillus terreus; Degradation pathway; Itaconic acid; Metabolic engineering

Indexed keywords

BIOCHEMISTRY; BIOINFORMATICS; ENZYMES; METABOLIC ENGINEERING; METABOLISM;

ASPERGILLUS TERREUS; BIO-BASED CHEMICALS; BIOSYNTHESIS PATHWAYS; CATABOLIC PATHWAY; DEGRADATION PATHWAYS; ENZYMATIC ANALYSIS; ITACONIC ACID; KEY ENZYMES;

ASPERGILLUS;

CITRAMALYL COENZYME A LYASE; COENZYME A; ITACONIC ACID; ITRACONYL COENZYME A HYDRATASE; ITRACONYL COENZYME A TRANSFERASE; PYRUVIC ACID; SUCCINIC ACID; SUCCINYL COENZYME A; UNCLASSIFIED DRUG; COENZYME A TRANSFERASE; FUNGAL PROTEIN; HYDROLYASE; LYASE; SUCCINIC ACID DERIVATIVE;

BIODEGRADATION; BIOENGINEERING; CATALYSIS; ENZYME; ENZYME ACTIVITY; FUNGUS; IDENTIFICATION METHOD; INORGANIC COMPOUND; ORGANIC ACID; REACTION KINETICS;

ARTICLE; ASPERGILLUS TERREUS; CATABOLISM; CONTROLLED STUDY; HETEROLOGOUS EXPRESSION; IN VITRO STUDY; INFECTION; METABOLIC ENGINEERING; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEOMICS; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS; ASPERGILLUS; BIOSYNTHESIS; METABOLISM; PHYSIOLOGY;

ASPERGILLUS TERREUS;

ASPERGILLUS; BIOSYNTHETIC PATHWAYS; CARBON-CARBON LYASES; COENZYME A-TRANSFERASES; FUNGAL PROTEINS; HYDRO-LYASES; METABOLIC ENGINEERING; PROTEOMICS; SUCCINATES;

EID: 85011741970     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-016-7554-0     Document Type: Article

References (31)

1. Adler J, Wang SF, Lardy HA (1957) The metabolism of itaconic acid by liver mitochondria. J Biol Chem 229(2):865–879
2. Arpai J (1958) Itaconicoxidase: an enzyme from an ultra-violet-induced mutant of Aspergillus terreus. Nature 182(4636):661–662. doi:10.1038/182661a0
3. Blumhoff ML, Steiger MG, Mattanovich D, Sauer M (2013) Targeting enzymes to the right compartment: metabolic engineering for itaconic acid production by Aspergillus niger. Metab Eng 19:26–32. doi:10.1016/j.ymben.2013.05.003
4. Bonnarme P, Gillet B, Sepulchre AM, Role C, Beloeil JC, Ducrocq C (1995) Itaconate biosynthesis in Aspergillus terreus. J Bacteriol 177(12):3573–3578
5. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254. doi:10.1016/0003-2697(76)90527-3
6. Cooper RA, Itiaba K, Kornberg HL (1965) The utilization of aconate and itaconate by Micrococcus sp. Biochem J 94:25–31. doi:10.1042/bj0940025
7. Cooper RA, Kornberg HL (1964) The utilization of itaconate by Pseudomonas sp. Biochem J 91(1):82–91. doi:10.1042/bj0910082
8. Dimroth P, Buckel W, Loyal R, Eggerer H (1977) Isolation and function of the subunits of citramalate lyase and formation of hybrids with the subunits of citrate lyase. Eur J Biochem 80(2):469–477. doi:10.1111/j.1432-1033.1977.tb11902.x
9. Hevekerl A, Kuenz A, Vorlop KD (2014) Influence of the pH on the itaconic acid production with Aspergillus terreus. Appl Microbiol Biotechnol 98:10005–10012. doi:10.1007/s00253-014-6047-2
10. Hillier S, Charnetzky WT (1981) Glyoxylate bypass enzymes in Yersinia species and multiple forms of isocitrate lyase in Yersinia pestis. J Bacteriol 145(1):452–458
11. Honer Zu Bentrup K, Miczak A, Swenson DL, Russell DG (1999) Characterization of activity and expression of isocitrate lyase in Mycobacterium avium and Mycobacterium tuberculosis. J Bacteriol 181(23):7161–7167
12. Huang X, Lu X, Li JJ (2014a) Cloning, characterization and application of a glyceraldehyde-3-phosphate dehydrogenase promoter from Aspergillus terreus. J Ind Microbiol 41(3):585–592. doi:10.1007/s10295-013-1385-0
13. Huang X, Lu X, Li Y, Li X, Li J (2014b) Improving itaconic acid production through genetic engineering of an industrial Aspergillus terreus strain. Microb Cell Factories 13:119. doi:10.1186/s12934-014-0119-y
14. Jaklitsch WM, Kubicek CP, Scrutton MC (1991) The subcellular organization of itaconate biosynthesis in Aspergillus terreus. J Gen Microbiol 137(3):533–539. doi:10.1099/00221287-137-3-533
15. Jakubowska J, Metodiewa D (1974) Studies on the metabolic pathway for itatartaric acid formation by Aspergillus terreus. II. Use of (−) citramalate, citraconate and itaconate by cell-free extracts. Acta Microbiol Pol B 6(2):51–61
16. Li A, van Luijk N, ter Beek M, Caspers M, Punt P, van der Werf M (2011) A clone-based transcriptomics approach for the identification of genes relevant for itaconic acid production in Aspergillus. Fungal Genet Biol 48(6):602–611. doi:10.1016/j.fgb.2011.01.013
17. Lin YH, Li YF, Huang MC, Tsai YC (2004) Intracellular expression of Vitreoscilla hemoglobin in Aspergillus terreus to alleviate the effect of a short break in aeration during culture. Biotechnol Lett 26(13):1067–1072. doi:10.1023/B:BILE.0000032964.15178.7c
18. Lubertozzi D, Keasling JD (2009) Developing Aspergillus as a host for heterologous expression. Biotechnol Adv 27(1):53–75. doi:10.1016/j.biotechadv.2008.09.001
19. Martin WR, Frigan F, Bergman EH (1961) Noninductive metabolism of itaconic acid by Pseudomonas and Salmonella species. J Bacteriol 82:905–908
20. Michelucci A, Cordes T, Ghelfi J, Pailot A, Reiling N, Goldmann O, Binz T, Wegner A, Tallam A, Rausell A, Buttini M, Linster CL, Medina E, Balling R, Hiller K (2013) Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proc Natl Acad Sci U S A 110(19):7820–7825. doi:10.1073/pnas.1218599110
21. Okabe M, Lies D, Kanamasa S, Park EY (2009) Biotechnological production of itaconic acid and its biosynthesis in Aspergillus terreus. Appl Microbiol Biotechnol 84(4):597–606. doi:10.1007/s00253-009-2132-3
22. Reddy CS, Singh RP (2002) Enhanced production of itaconic acid from corn starch and market refuse fruits by genetically manipulated Aspergillus terreus SKR10. Bioresour Technol 85(1):69–71. doi:10.1016/S0960-8524(02)00075-5
23. Rychtera M, Wase DAJ (1981) The growth of Aspergillus terreus and the production of itaconic acid in batch and continuous cultures. The influence of pH. J Chem Technol Biotechnol 31(8):509–521. doi:10.1002/jctb.503310168
24. Sasikaran J, Ziemski M, Zadora PK, Fleig A, Berg IA (2014) Bacterial itaconate degradation promotes pathogenicity. Nat Chem Biol 10(5):371–377. doi:10.1038/nchembio.1482
25. Strelko CL, Lu W, Dufort FJ, Seyfried TN, Chiles TC, Rabinowitz JD, Roberts MF (2011) Itaconic acid is a mammalian metabolite induced during macrophage activation. J Am Chem Soc 133(41):16386–16389. doi:10.1021/ja2070889
26. Tate H (1981) Assessing tumour markers. Br J Cancer 44(5):643–651
27. Tevz G, Bencina M, Legisa M (2010) Enhancing itaconic acid production by Aspergillus terreus. Appl Microbiol Biotechnol 87(5):1657–1664. doi:10.1007/s00253-010-2642-z
28. Wang SF, Adler J, Lardy HA (1961) The pathway of itaconate metabolism by liver mitochondria. J Biol Chem 236:26–30
29. Willadsen P, Eggerer H (1975) Substrate stereochemistry of the enoyl-CoA hydratase reaction. Eur J Biochem 54(1):247–252. doi:10.1111/j.1432-1033.1975.tb04134.x
30. Williams JO, Roche TE, McFadden BA (1971) Mechanism of action of isocitrate lyase from Pseudomonas indigofera. Biochemistry 10(8):1384–1390. doi:10.1021/bi00784a017
31. Yu CS, Chen YC, Lu CH, Hwang JK (2006) Prediction of protein subcellular localization. Proteins 64(3):643–651. doi:10.1002/prot.21018