Specific circulating phospholipids, acylcarnitines, amino acids and biogenic amines are aerobic exercise markers

Journal of Science and Medicine in Sport

Volumn 20, Issue 7, 2017, Pages 700-705

  Felder, Thomas K ^a   Ring Dimitriou, Susanne ^b   Auer, Simon ^a   Soyal, Selma M ^a   Kedenko, Ludmilla ^a   Rinnerthaler, Mark ^b   Cadamuro, Janne ^a   Haschke Becher, Elisabeth ^a   Aigner, Elmar ^a   Paulweber, Bernhard ^a   Patsch, Wolfgang ^a  

^a PARACELSUS MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Exercise; LysoPC; Metabolomics; Sarcosine; Serine metabolism

Indexed keywords

ACYLCARNITINE; AMINO ACID; BIOGENIC AMINE; GLUTAMIC ACID; HISTIDINE; ISOLEUCINE; KYNURENINE; LEUCINE; LYSOPHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; PLASMALOGEN; SARCOSINE; SERINE; THREONINE; VALINE; BIOLOGICAL MARKER; CARNITINE;

AEROBIC EXERCISE; ARTICLE; BODY MASS; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; EXERCISE TEST; FAT MASS; HUMAN; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; NORMAL HUMAN; SYSTOLIC BLOOD PRESSURE; ANALOGS AND DERIVATIVES; BLOOD; EXERCISE; LIQUID CHROMATOGRAPHY; MIDDLE AGED; PHYSIOLOGY; TANDEM MASS SPECTROMETRY;

AMINO ACIDS; BIOGENIC AMINES; BIOMARKERS; CARNITINE; CHROMATOGRAPHY, LIQUID; CROSS-SECTIONAL STUDIES; EXERCISE; HUMANS; MALE; MIDDLE AGED; PHOSPHOLIPIDS; TANDEM MASS SPECTROMETRY;

EID: 85011629878     PISSN: 14402440     EISSN: 18781861     Source Type: Journal    
DOI: 10.1016/j.jsams.2016.11.011     Document Type: Article

References (30)

1. Lee, I.M., Shiroma, E.J., Lobelo, F., et al. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet 380:9838 (2012), 219–229.
2. Erickson, K.I., Kramer, A.F., Aerobic exercise effects on cognitive and neural plasticity in older adults. Br J Sports Med 43:1 (2009), 22–24.
3. Powers, S.K., Jackson, M.J., Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev 88:4 (2008), 1243–1276.
4. Powers, S.K., Ji, L.L., Leeuwenburgh, C., Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review. Med Sci Sports Exerc 31:7 (1999), 987–997.
5. Ristow, M., Zarse, K., Oberbach, A., et al. Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci U S A 106:21 (2009), 8665–8670.
6. Watson, J.D., Type 2 diabetes as a redox disease. Lancet 383:9919 (2014), 841–843.
7. Ring-Dimitriou, S., Kedenko, L., Kedenko, I., et al. Does genetic variation in PPARGC1A affect exercise-induced changes in ventilatory thresholds and metabolic syndrome?. J Exerc Physiol Online 17:2 (2014), 1–18.
8. Esterbauer, H., Schneitler, C., Oberkofler, H., et al. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nat Genet 28:2 (2001), 178–183.
9. Lewis, G.D., Farrell, L., Wood, M.J., et al. Metabolic signatures of exercise in human plasma. Sci Transl Med, 2(33), 2010, 33ra37.
10. 2+ handling, and red cell function in athletes and untrained subjects. Cell Calcium 60:4 (2016), 235–244.
11. Kingsbury, K.J., Kay, L., Hjelm, M., Contrasting plasma free amino acid patterns in elite athletes: association with fatigue and infection. Br J Sports Med 32:1 (1998), 25–32 discussion 32-23.
12. Kalhan, S.C., Hanson, R.W., Resurgence of serine: an often neglected but indispensable amino acid. J Biol Chem 287:24 (2012), 19786–19791.
13. Monteleone, P., Maj, M., Beinat, L., et al. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharmacol 42:4 (1992), 385–388.
14. Starks, M.A., Starks, S.L., Kingsley, M., et al. The effects of phosphatidylserine on endocrine response to moderate intensity exercise. J Int Soc Sports Nutr, 5, 2008, 11.
15. Jager, R., Purpura, M., Kingsley, M., Phospholipids and sports performance. J Int Soc Sports Nutr, 4, 2007, 5.
16. Kingsley, M.I., Kilduff, L.P., McEneny, J., et al. Phosphatidylserine supplementation and recovery following downhill running. Med Sci Sports Exerc 38:9 (2006), 1617–1625.
17. Fan, J., Ye, J., Kamphorst, J.J., et al. Quantitative flux analysis reveals folate-dependent NADPH production. Nature 510:7504 (2014), 298–302.
18. Sreekumar, A., Poisson, L.M., Rajendiran, T.M., et al. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 457:7231 (2009), 910–914.
19. Heger, Z., Gumulec, J., Ondrak, A., et al. Influence of long-distance bicycle riding on serum/urinary biomarkers of prostate cancer. Int J Mol Sci, 17(3), 2016, 377.
20. Cholewa, J.M., Guimaraes-Ferreira, L., Zanchi, N.E., Effects of betaine on performance and body composition: a review of recent findings and potential mechanisms. Amino Acids 46:8 (2014), 1785–1793.
21. Strasser, B., Geiger, D., Schauer, M., et al. Effects of exhaustive aerobic exercise on tryptophan-kynurenine metabolism in trained athletes. PLoS One, 11(4), 2016, e0153617.
22. Mudry, J.M., Alm, P.S., Erhardt, S., et al. Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes. Diabetes Metab Res Rev 32:7 (2016), 754–761.
23. Floegel, A., Stefan, N., Yu, Z., et al. Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. Diabetes 62:2 (2013), 639–648.
24. Liu, S., Brown, J.D., Stanya, K.J., et al. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature 502:7472 (2013), 550–554.
25. Yea, K., Kim, J., Yoon, J.H., et al. Lysophosphatidylcholine activates adipocyte glucose uptake and lowers blood glucose levels in murine models of diabetes. J Biol Chem 284:49 (2009), 33833–33840.
26. Osborn, O., Olefsky, J.M., The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med 18:3 (2012), 363–374.
27. Schmitz, G., Ruebsaamen, K., Metabolism and atherogenic disease association of lysophosphatidylcholine. Atherosclerosis 208:1 (2010), 10–18.
28. Lehmann, R., Franken, H., Dammeier, S., et al. Circulating lysophosphatidylcholines are markers of a metabolically benign nonalcoholic fatty liver. Diabetes Care 36:8 (2013), 2331–2338.
29. Floegel, A., Wientzek, A., Bachlechner, U., et al. Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study. Int J Obes 38:11 (2014), 1388–1396.
30. Mihalik, S.J., Goodpaster, B.H., Kelley, D.E., et al. Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity. Obesity (Silver Spring) 18:9 (2010), 1695–1700.