Colonization with enterotoxigenic Bacteroides fragilis is associated with early-stage colorectal neoplasia

PLoS ONE

Volumn 12, Issue 2, 2017, Pages

  Purcell, Rachel V ^a   Pearson, John ^a   Aitchison, Alan ^a   Dixon, Liane ^a   Frizelle, Frank A ^a   Keenan, Jacqueline I ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOMATOUS POLYP; ADULT; AGED; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTEROIDES FRAGILIS; BFT GENE; CANCER STAGING; COLON BIOPSY; COLON MUCOSA; COLON POLYP; COLON TISSUE; COLONOSCOPY; COLORECTAL CANCER; COLORECTAL TUMOR; CONTROLLED STUDY; DISEASE ASSOCIATION; DYSPLASIA; ENTEROTOXIGENIC BACTEROIDES FRAGILIS; FEMALE; GENE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NONHUMAN; POLYMERASE CHAIN REACTION; POPULATION ABUNDANCE; BACTEROIDES INFECTION; CHEMISTRY; COLON; COLORECTAL NEOPLASMS; COMPLICATION; INTESTINE MUCOSA; MICROBIOLOGY; VERY ELDERLY; YOUNG ADULT;

BACTERIAL TOXIN; FRAGILYSIN; METALLOPROTEINASE;

ADULT; AGED; AGED, 80 AND OVER; BACTERIAL TOXINS; BACTEROIDES FRAGILIS; BACTEROIDES INFECTIONS; COLON; COLORECTAL NEOPLASMS; FEMALE; HUMANS; INTESTINAL MUCOSA; MALE; METALLOENDOPEPTIDASES; MIDDLE AGED; POLYMERASE CHAIN REACTION; YOUNG ADULT;

EID: 85011319812     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0171602     Document Type: Article

References (30)

1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al., Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015; 136(5): E359-86. doi: 10.1002/ijc.29210 PMID: 25220842
2. Ministry of Health N. Selected Cancer 2012, 2013, 2014. In: Health Mo, editor. Wellington 2015.
3. Brücher BL, Jamall IS, Epistemology of the origin of cancer: a new paradigm. BMC Cancer. 2014; 14:331. doi: 10.1186/1471-2407-14-331 PMID: 24885752
4. Wu S, Lim KC, Huang J, Saidi RF, Sears CL, Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin. Proc Natl Acad Sci USA. 1998; 95(25):14979-84. PMID: 9844001
5. Wu S, Shin J, Zhang G, Cohen M, Franco A, Sears CL, The Bacteroides fragilis toxin binds to a specific intestinal epithelial cell receptor. Infect Immun. 2006; 74(9):5382-90. doi: 10.1128/IAI.00060-06 PMID: 16926433
6. Maeda H, Akaike T., Nitric oxide and oxygen radicals in infection, inflammation, and cancer. Biochemistry (Mosc). 1998; 63(7):854-65.
7. Ismail S, Hampton MB, Keenan JI, Helicobacter pylori outer membrane vesicles modulate proliferation and interleukin-8 production by gastric epithelial cells. Infect Immun. 2003; 71(10):5670-5. doi: 10. 1128/IAI.71.10.5670-5675.2003 PMID: 14500487
8. Mantovani A, Allavena P, Sica A, Balkwill F., Cancer-related inflammation. Nature. 2008; 454 (7203):436-44. doi: 10.1038/nature07205 PMID: 18650914
9. Tjalsma H, Boleij A, Marchesi JR, Dutilh BE, A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects. Nat Rev Microbiol. 2012; 10(8):575-82. doi: 10.1038/nrmicro2819 PMID: 22728587
10. Sears CL, Geis AL, Housseau F., Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis. J Clin Invest. 2014; 124(10):4166-72. doi: 10.1172/JCI72334 PMID: 25105360
11. Hwang S, Gwon SY, Kim MS, Lee S, Rhee KJ, Bacteroides fragilis Toxin Induces IL-8 Secretion in HT29/C1 Cells through Disruption of E-cadherin Junctions. Immune Netw. 2013; 13(5):213-7. doi: 10.4110/in.2013.13.5.213 PMID: 24198747
12. Wu S, Powell J, Mathioudakis N, Kane S, Fernandez E, Sears CL, Bacteroides fragilis enterotoxin induces intestinal epithelial cell secretion of interleukin-8 through mitogen-activated protein kinases and a tyrosine kinase-regulated nuclear factor-kappaB pathway. Infect Immun. 2004; 72(10):5832-9. doi: 10.1128/IAI.72.10.5832-5839.2004 PMID: 15385484
13. Sanfilippo L, Li CK, Seth R, Balwin TJ, Menozzi MG, Mahida YR, Bacteroides fragilis enterotoxin induces the expression of IL-8 and transforming growth factor-beta (TGF-beta) by human colonic epithelial cells. Clin Exp Immunol. 2000; 119(3):456-63. doi: 10.1046/j.1365-2249.2000.01155.x PMID: 10691917
14. Moncrief JS, Duncan AJ, Wright RL, Barroso LA, Wilkins TD, Molecular characterization of the fragilysin pathogenicity islet of enterotoxigenic Bacteroides fragilis. Infection and immunity. 1998; 66(4):1735-9. PMID: 9529104
15. Flanagan L, Schmid J, Ebert M, Soucek P, Kunicka T, Liska V, et al., Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome. Eur J Clin Microbiol Infect Dis. 2014; 33(8):1381-90. doi: 10.1007/s10096-014-2081-3 PMID: 24599709
16. Chen LA, Van Meerbeke S, Albesiano E, Goodwin A, Wu S, Yu H, et al., Fecal detection of enterotoxigenic Bacteroides fragilis. Eur J Clin Microbiol Infect Dis. 2015; 34(9):1871-7. doi: 10.1007/s10096-015-2425-7 PMID: 26173688
17. Castellarin M, Warren RL, Freeman JD, Dreolini L, Krzywinski M, Strauss J, et al., Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res. 2012; 22(2):299-306. doi: 10. 1101/gr.126516.111 PMID: 22009989
18. Snover D AD, Burt RW, and Odze RD. Serrated polyps of the colon and rectum and serrated ("hyperplastic") polyposis. In: Bosman FT CF, Hruban RH, and Theise ND, editor. WHO classification of Tumours Pathology and genetics Tumours of the digestive system. Lyon: International Agency for Research on Cancer (IARC); 2010. p. 160-5.
19. Sears CL, Garrett WS, Microbes, microbiota, and colon cancer. Cell Host Microbe. 2014; 15(3):317-28. doi: 10.1016/j.chom.2014.02.007 PMID: 24629338
20. Gagniere J, Raisch J, Veziant J, Barnich N, Bonnet R, Buc E, et al., Gut microbiota imbalance and colorectal cancer. World J Gastroenterol. 2016; 22(2):501-18. doi: 10.3748/wjg.v22.i2.501 PMID: 26811603
21. Hajishengallis G, Darveau RP, Curtis MA, The keystone-pathogen hypothesis. Nat Rev Microbiol. 2012; 10(10):717-25. doi: 10.1038/nrmicro2873 PMID: 22941505
22. Hajishengallis G, Lamont RJ, Dancing with the Stars: How Choreographed Bacterial Interactions Dictate Nososymbiocity and Give Rise to Keystone Pathogens, Accessory Pathogens, and Pathobionts. Trends Microbiol. 2016; 24(6):477-89. doi: 10.1016/j.tim.2016.02.010 PMID: 26968354
23. Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, et al., A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med. 2009; 15(9):1016-22. doi: 10.1038/nm.2015 PMID: 19701202
24. Xie LL, Wu N, Zhu YM, Qiu XY, Chen GD, Zhang LM, et al., Expression of enterotoxigenic Bacteroides fragilis and polyketide synthase gene-expressing Escherichia coli in colorectal adenoma patients. Zhonghua Yi Xue Za Zhi. 2016; 96(12):954-9. doi: 10.3760/cma.j.issn.0376-2491.2016.12.010 PMID: 27045721
25. Geng J, Song Q, Tang X, Liang X, Fan H, Peng H, et al., Co-occurrence of driver and passenger bacteria in human colorectal cancer. Gut Pathog. 2014; 6:26. doi: 10.1186/1757-4749-6-26 PMID: 24995042
26. Boleij A, Hechenbleikner EM, Goodwin AC, Badani R, Stein EM, Lazarev MG, et al., The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients. Clin Infect Dis. 2015; 60(2):208-15. doi: 10.1093/cid/ciu787 PMID: 25305284
27. Viljoen KS, Dakshinamurthy A, Goldberg P, Blackburn JM, Quantitative profiling of colorectal cancer-associated bacteria reveals associations between fusobacterium spp., enterotoxigenic Bacteroides fragilis (ETBF) and clinicopathological features of colorectal cancer. PLoS One. 2015; 10(3):e0119462. doi: 10.1371/journal.pone.0119462 PMID: 25751261
28. Dejea CM, Wick EC, Hechenbleikner EM, White JR, Mark Welch JL, Rossetti BJ, et al., Microbiota organization is a distinct feature of proximal colorectal cancers. Proc Natl Acad Sci USA. 2014; 111(51):18321-6. doi: 10.1073/pnas.1406199111 PMID: 25489084
29. Flemer B, Lynch DB, Brown JM, Jeffery IB, Ryan FJ, Claesson MJ, et al., Tumour-associated and non-tumour-associated microbiota in colorectal cancer. Gut. 2016.
30. Purcell RV, Pearson J, Frizelle FA, Keenan JI, Comparison of standard, quantitative and digital PCR in the detection of enterotoxigenic Bacteroides fragilis. Sci Rep. 2016; 6:34554. doi: 10.1038/srep34554 PMID: 27686415