Poly-lactic acid nanoparticles (PLA-NP) promote physiological modifications in lung epithelial cells and are internalized by clathrin-coated pits and lipid rafts

Journal of Nanobiotechnology

Volumn 15, Issue 1, 2017, Pages

  Luz, Camila Macedo ^a   Boyles, Matthew Samuel Powys ^b,c   Falagan Lotsch, Priscila ^a   Pereira, Mariana Rodrigues ^d   Tutumi, Henrique Rudolf ^a   Oliveira Santos, Eidy ^a,e   Martins, Nathalia Balthazar ^a   Himly, Martin ^b   Sommer, Aniela ^b   Foissner, Ilse ^b   Duschl, Albert ^b   Granjeiro, José Mauro ^a,d   Leite, Paulo Emílio Corrêa ^a,f  

^a Quality and Technology (INMETRO)   (Brazil)

^b UNIVERSITY OF SALZBURG   (Austria)

^c HERIOT WATT UNIVERSITY   (United Kingdom)

^d FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^e STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^f Department of Cell Biology ^*  (Brazil)

Author keywords

Clathrin coated pits; Drug delivery; Endocytosis; Lipid rafts; Nanoparticles

Indexed keywords

BIOCOMPATIBILITY; BIOLOGICAL ORGANS; CELL DEATH; CONTROLLED DRUG DELIVERY; DRUG DELIVERY; DRUG PRODUCTS; FUNCTIONAL POLYMERS; MOLECULAR BIOLOGY; NANOPARTICLES; TARGETED DRUG DELIVERY;

CLATHRINS; DRUG DELIVERY SYSTEM; ENDOCYTOSIS; EPIDERMAL GROWTH FACTORS; HIGH THROUGHPUT SCREENING; INFLAMMATORY MEDIATORS; LIPID RAFT; LUNG EPITHELIAL CELLS;

LACTIC ACID;

INTERLEUKIN 12P70; MICRORNA 155; NANOPARTICLE; POLYLACTIC ACID; POLYLACTIC ACID NANOPARTICLE; PROTEOME; STAUROSPORINE; UNCLASSIFIED DRUG; VASCULOTROPIN; BIOMATERIAL; CLATHRIN; INTERLEUKIN 12; MICRORNA; MIRN155 MICRORNA, HUMAN; POLYESTER; POLYLACTIDE; VASCULOTROPIN A;

A-549 CELL LINE; ARTICLE; CELL DEATH; CELL FUNCTION; CELL PROLIFERATION; CELL VIABILITY; CLATHRIN-COATED VESICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; ENDOCYTOSIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IMMUNOMODULATION; INTERNALIZATION; LIPID RAFT; PINOCYTOSIS; CAVEOLA; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; EPITHELIUM CELL; MEMBRANE MICRODOMAIN; METABOLISM; PARTICLE SIZE;

A549 CELLS; BIOCOMPATIBLE MATERIALS; CAVEOLAE; CELL SURVIVAL; CLATHRIN; DRUG DELIVERY SYSTEMS; EPITHELIAL CELLS; HUMANS; INTERLEUKIN-12; MEMBRANE MICRODOMAINS; MICRORNAS; NANOPARTICLES; PARTICLE SIZE; PINOCYTOSIS; POLYESTERS; PROTEOME; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 85011017845     PISSN: None     EISSN: 14773155     Source Type: Journal    
DOI: 10.1186/s12951-016-0238-1     Document Type: Article

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