Ethics of mitochondrial replacement techniques: A habermasian perspective

Bioethics

Volumn 31, Issue 1, 2017, Pages 27-36

  Palacios González, César ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Habermas; Maternal spindle transfer; Mitochondrial donation; Mitochondrial replacement techniques; Mitochondrial replacement therapy; Prenatal genetic manipulation; Pronuclear transfer; Three parent babies; Three parent IVF

Indexed keywords

ETHICS; GENETIC MANIPULATION; HUMAN; LAW; MITOCHONDRIAL REPLACEMENT THERAPY; MITOCHONDRION; MORALITY; SPERM; STANDING; GENE THERAPY; GENETIC ENHANCEMENT;

GENETIC ENHANCEMENT; GENETIC THERAPY; HUMANS; MITOCHONDRIA; MITOCHONDRIAL REPLACEMENT THERAPY; MORALS;

EID: 85010908035     PISSN: 02699702     EISSN: 14678519     Source Type: Journal    
DOI: 10.1111/bioe.12307     Document Type: Article

References (47)

1. S.A. Newman. FDA Asked to Approve Creation of GeneticallyModified Children. Huffington Post. 2014. Available at: http://www.huffingtonpost.com/stuart-a-newman/fda-askedto-approve-crea_b_4809876.html [accessed 2 April 2014]
2. S.A. Newman. Deceptive Labeling of a Radical Embryo Construction Technique. Huffington Post. 2014. Available at: http://www.huffingtonpost.com/stuart-a-newman/deceptive-labeling-of-a-r_b_6213320.html [Accessed 17 December 2014]
3. V. Ravitsky, S. Birko, R. Dupras-Leduc. The ‘Three-Parent Baby’: A Case Study of How Language Frames the Ethical Debate Regarding an Emerging Technology. Am J Bioeth 2015; 15(12): 57-60.
4. C. Palacios-González. Mitochondrial replacement techniques: egg donation, genealogy and eugenics. Monash Bioeth Rev 2016; 34: 37-51.
5. C. MacKellar. 2014. Should persons affected by mitochondrial disorders not be brought into existence? BioNews. Available at: http://www.bionews.org.uk/page_385343.asp [Accessed 13 May 2016]
6. C. MacKellar. Questions relating to ‘mitochondrial replacement’. BioNews. Available at: http://www.bionews. org.uk/page_395064.asp [Accessed 13 May 2016]
7. S.A. Newman. 2013. The British Embryo Authority and the Chamber of Eugenics. The Huffington Post. [Online]. Available at: http://www.huffingtonpost.com/stuart-a-newman/mitochondrial-replacement-ethics_b_2837818.html [Accessed 25 Jan 2016]
8. F. Baylis. The ethics of creating children with three genetic parents. Reprod Biomed Online 2013; 26(6): 531-534.
9. A. Wrigley, S. Wilkinson, J.B. Appleby. Mitochondrial Replacement: Ethics and Identity. Bioethics 2015; 29(9): 631-8.
10. J.B. Appleby. The ethical challenges of the clinical introduction of mitochondrial replacement techniques. Med Health Care Philos 2015; 18(4): 501-14
11. M.H. Johnson. Tri-parenthood-a simply misleading term or an ethicallymisguided approach? Reprod Biomed Online 2013; 26(6): 516-9
12. A.L. Bredenoord, W. Dondorp, G. Pennings, G. De Wert. Avoiding transgenerational risks of mitochondrial DNA disorders: a morally acceptable reason for sex selection? HumReprodOxf Engl 2010; 25(6): 1354-60.
13. J. Harris. GermlineManipulation andOur Future Worlds. AJOB 2015; 15(12): 30-34
14. J. Harris. Germline Modification and the Burden of Human Existence. Camb Q Healthc Ethics 2016; 25(1): 6-18
15. I. de Melo-Martin I. When the MilkofHumanKindness Becomes a Luxury (and Untested)Good. A Reply to Harris; Unconditional Embrace of MitochondrialReplacement Techniques. CambQHealthc Ethics Forthcoming
16. J. Harris. How toWelcome New Technologies: Some Comments on Inmaculada De Melo-Martin’. Camb Q Healthc Ethics Forthcoming
17. C. Palacios-González. Resource Allocation, Treatment, Disclosure, and Mitochondrial Replacement Techniques: Some Comments on de Melo-Martin and Harris. CambQHealthc Ethics Forthcoming.
18. A.L. Bredenoord, P. Braude. Ethics of mitochondrial gene replacement: from bench to bedside. BMJ 2010; 341(nov08 1): c6021-c6021.
19. M.J. Sandel. 2009. The Case Against Perfection. Cambridge, Mass: Belknap Press.
20. G.J. Annas. Why we should ban human cloning. N Engl J Med 1998; 339(2): 122-5.
21. L.R. Kass. Wisdom of Repugnance:WhyWe Should Ban the Cloning of Humans, The. Valpso Univ Law Rev 1998; 32(2): 679-705.
22. J. Habermas. 2003. The Future of Human Nature. Cambridge, UK: Polity Press.
23. J. Pugh. Autonomy, Natality and Freedom: A Liberal Re-examination of Habermas in the Enhancement Debate. Bioethics 2015; 29(3): 145-52.
24. I.G. Cohen, J. Savulescu, E.Y. Adashi. Transatlantic lessons in regulation of mitochondrial replacement therapy. Science 2015; 348(6231): 178-80.
25. C. Palacios-González, J. Harris, G. Testa. Multiplex parenting: IVG and the generations to come. J Med Ethics 2014; 40(11): 752-8.
26. R.W. Taylor, G.A. Taylor, S.E. Durham, D.M. Turnbull. The determination of complete human mitochondrialDNA sequences in single cells: implications for the study of somatic mitochondrial DNA point mutations. Nucleic Acids Res 2001; 29(15): e74-e74.
27. Nuffield Council on Bioethics. 2012. Novel techniques for the prevention of mitochondrial DNA disorders: an ethical review. London: Nuffield Council on Bioethics: 7.
28. Department of Health (DH). 2014. Mitochondrial Donation: A consultation on draft regulations to permit the use of new treatment techniques to prevent the transmission of a serious mitochondrial disease from mother to child. Available at: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/285251/mitochondrial_donation_consultation_ document_24_02_14áccessible_V0.4.pdf [Accessed 5 Jan 2015]
29. A.M. Schaefer, R. McFarland, E.L. Blakely, L. He, R.G. Whittaker, R.W. Taylor, et al. Prevalence of mitochondrialDNA disease in adults. Ann Neurol 2008; 63(1): 35-9
30. H.J. Smeets, S.C. Sallevelt, J.C. Dreesen, C.E. de Die-Smulders, I.F. de Coo. Preventing the transmission of mitochondrialDNA disorders using prenatal or preimplantation genetic diagnosis. Ann N YAcad Sci 2015; 1350:29-36.
31. L. Craven, H.A. Tuppen, G.D. Greggains, S.J. Harbottle, J.L. Murphy, L.M. Cree, et al. Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease. Nature 2010; 465(7294): 82-5
32. M. Tachibana, M. Sparman, H. Sritanaudomchai, H. Ma, L. Clepper, J. Woodward, et al. Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature 2009; 461(7262): 367-72
33. A. Yabuuchi, Z. Beyhan, N. Kagawa, C. Mori, K. Ezoe, K. Kato, et al. Prevention of mitochondrial disease inheritance by assisted reproductive technologies: Prospects and challenges. Biochim Biophys Acta BBA-Gen Subj 2012; 1820(5): 637-42.
34. J.B. Appleby. Should mitochondrial donation be anonymous? J Med Philos Forthcoming
35. R. Brandt. Mitochondrial donation and ‘the right to know.; J Med Ethics Published Online First 2016; 1-8 medethics-2016-103587
36. M. Piotrowska, M. Why Is An Egg Donor a Genetic Parent, But Not a Mitochondrial Donor? Camb Q Healthc Ethics Forthcoming.
37. L.A. Hyslop, P. Blakeley, L. Craven, et al. Towards Clinical Application of Pronuclear Transfer to PreventMitochondrial DNA Disease. Nature 2016; 534(7607): 383-386
38. M. Yamada, V. Emmanuele, M.J. Sanchez-Quintero, et al. Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer inHuman Oocytes’. Cell Stem Cell 2016; 18(6): 749-54.
39. N. Agar. Liberal Eugenics. Public AffQ 1998; 12(2): 141.
40. D. Boonin. Howto Solve theNon-Identity Problem. Public AffQ2008; 22(2): 129-59.
41. D. Gunson.What Is the Habermasian Perspective in Bioethics? Camb Q Healthc Ethics 2012; 21(2): 190.
42. S. Wilkinson. 2010. Choosing Tomorrow’s Children: The Ethics of Selective Reproduction. Oxford: Oxford University Press; 191.
43. S.C. Sallevelt, J.C. Dreesen, M. Drüsedau, S. Spierts, E. Coonen, F.H. van Tienen, et al. Preimplantation genetic diagnosis in mitochondrial DNA disorders: challenge and success. J Med Genet 2013; 50(2): 125-32.
44. A.L. Bredenoord, W. Dondorp, G. Pennings, C. de Die-Smulders, B. Smeets, G. de Wert. Preimplantation genetic diagnosis for mitochondrialDNA disorders: ethical guidance for clinical practice. Eur J Hum Genet 2009; 17(12): 1550-9.
45. T. Pal, J. Permuth-Wey, J.A. Betts, J.P. Krischer, J. Fiorica, H. Arango, et al. BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases. Cancer 2005; 104(12): 2807-16.
46. E. Barnes. Valuing Disability, Causing Disability. Ethics 2014; 125(1): 89.
47. R. Cooper. Can It Be a Good Thing to Be Deaf? J Med Philos 2007; 32(6): 563-83.