Quantitative retinal optical coherence tomography angiography in patients with diabetes without diabetic retinopathy

Investigative Ophthalmology and Visual Science

Volumn 58, Issue 1, 2017, Pages 190-196

  Dimitrova, Galina ^a   Chihara, Etsuo ^b   Takahashi, Hirokazu ^b   Amano, Hiroyuki ^b   Okazaki, Kazushiro ^b  

^a General City Hospital 8th September   (Macedonia)

^b Sensho kai Eye Institute   (Japan)

Author keywords

Angiography; Blood flow; Diabetic retinopathy; Pathogenesis

Indexed keywords

ADULT; ARTICLE; BEST CORRECTED VISUAL ACUITY; BLOOD FLOW; BLOOD PRESSURE; CAPILLARY DENSITY; CHOROID CAPILLARY LAYER; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CONTROLLED STUDY; DIABETES MELLITUS; EYE PHOTOGRAPHY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OPHTHALMOSCOPY; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; REFRACTION ERROR; RETINA FOVEA; RETINAL THICKNESS; AGED; COMPARATIVE STUDY; DIABETIC RETINOPATHY; EYE FUNDUS; FLUORESCENCE ANGIOGRAPHY; FOLLOW UP; MICROCIRCULATION; PATHOLOGY; PATHOPHYSIOLOGY; PHOTORECEPTOR INNER SEGMENT; PHOTORECEPTOR OUTER SEGMENT; PROCEDURES; PROSPECTIVE STUDY; RETINA BLOOD VESSEL;

AGED; DIABETIC RETINOPATHY; FEMALE; FLUORESCEIN ANGIOGRAPHY; FOLLOW-UP STUDIES; FOVEA CENTRALIS; FUNDUS OCULI; HUMANS; MALE; MICROCIRCULATION; PROSPECTIVE STUDIES; RETINAL PHOTORECEPTOR CELL INNER SEGMENT; RETINAL PHOTORECEPTOR CELL OUTER SEGMENT; RETINAL VESSELS; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 85010868204     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.16-20531     Document Type: Article

References (33)

1. Prokofyeva E, Zrenner E. Epidemiology of major eye diseases leading to blindness in Europe: a literature review. Ophthalmic Res. 2012; 47: 171–188.
2. Dimitrova G, Kato S, Yamashita H, et al. Relation between retrobulbar circulation and progression of diabetic retinopathy. Br J Ophthalmol. 2003; 87: 622–625.
3. Arend O, Wolf S, Jung F, et al. Retinal microcirculation in patients with diabetes mellitus: dynamic and morphological analysis of perifoveal capillary network. Br J Ophthalmol. 1991; 75: 514–518.
4. Rimmer T, Fallon TJ, Kohner EM. Long-term follow-up of retinal blood flow in diabetes using the blue light entoptic phenomenon. Br J Ophthalmol. 1989; 73: 1–5.
5. Grunwald JE, Riva CE, Sinclair SH, Baine J, Brucker AJ. Total retinal volumetric blood flow rate in diabetic patients with poor glycaemic control. Invest Ophthalmol Vis Sci. 1992; 33: 356–363.
6. Burgansky-Eliash Z, Barak A, Barash H, et al. Increased retinal blood flow velocity in patients with early diabetes mellitus. Retina. 2012; 32: 112–119.
7. Pemp B, Polska E, Garhofer G, Bayerle-Eder M, Kautzky-Willer A, Schmetterer L. Retinal blood flow in type 1 diabetic patients with no or mild diabetic retinopathy during euglycemic clamp. Diabetes Care. 2010; 33: 2038–2042.
8. Patel V, Rassam S, Newsom R, Wiek J, Kohner E. Retinal blood flow in diabetic retinopathy. BMJ. 1992; 305: 678–683.
9. Lorenzi M, Feke GT, Pitler L, Berisha F, Kolodjaschna J, McMeel JW. Defective myogenic response to posture change in retinal vessels of well-controlled type 1 diabetic patients with no retinopathy. Invest Ophthalmol Vis Sci. 2010; 51: 6770–6775.
10. Shahlaee A, Samara WA, Hsu J, et al. In vivo assessment of macular vascular density in healthy human eyes using optical coherence tomography angiography. Am J Ophthalmol. 2016; 165: 39–46.
11. Li J, Yang YQ, Yang DY, et al. Reproducibility of perfusion parameters of optic disc and macula in rhesus monkeys by optical coherence tomography angiography. Chin Med J (Engl). 2016; 129: 1087–1090.
12. Di G, Weihong Y, Xiao Z, et al. A morphological study of the foveal avascular zone in patients with diabetes mellitus using optical coherence tomography angiography. Graefes Arch Clin Exp Ophthalmol. 2016; 254: 873–879.
13. Freiberg FJ, Pfau M, Wons J, Wirth MA, Becker MD, Michels S. Optical coherence tomography angiography of the foveal avascular zone in diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol. 2016; 254: 1051–1058.
14. de Carlo TE, Chin AT, Bonini Filho MA, et al. Detection of microvascular changes in eyes of patients with diabetes but not clinical clinical diabetic retinopathy using optical coherence tomography angiography. Retina. 2015; 35: 2364–2370.
15. Takase N, Nozaki M, Kato A, Ozeki H, Yoshida M, Ogura Y. Enlargement of foveal avascular zone in diabetic eyes evaluated by en face optical coherence tomography angiography. Retina. 2015; 35: 2377–2383.
16. Hasegawa N, Nozaki M, Takase N, Yoshida M, Ogura Y. New insights into microaneurysms in the deep capillary plexus detected by optical coherence tomography angiography in diabetic macular edema. Invest Ophthalmol Vis Sci. 2016; 57: OCT348–OCT355.
17. Ishibazawa A, Nagaoka T, Takahashi A, et al. Optical coherence tomography angiography in diabetic retinopathy: a prospective pilot study. Am J Ophthalmol. 2015; 160: 35-44.e1.
18. Couturier A, Mané V, Bonnin S, et al. Capillary plexus anomalies in diabetic retinopathy on optical coherence tomography angiography. Retina. 2015; 35: 2384–2391.
19. Scarinci F, Jampol LM, Linsenmeier RA, Fawzi AA. Association of diabetic macular nonperfusion with outer retinal disruption on optical coherence tomography. JAMA Ophthalmol. 2015; 133: 1036–1044.
20. Dimitrova G, Kato S, Tamaki Y, et al. Choroidal circulation in diabetic patients. Eye (Lond). 2001; 15: 602–607.
21. Yu J, Gu R, Zong Y, et al. Relationship between retinal perfusion and retinal thickness in healthy subjects: an optical coherence tomography angiography study. Invest Ophthalmol Vis Sci. 2016; 57: OCT204–OCT210.
22. Genevois O, Paques M, Simonutti M, et al. Microvascular remodeling after occlusion-recanalization of a branch retinal vein in rats. Invest Ophthalmol Vis Sci. 2004; 45: 594–600.
23. Coscas F, Sellam A, Glacet-Bernard A, et al. Normative data for vascular density in superficial and deep capillary plexuses of healthy adults assessed by optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2016; 57: 211–223.
24. Liu L, Wu J, Yue S, et al. Incidence density and risk factors of diabetic retinopathy within type 2 diabetes: a five-year cohort study in China. Int J Environ Res Public Health. 2015; 12: 7899–7909.
25. Klein R, Sharrett AR, Klein BE, et al.; ARIC Group. The association of atherosclerosis, vascular risk factors, and retinopathy in adults with diabetes: the atherosclerosis risk in communities study. Ophthalmology. 2002; 109: 1225–1234.
26. van Hecke MV, Dekker JM, Stehouwer CD, et al. Diabetic retinopathy is associated with mortality and cardiovascular disease incidence: the EURODIAB prospective complications study. Diabetes Care. 2005; 28: 1383–1389.
27. McAllister A. A review of the vascular anatomy of the optic nerve head and its clinical implications. Cureus. 2013; 5: e98.
28. Dimitrova G. Morphometric characteristics of central retinal artery and vein in the optic nerve head of patients with diabetes. Invest Ophthalmol Vis Sci. 2012; 53: 1637.
29. Miwa Y, Murakami T, Suzuma K, et al. Relationship between functional and structural changes in diabetic vessels in optical coherence tomography angiography. Sci Rep. 2016; 28: 29064.
30. Kim AY, Chu Z, Shahidzadeh A, Wang RK, Puliafito CA, Kashani AH. Quantifying microvascular density and morphology in diabetic retinopathy using spectral-domain optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2016; 57: OCT362–OCT370.
31. Agemy SA, Scripsema NK, Shah CM, et al. Retinal vascular perfusion density mapping using optical coherence tomography angiography in normals and diabetic retinopathy patients. Retina. 2015; 35: 2353–2363.
32. Bursell SE, Clermont AC, Kinsley BT, Simonson DC, Aiello LM, Wolpert HA. Retinal blood flow changes in patients with insulin-dependent diabetes mellitus and no diabetic retinopathy. Invest Ophthalmol Vis Sci. 1996; 37: 886–897.
33. Forst T, Weber MM, Mitry M, et al. Pilot study for the evaluation of morphological and functional changes in retinal blood flow in patients with insulin resistance and/or type 2 diabetes mellitus. J Diabetes Sci Technol. 2012; 6: 163–168.