Normative data for vascular density in superficial and deep capillary plexuses of healthy adults assessed by optical coherence tomography angiography

Investigative Ophthalmology and Visual Science

Volumn 57, Issue 9, 2016, Pages OCT211-OCT223

  Coscas, Florence ^a   Sellam, Alexandre ^a   Glacet Bernard, Agnès ^a   Jung, Camille ^a   Goudot, Mathilde ^a   Miere, Alexandra ^a   Souied, Eric H ^a  

^a CENTRE HOSPITALIER INTERCOMMUNAL DE CRÉTEIL   (France)

Author keywords

Adult; Deep capillary plexus; Foveal avascular zone; Healthy; Nonflow area; Normal subject; Normative database; OCT angiography; Optical coherence tomography angiography; Superficial capillary plexus; Vascular density

Indexed keywords

A SCAN; ADULT; AGED; ANGIOGRAPHY; ARTICLE; B SCAN; CAPILLARY DENSITY; CONTROLLED STUDY; FEMALE; FOVEAL AVASCULAR ZONE AREA; HUMAN; IMAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; MEASUREMENT REPEATABILITY; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; REPRODUCIBILITY; RETINA FOVEA; RETROSPECTIVE STUDY; SENSORY SYSTEM PARAMETERS; SLIT LAMP; VISUAL ACUITY; AGING; CAPILLARY; DIAGNOSTIC IMAGING; EYE FUNDUS; FLUORESCENCE ANGIOGRAPHY; FOLLOW UP; MIDDLE AGED; PROCEDURES; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; RETINA BLOOD VESSEL; RETINA MACULA LUTEA; YOUNG ADULT;

ADULT; AGED; AGING; CAPILLARIES; FEMALE; FLUORESCEIN ANGIOGRAPHY; FOLLOW-UP STUDIES; FUNDUS OCULI; HUMANS; MACULA LUTEA; MALE; MIDDLE AGED; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; RETINAL VESSELS; RETROSPECTIVE STUDIES; ROC CURVE; TOMOGRAPHY, OPTICAL COHERENCE; YOUNG ADULT;

EID: 84978517830     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.15-18793     Document Type: Article

References (43)

1. Buttery RG, Hinrichsen CF, Weller WL, Haight JR. How thick should a retina be? A comparative study of mammalian species with and without intraretinal vasculature. Vision Res. 1991; 31: 169-178.
2. Gariano RF, Iruela-Arispe ML, Hendrickson AE. Vascular development in primate retina: comparison of laminar plexus formation in monkey and human. Invest Ophthalmol Vis Sci. 1994; 35: 3442-3455.
3. Hughes S, Yang H, Chan-Ling T. Vascularization of the human fetal retina: roles of vasculogenesis and angiogenesis. Invest Ophthalmol Vis Sci. 2000; 41: 1217-1228.
4. Tan PE, Yu PK, Balaratnasingam C, et al. Quantitative confocal imaging of the retinal microvasculature in the human retina. Invest Ophthalmol Vis Sci. 2012; 53: 5728-5736.
5. Spaide RF, Klancnik JM Jr, Cooney MJ. Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography. JAMA Ophthalmol. 2015; 133: 45-50.
6. Paques M, Tadayoni R, Sercombe R, et al. Structural and hemodynamic analysis of the mouse retinal microcirculation. Invest Ophthalmol Vis Sci. 2003; 44: 4960-4967.
7. Chan-Ling TL, Halasz P, Stone J. Development of retinal vasculature in the cat: processes and mechanisms. Curr Eye Res. 1990; 9: 459-478.
8. Novotny HR, Alvis DL. A method of photographing fluorescence in circulating blood in the human retina. Circulation. 1961; 24: 82-86.
9. Jia Y, Tan O, Tokayer J, et al. Split-spectrum amplitudedecorrelation angiography with optical coherence tomography. Opt Express. 2012; 20: 4710-4725.
10. Tokayer J, Jia Y, Dhalla AH, Huang D. Blood flow velocity quantification using split-spectrum amplitude-decorrelation angiography with optical coherence tomography. Biomed Opt Express. 2013; 4: 1909-1924.
11. Choi W, Mohler KJ, Potsaid B, et al. Choriocapillaris and choroidal microvasculature imaging with ultrahigh speed OCT angiography. PLoS One. 2013; 8: e81499.
12. Matsunaga D, Puliafito CA, Kashani AH. OCT angiography in healthy human subjects. Ophthalmic Surg Lasers Imaging Retina. 2014; 45: 510-515.
13. Coscas F, Glacet-Bernard A, Miere A, et al. Optical coherence angiography in retinal vein occlusion: evaluation of superficial and deep capillary plexuses. Am J Ophthalmol. 2016; 161: 160-171.
14. Couturier A, Mané V, Bonnin S, et al. Capillary plexus anomalies in diabetic retinopathy on optical coherence tomography angiography. Retina. 2015; 35: 2384-2391.
15. Thorell MR, Zhang Q, Huang Y, et al. Swept-source OCT angiography of macular telangiectasia type 2. Ophthalmic Surg Lasers Imaging Retina. 2014; 45: 369-380.
16. Agemy SA, Scripsema NK, Shah CM, et al. Retinal vascular perfusion density mapping using optical coherence tomography angiography in normals and diabetic retinopathy patients. Retina. 2015; 35: 2353-2363.
17. De Carlo TE, Chin AT, Bonini Filho MA, et al. Detection of microvascular changes in eyes of patients with diabetes but not clinical diabetic retinopathy using optical coherence tomography angiography. Retina. 2015; 35: 2229-2235.
18. Veverka KK, AbouChehade JE, Iezzi R Jr, Pulido JS. Noninvasive grading of radiation retinopathy: the use of optical coherence tomography angiography. Retina. 2015; 35: 2400-2410.
19. Kraus MF, Potsaid B, Mayer MA, et al. Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns. Biomed Opt Express. 2012; 3: 1182-1199.
20. Snodderly DM, Weinhaus RS, Choi JC. Neural-vascular relationships in central retina of macaque monkeys (Macaca fascicularis). J Neurosci. 1992; 12: 1169-1193.
21. Adhi M, Aziz S, Muhammad K, Adhi MI. Macular thickness by age and gender in healthy eyes using spectral domain optical coherence tomography. PLoS One. 2012; 7: e37638.
22. Liu T, Hu AY, Kaines A, Yu F, Schwartz SD, Hubschman JP. A pilot study of normative data for macular thickness and volume measurements using cirrus high-definition optical coherence tomography. Retina. 2011; 31: 1944-1950.
23. Chan G, Balaratnasingam C, Yu PK, et al. Quantitative morphometry of perifoveal capillary networks in the human retina. Invest Ophthalmol Vis Sci. 2012; 53: 5502-5514.
24. Coscas GJ, Lupidi M, Coscas F, Cagini C, Souied EH. Optical coherence tomography angiography versus traditional multimodal imaging in assessing the activity of exudative age-related macular degeneration: a new diagnostic challenge. Retina. 2015; 35: 2219-2228.
25. Wang X, Jiang C, Ko T, et al. Correlation between optic disc perfusion and glaucomatous severity in patients with openangle glaucoma: an optical coherence tomography angiography study. Graefes Arch Clin Exp Ophthalmol. 2015; 253: 1557-1564.
26. Freiberg FJ, Pfau M, Wons J, Wirth MA, Becker MD, Michels S. Optical coherence tomography angiography of the foveal avascular zone in diabetic retinopathy [published online ahead of print September 4, 2015]. Graefes Arch Clin Exp Ophthalmol.
27. Bonini F, Marco A, Adhi M, et al. Optical coherence tomography angiography in retinal artery occlusion. Retina. 2015; 35: 2339-2346.
28. Bonnin S, Mané V, Couturier A, et al. New insight into the macular deep vascular plexus imaged by optical coherence tomography angiography. Retina. 2015; 35: 2347-2352.
29. John D, Kuriakose T, Devasahayam S, Braganza A. Dimensions of the foveal avascular zone using the Heidelberg retinal angiogram-2 in normal eyes. Indian J Ophthalmol. 2011; 59: 9-11.
30. Tam J, Martin JA, Roorda A. Noninvasive visualization and analysis of parafoveal capillaries in humans. Invest Ophthalmol Vis Sci. 2010; 51: 1691-1698.
31. Kim DY, Fingler J, Zawadzki RJ, et al. Noninvasive imaging of the foveal avascular zone with high-speed phase-variance optical coherence tomography. Invest Ophthalmol Vis Sci. 2012; 53: 85-92.
32. Chui TY, Vannasdale DA, Elsner AE, Burns SA. The association between the foveal avascular zone and retinal thickness. Invest Ophthalmol Vis Sci. 2014; 55: 6870-6877.
33. Bresnick GH, Condit R, Syrjala S, et al. Abnormalities of the foveal avascular zone in diabetic retinopathy. Arch Ophthalmol. 1984; 102: 1286-1293
34. Arend O, Wolf S, Harris A, et al. The relationship of macular microcirculation to visual acuity in diabetic patients. Arch Ophthalmol. 1995; 113: 610-614.
35. Carpineto P, Mastropasqua R, Marchini G, et al. Reproducibility and repeatability of foveal avascular zone measurements in healthy subjects by optical coherence tomography angiography. Br J Ophthalmol. 2016; 100: 671-676.
36. Takase N, Nozaki M, Kato A, Ozeki H, Yoshida M, Ogura Y. Enlargement of foveal avascular zone in diabetic eyes evaluated by en face optical coherence tomography angiography. Retina. 2015; 35: 2377-2383.
37. Samara WA, Say EA, Khoo CT, et al. Correlation of foveal avascular zone size with foveal morphology in normal eyes using optical coherence tomography angiography. Retina. 2015; 35: 2188-2195.
38. Kuehlewein L, Tepelus TC, An L, et al. Noninvasive visualization and analysis of the human parafoveal capillary network using swept source OCT optical microangiography. Invest Ophthalmol Vis Sci. 2015; 56: 3984-3988.
39. Bird AC, Weale RA. On the retinal vasculature of the human fovea. Exp Eye Res. 1974; 19: 409-417.
40. Hayreh SS. In vivo choroidal circulation and its watershed zones. Eye (Lond). 1990; 4 (pt 2): 273-289.
41. Spaide RF, Fujimoto JG, Waheed NK. Image artifacts in optical coherence tomography angiography. Retina. 2015; 35: 2163-2180.
42. Jia Y, Bailey S, Hwang T, et al. Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye. Proc Natl Acad Sci U S A. 2015; 112: E2395-E2402.
43. Gadde SG, Anegondi N, Bhanushali D, et al. Quantification of vascular density in retinal optical coherence tomography angiography images using local fractal dimension. Invest Ophthalmol Vis Sci. 2016; 57: 246-252.