Gel-free proteomics reveals neoplastic potential in endometrium of infertile patients with stage IV ovarian endometriosis

Journal of Reproductive Health and Medicine

Volumn 1, Issue 2, 2015, Pages 83-95

  Ghosh, D ^a   Nagpal, S ^b   Bhat, M A ^a   Anupa, G ^a   Srivastava, A ^a   Sharma, J B ^a   Sengupta, Jayasree ^a,c  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b SMS India Pvt Ltd   (India)

^c HINDU RAO HOSPITAL   (India)

Author keywords

Differential display; Endometriosis; Endometrium; Gel free 2D proteomics

Indexed keywords

ALPHA TUBULIN; AUTOPHAGY PROTEIN 5; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CYTOSKELETON PROTEIN; HEAT SHOCK PROTEIN 90; HEMOPEXIN; LIPOCORTIN 2; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; TRANSFORMING GROWTH FACTOR;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ENDOMETRIOSIS; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GEL ELECTROPHORESIS; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INFERTILITY; LAPAROSCOPY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NEOPLASM; PROTEIN DENATURATION; PROTEIN EXPRESSION; PROTEOMICS; REGULATORY MECHANISM; TELOMERE HOMEOSTASIS; VALIDATION PROCESS;

EID: 85010835443     PISSN: 2214420X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jrhm.2015.06.003     Document Type: Article

References (83)

1. Guo SW, Wang Y. The prevalence of endometriosis in women with chronic pelvic pain. Fertil Steril. 2006;62:121-130.
2. Knapp VJ. How old is endometriosis? Late 17th-and 18thcentury European descriptions of the disease. Fertil Steril. 1999;72:10-14.
3. Acién P, Velasco I. Endometriosis: a disease that remains enigmatic. ISRN Obstet Gynecol. 2013;242149.
4. May KE, Villar J, Kirtley S, Kennedy SH, Becker CM. Endometrial alterations in endometriosis: a systematic review of putative biomarkers. Hum Reprod Update. 2011;17:637-653.
5. Aghajanova L, Giudice LC. Molecular evidence for differences in endometrium in severe versus mild endometriosis. Reprod Sci. 2011;18:229-251.
6. Khan MA, Sengupta J, Mittal S, Ghosh D. Genome-wide expressions in autologous eutopic and ectopic endometrium of fertile women with endometriosis. Reprod Biol Endocrinol. 2012;10:84.
7. Wölfler MM, Meinhold-Heerlein IM, Söhngen L, et al. Twodimensional gel electrophoresis in peritoneal fluid samples identifies differential protein regulation in patients suffering from peritoneal or ovarian endometriosis. Fertil Steril. 2011;95:2764-2768.
8. Donnez J, Donnez O, Lousse J-C, Squifflet J. Peritoneal, ovarian, and rectovaginal endometriosis are three different entities. In: Giudice LC, Evers JLH, Healy DL, eds. In: Endometriosis: Science and Practice. Oxford: Wiley-Blackwell; 2011:51.
9. Ab S, Srivastava P, Shivaji S. Understanding the pathogenesis of endometriosis through proteomics: recent advances and future prospects. Proteomics Clin Appl. 2014;8:86-98.
10. Tambor V, Fucíková A, Lenco J, et al. Application of proteomics in biomarker discovery: a primer for the clinician. Physiol Res. 2010;59:471-497.
11. Fields S. Proteomics in genomeland. Science. 2001;291:1221-1224.
12. Ghochani FNM, Gilany K. Proteomics a key tool for a better understanding of endometriosis: a mini-review. J Paramed Sci. 2011;2:51-58.
13. Chevalier F. Highlights on the capacities of ''Gel-based'' proteomics. Proteome Sci. 2010;8:23.
14. Scherp P, Ku G, Coleman L, Kheterpal I. Gel-based and gel-free proteomic technologies. Methods Mol Biol. 2011;702:163-190.
15. Hörth P, Miller CA, Preckel T, Wenz C. Efficient fractionation and improved protein identification by peptide OFFGEL electrophoresis. Mol Cell Proteomics. 2006;5:1968-1974.
16. Salowsky R, Babu S, Wenz C, Ruefer A. Separation and detection of protein charge isoforms with a combination of OFFGEL-and Lab on-Chip electrophoresis and mass spectrometry. J Biomol Techniques. 2011;22:S63-S64.
17. Khan MA, Sengupta J, Giudice LC, et al. cDNA-based transcript analysis of autologous eutopic and ectopic endometrium of women with moderate and severe endometriosis. J Endometriosis. 2011;3:8-33.
18. Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril. 1997;67:817-821.
19. Hörth P, Preckel T, Wenz C. Efficient peptide fractionation and improved protein identification with the Agilent 3100 OFFGEL Fractionator. In: Agilent Application Note. 2006. 5989-5206EN.
20. Kuschel M. Analysis of messenger RNA using the Agilent 2100 Bioanalyzer and the RNA 6000 LabChip® kit. In: Agilent Application Note. 2013. G2938-90034.
21. Kinter M, Sherman NE. Protein Sequencing and Identification using Tandem Mass Spectrometry. John Wiley & Sons, Inc.; 2000 :161-163.
22. Kislinger T, Emili A. Going global: protein expression profiling using shotgun mass spectrometry. Curr Opin Mol Ther. 2003;5:285-293.
23. Sengupta J, Khan MA, Huppertz B, Ghosh D. In-vitro effects of the antimicrobial peptide Ala8,13,18-magainin II amide on isolated human first trimester villous trophoblast cells. Reprod Biol Endocrinol. 2011;9:49.
24. Srivastava A, Sengupta J, Kriplani A, Roy KK, Ghosh D. Profiles of cytokines secreted by isolated human endometrial cells under the influence of chorionic gonadotropin during the window of embryo implantation. Reprod Biol Endocrinol. 2013;11:e116.
25. Brewis IA, Brennan P. Proteomics technologies for the global identification and quantification of proteins. Adv Protein Chem Struct Biol. 2010;80:1-44.
26. Brosens I, Brosens JJ, Benagiano G. The eutopic endometrium in endometriosis: are the changes of clinical significance? Reprod Biomed Online. 2012;24:496-502.
27. Defrère S, Lousse JC, González-Ramos R, Colette S, Donnez J, Van Langendonckt A. Potential involvement of iron in the pathogenesis of peritoneal endometriosis. Mol Hum Reprod. 2008;14:377-385.
28. Augoulea A, Mastorakos G, Lambrinoudaki I, Christodoulakos G, Creatsas G. The role of the oxidativestress in the endometriosis-related infertility. Gynecol Endocrinol. 2009;25:75-81.
29. Van Langendonckt A, Casanas-Roux F, Dolmans MM, Donnez J. Potential involvement of hemoglobin and heme in the pathogenesis of peritoneal endometriosis. Fertil Steril. 2002;77:561-570.
30. Nava VE, Lacana E, Poulton S, et al. Functional characterization of human sphingosine kinase-1. FEBS Lett. 2000;473:81-84.
31. Spiegel S, Milstien S. Sphingosine-1-phosphate: signaling inside and out. FEBS Lett. 2000;476:55-57.
32. Xia P, Wang L, Moretti PA, et al. Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling. J Biol Chem. 2002;277:7996-8003.
33. Nasu K, Yuge A, Tsuno A, Nishida M, Narahara H. Involvement of resistance to apoptosis in the pathogenesis of endometriosis. Histol Histopathol. 2009;24:1181-1192.
34. Al-Jefout M, Dezarnaulds G, Cooper M, et al. Diagnosis of endometriosis by detection of nerve fibres in an endometrial biopsy: a double blind study. Hum Reprod. 2009;24:3019-3024.
35. Bokor A, Kyama CM, Vercruysse L, et al. Density of small diameter sensory nerve fibres in endometrium: a semiinvasive diagnostic test for minimal to mild endometriosis. Hum Reprod. 2009;24:3025-3032.
36. Wang G, Tokushige N, Russell P, Dubinovsky S, Markham R, Fraser IS. Neuroendocrine cells in eutopic endometrium of women with endometriosis. Hum Reprod. 2009;25:387-391.
37. Tariverdian N, Rucke M, Szerkes-Bartho J, et al. Neuroendocrine circuitry and endometriosis: progesterone derivative dampens corticotrophin-releasing hormone induced inflammation by peritoneal cells in vitro. J Mol Med. 2010;88:267-278.
38. Fowler PA, Tattum J, Bhattacharya S, et al. An investigation of the effects of endometriosis on the proteome of human eutopic endometrium: a heterogeneous tissue with a complex disease. Proteomics. 2007;7:130-142.
39. Stephens AN, Hannan NJ, Rainczuk A, et al. Posttranslational modifications and protein-specific isoforms in endometriosis revealed by 2D DIGE. J Proteome Res. 2010;9:2438-2449.
40. Kogan I, Ramjeesingh M, Li C, et al. CFTR directly mediates nucleotide-regulated glutathione flux. EMBO J. 2003;22:1981-1999.
41. Guggino WB, Stanton BA. New insights into cystic fibrosis: molecular switches that regulate CFTR. Nat Rev Mol Cell Biol. 2006;7:426-436.
42. Chan HC, Shi QX, Zhou CX, et al. Critical role of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm. Mol Cell Endocrinol. 2006;250:106-113.
43. Minici F, Tiberi F, Tropea A, et al. Endometriosis and human infertility: a new investigation into the role of eutopic endometrium. Hum Reprod. 2008;23:530-537.
44. Liu H, Lang JH. Is abnormal eutopic endometrium the cause of endometriosis? The role of eutopic endometrium in pathogenesis of endometriosis. Med Sci Monit. 2011;17:RA92-RA99.
45. Zhou S, Yi T, Liu R, et al. Proteomics identification of annexin A2 as a key mediator in the metastasis and proangiogenesis of endometrial cells in human adenomyosis. Mol Cell Proteomics. 2012;11:1-20.
46. Fedele L, Marchini M, Bianchi S, Dorta M, Arcaini L, Fontana PE. Structural and ultrastructural defects in preovulatory endometrium of normo-ovulating infertile women with minimal or mild endometriosis. Fertil Steril. 1990;53:989-993.
47. Cunha-Filho JS, Gross JL, Lemos NA, Brandelli A, Castillos M, Passos EP. Hyperprolactinemia and luteal insufficiency in infertile patients with mild and minimal endometriosis. Horm Metab Res. 2001;33:216-220.
48. Ordi J, Creus M, Casamitjana R, Cardesa A, Vanrell JA, Balasch J. Endometrial pinopode and alphavbeta3 integrin expression is not impaired in infertile patients with endometriosis. Assist Reprod Genet. 2003;20:465-473.
49. Varma R, Rollason T, Gupta JK, Maher ER. Endometriosis and the neoplastic process. Reproduction. 2004;127:293-304.
50. Brinton LA, Gridley G, Persson I, Baron J, Bergqvist A. Cancer risk after a hospital discharge diagnosis of endometriosis. Am J Obstet Gynecol. 1997;176:572-579.
51. Stern RC, Dash R, Bentley RC, Snyder MJ, Haney AF, Robboy SJ. Malignancy in endometriosis: frequency and comparison of ovarian and extraovarian types. Int J Gynecol Pathol. 2001;20:133-139.
52. Zaino R, Whitney C, Brady MF, DeGeest K, Burger RA, Buller RE. Simultaneously detected endometrial and ovarian carcinomas-a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecol Oncol. 2001;83:355-362.
53. Vlahos NF, Kalampokas T, Fotiou S. Endometriosis and ovarian cancer: a review. Gynecol Endocrinol. 2010;26:213-219.
54. Kurman RJ, Shih IM. Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer-shifting the paradigm. Hum Pathol. 2011;42:918-993.
55. Kim CM, Oh YJ, Cho SH, et al. Increased telomerase activity and human telomerase reverse transcriptase mRNA expression in the endometrium of patients with endometriosis. Hum Reprod. 2007;22:843-849.
56. Hapangama DK, Turner MA, Drury JA, et al. Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length. Hum Reprod. 2008;23:1511-1519.
57. Hapangama DK, Turner MA, Drury JA, et al. Sustained replication in endometrium of women with endometriosis occurs without evoking a DNA damage response. Hum Reprod. 2009;24:687-696.
58. Omwandho CO, Konrad L, Halis G, Oehmke F, Tinneberg HR. Role of TGF-betas in normal human endometrium and endometriosis. Hum Reprod. 2010;25:101-109.
59. Matsuzaki S, Darcha C. Epithelial to mesenchymal transition-like and mesenchymal to epithelial transitionlike processes might be involved in the pathogenesis of pelvic endometriosis. Hum Reprod. 2012;27:712-721.
60. Young VJ, Brown JK, Saunders PT, Horne AW. The role of the peritoneum in the pathogenesis of endometriosis. Hum Reprod Update. 2013;19:558-569.
61. Bartley J, Jülicher A, Hotz B, Mechsner S, Hotz H. Epithelial to mesenchymal transition (EMT) seems to be regulated differently in endometriosis and the endometrium. Arch Gynecol Obstet. 2014;289:871-881.
62. Zhou XM, Zhang H, Han X. Role of epithelial to mesenchymal transition proteins in gynecological cancers: pathological and therapeutic perspectives. Tumour Biol. 2014;35:9523-9530.
63. Rai P, Kota V, Deendayal M, Shivaji S. Differential proteome profiling of eutopic endometrium from women with endometriosis to understand etiology of endometriosis. J Proteome Res. 2010;9:4407-4419.
64. Koya RC, Fujita H, Shimizu S, et al. Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release. J Biol Chem. 2000;275:15343-15349.
65. Kusano H, Shimizu S, Koya RC, et al. Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC. Oncogene. 2000;19:4807-4814.
66. Van den Abbeele A, De Corte V, Van Impe K, et al. Downregulation of gelsolin family proteins counteracts cancer cell invasion in vitro. Cancer Lett. 2007;255:57-70.
67. Zhuo J, Tan EH, Yan B, et al. Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade. PLoS One. 2012;7:. e43594.
68. Abedini MR, Wang PW, Huang YF, et al. Cell fate regulation by gelsolin in human gynecologic cancers. Proc Natl Acad Sci USA. 2014;111:14442-14447.
69. Shu K, Xiao Z, Long S, et al. Expression of DJ-1 in endometrial cancer: close correlation with clinicopathological features and apoptosis. Int J Gynecol Cancer. 2013;23:1029-1035.
70. Morelli M, Scumaci D, Di Cello A, et al. DJ-1 in endometrial cancer: a possible biomarker to improve differential diagnosis between subtypes. Int J Gynecol Cancer. 2014;24:649-658.
71. Wang CY, Lin CF. Annexin A2: its molecular regulation and cellular expression in cancer development. Disease Marker. 2014. http://dx.doi.org/10.1155/2014/308976.
72. Trepel J, Mollapour M, Giaccone G, Neckers L. Targeting the dynamic HSP90 complex in cancer. Nat Rev. 2010;10:537-549.
73. Jechlinger M, Sommer A, Moriggl R, et al. Autocrine PDGFR signaling promotes mammary cancer metastasis. J Clin Invest. 2006;116:1561-1570.
74. Ostman A, Heldin CH. PDGF receptors as targets in tumor treatment. Adv Cancer Res. 2007;97:247-274.
75. Giarnieri E, De Francesco GP, Carico E, et al. Alpha-and betatubulin expression in rectal cancer development. Anticancer Res. 2005;25:3237-3241.
76. Tang SC. Predictive markers of tubulin-targeting agents in breast cancer. Clin Breast Cancer. 2008;8(suppl 2):S79-S84.
77. Kyama CM, T'Jampens D, Mihalyi A, et al. ProteinChip technology is a useful method in the pathogenesis and diagnosis of endometriosis: a preliminary study. Fertil Steril. 2006;86:203-209.
78. Zhang H, Niu Y, Feng J, Guo H, Ye X, Cui H. Use of proteomic analysis of endometriosis to identify different protein expression in patients with endometriosis versus normal controls. Fertil Steril. 2006;86:274-282.
79. ten Have S, Fraser I, Markham R, Lam A, Matsumoto I. Proteomic analysis of protein expression in the eutopic endometrium of women with endometriosis. Proteomics Clin Appl. 2007;1:1243-1251.
80. Wang L, Zheng W, Ding XY, Yu JK, Jiang WZ, Zhang SZ. Identification biomarkers of eutopic endometrium in endometriosis using artificial neural networks and protein fingerprinting. Fertil Steril. 2010;93:2460-2462.
81. Kyama CM, Mihalyi A, Gevaert O, et al. Evaluation of endometrial biomarkers for semi-invasive diagnosis of endometriosis. Fertil Steril. 2011;95:1338-1343.
82. Fassbender A, Simsa P, Kyama CM, et al. TRIzol treatment of secretory phase endometrium allows combined proteomic and mRNA microarray analysis of the same sample in women with and without endometriosis. Reprod Biol Endocrinol. 2010;8:123.
83. Fassbender A, Verbeeck N, Börnigen D, et al. Combined mRNA microarray and proteomic analysis of eutopic endometrium of women with and without endometriosis. Hum Reprod. 2012;27:2020-2029.