Altered S-nitrosylation of p53 is responsible for impaired antioxidant response in skeletal muscle during aging

Aging

Volumn 8, Issue 12, 2016, Pages 3450-3467

  Baldelli, Sara ^a,c   Ciriolo, Maria Rosa ^b,c  

^a Faculty of Architecture and Industrial Design   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c IRCCS SAN RAFFAELE PISANA   (Italy)

Author keywords

Aging; Antioxidant; Atrophy; S nitrosylation; Sarcopenia

Indexed keywords

NITRIC OXIDE; PROTEIN P53;

AGING; ANIMAL; APOPTOSIS; CELL LINE; HUMAN; METABOLISM; MOUSE; MYOBLAST; OXIDATIVE STRESS; PHYSIOLOGY; PROMOTER REGION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

AGING; ANIMALS; APOPTOSIS; CELL LINE; HUMANS; MICE; MUSCLE, SKELETAL; MYOBLASTS; NITRIC OXIDE; OXIDATIVE STRESS; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85010576304     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.101139     Document Type: Article

References (31)

1. Wall BT, Dirks ML, van Loon LJ. Skeletal muscle atrophy during short-term disuse: implications for age-related sarcopenia. Ageing Res Rev. 2013; 12:898-906. doi: 10.1016/j.arr.2013.07.003
2. Bell KE, von Allmen MT, Devries MC, Phillips SM. Muscle disuse as a pivotal problem in sarcopeniarelated muscle loss and dysfunction. J Frailty Aging. 2016; 5:33-41. doi: 10.14283/jfa.2016.78
3. Doria E, Buonocore D, Focarelli A, Marzatico F. Relationship between human aging muscle and oxidative system pathway. Oxid Med Cell Longev. 2012; 2012:830257. doi: 10.1155/2012/830257
4. Aquilano K, Baldelli S, La Barbera L, Lettieri Barbato D, Tatulli G, Ciriolo MR. Adipose triglyceride lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARa-PGC-1a antioxidant response. Oncotarget. 2016; 7:23019-32. doi: 10.18632/oncotarget.8552
5. Molchadsky A, Rivlin N, Brosh R, Rotter V, Sarig R. p53 is balancing development, differentiation and de-differentiation to assure cancer prevention. Carcinogenesis. 2010; 31:1501-08. doi: 10.1093/carcin/bgq101
6. White JD, Rachel C, Vermeulen R, Davies M, Grounds MD. The role of p53 in vivo during skeletal muscle post-natal development and regeneration: studies in p53 knockout mice. Int J Dev Biol. 2002; 46:577-82.
7. Schwarzkopf M, Coletti D, Sassoon D, Marazzi G. Muscle cachexia is regulated by a p53-PW1/Peg3-dependent pathway. Genes Dev. 2006; 20:3440-52. doi: 10.1101/gad.412606
8. P orrello A, Cerone MA, Coen S, Gurtner A, Fontemaggi G, Cimino L, Piaggio G, Sacchi A, Soddu S. p53 regulates myogenesis by triggering the differentiation activity of pRb. J Cell Biol. 2000; 151:1295-304. doi: 10.1083/jcb.151.6.1295
9. Cam H, Griesmann H, Beitzinger M, Hofmann L, Beinoraviciute-Kellner R, Sauer M, Hüttinger-Kirchhof N, Oswald C, Friedl P, Gattenlöhner S, Burek C, Rosenwald A, Stiewe T. p53 family members in myogenic differentiation and rhabdomyosarcoma development. Cancer Cell. 2006; 10:281-93. doi: 10.1016/j.ccr.2006.08.024
10. Yang ZJ, Broz DK, Noderer WL, Ferreira JP, Overton KW, Spencer SL, Meyer T, Tapscott SJ, Attardi LD, Wang CL. p53 suppresses muscle differentiation at the myogenin step in response to genotoxic stress. Cell Death Differ. 2015; 22:560-73. doi: 10.1038/cdd.2014.189
11. Aquilano K, Baldelli S, Pagliei B, Cannata SM, Rotilio G, Ciriolo MR. p53 orchestrates the PGC-1a-mediated antioxidant response upon mild redox and metabolic imbalance. Antioxid Redox Signal. 2013; 18:386-99. doi: 10.1089/ars.2012.4615
12. Aquilano K, Baldelli S, La Barbera L, Lettieri Barbato D, Tatulli G, Ciriolo MR. Adipose triglyceride lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARa-PGC-1a antioxidant response. Oncotarget. 2016; 7:23019-32. doi: 10.18632/oncotarget.8552.
13. Aquilano K, Baldelli S, Cardaci S, Rotilio G, Ciriolo MR. Nitric oxide is the primary mediator of cytotoxicity induced by GSH depletion in neuronal cells. J Cell Sci. 2011; 124:1043-54. doi: 10.1242/jcs.077149
14. Gould N, Doulias PT, Tenopoulou M, Raju K, Ischiropoulos H. Regulation of protein function and signaling by reversible cysteine S-nitrosylation. J Biol Chem. 2013; 288:26473-79. doi: 10.1074/jbc.R113.460261
15. Schonhoff CM, Daou MC, Jones SN, Schiffer CA, Ross AH. Nitric oxide-mediated inhibition of Hdm2-p53 binding. Biochemistry. 2002; 41:13570-74. doi: 10.1021/bi026262q
16. Rainwater R, Parks D, Anderson ME, Tegtmeyer P, Mann K. Role of cysteine residues in regulation of p53 function. Mol Cell Biol. 1995; 15:3892-903. doi: 10.1128/MCB.15.7.3892
17. Aquilano K, Baldelli S, Ciriolo MR. Nuclear recruitment of neuronal nitric-oxide synthase by a-syntrophin is crucial for the induction of mitochondrial biogenesis. J Biol Chem. 2014; 289:365-78. doi: 10.1074/jbc.M113.506733
18. Sakuma K, Aoi W, Yamaguchi A. The intriguing regulators of muscle mass in sarcopenia and muscular dystrophy. Front Aging Neurosci. 2014; 6:230. doi: 10.3389/fnagi.2014.00230
19. Baldelli S, Lettieri Barbato D, Tatulli G, Aquilano K, Ciriolo MR. The role of nNOS and PGC-1a in skeletal muscle cells. J Cell Sci. 2014; 127:4813-20. doi: 10.1242/jcs.154229
20. Brioche T, Lemoine-Morel S. Oxidative stress, sarcopenia, antioxidant strategies and exercise: molecular aspects. Curr Pharm Des. 2016; 22:2664-78 doi: 10.2174/1381612822666160219120531
21. Jackson MJ. Reactive oxygen species in sarcopenia: should we focus on excess oxidative damage or defective redox signalling? Mol Aspects Med. 2016; 50:33-40. doi: 10.1016/j.mam.2016.05.002
22. Hogg N. The biochemistry and physiology of Snitrosothiols. Annu Rev Pharmacol Toxicol. 2002; 42:585-600. doi: 10.1146/annurev.pharmtox.42.092501.104328
23. Edwards MG, Anderson RM, Yuan M, Kendziorski CM, Weindruch R, Prolla TA. Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program. BMC Genomics. 2007; 8:80. doi: 10.1186/1471-2164-8-80
24. Rodier F, Campisi J, Bhaumik D. Two faces of p53: aging and tumor suppression. Nucleic Acids Res. 2007; 35:7475-84. doi: 10.1093/nar/gkm744
25. Feng Z, Hu W, Teresky AK, Hernando E, Cordon-Cardo C, Levine AJ. Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations. Proc Natl Acad Sci USA. 2007; 104:16633-38. doi: 10.1073/pnas.0708043104
26. Saleem A, Adhihetty PJ, Hood DA. Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle. Physiol Genomics. 2009; 37:58-66. doi: 10.1152/physiolgenomics.90346.2008
27. Baldelli S, Aquilano K, Rotilio G, Ciriolo MR. Glutathione and copper, zinc superoxide dismutase are modulated by overexpression of neuronal nitric oxide synthase. Int J Biochem Cell Biol. 2008; 40:2660-70. doi: 10.1016/j.biocel.2008.05.013
28. Pagliei B, Aquilano K, Baldelli S, Ciriolo MR. Garlicderived diallyl disulfide modulates peroxisome proliferator activated receptor gamma co-activator 1 alpha in neuroblastoma cells. Biochem Pharmacol. 2013; 85:335-44. doi: 10.1016/j.bcp.2012.11.007
29. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193:265-75.
30. Baldelli S, Aquilano K, Rotilio G, Ciriolo MR. Neuronal nitric oxide synthase interacts with Sp1 through the PDZ domain inhibiting Sp1-mediated copper-zinc superoxide dismutase expression. Int J Biochem Cell Biol. 2011; 43:163-69. doi: 10.1016/j.biocel.2010.10.016
31. Im H, Grass JA, Johnson KD, Boyer ME, Wu J, Bresnick EH. Measurement of protein-DNA interactions in vivo by chromatin immunoprecipitation. Methods Mol Biol. 2004; 284:129-46. doi: 10.1385/1-59259-816-1:129