Effectiveness and safety of tranexamic acid in spinal deformity surgery

Journal of Korean Neurosurgical Society

Volumn 60, Issue 1, 2017, Pages 75-81

  Choi, Ho Yong ^a   Hyun, Seung Jae ^a   Kim, Ki Jeong ^a   Jahng, Tae Ahn ^a   Kim, Hyun Jib ^a  

^a Seoul National University Bundang Hospital   (South Korea)

Author keywords

Antifibrinolytics; Spinal surgery; Surgical blood loss; Tranexamic acid

Indexed keywords

ELECTROLYTE; HEMOGLOBIN; LIVER ENZYME; TRANEXAMIC ACID;

ACUTE KIDNEY FAILURE; ADULT; ALLERGIC REACTION; ANGINA PECTORIS; ARTICLE; BLOOD TRANSFUSION; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DESCRIPTIVE RESEARCH; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEART ARRHYTHMIA; HEART INFARCTION; HUMAN; LOADING DRUG DOSE; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OPERATION DURATION; OPERATIVE BLOOD LOSS; OSTEOTOMY; PNEUMONIA; POSTOPERATIVE HEMORRHAGE; SIDE EFFECT; SKIN INCISION; SPINE FUSION; SPINE MALFORMATION; TREATMENT OUTCOME; URINARY TRACT INFECTION; WOUND;

EID: 85010443392     PISSN: 20053711     EISSN: 15987876     Source Type: Journal    
DOI: 10.3340/jkns.2016.0505.004     Document Type: Article

References (27)

1. Baldus CR, Bridwell KH, Lenke LG, Okubadejo GO: Can we safely reduce blood loss during lumbar pedicle subtraction osteotomy procedures using tranexamic acid or aprotinin? A comparative study with controls. Spine (Phila Pa 1976) 35: 235-239, 2010
2. Bess RS, Lenke LG, Bridwell KH, Steger-May K, Hensley M: Wasting of preoperatively donated autologous blood in the surgical treatment of adolescent idiopathic scoliosis. Spine (Phila Pa 1976) 31: 2375-2380, 2006
3. Cardone D, Klein AA: Perioperative blood conservation. Eur J Anaesthesiol 26: 722-729, 2009
4. Casati V, Della Valle P, Benussi S, Franco A, Gerli C, Baili P, et al.: Effects of tranexamic acid on postoperative bleeding and related hematochemical variables in coronary surgery: Comparison between on-pump and off-pump techniques. J Thorac Cardiovasc Surg 128: 83-91, 2004
5. Cheriyan T, Maier SP 2nd, Bianco K, Slobodyanyuk K, Rattenni RN, Lafage V, et al.: Efficacy of tranexamic acid on surgical bleeding in spine surgery: a meta-analysis. Spine J 15: 752-761, 2015
6. Despotis GJ, Avidan MS, Hogue CW Jr: Mechanisms and attenuation of hemostatic activation during extracorporeal circulation. Ann Thorac Surg 72: S1821-S1831, 2001
7. Dunn CJ, Goa KL: Tranexamic acid: a review of its use in surgery and other indications. Drugs 57: 1005-1032, 1999
8. Elwatidy S, Jamjoom Z, Elgamal E, Zakaria A, Turkistani A, El-Dawlatly A: Efficacy and safety of prophylactic large dose of tranexamic acid in spine surgery: a prospective, randomized, double-blind, placebo-controlled study. Spine (Phila Pa 1976) 33: 2577-2580, 2008
9. Friedman R, Homering M, Holberg G, Berkowitz SD: Allogeneic blood transfusions and postoperative infections after total hip or knee arthroplasty. J Bone Joint Surg Am 96: 272-278, 2014
10. Gill JB, Chin Y, Levin A, Feng D: The use of antifibrinolytic agents in spine surgery. A meta-analysis. J Bone Joint Surg Am 90: 2399-2407, 2008
11. Hyun SJ, Kim YJ, Rhim SC: Spinal pedicle subtraction osteotomy for fixed sagittal imbalance patients. World J Clin Cases 1: 242-248, 2013
12. Hyun SJ, Rhim SC: Clinical outcomes and complications after pedicle subtraction osteotomy for fixed sagittal imbalance patients: a long-term follow-up data. J Korean Neurosurg Soc 47: 95-101, 2010
13. Janssen SJ, Braun Y, Wood KB, Cha TD, Schwab JH: Allogeneic blood transfusions and postoperative infections after lumbar spine surgery. Spine J 15: 901-909, 2015
14. Keyl C, Uhl R, Beyersdorf F, Stampf S, Lehane C, Wiesenack C, et al.: High-dose tranexamic acid is related to increased risk of generalized seizures after aortic valve replacement. Eur J Cardiothorac Surg 39: e114-e121, 2011
15. Lentschener C, Cottin P, Bouaziz H, Mercier FJ, Wolf M, Aljabi Y, et al.: Reduction of blood loss and transfusion requirement by aprotinin in posterior lumbar spine fusion. Anesth Analg 89: 590-597, 1999
16. Martin K, Knorr J, Breuer T, Gertler R, Macguill M, Lange R, et al.: Seizures after open heart surgery: comparison of epsilon-aminocaproic acid and tranexamic acid. J Cardiothorac Vasc Anesth 25: 20-25, 2011
17. Neilipovitz DT, Murto K, Hall L, Barrowman NJ, Splinter WM: A randomized trial of tranexamic acid to reduce blood transfusion for scoliosis surgery. Anesth Analg 93: 82-87, 2001
18. Ng BK, Chau WW, Hung AL, Hui AC, Lam TP, Cheng JC: Use of Tranexamic Acid (TXA) on reducing blood loss during scoliosis surgery in Chinese adolescents. Scoliosis 10: 28, 2015
19. Nuttall GA, Horlocker TT, Santrach PJ, Oliver WC Jr, Dekutoski MB, Bryant S: Predictors of blood transfusions in spinal instrumentation and fusion surgery. Spine (Phila Pa 1976) 25: 596-601, 2000
20. Peters A, Verma K, Slobodyanyuk K, Cheriyan T, Hoelscher C, Schwab F, et al.: Antifibrinolytics reduce blood loss in adult spinal deformity surgery: a prospective, randomized controlled trial. Spine (Phila Pa 1976) 40: E443-E449, 2015
21. Urban MK, Beckman J, Gordon M, Urquhart B, Boachie-Adjei O: The efficacy of antifibrinolytics in the reduction of blood loss during complex adult reconstructive spine surgery. Spine (Phila Pa 1976): 1152-1156, 2001
22. Verma K, Errico T, Diefenbach C, Hoelscher C, Peters A, Dryer J, et al.: The relative efficacy of antifibrinolytics in adolescent idiopathic scoliosis: a prospective randomized trial. J Bone Joint Surg Am 96: e80, 2014
23. Wang M, Zheng XF, Jiang LS: Efficacy and safety of antifibrinolytic agents in reducing perioperative blood loss and transfusion requirements in scoliosis surgery: a systematic review and meta-analysis. PLoS One 10: e0137886, 2015
24. Wang Q, Liu J, Fan R, Chen Y, Yu H, Bi Y, et al.: Tranexamic acid reduces postoperative blood loss of degenerative lumbar instability with stenosis in posterior approach lumbar surgery: a randomized controlled trial. Eur Spine J 22: 2035-2038, 2013
25. Wong J, El Beheiry H, Rampersaud YR, Lewis S, Ahn H, De Silva Y, et al.: Tranexamic Acid reduces perioperative blood loss in adult patients having spinal fusion surgery. Anesth Analg 107: 1479-1486, 2008
26. Xie J, Lenke LG, Li T, Si Y, Zhao Z, Wang Y, et al.: Preliminary investigation of high-dose tranexamic acid for controlling intraoperative blood loss in patients undergoing spine correction surgery. Spine J 15: 647-654, 2015
27. Yagi M, Hasegawa J, Nagoshi N, Iizuka S, Kaneko S, Fukuda K, et al.: Does the intraoperative tranexamic acid decrease operative blood loss during posterior spinal fusion for treatment of adolescent idiopathic scoliosis? Spine (Phila Pa 1976) 37: E1336-E1342, 2012