The obesity paradox and mortality after colorectal cancer: A causal conundrum

JAMA Oncology

Volumn 2, Issue 9, 2016, Pages 1127-1129

  Renehan, Andrew G ^a   Sperrin, Matthew ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COLORECTAL NEOPLASMS; HUMAN; INCIDENCE; MORTALITY; OBESITY; PROGNOSIS; RISK FACTOR;

COLORECTAL NEOPLASMS; HUMANS; INCIDENCE; OBESITY; PROGNOSIS; RISK FACTORS;

EID: 85010304002     PISSN: 23742437     EISSN: 23742445     Source Type: Journal    
DOI: 10.1001/jamaoncol.2016.0868     Document Type: Editorial

References (15)

1. Renehan AG, Zwahlen M, Egger M. Adiposity and cancer risk: new mechanistic insights from epidemiology. Nat Rev Cancer. 2015;15(8):484-498.
2. Arnold M, Pandeya N, Byrnes G, et al. Global burden of cancer attributable to high body-mass index in 2012: a population-based study. Lancet Oncol. 2015;16(1):36-46.
3. Chan DS, Vieira AR, Aune D, et al. Body mass index and survival in women with breast cancer-systematic literature review and meta-analysis of 82 follow-up studies. Ann Oncol. 2014;25(10):1901-1914.
4. Ligibel JA, Alfano CM, Courneya KS, et al. American Society of Clinical Oncology position statement on obesity and cancer. J Clin Oncol. 2014;32(31):3568-3574.
5. Crosbie EJ, Roberts C, Qian W, Swart AM, Kitchener HC, Renehan AG. Body mass index does not influence post-treatment survival in early stage endometrial cancer: results from the MRC ASTEC trial. Eur J Cancer. 2012;48(6):853-864.
6. World Cancer Research Fund. World Cancer Research Fund International. Continuous Update Project Report: Diet, Nutrition, Physical Activity, and Breast Cancer Survivors. http://www.wcrf.org/sites/default/files/Breast-Cancer-Survivors-2014-Report.pdf. Accessed December 20, 2014.
7. Hakimi AA, Furberg H, Zabor EC, et al. An epidemiologic and genomic investigation into the obesity paradox in renal cell carcinoma. J Natl Cancer Inst. 2013;105(24):1862-1870.
8. Schlesinger S, Siegert S, Koch M, et al. Postdiagnosis body mass index and risk of mortality in colorectal cancer survivors: a prospective study and meta-analysis. Cancer Causes Control. 2014;25(10):1407-1418.
9. Kroenke CH, Neugebauer R, Meyerhardt J, et al. Analysis of body mass index and mortality in patients with colorectal cancer using causal diagrams [published online May 19, 2016]. JAMA Oncol. doi:10.1001/jamaoncol.2016.0732.
10. Banack HR, Kaufman JS. The obesity paradox: understanding the effect of obesity on mortality among individuals with cardiovascular disease. Prev Med. 2014;62:96-102.
11. Hernán MA, Hernández-Díaz S, Robins JM. A structural approach to selection bias. Epidemiology. 2004;15(5):615-625.
12. Cole SR, Platt RW, Schisterman EF, et al. Illustrating bias due to conditioning on a collider. Int J Epidemiol. 2010;39(2):417-420.
13. Banack HR, Kaufman JS. From bad to worse: collider stratification amplifies confounding bias in the "obesity paradox." Eur J Epidemiol. 2015;30(10):1111-1114.
14. Sperrin M, Candlish J, Badrick E, Renehan A, Buchan I. Collider bias is only a partial explanation for the obesity paradox [published online April 5, 2016]. Epidemiology. doi:10.1097/EDE.0000000000000493.
15. Doehner W, von Haehling S, Anker SD. Protective overweight in cardiovascular disease: moving from "paradox" to "paradigm." Eur Heart J. 2015;36(40):2729-2732.