Analysis of body mass index and mortality in patients with colorectal cancer using causal diagrams

JAMA Oncology

Volumn 2, Issue 9, 2016, Pages 1137-1145

  Kroenke, Candyce H ^a   Neugebauer, Romain ^a   Meyerhardt, Jeffrey ^b   Prado, Carla M ^c   Weltzien, Erin ^a   Kwan, Marilyn L ^a   Xiao, Jingjie ^c   Caan, Bette J ^a  

^a DIVISION OF RESEARCH   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; BODY MASS; CALIFORNIA; CAUSALITY; CAUSE OF DEATH; COLORECTAL NEOPLASMS; FEMALE; HUMAN; MALE; MIDDLE AGED; MORTALITY; OBESITY; OVERWEIGHT; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; RISK FACTOR; SEVERITY OF ILLNESS INDEX; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BODY MASS INDEX; CALIFORNIA; CAUSALITY; CAUSE OF DEATH; COLORECTAL NEOPLASMS; FEMALE; HUMANS; MALE; MIDDLE AGED; OBESITY; OVERWEIGHT; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 85010692869     PISSN: 23742437     EISSN: 23742445     Source Type: Journal    
DOI: 10.1001/jamaoncol.2016.0732     Document Type: Article

References (55)

1. Aleksandrova K, Pischon T, Buijsse B, et al. Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition. Eur J Cancer. 2013;49(16):3526-3536.
2. KeimlingM, Renehan AG, Behrens G, et al. Comparison of associations of body mass index, abdominal adiposity, and risk of colorectal cancer in a large prospective cohort study. Cancer Epidemiol Biomarkers Prev. 2013;22(8):1383-1394.
3. Renehan AG, Flood A, Adams KF, et al. Body mass index at different adult ages, weight change, and colorectal cancer risk in the National Institutes of Health-AARP Cohort. Am J Epidemiol. 2012;176 (12):1130-1140.
4. Li H, Yang G, Xiang YB, et al. Body weight, fat distribution and colorectal cancer risk: a report from cohort studies of 134255 Chinese men and women. Int J Obes (Lond). 2013;37(6):783-789.
5. Odegaard AO, Koh WP, Yu MC, Yuan JM. Body mass index and risk of colorectal cancer in Chinese Singaporeans: the Singapore Chinese Health Study. Cancer. 2011;117(16):3841-3849.
6. Laake I, Thune I, Selmer R, Tretli S, SlatteryML, Veierod MB. A prospective study of body mass index, weight change, and risk of cancer in the proximal and distal colon. Cancer Epidemiol Biomarkers Prev. 2010;19(6):1511-1522.
7. Campbell PT, Cotterchio M, Dicks E, Parfrey P, Gallinger S, McLaughlin JR. Excess body weight and colorectal cancer risk in Canada: associations in subgroups of clinically defined familial risk of cancer. Cancer Epidemiol Biomarkers Prev. 2007;16 (9):1735-1744.
8. Lin J, Zhang SM, Cook NR, Rexrode KM, Lee IM, Buring JE. Body mass index and risk of colorectal cancer in women (United States). Cancer Causes Control. 2004;15(6):581-589.
9. Caan BJ, Coates AO, SlatteryML, Potter JD, Quesenberry CP Jr, Edwards SM. Body size and the risk of colon cancer in a large case-control study. Int J Obes Relat Metab Disord. 1998;22(2):178-184.
10. Sinicrope FA, Foster NR, Yothers G, et al; Adjuvant Colon Cancer Endpoints (ACCENT) Group. Body mass index at diagnosis and survival among colon cancer patients enrolled in clinical trials of adjuvant chemotherapy. Cancer. 2013;119(8): 1528-1536.
11. Meyerhardt JA, Niedzwiecki D, Hollis D, et al; Cancer and Leukemia Group B 89803. Impact of body mass index and weight change after treatment on cancer recurrence and survival in patients with stage III colon cancer: findings from Cancer and Leukemia Group B 89803. J Clin Oncol. 2008;26(25):4109-4115.
12. Dignam JJ, Polite BN, Yothers G, et al. Body mass index and outcomes in patients who receive adjuvant chemotherapy for colon cancer. J Natl Cancer Inst. 2006;98(22):1647-1654.
13. Prizment AE, Flood A, Anderson KE, Folsom AR. Survival of women with colon cancer in relation to precancer anthropometric characteristics: the Iowa Women's Health Study. Cancer Epidemiol Biomarkers Prev. 2010;19(9):2229-2237.
14. Sinicrope FA, Foster NR, Sargent DJ, O'Connell MJ, Rankin C. Obesity is an independent prognostic variable in colon cancer survivors. Clin Cancer Res. 2010;16(6):1884-1893.
15. Doria-Rose VP, Newcomb PA, Morimoto LM, Hampton JM, Trentham-Dietz A. Body mass index and the risk of death following the diagnosis of colorectal cancer in postmenopausal women (United States). Cancer Causes Control. 2006;17(1): 63-70.
16. Murphy TK, Calle EE, Rodriguez C, Kahn HS, Thun MJ. Body mass index and colon cancer mortality in a large prospective study.AmJ Epidemiol. 2000;152(9):847-854.
17. Alipour S, Kennecke HF,Woods R, et al. Body mass index and body surface area and their associations with outcomes in stage II and III colon cancer. J Gastrointest Cancer. 2013;44(2):203-210.
18. Schlesinger S, Siegert S, Koch M, et al. Postdiagnosis body mass index and risk of mortality in colorectal cancer survivors: a prospective study and meta-analysis. Cancer Causes Control. 2014;25 (10):1407-1418.
19. Pearl J. Causal diagrams for empirical research. Biometrika. 1995;82:669-710.
20. Hernan MA, Hernandez-Diaz S, Robins JM. A structural approach to selection bias. Epidemiology. 2004;15(5):615-625.
21. Banack HR, Kaufman JS. The obesity paradox: understanding the effect of obesity on mortality among individuals with cardiovascular disease. Prev Med. 2014;62:96-102.
22. Flegal KM, Graubard BI, Williamson DF, Cooper RS. Reverse causation and illness-related weight loss in observational studies of body weight and mortality. Am J Epidemiol. 2011;173(1):1-9.
23. Pearl J. An introduction to causal inference. Int J Biostat. 2010;6(2):7.
24. Gordon NP. Characteristics of Adult Health Plan Members in Kaiser Permanente's Northern California Region, as Estimated from the 2011 Member Health Survey. Oakland, CA: Division of Research, Kaiser Permanente Medical Care Program; 2013.
25. Classification BMI.World Health Organization; 2014. http://apps.who.int/bmi/index.jsp ?introPage=intro-3.html. Accessed April 7, 2014.
26. Winter JE, MacInnis RJ,Wattanapenpaiboon N, Nowson CA. BMI and all-cause mortality in older adults: ameta-analysis. Am J Clin Nutr. 2014;99(4): 875-890.
27. Greenland S, Pearl J, Robins JM. Causal diagrams for epidemiologic research. Epidemiology. 1999;10(1):37-48.
28. Durrleman S, Simon R. Flexible regression models with cubic splines. Stat Med. 1989;8(5): 551-561.
29. Pelser C, Arem H, Pfeiffer RM, et al. Prediagnostic lifestyle factors and survival after colon and rectal cancer diagnosis in the National Institutes of Health (NIH)-AARP Diet and Health Study. Cancer. 2014;120(10):1540-1547.
30. Campbell PT, Newton CC, Dehal AN, Jacobs EJ, Patel AV, Gapstur SM. Impact of body mass index on survival after colorectal cancer diagnosis: the Cancer Prevention Study-II Nutrition Cohort. J Clin Oncol. 2012;30(1):42-52.
31. Meyerhardt JA, Tepper JE, Niedzwiecki D, et al. Impact of body mass index on outcomes and treatment-related toxicity in patients with stage II and III rectal cancer: findings from Intergroup Trial 0114. J Clin Oncol. 2004;22(4):648-657.
32. Kuiper JG, Phipps AI, Neuhouser ML, et al. Recreational physical activity, body mass index, and survival in women with colorectal cancer. Cancer Causes Control. 2012;23(12):1939-1948.
33. Baade PD, Meng X, Youl PH, Aitken JF, Dunn J, Chambers SK. The impact of body mass index and physical activity on mortality among patients with colorectal cancer in Queensland, Australia. Cancer Epidemiol Biomarkers Prev. 2011;20(7):1410-1420.
34. Lajous M, Bijon A, Fagherazzi G, et al. Body mass index, diabetes, and mortality in French women: explaining away a "paradox". Epidemiology. 2014;25(1):10-14.
35. Carnethon MR, De Chavez PJ, Biggs ML, et al. Association of weight status with mortality in adults with incident diabetes. JAMA. 2012;308(6):581-590.
36. Casas-Vara A, Santolaria F, Fernandez- Bereciartua A, Gonzalez-Reimers E, Garcia-Ochoa A, Martinez-Riera A. The obesity paradox in elderly patients with heart failure: analysis of nutritional status. Nutrition. 2012;28(6):616-622.
37. DoehnerW, Erdmann E, Cairns R, et al. Inverse relation of body weight and weight change with mortality and morbidity in patients with type 2 diabetes and cardiovascular co-morbidity: an analysis of the PROactive study population. Int J Cardiol. 2012;162(1):20-26.
38. Kim BJ, Lee SH, Jung KH, Yu KH, Lee BC, Roh JK; For Korean Stroke Registry investigators. Dynamics of obesity paradox after stroke, related to time from onset, age, and causes of death. Neurology. 2012;79(9):856-863.
39. Lancefield T, Clark DJ, Andrianopoulos N, et al; MIG (Melbourne Interventional Group) Registry. Is there an obesity paradox after percutaneous coronary intervention in the contemporary era? An analysis from a multicenter Australian registry. JACC Cardiovasc Interv. 2010;3(6):660-668.
40. Lavie CJ, De Schutter A, Patel D, Artham SM, Milani RV. Body composition and coronary heart disease mortality-an obesity or a lean paradox? Mayo Clin Proc. 2011;86(9):857-864.
41. Tseng CH. Obesity paradox: differential effects on cancer and noncancer mortality in patients with type 2 diabetes mellitus. Atherosclerosis. 2013; 226(1):186-192.
42. Uretsky S, Messerli FH, Bangalore S, et al. Obesity paradox in patients with hypertension and coronary artery disease. Am J Med. 2007;120(10): 863-870.
43. Angeras O, Albertsson P, Karason K, et al. Evidence for obesity paradox in patients with acute coronary syndromes: a report from the Swedish Coronary Angiography and Angioplasty Registry. Eur Heart J. 2013;34(5):345-353.
44. Blum A, Simsolo C, Sirchan R, Haiek S. "Obesity paradox" in chronic obstructive pulmonary disease. Isr Med Assoc J. 2011;13(11):672-675.
45. Jackson RS, Black JH III, LumYW, et al. Class I obesity is paradoxically associated with decreased risk of postoperative stroke after carotid endarterectomy. J Vasc Surg. 2012;55(5):1306-1312.
46. JialinW, Yi Z,Weijie Y. Relationship between body mass index and mortality in hemodialysis patients: ameta-analysis. Nephron Clin Pract. 2012; 121(3-4):c102-c111.
47. Komukai K, Minai K, Arase S, et al. Impact of body mass index on clinical outcome in patients hospitalized with congestive heart failure. Circ J. 2012;76(1):145-151.
48. Stein PD, Matta F, Goldman J. Obesity and pulmonary embolism: the mounting evidence of risk and the mortality paradox. Thromb Res. 2011; 128(6):518-523.
49. Schenkeveld L, Magro M, Oemrawsingh RM, et al. The influence of optimal medical treatment on the 'obesity paradox', body mass index and long-term mortality in patients treated with percutaneous coronary intervention: a prospective cohort study. BMJ Open. 2012;2:e000535.
50. Biasucci LM, Graziani F, Rizzello V, et al. Paradoxical preservation of vascular function in severe obesity. Am J Med. 2010;123(8):727-734.
51. Graziani F, Biasucci LM, Cialdella P, et al. Thromboxane production in morbidly obese subjects. Am J Cardiol. 2011;107(11):1656-1661.
52. Lund LH, Williams JJ, Freda P, LaManca JJ, LeJemtel TH, Mancini DM. Ghrelin resistance occurs in severe heart failure and resolves after heart transplantation. Eur J Heart Fail. 2009;11(8):789-794.
53. Feldman AM, Combes A,Wagner D, et al. The role of tumor necrosis factor in the pathophysiology of heart failure. J AmColl Cardiol. 2000;35(3): 537-544.
54. McTiernan CF, Feldman AM. The role of tumor necrosis factor alpha in the pathophysiology of congestive heart failure. Curr Cardiol Rep. 2000;2 (3):189-197.
55. Glymour MM, Vittinghoff E. Commentary: selection bias as an explanation for the obesity paradox: just because it's possible doesn't mean it's plausible. Epidemiology. 2014;25(1):4-6.