A 5' noncoding exon containing engineered intron enhances transgene expression from recombinant AAV vectors in vivo

Human Gene Therapy

Volumn 28, Issue 1, 2017, Pages 125-134

  Lu, Jiamiao ^a   Williams, James A ^b   Luke, Jeremy ^b   Zhang, Feijie ^a   Chu, Kirk ^a   Kay, Mark A ^a  

^a STANFORD UNIVERSITY   (United States)

^b NATURE TECHNOLOGY CORPORATION   (United States)

Author keywords

AAV vectors; Enhance transgene expression; Intron; Mini intronic plasmid; Miniorigins

Indexed keywords

ADENO ASSOCIATED VIRUS VECTOR; GENOMIC DNA; MINICIRCLE DNA; 5' UNTRANSLATED REGION;

5' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ARTICLE; COPY NUMBER VARIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXON; FEMALE; GENE EXPRESSION; GENE EXPRESSION SYSTEM; IN VIVO STUDY; INTRON; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; TRANSGENE; ADMINISTRATION AND DOSAGE; ANIMAL; C57BL MOUSE; DEPENDOPARVOVIRUS; DNA REPLICATION; GENE VECTOR; GENETIC RECOMBINATION; GENETICS; HUMAN; PHYSIOLOGY; REPORTER GENE;

5' UNTRANSLATED REGIONS; ANIMALS; DEPENDOVIRUS; DNA REPLICATION; EXONS; FEMALE; GENES, REPORTER; GENETIC VECTORS; HUMANS; INTRONS; MICE; MICE, INBRED C57BL; RECOMBINATION, GENETIC; TRANSGENES;

EID: 85009985975     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2016.140     Document Type: Article

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