Iloprost improves ventricular function in the hypertrophic and functionally impaired right heart by direct stimulation

Pulmonary Circulation

Volumn 3, Issue 4, 2013, Pages 870-879

  Holmboe, Sarah ^a   Andersen, Asger ^a   Vildbrad, Mads D ^a   Nielsen, Jan M ^a   Ringgaard, Steffen ^a   Nielsen Kudsk, Jens E ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Heart failure; Inotropy; Prostacyclin; Pulmonary hypertension; Right heart

Indexed keywords

EID: 85009984772     PISSN: 20458932     EISSN: 20458940     Source Type: Journal    
DOI: 10.1086/674760     Document Type: Article

References (28)

1. Humbert M, Sitbon O, Chaouat A, Bertocchi M, Habib G, Gressin V, Yaïci A, et al. Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation 2010;122:156–163.
2. Davlouros PA, Niwa K, Webb G, Gatzoulis MA. The right ventricle in congenital heart disease. Heart 2006;92(suppl 1): i27–i38.
3. Voelkel NF, Quaife RA, Leinwand LA, Barst RJ, McGoon MD, Meldrum DR, Dupuis J, et al. Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure. Circulation 2006;114:1883–1891.
4. Galiè N, Hoeper MM, Humbert M, Torbicki A, Vachiery J-L, Barbera JA, Beghetti M, et al. Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur Heart J 2009;30:2493–2537.
5. Karazyn M, Horrobin DF, Manku MS, Cunnane SC, Karmali RA, Ally AI, Morgan RO, Nicolaou KC, Barnette WE. Effect of prostacyclin on perfusion pressure, electrical activity, rate and force of contraction in isolated rat and rabbit hearts. Life Sci 1978;22:2079–2085.
6. Pavlović M, Petković D, Cvetković M, Macut DJ, Zdjelar K, Nesˇić M, Bosnić O, Radulović R, Mihajlović M. The influence of prostacyclin (PGI2) on contractile properties of isolated right ventricle of rat heart. Experientia 1995;51: 941–944.
7. Fontana M, Olschewski H, Olschewski A, Schluter KD. Treprostinil potentiates the positive inotropic effect of catecholamines in adult rat ventricular cardiomyocytes. Br J Pharmacol 2007;151:779–786.
8. Riise J, Nguyen CH, Hussain RI, Dahl CP, Ege MS, Osnes J-B, Skomedal T, Sandnes DL, Levy FO, Krobert KA. Prostanoid-mediated inotropic responses are attenuated in failing human and rat ventricular myocardium. Eur J Pharmacol 2012;686:66–73.
9. 2 aerosol partly relies on enhanced myocardial contractility. Eur Surg Res 2005;37:9–17.
10. Kisch-Wedel H, Kemming G, Meisner F, Flondor M, Kuebler WM, Bruhn S, Koehler C, Zwissler B. The prostaglandins epoprostenol and iloprost increase left ventricular contractility in vivo. Intensive Care Med 2003;29:1574–1583.
11. Andersen A, Nielsen JM, Peters CD, Schou UK, Sloth E, Nielsen-Kudsk JE. Effects of phosphodiesterase-5 inhibition by sildenafil in the pressure overloaded right heart. Eur J Heart Fail 2008;10:1158–1165.
12. Hardziyenka M, Campian ME, de Bruin-Bon HA, Michel MC, Tan HL. Sequence of echocardiographic changes during development of right ventricular failure in rat. J Am Soc Echocardiogr 2006;19:1272–1279.
13. Ghio S, Recusani F, Klersy C, Sebastiani R, Laudisa ML, Campana C, Gavazzi A, Tavazzi L. Prognostic usefulness of the tricuspid annular plane systolic excursion in patients with congestive heart failure secondary to idiopathic or ischemic dilated cardiomyopathy. Am J Cardiol 2000;85:837–842.
14. Schermuly RT, Kreisselmeier KP, Ghofrani HA, Samidurai A, Pullamsetti S, Weissmann N, Schudt C, Ermert L, Seeger W, Grimminger F. Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension. Circ Res 2004;94:1101–1108.
15. Haddad F, Ashley E, Michelakis ED. New insights for the diagnosis and management of right ventricular failure, from molecular imaging to targeted right ventricular therapy. Curr Opin Cardiol 2010;25:131–140.
16. Schou UK, Peters CD, Wan Kim S, Frokiaer J, Nielsen S. Characterization of a rat model of right-sided heart failure induced by pulmonary trunk banding. J Exp Anim Sci 2007;43:237–254.
17. Bogaard HJ, Natarajan R, Henderson SC, Long CS, Kraskauskas D, Smithson L, Ockaili R, McCord JM, Voelkel NF. Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure. Circulation 2009;120: 1951–1960.
18. Akhavein F, St-Michel EJ, Seifert E, Rohlicek CV. Decreased left ventricular function, myocarditis, and coronary arteriolar medial thickening following monocrotaline administration in adult rats. J Appl Physiol 2007;103:287–295.
19. Hirokawa E, Kotani T, Yamate J, Kuwamura M, Sakuma S. Myocardiopathy and expression of atrial natriuretic peptide in rats with monocrotaline-induced pulmonary hypertension. J Vet Med Sci 1994;56:651–655.
20. Scott JP, Higenbottam T, Wallwork J. The acute effect of the synthetic prostacyclin analogue iloprost in primary pulmonary hypertension. Br J Clin Pract 1990;44:231–234.
21. Zhang HL, Liu ZH, Wang Y, Xiong CM, Ni XH, He JG, Luo Q, Zhao ZH, Zhao Q, Sun XG. Acute responses to inhalation of iloprost in patients with pulmonary hypertension. Chin Med J (Engl) 2012;125:2826–2831.
22. Rex S, Missant C, Claus P, Buhre W, Wouters PF. Effects of inhaled iloprost on right ventricular contractility, right ventriculo-vascular coupling and ventricular interdependence: a randomized placebo-controlled trial in an experimental model of acute pulmonary hypertension. Crit Care 2008;12:R113.
23. Kerbaul F, Brimioulle S, Rondelet B, Dewachter C, Hubloue I, Naeije R. How prostacyclin improves cardiac output in right heart failure in conjunction with pulmonary hypertension. Am J Respir Crit Care Med 2007;175:846–850.
24. Wauthy P, Abdel Kafi S, Mooi WJ, Naeije R, Brimioulle S. Inhaled nitric oxide versus prostacyclin in chronic shuntinduced pulmonary hypertension. J Thorac Cardiovasc Surg 2003;126:1434–1441.
25. 3 receptors. Eur J Pharmacol 2011;654:258–265.
26. Abramovitz M, Adam M, Boie Y, Carrière M-C, Denis D, Godbout C, Lamontagne S, Rochette C, et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 2000;1483:285–293.
27. Kieler-Jensen N, Milocco I, Ricksten SE. Pulmonary vasodilation after heart transplantation: a comparison among prostacyclin, sodium nitroprusside, and nitroglycerin on right ventricular function and pulmonary selectivity. J Heart Lung Transplant 1993;12:179–184.
28. Kieler-Jensen N, Houltz E, Ricksten SE. A comparison of prostacyclin and sodium nitroprusside for the treatment of heart failure after cardiac surgery. J Cardiothorac Vasc Anesth 1995;9:641–646