Effects of inhaled iloprost on right ventricular contractility, right ventriculo-vascular coupling and ventricular interdependence: A randomized placebo-controlled trial in an experimental model of acute pulmonary hypertension

Critical Care

Volumn 12, Issue 5, 2008, Pages

  Rex, Steffen ^a,b   Missant, Carlo ^a   Claus, Piet ^a   Buhre, Wolfgang ^c   Wouters, Patrick F ^d  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c UNIVERSITY OF WITTEN HERDECKE   (Germany)

^d GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ILOPROST; PLACEBO;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY BLOOD FLOW; ARTERY COMPLIANCE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CONTROLLED STUDY; DRUG MECHANISM; HEART AFTERLOAD; HEART HEMODYNAMICS; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART MUSCLE CONTRACTILITY; HEART OUTPUT; HEART PRELOAD; HEART RIGHT VENTRICLE; HEART VENTRICLE CONTRACTILITY; HYPOXIA; INOTROPISM; LUNG ARTERY PRESSURE; NERVE BLOCK; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; SWINE; ACUTE DISEASE; ANIMAL; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; DISEASE MODEL; DRUG EFFECT; HEART LEFT VENTRICLE FUNCTION; HEART RIGHT VENTRICLE FUNCTION; INHALATIONAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PHYSIOLOGY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL;

ACUTE DISEASE; ADMINISTRATION, INHALATION; ANIMALS; CARDIAC OUTPUT; DISEASE MODELS, ANIMAL; HYPERTENSION, PULMONARY; ILOPROST; PROSPECTIVE STUDIES; SUS SCROFA; VENTRICULAR FUNCTION, LEFT; VENTRICULAR FUNCTION, RIGHT;

EID: 52449095377     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc7005     Document Type: Article

References (49)

1. Olschewski H Simonneau G Galie N Higenbottam T Naeije R Rubin LJ Nikkho S Speich R Hoeper MM Behr J Winkler J Sitbon O Popov W Ghofrani HA Manes A Kiely DG Ewert R Meyer A Corris PA Delcroix M Gomez-Sanchez M Siedentop H Seeger W Inhaled iloprost for severe pulmonary hypertension N Engl J Med 2002, 347:322-329. 12151469 10.1056/NEJMoa020204
2. Rex S Busch T Vettelschoss M de Rossi L Rossaint R Buhre W Intraoperative management of severe pulmonary hypertension during cardiac surgery with inhaled iloprost Anesthesiology 2003, 99:745-747. 12960562 10.1097/00000542-200309000-00033
3. Kramm T Eberle B Guth S Mayer E Inhaled iloprost to control residual pulmonary hypertension following pulmonary endarterectomy Eur J Cardiothorac Surg 2005, 28:882-888. 16242948 10.1016/j.ejcts.2005.09.007
4. Rex S Schaelte G Metzelder S Flier S de Waal EE Autschbach R Rossaint R Buhre W Inhaled iloprost to control pulmonary artery hypertension in patients undergoing mitral valve surgery: A prospective, randomized-controlled trial Acta Anaesthesiol Scand 2008, 52:65-72. 17976224
5. Olschewski H Rose F Schermuly R Ghofrani HA Enke B Olschewski A Seeger W Prostacyclin and its analogues in the treatment of pulmonary hypertension Pharmacol Ther 2004, 102:139-153. 15163595 10.1016/ j.pharmthera.2004.01.003
6. Montalescot G Drobinski G Meurin P Maclouf J Sotirov I Philippe F Choussat R Morin E Thomas D Effects of prostacyclin on the pulmonary vascular tone and cardiac contractility of patients with pulmonary hypertension secondary to end-stage heart failure Am J Cardiol 1998, 82:749-755. 9761085 10.1016/S0002-9149(98)00439-1
7. Kisch-Wedel H Kemming G Meisner F Flondor M Kuebler WM Bruhn S Koehler C Zwissler B The prostaglandins epoprostenol and iloprost increase left ventricular contractility in vivo Intensive Care Med 2003, 29:1574-1583. 12908096 10.1007/s00134-003-1891-z
8. Rex S Missant C Segers P Rossaint R Wouters PF Epoprostenol treatment of acute pulmonary hypertension is associated with a paradoxical decrease in right ventricular contractility Intensive Care Med 2008, 34:179-189. 17710383 10.1007/s00134-007-0831-8
9. Kerbaul F Brimioulle S Rondelet B Dewachter C Hubloue I Naeije R How prostacyclin improves cardiac output in right heart failure in conjunction with pulmonary hypertension Am J Respir Crit Care Med 2007, 175:846-850. 17272784 10.1164/rccm.200611-1615OC
10. Hoeper MM Olschewski H Ghofrani HA Wilkens H Winkler J Borst MM Niedermeyer J Fabel H Seeger W A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension. German PPH study group J Am Coll Cardiol 2000, 35:176-182. 10636277 10.1016/S0735-1097(99)00494-5
11. Rimoldi O Pierini S Pagani MR Pagani M Reduced cardiovascular sympathetic excitatory responses during iloprost infusion in conscious dogs Cardiovasc Res 1991, 25:793-801. 1721003 10.1093/cvr/25.10.793a
12. Malik KU Sehic E Prostaglandins and the release of the adrenergic transmitter Ann N Y Acad Sci 1990, 604:222-236. 1977349 10.1111/ j.1749-6632.1990.tb31996.x
13. Lanier SM Malik KU Inhibition by prostaglandins of adrenergic transmission in the left ventricular myocardium of anesthetized dogs J Cardiovasc Pharmacol 1985, 7:653-659. 2410704 10.1097/ 00005344-198507000-00007
14. Panzenbeck MJ Hintze TH Kaley G 6-Keto-prostaglandin E1 is a potent coronary vasodilator and stimulates a vagal reflex in dogs J Pharmacol Exp Ther 1988, 244:814-819. 3075239
15. Olschewski H Rohde B Behr J Ewert R Gessler T Ghofrani HA Schmehl T Pharmacodynamics and pharmacokinetics of inhaled iloprost, aerosolized by three different devices, in severe pulmonary hypertension Chest 2003, 124:1294-1304. 14555558 10.1378/chest.124.4.1294
16. Schermuly RT Schulz A Ghofrani HA Breitenbach CS Weissmann N Hildebrand M Kurz J Grimminger F Seeger W Comparison of pharmacokinetics and vasodilatory effect of nebulized and infused iloprost in experimental pulmonary hypertension: Rapid tolerance development J Aerosol Med 2006, 19:353-363. 17034310 10.1089/jam.2006.19.353
17. Guide for the Care and Use of Laboratory Animals http://www.nap.edu/ openbook.php?record_id=5140
18. Leeuwenburgh BP Helbing WA Steendijk P Schoof PH Baan J Biventricular systolic function in young lambs subject to chronic systemic right ventricular pressure overload Am J Physiol Heart Circ Physiol 2001, 281:H2697-H2704. 11709439
19. Segers P Georgakopoulos D Afanasyeva M Champion HC Judge DP Millar HD Verdonck P Kass DA Stergiopulos N Westerhof N Conductance catheter-based assessment of arterial input impedance, arterial function, and ventricular-vascular interaction in mice Am J Physiol Heart Circ Physiol 2005, 288:H1157-H1164. 15604134 10.1152/ajpheart.00414.2004
20. Steendijk P Staal E Jukema JW Baan J Hypertonic saline method accurately determines parallel conductance for dual-field conductance catheter Am J Physiol Heart Circ Physiol 2001, 281:H755-H763. 11454580
21. Rex S Missant C Segers P Wouters PF Thoracic epidural anesthesia impairs the hemodynamic response to acute pulmonary hypertension by deteriorating right ventricular-pulmonary arterial coupling Crit Care Med 2007, 35:222-229. 17095942 10.1097/01.CCM.0000250357.35250.A2
22. Missant C Rex S Segers P Wouters PF Levosimendan improves right ventriculovascular coupling in a porcine model of right ventricular dysfunction Crit Care Med 2007, 35:707-715. 17255859 10.1097/ 01.CCM.0000257326.96342.57
23. Suga H Global cardiac function: Mechano-energetico-informatics J Biomech 2003, 36:713-720. 12695001 10.1016/S0021-9290(02)00449-9
24. Huez S Retailleau K Unger P Pavelescu A Vachiery JL Derumeaux G Naeije R Right and left ventricular adaptation to hypoxia: A tissue Doppler imaging study Am J Physiol Heart Circ Physiol 2005, 289:H1391-H1398. 15923316 10.1152/ajpheart.00332.2005
25. Leeuwenburgh BP Steendijk P Helbing WA Baan J Indexes of diastolic RV function: Load dependence and changes after chronic RV pressure overload in lambs Am J Physiol Heart Circ Physiol 2002, 282:H1350-H1358. 11893571
26. Zong P Tune JD Downey HF Mechanisms of oxygen demand/supply balance in the right ventricle Exp Biol Med (Maywood) 2005, 230:507-519. 16118400
27. Suga H Hayashi T Shirahata M Ventricular systolic pressure-volume area as predictor of cardiac oxygen consumption Am J Physiol 1981, 240:H39-H44. 7457620
28. Martinez RR Setty S Zong P Tune JD Downey HF Nitric oxide contributes to right coronary vasodilation during systemic hypoxia Am J Physiol Heart Circ Physiol 2005, 288:H1139-H1146. 15513958 10.1152/ajpheart.01139.2003
29. Hettrick DA Warltier DC Ventriculoarterial coupling Ventricular Function Warltier DC. Baltimore: Williams &Wilkins 1 1995, 153-180
30. Segers P Verdonck P Deryck Y Brimioulle S Naeije R Carlier S Stergiopulos N Pulse pressure method and the area method for the estimation of total arterial compliance in dogs: Sensitivity to wave reflection intensity Ann Biomed Eng 1999, 27:480-485. 10468232 10.1114/ 1.192
31. Brimioulle S Maggiorini M Stephanazzi J Vermeulen F Lejeune P Naeije R Effects of low flow on pulmonary vascular flow-pressure curves and pulmonary vascular impedance Cardiovasc Res 1999, 42:183-192. 10435009 10.1016/S0008-6363(98)00301-0
32. Ludbrook J Repeated measurements and multiple comparisons in cardiovascular research Cardiovasc Res 1994, 28:303-311. 8174149 10.1093/ cvr/28.3.303
33. Ludbrook J Multiple comparison procedures updated Clin Exp Pharmacol Physiol 1998, 25:1032-1037. 9888002 10.1111/j.1440-1681.1998.tb02179.x
34. Fassina G Tessari F Dorigo P Positive inotropic effect of a stable analogue of PGI2 and of PGI2 on isolated guinea pig atria. Mechanism of action Pharmacol Res Commun 1983, 15:735-749. 6138778 10.1016/ S0031-6989(83)80003-4
35. Pavlovic M Petkovic D Cvetkovic M Macut DJ Zdjelar K Nesic M Bosnic O Radulovic R Mihajlovic M The influence of prostacyclin (PGI2) on contractile properties of isolated right ventricle of rat heart Experientia 1995, 51:941-944. 7556575 10.1007/BF01921744
36. Hinderliter AL Willis PW Barst RJ Rich S Rubin LJ Badesch DB Groves BM McGoon MD Tapson VF Bourge RC Brundage BH Koerner SK Langleben D Keller CA Murali S Uretsky BF Koch G Li S Clayton LM Jobsis MM Blackburn SD Jr Crow JW Long WA Effects of long-term infusion of prostacyclin (epoprostenol) on echocardiographic measures of right ventricular structure and function in primary pulmonary hypertension. Primary Pulmonary Hypertension Study Group Circulation 1997, 95:1479-1486. 9118516
37. Ricksten SE Is prostacyclin an inodilator? Intensive Care Med 2003, 29:1403-1405. 12904857 10.1007/s00134-003-1834-8
38. Kuehne T Yilmaz S Steendijk P Moore P Groenink M Saaed M Weber O Higgins CB Ewert P Fleck E Nagel E Schulze-Neick I Lange P Magnetic resonance imaging analysis of right ventricular pressure-volume loops: In vivo validation and clinical application in patients with pulmonary hypertension Circulation 2004, 110:2010-2016. 15451801 10.1161/ 01.CIR.0000143138.02493.DD
39. Morris CE Mechanosensitive ion channels J Membr Biol 1990, 113:93-107. 1690807 10.1007/BF01872883
40. Brutsaert DL Meulemans AL Sipido KR Sys SU Effects of damaging the endocardial surface on the mechanical performance of isolated cardiac muscle Circ Res 1988, 62:358-366. 3338120
41. Velez-Roa S Ciarka A Najem B Vachiery JL Naeije R van de BP Increased sympathetic nerve activity in pulmonary artery hypertension Circulation 2004, 110:1308-1312. 15337703 10.1161/01.CIR.0000140724.90898.D3
42. Wauthy P Abdel KS Mooi WJ Naeije R Brimioulle S Inhaled nitric oxide versus prostacyclin in chronic shunt-induced pulmonary hypertension J Thorac Cardiovasc Surg 2003, 126:1434-1441. 14666016 10.1016/ S0022-5223(03)01183-8
43. Santamore WP Gray L Jr Significant left ventricular contributions to right ventricular systolic function. Mechanism and clinical implications Chest 1995, 107:1134-1145. 7705127 10.1378/chest.107.4.1134
44. Ama R Leather HA Segers P Vandermeersch E Wouters PF Acute pulmonary hypertension causes depression of left ventricular contractility and relaxation Eur J Anaesthesiol 2006, 23:824-831. 16953943 10.1017/ S0265021506000317
45. Davila-Roman VG Waggoner AD Hopkins WE Barzilai B Right ventricular dysfunction in low output syndrome after cardiac operations: Assessment by transesophageal echocardiography Ann Thorac Surg 1995, 60:1081-1086. 7574953 10.1016/0003-4975(95)00526-Q
46. Belenkie I Sas R Mitchell J Smith ER Tyberg JV Opening the pericardium during pulmonary artery constriction improves cardiac function J Appl Physiol 2004, 96:917-922. 14578366 10.1152/japplphysiol.00722.2003
47. Dembinski R Brackhahn W Henzler D Rott A Bensberg R Kuhlen R Rossaint R Cardioulmonary effects of iloprost in experimental acute lung injury Eur Respir J 2005, 25:81-87. 15640327 10.1183/09031936.04.10085504
48. van Wolferen SA Marcus JT Westerhof N Spreeuwenberg MD Marques KM Bronzwaer JG Henkens IR Gan CT Boonstra A Postmus PE Vonk-Noordegraaf A Right coronary artery flow impairment in patients with pulmonary hypertension Eur Heart J 2008, 29:120-127. 18065750 10.1093/eurheartj/ ehm567
49. Schermuly RT Yilmaz H Ghofrani HA Woyda K Pullamsetti S Schulz A Gessler T Dumitrascu R Weissmann N Grimminger F Seeger W Inhaled iloprost reverses vascular remodeling in chronic experimental pulmonary hypertension Am J Respir Crit Care Med 2005, 172:358-363. 15879421 10.1164/rccm.200502-296OC