Interference with the HSF1/HSP70/BAG3 pathway primes glioma cells to matrix detachment and BH3 mimetic-induced apoptosis

Molecular Cancer Therapeutics

Volumn 16, Issue 1, 2017, Pages 156-168

  Antonietti, Patrick ^a   Linder, Benedikt ^a   Hehlgans, Stephanie ^a   Mildenberger, Iris C ^a   Burger, Michael C ^a   Fulda, Simone ^a,b   Steinbach, Joachim P ^a,b   Gessler, Florian ^a   Röodel, Franz ^a,b   Mittelbronn, Michel ^a,b   Köogel, Donat ^a,b  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; BCL 2 ASSOCIATED ATHANOGENE 3 PROTEIN; BH3 PROTEIN; CASPASE 3; CHAPERONE; CYTOCHROME C; HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOSORBIDE; KRIBB 11; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN INHIBITOR; SURVIVIN; TEMOZOLOMIDE; UNCLASSIFIED DRUG; [2 [[3 ETHYL 5 (3 METHYLBENZO[D]THIAZOL 2(3H) YLIDENE] 4 OXOTHIAZOLIDIN 2 YLIDENE]METHYL] 1 METHYLPYRIDIN 1 IUM CHLORIDE; ABT-737; APOPTOSIS REGULATORY PROTEIN; BAG3 PROTEIN, HUMAN; BIPHENYL DERIVATIVE; BIRC5 PROTEIN, HUMAN; DNA BINDING PROTEIN; GOSSYPOL; GOSSYPOL ACETIC ACID; HEAT SHOCK TRANSCRIPTION FACTOR; INHIBITOR OF APOPTOSIS PROTEIN; NITROPHENOL; PIPERAZINE DERIVATIVE; PROTEIN BCL X; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMALL INTERFERING RNA; SULFONAMIDE; TRANSCRIPTION FACTOR; TUMOR MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG SENSITIZATION; EXTRACELLULAR MATRIX; GLIOMA CELL; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; CELL ADHESION; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION; GENE SILENCING; GENETICS; GLIOMA; HUMAN; METABOLISM; MOLECULAR MIMICRY; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-X PROTEIN; BIOMARKERS, TUMOR; BIPHENYL COMPOUNDS; CELL ADHESION; CELL LINE, TUMOR; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; GLIOMA; GOSSYPOL; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MICE; MOLECULAR MIMICRY; NF-KAPPA B; NITROPHENOLS; PIPERAZINES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SULFONAMIDES; TRANSCRIPTION FACTORS;

EID: 85009968750     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-16-0262     Document Type: Article

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