Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction

Placenta

Volumn 51, Issue , 2017, Pages 1-9

  Hannan, Natalie J ^a   Beard, Sally ^a   Binder, Natalie K ^a   Onda, Kenji ^a,b   Kaitu'u Lino, Tu'uhevaha J ^a   Chen, Qi ^c   Tuohey, Laura ^a   De Silva, Manarangi ^a   Tong, Stephen ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^c THE UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Fetal growth restriction; Necroptosis; Preeclampsia

Indexed keywords

MESSENGER RNA; PHOSPHOTRANSFERASE; RECEPTOR INTERACTING KINASE 1; RECEPTOR INTERACTING KINASE 3; SIRTUIN 2; UNCLASSIFIED DRUG; MLKL PROTEIN, HUMAN; PROTEIN KINASE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK1 PROTEIN, HUMAN; RIPK3 PROTEIN, HUMAN; SIRT2 PROTEIN, HUMAN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; DISEASE SEVERITY; FEMALE; FETUS; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; INTRAUTERINE GROWTH RETARDATION; LEUKOCYTE; NECROPTOSIS; PATHOPHYSIOLOGY; PLACENTA; POLYMERASE CHAIN REACTION; PREECLAMPSIA; PREGNANCY COMPLICATION; PREMATURE LABOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; TROPHOBLAST; VASCULARIZATION; WESTERN BLOTTING; CELL DEATH; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; PREGNANCY; THIRD TRIMESTER PREGNANCY; YOUNG ADULT;

ADULT; CELL DEATH; FEMALE; FETAL GROWTH RETARDATION; HUMANS; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY TRIMESTER, THIRD; PROTEIN KINASES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SIRTUIN 2; TROPHOBLASTS; YOUNG ADULT;

EID: 85009904433     PISSN: 01434004     EISSN: 15323102     Source Type: Journal    
DOI: 10.1016/j.placenta.2017.01.002     Document Type: Article

References (22)

1. [1] Conrad, M., Angeli, J.P., Vandenabeele, P., Stockwell, B.R., Regulated necrosis: disease relevance and therapeutic opportunities. Nat. Rev. Drug Discov., 2016, 10.1038/nrd.2015.6 PubMed PMID: 26775689.
2. [2] Narayan, N., Lee, I.H., Borenstein, R., Sun, J., Wong, R., Tong, G., et al. The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature 492:7428 (2012), 199–204, 10.1038/nature11700 PubMed PMID: 23201684.
3. [3] Silke, J., Rickard, J.A., Gerlic, M., The diverse role of RIP kinases in necroptosis and inflammation. Nat. Immunol. 16:7 (2015), 689–697, 10.1038/ni.3206 PubMed PMID: 26086143.
4. [4] Heazell, A.E., Worton, S.A., Higgins, L.E., Ingram, E., Johnstone, E.D., Jones, R.L., et al. IFPA Gabor than Award Lecture: recognition of placental failure is key to saving babies’ lives. Placenta 36:Suppl 1 (2015), S20–S28, 10.1016/j.placenta.2014.12.017 PubMed PMID: 25582276.
5. [5] Chaddha, V., Viero, S., Huppertz, B., Kingdom, J., Developmental biology of the placenta and the origins of placental insufficiency. Semin. Fetal Neonatal Med. 9:5 (2004), 357–369, 10.1016/j.siny.2004.03.006 PubMed PMID: 15691771.
6. [6] Huppertz, B., Kadyrov, M., Kingdom, J.C., Apoptosis and its role in the trophoblast. Am. J. obstetrics Gynecol. 195:1 (2006), 29–39, 10.1016/j.ajog.2005.07.039 PubMed PMID: 16579915.
7. [7] Kadyrov, M., Kingdom, J.C., Huppertz, B., Divergent trophoblast invasion and apoptosis in placental bed spiral arteries from pregnancies complicated by maternal anemia and early-onset preeclampsia/intrauterine growth restriction. Am. J. obstetrics Gynecol. 194:2 (2006), 557–563, 10.1016/j.ajog.2005.07.035 PubMed PMID: 16458661.
8. [8] Naicker, T., Dorsamy, E., Ramsuran, D., Burton, G.J., Moodley, J., The role of apoptosis on trophoblast cell invasion in the placental bed of normotensive and preeclamptic pregnancies. Hypertens. Pregnancy 32:3 (2013), 245–256, 10.3109/10641955.2013.796969 PubMed PMID: 23782106.
9. [9] Huppertz, B., Frank, H.G., Reister, F., Kingdom, J., Korr, H., Kaufmann, P., Apoptosis cascade progresses during turnover of human trophoblast: analysis of villous cytotrophoblast and syncytial fragments in vitro. Laboratory investigation. a J. Tech. methods pathology 79:12 (1999), 1687–1702 PubMed PMID: 10616217.
10. [10] Huppertz, B., Tews, D.S., Kaufmann, P., Apoptosis and syncytial fusion in human placental trophoblast and skeletal muscle. Int. Rev. Cytol. 205 (2001), 215–253 PubMed PMID: 11336392.
11. [11] Arnholdt, H., Meisel, F., Fandrey, K., Lohrs, U., Proliferation of villous trophoblast of the human placenta in normal and abnormal pregnancies. Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. 60:6 (1991), 365–372 PubMed PMID: 1683053.
12. [12] Linkermann, A., Green, D.R., Necroptosis. N. Engl. J. Med. 370:5 (2014), 455–465, 10.1056/NEJMra1310050 PubMed PMID: 24476434; PubMed Central PMCID: PMCPMC4035222.
13. [13] Chamley, L.W., Holland, O.J., Chen, Q., Viall, C.A., Stone, P.R., Abumaree, M., Review: where is the maternofetal interface?. Placenta, 35(Suppl:S74–80), 2014, 10.1016/j.placenta.2013.10.014 PubMed PMID: 24239157.
14. [14] Abumaree, M.H., Stone, P.R., Chamley, L.W., An in vitro model of human placental trophoblast deportation/shedding. Mol. Hum. Reprod. 12:11 (2006), 687–694, 10.1093/molehr/gal073 PubMed PMID: 16988002.
15. [15] Chen, Q., Stone, P., Ching, L.M., Chamley, L., A role for interleukin-6 in spreading endothelial cell activation after phagocytosis of necrotic trophoblastic material: implications for the pathogenesis of pre-eclampsia. J. pathology 217:1 (2009), 122–130, 10.1002/path.2425 PubMed PMID: 18825657.
16. [16] Lappas, M., Mitton, A., Lim, R., Barker, G., Riley, C., Permezel, M., SIRT1 is a novel regulator of key pathways of human labor. Biol. Reprod. 84:1 (2011), 167–178, 10.1095/biolreprod.110.086983 PubMed PMID: 20844277.
17. [17] Kroemer, G., Galluzzi, L., Kepp, O., Zitvogel, L., Immunogenic cell death in cancer therapy. Annu. Rev. Immunol. 31 (2013), 51–72, 10.1146/annurev-immunol-032712-100008 PubMed PMID: 23157435.
18. [18] Hildebrand, J.M., Tanzer, M.C., Lucet, I.S., Young, S.N., Spall, S.K., Sharma, P., et al. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death. Proc. Natl. Acad. Sci. U. S. A. 111:42 (2014), 15072–15077, 10.1073/pnas.1408987111 PubMed PMID: 25288762; PubMed Central PMCID: PMCPMC4210347.
19. [19] Stock, O., Gordon, L., Kapoor, J., Walker, S.P., Whitehead, C., Kaitu'u-Lino, T.J., et al. Chorioamnionitis occurring in women with preterm rupture of the fetal membranes is associated with a dynamic increase in mRNAs coding cytokines in the maternal circulation. Reprod. Sci. 22:7 (2015), 852–859, 10.1177/1933719114565034 PubMed PMID: 25616398; PubMed Central PMCID: PMCPMC4565477.
20. [20] Rajakumar, A., Cerdeira, A.S., Rana, S., Zsengeller, Z., Edmunds, L., Jeyabalan, A., et al. Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia. Hypertension 59:2 (2012), 256–264, 10.1161/HYPERTENSIONAHA.111.182170 PubMed PMID: 22215706; PubMed Central PMCID: PMCPMC3319764.
21. [21] Calvert, S.J., Jones, C.J., Sibley, C.P., Aplin, J.D., Heazell, A.E., Analysis of syncytial nuclear aggregates in preeclampsia shows increased sectioning artefacts and decreased inter-villous bridges compared to healthy placentas. Placenta 34:12 (2013), 1251–1254, 10.1016/j.placenta.2013.10.001 PubMed PMID: 24172869.
22. [22] Pantham, P., Viall, C.A., Chen, Q., Kleffmann, T., Print, C.G., Chamley, L.W., Antiphospholipid antibodies bind syncytiotrophoblast mitochondria and alter the proteome of extruded syncytial nuclear aggregates. Placenta 36:12 (2015), 1463–1473, 10.1016/j.placenta.2015.10.006 PubMed PMID: 26506561.