Analysis of syncytial nuclear aggregates in preeclampsia shows increased sectioning artefacts and decreased inter-villous bridges compared to healthy placentas

Placenta

Volumn 34, Issue 12, 2013, Pages 1251-1254

  Calvert, S J ^a   Jones, C J P ^a   Sibley, C P ^a   Aplin, J D ^a   Heazell, A E P ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Fetal growth restriction; Preeclampsia; Sectioning artefact; Syncytial bridge; Syncytial knot; Syncytiotrophoblast

Indexed keywords

ADULT; ARTICLE; ARTIFACT; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; INTERVILLOUS BRIDGE; INTRAUTERINE GROWTH RETARDATION; PLACENTA; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; SYNCYTIAL NUCLEAR AGGREGATE; SYNCYTIOTROPHOBLAST; SYNCYTIUM; TROPHOBLAST;

FETAL GROWTH RESTRICTION; PREECLAMPSIA; SECTIONING ARTEFACT; SYNCYTIAL BRIDGE; SYNCYTIAL KNOT; SYNCYTIOTROPHOBLAST;

ADULT; ARTIFACTS; CELL NUCLEUS; CELL NUCLEUS SHAPE; CESAREAN SECTION; CHORIONIC VILLI; FEMALE; FETAL GROWTH RETARDATION; HUMANS; MICROTOMY; PLACENTATION; PRE-ECLAMPSIA; PREGNANCY; TROPHOBLASTS; YOUNG ADULT;

EID: 84888363164     PISSN: 01434004     EISSN: 15323102     Source Type: Journal    
DOI: 10.1016/j.placenta.2013.10.001     Document Type: Article

References (27)

1. S.J. Coleman, L. Gerza, C.J.P. Jones, C.P. Sibley, J.D. Aplin, and A.E.P. Heazell Syncytial nuclear aggregates in normal placenta show increased nuclear condensation, but apoptosis and cytoskeletal redistribution are uncommon Placenta 34 5 2013 449 455
2. S.Y. Park, M.Y. Kim, Y.J. Kim, Y.K. Chun, H.S. Kim, and H.S. Kim Placental pathology in intrauterine growth retardation Korean J Pathol 36 1 2002 30 37
3. S.C. Smith, P.N. Baker, and E.M. Symonds Increased placental apoptosis in intrauterine growth restriction Am J Obstet Gynecol 177 6 1997 1395 1401
4. R.R.M. Corrêa, D.B. Gilio, C.L. Cavellani, M.C. Paschoini, F.A. Oliveira, and L.C. Peres Placental morphometrical and histopathology changes in the different clinical presentations of hypertensive syndromes in pregnancy Arch Gynecol Obstet 277 3 2008 201 206
5. D. Davey, and I. MacGillivray The classification and definition of the hypertensive disorders of pregnancy Am J Obstet Gynecol 158 4 1988 892 898
6. N.M.E. Fogarty, A.C. Ferguson-Smith, and G.J. Burton Syncytial knots (Tenney-Parker changes) in the human placenta: evidence of loss of transcriptional activity and oxidative damage Am J Pathol 183 1 2013 144 152
7. H. Fox The significance of villous syncytial knots in the human placenta J Obstet Gynaecol Br Commonw 72 1 944 1965 347 355
8. C.J. Jones, and H. Fox Syncytial knots and intervillous bridges in the human placenta: an ultrastructural study J Anat 124 2 1977 275 286
9. G.J. Burton Intervillous connections in the mature human placenta: instances of syncytial fusion or section artifacts? J Anat 145 1986 13 23
10. K. Benirschke, G.J. Burton, and R.N. Baergen Pathology of the human placenta 2012 Springer Berlin, Heidelberg 411 427
11. Calvert I. Baess-a serial section analyser. Available from: http://figshare.com/articles/Baess-A-serial-section-analyser/106949 [accessed 15.02.13].
12. C.M. Scifres, and D.M. Nelson Intrauterine growth restriction, human placental development and trophoblast cell death J Physiol 587 14 2009 3453
13. K. Loukeris, R. Sela, and R.N. Baergen Syncytial knots as a reflection of placental maturity: reference values for 20 to 40 weeks' gestational age Pediatr Dev Pathol 13 4 2010 305 309
14. N.H. Anderson, L.M.E. McCowan, E. Fyfe, E. Chan, R. Taylor, and A. Stewart The impact of maternal body mass index on the phenotype of pre-eclampsia: a prospective cohort study BJOG 119 5 2012 589 595
15. T. O'Brien, J. Ray, and W. Chan Maternal body mass index and the risk of preeclampsia: a systematic overview Epidemiology 14 3 2003 368 374
16. L. Higgins, T.A. Mills, S.L. Greenwood, E.J. Cowley, C.P. Sibley, and R.L. Jones Maternal obesity and its effect on placental cell turnover J Matern Fetal Neonatal Med 26 8 2013 783 788
17. K.A. Roberts, S.C. Riley, R.M. Reynolds, S. Barr, M. Evans, and A. Statham Placental structure and inflammation in pregnancies associated with obesity Placenta 32 3 2011 247 254
18. B. Huppertz, P. Kaufmann, and J. Kingdom Trophoblast turnover in health and disease Fetal Matern Med Rev 13 02 2002 103 118
19. B. Huppertz, J. Kingdom, I. Caniggia, G. Desoye, S. Black, and H. Korr Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation Placenta 24 2-3 2003 181 190
20. T.M. Mayhew, D.S. Charnock-Jones, and P. Kaufmann Aspects of human fetoplacental vasculogenesis and angiogenesis. III. Changes in complicated pregnancies Placenta 25 2-3 2004 127 139
21. C.P. Chen, R. Bajoria, and J.D. Aplin Decreased vascularization and cell proliferation in placentas of intrauterine growth-restricted fetuses with abnormal umbilical artery flow velocity waveforms Am J Obstet Gynecol 187 3 2002 764 769
22. H. Arnholdt, F. Meisel, K. Fandrey, and U. Löhrs Proliferation of villous trophoblast of the human placenta in normal and abnormal pregnancies Virchows Arch 60 6 1991 365 372
23. D. Leung, S. Smith, K. To, D. Sahota, and P.N. B Increased placental apoptosis in pregnancies complicated by preeclampsia Am J Obstet Gynecol 184 6 2001 1249 1250
24. S.Z. Tomas, D. Roje, I.K. Prusac, I. Tadin, and V. Capkun Morphological characteristics of placentas associated with idiopathic intrauterine growth retardation: a clinicopathologic study Eur J Obstet Gynecol Reprod Biol 152 1 2010 39 43
25. N. Hendrix, and V. Berghella Non-placental causes of intrauterine growth restriction Semin Perinatol 32 3 2008 161 165
26. H. Derricott, R.L. Jones, and A.E.P. Heazell Investigating the association of villitis of unknown etiology with stillbirth and fetal growth restriction - a systematic review Placenta 34 10 2013 856 862 (Published October 2013)
27. A.E.P. Heazell, S.J. Moll, C.J.P. Jones, P.N. Baker, and I.P. Crocker Formation of syncytial knots is increased by hyperoxia, hypoxia and reactive oxygen species Placenta 28 Suppl. A 2007 S33 S40