Mineralocorticoid Receptor Blockade for Prevention of Acute Kidney Injury: An Elusive Target

American Journal of Kidney Diseases

Volumn 69, Issue 2, 2017, Pages 166-168

  Bar Nur, Daphna ^a,b   Jaber, Bertrand L ^a,b  

^a ST ELIZABETH'S MEDICAL CENTER   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; CREATININE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HEMOGLOBIN; MINERALOCORTICOID ANTAGONIST; NITRIC OXIDE SYNTHASE; POTASSIUM; RAMIPRIL; SPIRONOLACTONE; ALDOSTERONE; MINERALOCORTICOID RECEPTOR;

ACUTE KIDNEY FAILURE; ADRENALECTOMY; ARTERIAL PRESSURE; CARDIOPULMONARY BYPASS; CHRONIC KIDNEY FAILURE; CREATININE BLOOD LEVEL; DIABETES MELLITUS; EDITORIAL; ELIMINATION HALF-LIFE; GLOMERULUS FILTRATION RATE; HEART SURGERY; HEMOGLOBIN BLOOD LEVEL; HUMAN; INTENSIVE CARE UNIT; ISCHEMIA; LENGTH OF STAY; MACULA DENSA; META ANALYSIS (TOPIC); NONHUMAN; OXIDATIVE STRESS; PLASMA VOLUME; POSTOPERATIVE COMPLICATION; POTASSIUM BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RENAL REPLACEMENT THERAPY; REPERFUSION INJURY; SURGICAL MORTALITY; URINE VOLUME; KIDNEY;

ACUTE KIDNEY INJURY; ALDOSTERONE; HUMANS; KIDNEY; MINERALOCORTICOID RECEPTOR ANTAGONISTS; RECEPTORS, MINERALOCORTICOID; SPIRONOLACTONE;

EID: 85009833863     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2016.11.001     Document Type: Editorial

References (25)

1. 1 Chertow, G.M., Levy, E.M., Hammermeister, K.E., Grover, F., Daley, J., Independent association between acute renal failure and mortality following cardiac surgery. Am J Med 104:4 (1998), 343–348.
2. 2 Conlon, P.J., Stafford-Smith, M., White, W.D., et al. Acute renal failure following cardiac surgery. Nephrol Dial Transplant 14:5 (1999), 1158–1162.
3. 3 Rosner, M.H., Okusa, M.D., Acute kidney injury associated with cardiac surgery. Clin J Am Soc Nephrol 1:1 (2006), 19–32.
4. 4 Susantitaphong, P., Cruz, D.N., Cerda, J., et al. World incidence of AKI: a meta-analysis. Clin J Am Soc Nephrol 8:9 (2013), 1482–1493.
5. 5 Loef, B.G., Epema, A.H., Smilde, T.D., et al. Immediate postoperative renal function deterioration in cardiac surgical patients predicts in-hospital mortality and long-term survival. J Am Soc Nephrol 16:1 (2005), 195–200.
6. 6 Coca, S.G., Yusuf, B., Shlipak, M.G., Garg, A.X., Parikh, C.R., Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis 53:6 (2009), 961–973.
7. 7 Elmistekawy, E., McDonald, B., Hudson, C., et al. Clinical impact of mild acute kidney injury after cardiac surgery. Ann Thorac Surg 98:3 (2014), 815–822.
8. 8 Pickering, J.W., James, M.T., Palmer, S.C., Acute kidney injury and prognosis after cardiopulmonary bypass: a meta-analysis of cohort studies. Am J Kidney Dis 65:2 (2015), 283–293.
9. 9 Faubel, S., Chawla, L.S., Chertow, G.M., et al. Ongoing clinical trials in AKI. Clin J Am Soc Nephrol 7:5 (2012), 861–873.
10. 10 Arima, S., Kohagura, K., Xu, H.L., et al. Nongenomic vascular action of aldosterone in the glomerular microcirculation. J Am Soc Nephrol 14:9 (2003), 2255–2263.
11. 11 Gros, R., Ding, Q., Armstrong, S., O'Neil, C., Pickering, J.G., Feldman, R.D., Rapid effects of aldosterone on clonal human vascular smooth muscle cells. Am J Physiol Cell Physiol 292:2 (2007), C788–C794.
12. 12 Leopold, J.A., Dam, A., Maron, B.A., et al. Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nat Med 13:2 (2007), 189–197.
13. 13 Jaisser, F., Farman, N., Emerging roles of the mineralocorticoid receptor in pathology: toward new paradigms in clinical pharmacology. Pharmacol Rev 68:1 (2016), 49–75.
14. 14 Mejia-Vilet, J.M., Ramirez, V., Cruz, C., Uribe, N., Gamba, G., Bobadilla, N.A., Renal ischemia-reperfusion injury is prevented by the mineralocorticoid receptor blocker spironolactone. Am J Physiol Renal Physiol 293:1 (2007), F78–F86.
15. 15 Ramirez, V., Trujillo, J., Valdes, R., et al. Adrenalectomy prevents renal ischemia-reperfusion injury. Am J Physiol Renal Physiol 297:4 (2009), F932–F942.
16. 16 Sanchez-Pozos, K., Barrera-Chimal, J., Garzon-Muvdi, J., et al. Recovery from ischemic acute kidney injury by spironolactone administration. Nephrol Dial Transplant 27:8 (2012), 3160–3169.
17. 17 Barrera-Chimal, J., Perez-Villalva, R., Rodriguez-Romo, R., et al. Spironolactone prevents chronic kidney disease caused by ischemic acute kidney injury. Kidney Int 83:1 (2013), 93–103.
18. 18 Barba-Navarro, R., Tapia-Silva, M., Garza-Garcia, C., et al. The effect of spironolactone on acute kidney injury after cardiac surgery: a randomized, placebo-controlled trial. Am J Kidney Dis 69:2 (2017), 192–199.
19. 19 Liangos, O., Wald, R., O'Bell, J.W., Price, L., Pereira, B.J., Jaber, B.L., Epidemiology and outcomes of acute renal failure in hospitalized patients: a national survey. Clin J Am Soc Nephrol 1:1 (2006), 43–51.
20. 20 Khosla, N., Soroko, S.B., Chertow, G.M., et al. Preexisting chronic kidney disease: a potential for improved outcomes from acute kidney injury. Clin J Am Soc Nephrol 4:12 (2009), 1914–1919.
21. 21 Fu, Y., Hall, J.E., Lu, D., et al. Aldosterone blunts tubuloglomerular feedback by activating macula densa mineralocorticoid receptors. Hypertension 59:3 (2012), 599–606.
22. 22 Yacoub, R., Patel, N., Lohr, J.W., Rajagopalan, S., Nader, N., Arora, P., Acute kidney injury and death associated with renin angiotensin system blockade in cardiothoracic surgery: a meta-analysis of observational studies. Am J Kidney Dis 62:6 (2013), 1077–1086.
23. 23 Rim, M.Y., Ro, H., Kang, W.C., et al. The effect of renin-angiotensin-aldosterone system blockade on contrast-induced acute kidney injury: a propensity-matched study. Am J Kidney Dis 60:4 (2012), 576–582.
24. 24 Pretorius, M., Murray, K.T., Yu, C., et al. Angiotensin-converting enzyme inhibition or mineralocorticoid receptor blockade do not affect prevalence of atrial fibrillation in patients undergoing cardiac surgery. Crit Care Med 40:10 (2012), 2805–2812.
25. 25 Palevsky, P.M., Molitoris, B.A., Okusa, M.D., et al. Design of clinical trials in acute kidney injury: report from an NIDDK workshop on trial methodology. Clin J Am Soc Nephrol 7:5 (2012), 844–850.