Enhanced terminal room disinfection and acquisition and infection caused by multidrug-resistant organisms and Clostridium difficile (the Benefits of Enhanced Terminal Room Disinfection study): a cluster-randomised, multicentre, crossover study

The Lancet

Volumn 389, Issue 10071, 2017, Pages 805-814

  Anderson, Deverick J ^a   Chen, Luke F ^a   Weber, David J ^b   Moehring, Rebekah W ^c   Lewis, Sarah S ^a   Triplett, Patricia F ^b,d   Blocker, Michael ^e,f   Becherer, Paul ^g   Schwab, J Conrad ^h   Knelson, Lauren P ^a   Lokhnygina, Yuliya ^a   Rutala, William A ^b   Kanamori, Hajime ^b   Gergen, Maria F ^b   Sexton, Daniel J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c DURHAM VA MEDICAL CENTER   (United States)

^d High Point Regional Hospital   (United States)

^e Alamance Regional Medical Center   (United States)

^f CAROLINAS MEDICAL CENTER   (United States)

^g Rex Healthcare   (United States)

^h Clinical Operations   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEACHING AGENT; DISINFECTANT AGENT; HYPOCHLORITE SODIUM; QUATERNARY AMMONIUM DERIVATIVE;

ACINETOBACTER; ADULT; ARTICLE; BACTERIAL COLONIZATION; CLOSTRIDIUM DIFFICILE INFECTION; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISINFECTION; FEMALE; HOSPITAL; HOSPITAL ADMISSION; HUMAN; INFECTION; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MULTICENTER STUDY; MULTIDRUG RESISTANT ACINETOBACTER; OUTCOME ASSESSMENT; PEPTOCLOSTRIDIUM DIFFICILE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ULTRAVIOLET RADIATION; UNITED STATES; VANCOMYCIN RESISTANT ENTEROCOCCUS; CLINICAL TRIAL; CLOSTRIDIUM INFECTION; CROSS INFECTION; HEALTH CARE FACILITY; MICROBIOLOGY; MIDDLE AGED; MULTIDRUG RESISTANCE; PROCEDURES; STANDARDS;

CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; CROSS INFECTION; CROSS-OVER STUDIES; DISINFECTANTS; DISINFECTION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; FEMALE; HUMANS; MALE; MIDDLE AGED; PATIENTS' ROOMS; QUATERNARY AMMONIUM COMPOUNDS; SODIUM HYPOCHLORITE; ULTRAVIOLET RAYS; UNITED STATES;

EID: 85009819888     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(16)31588-4     Document Type: Article

References (30)

1. 1 Tackling drug-resistant infections globally: final report and recommendations. http://amr-review.org/sites/default/files/160525_Final%20paper_with%20cover.pdf, 2016 (accessed June 1, 2016).
2. 2 Dancer, SJ, Importance of the environment in meticillin-resistant Staphylococcus aureus acquisition: the case for hospital cleaning. Lancet Infect Dis 8 (2008), 101–113.
3. 3 Kramer, A, Schwebke, I, Kampf, G, How long do nosocomial pathogens persist on inanimate surfaces? A systematic review. BMC Infect Dis, 6, 2006, 130.
4. 4 Carling, PC, Parry, MM, Rupp, ME, Po, JL, Dick, B, Von Beheren, S, Improving cleaning of the environment surrounding patients in 36 acute care hospitals. Infect Control Hosp Epidemiol 29 (2008), 1035–1041.
5. 5 Mitchell, BG, Dancer, SJ, Anderson, M, Dehn, E, Risk of organism acquisition from prior room occupants: a systematic review and meta-analysis. J Hosp Infect 91 (2015), 211–227.
6. 6 Guerrero, DM, Nerandzic, MM, Jury, LA, Jinno, S, Chang, S, Donskey, CJ, Acquisition of spores on gloved hands after contact with the skin of patients with Clostridium difficile infection and with environmental surfaces in their rooms. Am J Infect Control 40 (2012), 556–558.
7. 7 Hayden, MK, Blom, DW, Lyle, EA, Moore, CG, Weinstein, RA, Risk of hand or glove contamination after contact with patients colonized with vancomycin-resistant enterococcus or the colonized patients' environment. Infect Control Hosp Epidemiol 29 (2008), 149–154.
8. 8 Stiefel, U, Cadnum, JL, Eckstein, BC, Guerrero, DM, Tima, MA, Donskey, CJ, Contamination of hands with methicillin-resistant Staphylococcus aureus after contact with environmental surfaces and after contact with the skin of colonized patients. Infect Control Hosp Epidemiol 32 (2011), 185–187.
9. 9 Han, JH, Sullivan, N, Leas, BF, Pegues, DA, Kaczmarek, JL, Unscheid, CA, Cleaning hospital room surfaces to prevent health care-associated infections: a technical brief. Ann Intern Med 163 (2015), 598–607.
10. 10 Anderson, DJ, Gergen, MF, Smathers, E, et al. Decontamination of targeted pathogens from patient rooms using an automated ultraviolet-C-emitting device. Infect Control Hosp Epidemiol 34 (2013), 466–471.
11. 11 Magiorakos, AP, Srinivasan, A, Carey, RB, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 18 (2012), 268–281.
12. 12 Bonten, MJ, Slaughter, S, Ambergen, AW, et al. The role of “colonization pressure” in the spread of vancomycin-resistant enterococci: an important infection control variable. JAMA Intern Med 158 (1998), 1127–1132.
13. 13 Deyo, RA, Cherkin, DC, Ciol, MA, Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 45 (1992), 613–619.
14. 14 Huang, SS, Rifas-Shiman, SL, Warren, DK, et al. Improving methicillin-resistant Staphylococcus aureus surveillance and reporting in intensive care units. J Infect Dis 195 (2007), 330–338.
15. 15 Avery, TR, Kleinman, KP, Klompas, M, Aschengrau, A, Huang, SS, Inclusion of 30-day postdischarge detection triples the incidence of hospital-onset methicillin-resistant Staphylococcus aureus. Infect Control Hosp Epidemiol 33 (2012), 114–121.
16. 16 McDonald, LC, Coignard, B, Dubberke, E, Song, X, Horan, T, Kutty, PK, Recommendations for surveillance of Clostridium difficile-associated disease. Infect Control Hosp Epidemiol 28 (2007), 140–145.
17. 17 Eckstein, BC, Adams, DA, Eckstein, EC, et al. Reduction of Clostridium difficile and vancomycin-resistant Enterococcus contamination of environmental surfaces after an intervention to improve cleaning methods. BMC Infect Dis, 7, 2007, 61.
18. 18 Datta, R, Platt, R, Yokoe, DS, Huang, SS, Environmental cleaning intervention and risk of acquiring multidrug-resistant organisms from prior room occupants. JAMA Intern Med 171 (2011), 491–494.
19. 19 Hayden, MK, Bonten, MJ, Blom, DW, Lyle, EA, van de Vijver, DA, Weinstein, RA, Reduction in acquisition of vancomycin-resistant enterococcus after enforcement of routine environmental cleaning measures. Clin Infect Dis 42 (2006), 1552–1560.
20. 20 Smith, DL, Gillanders, S, Holah, JT, Gush, C, Assessing the efficacy of different microfibre cloths at removing surface micro-organisms associated with healthcare-associated infections. J Hosp Infect 78 (2011), 182–186.
21. 21 Passaretti, CL, Otter, JA, Reich, NG, et al. An evaluation of environmental decontamination with hydrogen peroxide vapor for reducing the risk of patient acquisition of multidrug-resistant organisms. Clin Infect Dis 56 (2013), 27–35.
22. 22 Rutala, WA, Gergen, MF, Weber, DJ, Room decontamination with UV radiation. Infect Control Hosp Epidemiol 31 (2010), 1025–1029.
23. 23 Haas, JP, Menz, J, Dusza, S, Montecalvo, MA, Implementation and impact of ultraviolet environmental disinfection in an acute care setting. Am J Infect Control 42 (2014), 586–590.
24. 24 Levin, J, Riley, LS, Parrish, C, English, D, Ahn, S, The effect of portable pulsed xenon ultraviolet light after terminal cleaning on hospital-associated Clostridium difficile infection in a community hospital. Am J Infect Control 41 (2013), 746–748.
25. 25 Miller, R, Simmons, S, Dale, C, Stachowiak, J, Stibich, M, Utilization and impact of a pulsed-xenon ultraviolet room disinfection system and multidisciplinary care team on Clostridium difficile in a long-term acute care facility. Am J Infect Control 43 (2015), 1350–1353.
26. 26 Nagaraja, A, Visintainer, P, Haas, JP, Menz, J, Wormser, GP, Montecalvo, MA, Clostridium difficile infections before and during use of ultraviolet disinfection. Am J Infect Control 3 (2015), 940–945.
27. 27 Boyce, JM, Havill, NL, Moore, BA, Terminal decontamination of patient rooms using an automated mobile UV light unit. Infect Control Hosp Epidemiol 32 (2011), 737–742.
28. 28 Walker, AS, Eyre, DW, Wyllie, DH, et al. Characterisation of Clostridium difficile hospital ward-based transmission using extensive epidemiological data and molecular typing. PLoS Med, 9, 2012, e1001172.
29. 29 Eyre, DW, Cule, ML, Wilson, DJ, et al. Diverse sources of C. difficile infection identified on whole-genome sequencing. N Engl J Med 369 (2013), 1195–1205.
30. 30 Grabsch, EA, Mahony, AA, Cameron, DR, et al. Significant reduction in vancomycin-resistant enterococcus colonization and bacteraemia after introduction of a bleach-based cleaning-disinfection programme. J Hosp Infect 82 (2012), 234–242.