Molecular and genetic mechanisms of acute and chronic pancreatitis

International Congress Series

Volumn 1255, Issue C, 2003, Pages 49-60

  Whitcomb, David C ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

CFTR; Pancreatic secretory trypsin inhibitor; Pancreatitis; SPINK1; Trypsin

Indexed keywords

EID: 85009777097     PISSN: 05315131     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0531-5131(03)00674-5     Document Type: Article

References (56)

1. Chiari, H., Ueber selbstverdauung des menschlichen pankreas. Zeitschrift fur Heilkunde 17 (1896), 69–96.
2. Etemad, B., Whitcomb, D.C., Chronic pancreatitis: diagnosis, classification, and new genetic developments. Gastroenterology 120 (2001), 682–707.
3. Sarles, H., Pancreatitis: Symposium of Marseille, 1963. 1965, Karger, Basel.
4. Sarner, M., Pancreatitis definitions and classification. Vay Liang W Go, E.P.D., Gardner, J.D., Lebenthal, E., Reber, H.A., Scheele, G.A., (eds.) The Pancreas: Pathobiology and Disease, 2nd ed., 1993, Raven Press, New York, 575–580.
5. Clain, J.E., Pearson, R.K., Diagnosis of chronic pancreatitis: is a gold standard necessary?. Surgical Clinics of North America 79:4 (1999), 829–845.
6. Sarles, H., Camarena, T.J., Gomez, S.C., Choux, R., Iovanna, J., Acute pancreatitis is not a cause of chronic pancreatitis in the absence of residual duct strictures. Pancreas 8:3 (1993), 354–357.
7. Bernard, J.P., Adrich, Z., Montalto, G., De, C.A., De, R.M., Sarles, H., et al. Inhibition of nucleation and crystal growth of calcium carbonate by human lithostathine. Gastroenterology 103:4 (1992), 1277–1284.
8. Cavallini, G., Bovo, P., Bianchini, E., Carsana, A., Costanzo, C., Merola, M., et al. Lithostathine messenger RNA expression in different types of chronic pancreatitis. Molecular and Cellular Biochemistry 185:1–2 (1998), 147–152.
9. Bimmler, D., Graf, R., Scheele, G.A., Frick, T.W., Pancreatic stone protein (lithostathine), a physiologically relevant pancreatic calcium carbonate crystal inhibitor?. Journal of Biological Chemistry 272:5 (1997), 3073–3082.
10. Sarles, H., Proposal adopted unanimously by the participants of the symposium, Marseilles 1963. Bibliotheca Gastroenterologica 7 (1965), 7–8.
11. Singer, M.V., Gyr, K., Darles, H., Revised classification of pancreatitis. Gastroenterology 89 (1985), 683–690.
12. Sarles, H., Adler, G., Dani, R., Frey, C., Gullo, L., Harada, H., et al. The pancreatitis classification of Marseilles, Rome 1988. Scandinavian Journal of Gastroenterology, 24, 1989, 641.
13. Owyang, C., Levitt, M., Chronic pancreatitis. Yamada, T., (eds.) Textbook of Gastroenterology, 1991, Lippincott, Philadelphia, 1874–1893.
14. Steer, M.L., Waxman, I., Freedman, S., Chronic pancreatitis. New England Journal of Medicine 332:22 (1995), 1482–1490.
15. DiMagno, E., Layer, P., Clain, J., Chronic pancreatitis. Go, V., (eds.) The Pancreas: Biology, Pathophysiology and Disease, 1993, Raven Press, New York, 665–706.
16. Whitcomb, D.C., Pfützer, R.H., Slivka, A., Alcoholic chronic pancreatitis. Current Treatment Opinions in Gastroenterology 2:4 (1999), 273–282.
17. Bisceglie, A.M., Segal, I., Cirrhosis and chronic pancreatitis in alcoholics [editorial]. Journal of Clinical Gastroenterology 6:3 (1984), 199–200.
18. Gumaste, V.V., Alcoholic pancreatitis: unraveling the mystery. Gastroenterology 108:1 (1995), 297–299.
19. Durbec, J., Sarles, H., Multicenter survey of the etiology of pancreatic diseases. Relationship between the relative risk of developing chronic pancreatitis and alcohol, protein and lipid consumption. Digestion 18 (1978), 337–350.
20. Corrao, G., Bagnardi, V., Zambon, A., Arico, S., Exploring the dose–response relationship between alcohol consumption and the risk of several alcohol-related conditions: a meta-analysis. Addiction 94:10 (1999), 1551–1573.
21. Perkins, P.S., Rutherford, R.E., Pandol, S.J., Effect of chronic ethanol feeding on digestive enzyme synthesis and mRNA content in rat pancreas. Pancreas 10:1 (1995), 14–21.
22. Niebergall-Roth, E., Harder, H., Singer, M.V., A review: acute and chronic effects of ethanol and alcoholic beverages on the pancreatic exocrine secretion in vivo and in vitro. Alcoholism: Clinical and Experimental Research 22:7 (1998), 1570–1583.
23. Perrault, J., Hereditary pancreatitis. Gastroenterology Clinics of North America 23:4 (1994), 743–752.
24. Whitcomb, D.C., Hereditary pancreatitis: new insights into acute and chronic pancreatitis. Gut 45 (1999), 317–322.
25. Whitcomb, D.C., Genetic predispositions to acute and chronic pancreatitis. Medical Clinics of North America 84:2 (2000), 531–547.
26. Whitcomb, D.C., The spectrum in complications of hereditary pancreatitis: is this a model for future gene therapy?. Gastroenterology Clinics of North America 28:3 (1999), 525–541.
27. Le Bodic, L., Bignon, J.D., Raguenes, O., Mercier, B., Georgelin, T., Schnee, M., et al. The hereditary pancreatitis gene maps to long arm of chromosome 7. Human Molecular Genetics 5:4 (1996), 549–554.
28. Whitcomb, D.C., Gorry, M.C., Preston, R.A., Furey, W., Sossenheimer, M.J., Ulrich, C.D., et al. A gene for hereditary pancreatitis maps to chromosome 7q35. Gastroenterology 110:6 (1996), 1975–1980.
29. Whitcomb, D.C., Gorry, M.C., Preston, R.A., Furey, W., Sossenheimer, M.J., Ulrich, C.D., et al. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nature Genetics 14:2 (1996), 141–145.
30. Antonarakis, S.E., the_Nomenclature_Working_Group. Recommendations for a nomenclature system for human gene mutations. Human Mutation 11 (1998), 1–3.
31. Varallyay, E., Pal, G., Patthy, A., Szilagyi, L., Graf, L., Two mutations in rat trypsin confer resistance against autolysis. Biochemical and Biophysical Research Communications 243:1 (1998), 56–60.
32. Whitcomb, D.C., Early trypsinogen activation in acute pancreatitis. Gastroenterology 116:3 (1999), 770–773.
33. Grady, T., Mah'moud, M., Otani, T., Rhee, S., Learch, M.M., Gorelick, F.S., Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury. American Journal of Physiology 275 (1998), G1010–G1017.
34. Leach, S.D., Moldin, I.M., Sheele, G.A., Gorelick, F.S., Intracellular activation of digestive enzymes in rat pancreatic acini: stimulation by high dose of cholecystokinin. Journal of Clinical Investigation 87 (1991), 362–366.
35. Teich, N., Mössner, J., Keim, V., Systematic overview of genetic variants of cationic trypsinogen and SLONK1 in pancreatitis patients. Durie, P., Lerch, M.M., Lowenfels, A.B., Masionneuve, P., Ulrich, C.D., Whitcomb, D.C., (eds.) Genetic Disorders of the Exocrine Pancreas: An Overview and Update, 2002, Karger, Basel, 20–22.
36. Gorry, M.C., Gabbaizedeh, D., Furey, W., Gates, L.K. Jr., Preston, R.A., Aston, C.E., et al. Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis. Gastroenterology 113:4 (1997), 1063–1068.
37. Chen, J.M., Raguenes, O., Ferec, C., Deprez, P.H., Verellen-Dumoulin, C., Andriulli, A., The A16V signal peptide cleavage site mutation in the cationic trypsinogen gene and chronic pancreatitis [letter; comment]. Gastroenterology 117:6 (1999), 1508–1509.
38. Teich, N., Ockenga, J., Hoffmeister, A., Manns, M., Mossner, J., Keim, V., Mutations of the activation peptide of cationic trypsinogen may lead to chronic pancreatitis by facilitated activation of trypsinogen to trypsin. Gastroenterology, 118(4), 2000, A195.
39. Ferec, C., Raguenes, O., Salomon, R., Roche, C., Bernard, J.P., Guillot, M., et al. Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis. Journal of Medical Genetics 36:3 (1999), 228–232.
40. Simon, P., Weiss, F.U., Sahin-Toth, M., Parry, M., Nayler, O., Lenfers, B., et al. Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122uCys) that alters autoactivation and autodegradation of cationic trypsinogen. Journal of Biological Chemistry, 21, 2001, 21.
41. Pfützer, R.H., Myers, E., Applebaum-Shapiro, S.E., Finch, R., Ellis, I., Neoptolemos, J.P., et al. Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitis. Gut, 2001 (abstract; in press).
42. Le Marechal, C., Chen, J.M., Quere, I.I., Raguenes, O., Ferec, C., Auroux, J., Discrimination of three mutational events that result in a disruption of the R122 primary autolysis site of the human cationic trypsinogen (PRSS1) by denaturing high performance liquid chromatography. BMC Genetics, 2(1), 2001, 19.
43. Colomb, E., Guy, O., Deprez, P., Michel, R., Figarella, C., The two human trypsinogens: catalytic properties of the corresponding trypsins. Biochimica et Biophysica Acta 525 (1978), 186–193.
44. Mithofer, K., Fernandez-Del Castillo, C., Frick, T.W., Lewandrowski, K.B., Rattner, D.W., Warshaw, A.L., Acute hypercalcemia causes acute pancreatitis and ectopic trypsinogen activation in the rat. Gastroenterology 109:1 (1995), 239–246.
45. Frick, T.W., Fernandez-Del Castillo, C., Bimmler, D., Warshaw, A.L., Elevated calcium and activation of trypsinogen in rat pancreatic acini. Gut 41:3 (1997), 339–343.
46. Voronina, S., Longbottom, R., Sutton, R., Petersen, O.H., Tepikin, A., Bile acids induce calcium signals in mouse pancreatic acinar cells: implications for bile-induced pancreatic pathology. Journal of Physiology 540:Pt. 1 (2002), 49–55.
47. Schiesser, M., Bimmler, D., Frick, T.W., Graf, R., Conformational changes of pancreatitis-associated protein (PAP) activated by trypsin lead to insoluble protein aggregates. Pancreas 22:2 (2001), 186–192.
48. Witt, H., Luck, W., Hennies, H.C., Classen, M., Kage, A., Lass, U., et al. Mutations in the gene encoding the serine protease inhibitor, kazal type 1 are associated with chronic pancreatitis. Nature Genetics 25:2 (2000), 213–216.
49. Pfützer, R.H., Barmada, M.M., Brunskil, A.P.J., Finch, R., Hart, P.S., Neoptolemos, J., et al. SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis. Gastroenterology 119 (2000), 615–623.
50. Rossi, L., Pfützer, R.L., Parvin, S., Ali, L., Sattar, S., Azad Kahn, A.K., et al. SPINK1/PSTI mutations are associated with tropical pancreatitis in Bangladesh: a preliminary report. Pancreatology 1:3 (2001), 242–245.
51. Schneider, A., Whitcomb, D.C., Hereditary pancreatitis: a model for inflammatory diseases of the pancreas. Best Pract. Res. Clin. Gastroenterol. 16:3 (2002), 347–363.
52. Apte, M.V., Haber, P.S., Applegate, T.L., Norton, I.D., McCaughan, G.W., Korsten, M.A., et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 43:1 (1998), 128–133.
53. Bachem, M.G., Schneider, E., Gross, H., Weidenbach, H., Schmid, R.M., Menke, A., et al. Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 115:2 (1998), 421–432.
54. Schmid-Kotsas, A., Gross, H.J., Menke, A., Weidenbach, H., Adler, G., Siech, M., et al. Lipopolysaccharide-activated macrophages stimulate the synthesis of collagen type I and C-fibronectin in cultured pancreatic stellate cells. American Journal of Pathology 155:5 (1999), 1749–1758.
55. Mews, P., Phillips, P., Fahmy, R., Korsten, M., Pirola, R., Wilson, J., et al. Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis. Gut 50:4 (2002), 535–541.
56. Amann, S.T., Gates, L.K. Jr., Aston, C.E., Pandya, A., Bartness, M., Whitcomb, D.C., Expression and penetrance of the hereditary pancreatitis phenotype in monozygotic twins. Gut 48:4 (2001), 542–547.