Ferulic acid lowers body weight and visceral fat accumulation via modulation of enzymatic, hormonal and inflammatory changes in a mouse model of high-fat diet-induced obesity

Brazilian Journal of Medical and Biological Research

Volumn 50, Issue 1, 2017, Pages

  de Melo, T S ^a   Lima, P R ^b   Carvalho, K M M B ^b   Fontenele, T M ^a   Solon, F R N ^a   Tome A R ^c   de Lemos, T L G ^a   da Cruz Fonseca, S G ^a   Santos, F A ^b   Rao, V S ^b   de Queiroz, M G R ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b Federal University of Ceará   (Brazil)

^c STATE UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Anti obesity; Ferulic acid; High fat diet; Leptin; Lipase; Tumor necrosis factor

Indexed keywords

ACID LIPASE; ALANINE AMINOTRANSFERASE; AMYLASE; ASPARTATE AMINOTRANSFERASE; FERULIC ACID; GHRELIN; LEPTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; SIBUTRAMINE; TUMOR NECROSIS FACTOR; ANTIOBESITY AGENT; COUMARIC ACID; CYCLOBUTANE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HISTOLOGY; INSULIN BLOOD LEVEL; INTRAPERITONEAL FAT; LIPID PEROXIDATION; LIPID STORAGE; MALE; MOUSE; NONHUMAN; OBESITY; ADIPOSE TISSUE; ANIMAL; DISEASE MODEL; DRUG EFFECTS; INTRAABDOMINAL FAT; LIPID DIET; PATHOLOGY;

ADIPOSE TISSUE; ANIMALS; ANTI-OBESITY AGENTS; COUMARIC ACIDS; CYCLOBUTANES; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; INTRA-ABDOMINAL FAT; MALE; MICE; OBESITY;

EID: 85009775880     PISSN: None     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/1414-431X20165630     Document Type: Article

References (38)

1. Caveney E, Caveney BJ, Somaratne R, Turner JR, Gourgiotis L. Pharmaceutical interventions for obesity: a public health perspective. Diabetes Obes Metab 2011; 13: 490–497, doi: 10.1111/j.1463-1326.2010.01353.x.
2. Ohman MK, Wright AP, Wickenheiser KJ, Luo W, Eitzman DT. Visceral adipose tissue and atherosclerosis. Curr Vasc Pharmacol 2009; 7: 169–179, doi: 10.2174/157016109787455680.
3. Ling H, Lenz TL, Burns TL, Hilleman DE. Reducing the risk of obesity: defining the role of weight loss drugs. Pharmacotherapy 2013; 33: 1308–1321, doi: 10.1002/phar.1277.
4. Sumithran P, Proietto J. Benefit-risk assessment of orlistat in the treatment of obesity. Drug Saf 2014; 37: 597–608, doi: 10.1007/s40264-014-0210-7.
5. Cheng DM, Pogrebnyak N, Kuhn P, Poulev A, Waterman C, Rojas-Silva P, et al. Polyphenol-rich Rutgers Scarlet Lettuce improves glucose metabolism and liver lipid accumulation in diet-induced obese C57BL/6 mice. Nutrition 2014; 30: S52–S58, doi: 10.1016/j.nut.2014.02.022.
6. Alam MA, Subhan N, Hossain H, Hossain M, Reza HM, Rahman MM, et al. Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity. Nutr Metab 2016; 13: 27, doi: 10.1186/s12986-016-0080-3.
7. Zhao Z, Moghadasian MH. Chemistry, natural sources, dietary intake and pharmacokinetic properties of ferulic acid: A review. Food Chem 2008; 109: 691–702, doi: 10.1016/j.foodchem.2008.02.039.
8. Ardiansyah, Ohsaki Y, Shirakawa H, Koseki T, Komai M. Novel effects of a single administration of ferulic acid on the regulation of blood pressure and the hepatic lipid metabolic profile in stroke-prone spontaneously hypertensive rats. J Agric Food Chem 2008; 56: 2825–2830, doi: 10.1021/ jf072896y.
9. Srinivasan M, Sudheer AR, Menon VP. Ferulic acid: therapeutic potential through its antioxidant property. J Clin Biochem Nutr 2007; 40: 92–100, doi: 10.3164/jcbn.40.92.
10. Jung EH, Kim SR, Hwang IK, Ha TY. Hypoglycemic effects of a phenolic acid fraction of rice bran and ferulic acid in C57BL/KsJ-db/db mice. J Agric Food Chem 2007; 55: 9800–9804, doi: 10.1021/jf0714463.
11. Jin Son M, W Rico C, Hyun Nam S, Young Kang M. Influence of oryzanol and ferulic Acid on the lipid metabolism and antioxidative status in high fat-fed mice. J Clin Biochem Nutr 2010; 46: 150–156, doi: 10.3164/jcbn.09-98.
12. Ramar M, Manikandan B, Raman T, Priyadarsini A, Palanisamy S, Velayudam M, et al. Protective effect of ferulic acid and resveratrol against alloxan-induced diabetes in mice. Eur J Pharmacol 2012; 690: 226–235, doi: 10.1016/j.ejphar.2012.05.019.
13. Zhao Z, Egashira Y, Sanada H. Ferulic acid is quickly absorbed from rat stomach as the free form and then conjugated mainly in liver. J Nutr 2004; 134: 3083–3088.
14. Naowaboot J, Piyabhan P, Munkong N, Parklak W, Pannangpetch P. Ferulic acid improves lipid and glucose homeostasis in high-fat diet-induced obese mice. Clin Exp Pharmacol Physiol 2016; 43: 242–250, doi: 10.1111/1440-1681.12514.
15. Velloso LA, Araujo EP, de Souza CT. Diet-induced inflammation of the hypothalamus in obesity. Neuroimmunomodulation 2008; 15: 189–193, doi: 10.1159/000153423.
16. Das U, Manna K, Sinha M, Datta S, Das DK, Chakraborty A, et al. Role of ferulic acid in the amelioration of ionizing radiation induced inflammation: a murine model. PLoS One 2014; 9: e97599, doi: 10.1371/journal.pone.0097599.
17. Mancuso C, Santangelo R. Ferulic acid: pharmacological and toxicological aspects. Food Chem Toxicol 2014; 65: 185–195, doi: 10.1016/j.fct.2013.12.024.
18. Estadella D, Oyama LM, Damaso AR, Ribeiro EB, Oller Do Nascimento CM. Effect of palatable hyperlipidic diet on lipid metabolism of sedentary and exercised rats. Nutrition 2004; 20: 218–224, doi: 10.1016/j.nut.2003.10.008.
19. Carvalho KM, Marinho Filho JD, de Melo TS, Araujo AJ, Quetz JS, da Cunha MP, et al. The resin from protium heptaphyllum prevents high-fat diet-induced obesity in mice: scientific evidence and potential mechanisms. Evid Based Complement Alternat Med 2015; 2015: 106157, doi: 10.1155/2015/106157.
20. Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem 1968; 25: 192–205, doi: 10.1016/0003-2697(68)90092-4.
21. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95: 351–358, doi: 10.1016/0003-2697(79)90738-3.
22. Araujo JR, Martel F. Sibutramine effects on central mechanisms regulating energy homeostasis. Curr Neuropharmacol 2012; 10: 49–52, doi: 10.2174/157015912799362788.
23. Handjieva-Darlenska T, Boyadjieva N. The effect of high-fat diet on plasma ghrelin and leptin levels in rats. J Physiol Biochem 2009; 65: 157–164, doi: 10.1007/BF03179066.
24. Pan H, Guo J, Su Z. Advances in understanding the interrelations between leptin resistance and obesity. Physiol Behav 2014; 130: 157–169, doi: 10.1016/j.physbeh.2014.04.003.
25. Samaras K, Botelho NK, Chisholm DJ, Lord RV. Subcutaneous and visceral adipose tissue gene expression of serum adipokines that predict type 2 diabetes. Obesity 2010; 18: 884–889, doi: 10.1038/oby.2009.443.
26. Bremer AA, Jialal I. Adipose tissue dysfunction in nascent metabolic syndrome. J Obes 2013; 2013: 393192, doi: 10.1155/2013/393192.
27. Fisman EZ, Tenenbaum A. Adiponectin: a manifold therapeutic target for metabolic syndrome, diabetes, and coronary disease? Cardiovasc Diabetol 2014; 13: 103, doi: 10.1186/1475-2840-13-103.
28. Liang H, Yin B, Zhang H, Zhang S, Zeng Q, Wang J, et al. Blockade of tumor necrosis factor (TNF) receptor type 1-mediated TNF-alpha signaling protected Wistar rats from diet-induced obesity and insulin resistance. Endocrinology 2008; 149: 2943–2951, doi: 10.1210/en.2007-0978.
29. Baranowski M, Enns J, Blewett H, Yakandawala U, Zahradka P, Taylor CG. Dietary flaxseed oil reduces adipocyte size, adipose monocyte chemoattractant protein-1 levels and T-cell infiltration in obese, insulin-resistant rats. Cytokine 2012; 59: 382–391, doi: 10.1016/j.cyto.2012.04.004.
30. Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006; 17: 4–12.
31. Buchholz T, Melzig MF. Polyphenolic compounds as pancreatic lipase inhibitors. Planta Med 2015; 81: 771–783, doi: 10.1055/s-0035-1565716.
32. Kesh SB, Sikder K, Manna K, Das DK, Khan A, Das N, et al. Promising role of ferulic acid, atorvastatin and their combination in ameliorating high fat diet-induced stress in mice. Life Sci 2013; 92: 938–949, doi: 10.1016/j.lfs.2013.03.015.
33. Kim YJ, Choi MS, Park YB, Kim SR, Lee MK, Jung UJ. Garcinia Cambogia attenuates diet-induced adiposity but exacerbates hepatic collagen accumulation and inflammation. World J Gastroenterol 2013; 19: 4689–4701.
34. Oberholzer HM, Van Der Schoor C, Bester MJ. Sibutramine, a serotonin-norepinephrine reuptake inhibitor, causes fibrosis in rats. Environ Toxicol Pharmacol 2015; 40: 71–76. doi: 10.1016/j.etap.2015.05.011, doi: 10.1016/j.etap.2015.05.011.
35. Senaphan K, Kukongviriyapan U, Sangartit W, Pakdeechote P, Pannangpetch P, Prachaney P, et al. Ferulic acid alleviates changes in a rat model of metabolic syndrome induced by high-carbohydrate, high-fat diet. Nutrients 2015; 7: 6446–6464, doi: 10.3390/nu7085283.
36. Kamei T, Asano K, Nakamura S. Determination of serum glutamate oxaloacetate transaminase and glutamate pyruvate transaminase by using L-glutamate oxidase. Chem Pharm Bull 1986; 34: 409–412, doi: 10.1248/cpb.34.409.
37. Wang JM, Sheng YC, Ji LL, Wang ZT. Ferulic acid prevents liver injury and increases the anti-tumor effect of diosbulbin B in vivo. J Zhejiang Univ Sci B 2014; 15: 540–547, doi: 10.1631/jzus.B1300250.
38. Manikandan R, Beulaja M, Thiagarajan R, Pandi M, Arulvasu C, Prabhu NM, et al. Ameliorative effect of ferulic acid against renal injuries mediated by nuclear factorkappaB during glycerol-induced nephrotoxicity in Wistar rats. Ren Fail 2014; 36: 154–165, doi: 10.3109/0886022X.2013.835223.