Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response

Cell Chemical Biology

Volumn 24, Issue 2, 2017, Pages 182-194

  Sze, Kong Hung ^a,b   Lam, Wai Hei ^b,c   Zhang, Hongmin ^b,c,d   Ke, Yi hong ^a,b   Tse, Man Kit ^a,b   Woo, Patrick C Y ^a,b   Lau, Susanna K P ^a,b   Lau, Candy C Y ^a,b   Cai, Jian piao ^a,b   Tung, Edward T K ^a   Lo, Raymond K C ^a,b   Xu, Simin ^a,b   Kao, Richard Y T ^a,b   Hao, Quan ^b,c   Yuen, Kwok Yung ^a,b  

^a THE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c UNIVERSITY OF HONG KONG   (China)

^d SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

arachidonic acid; co immunoprecipitation; crystal structure; innate immune evasion; Mp1p LBD2; NMR interaction titration; Penicillium marneffei; proinflammatory signaling lipid; Talaromyces marneffei; virulence mechanism

Indexed keywords

INTERLEUKIN 6; LIPID; LIPOPOLYSACCHARIDE; MANNOPROTEIN; MP1P PROTEIN; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VIRULENCE FACTOR; ARACHIDONIC ACID; AUTACOID; FUNGUS ANTIGEN;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL CULTURE; CELL LYSATE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HYDROGEN BOND; HYDROPHOBICITY; IMMUNOPRECIPITATION; INNATE IMMUNITY; MACROPHAGE; METABOLITE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TARGETING; PROTON NUCLEAR MAGNETIC RESONANCE; TALAROMYCES MARNEFFEI; TANDEM MASS SPECTROMETRY; UPREGULATION; ANIMAL; CHEMISTRY; IMMUNOLOGY; INFLAMMATION; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; TALAROMYCES;

ANIMALS; ANTIGENS, FUNGAL; ARACHIDONIC ACID; CELLS, CULTURED; IMMUNITY, INNATE; INFLAMMATION; INFLAMMATION MEDIATORS; LIPIDS; MACROPHAGES; MICE; TALAROMYCES; VIRULENCE FACTORS;

EID: 85009759049     PISSN: 24519456     EISSN: 24519448     Source Type: Journal    
DOI: 10.1016/j.chembiol.2016.12.014     Document Type: Article

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