In vivo pharmacokinetic studies and intracellular delivery of methotrexate by means of glycine-tethered PLGA-based polymeric micelles

International Journal of Pharmaceutics

Volumn 519, Issue 1-2, 2017, Pages 138-144

  Madhwi, ^a   Kumar, Rajendra ^b   Kumar, Pramod ^a   Singh, Bhupinder ^b,c   Sharma, Gajanand ^c   Katare, Om Prakash ^c   Raza, Kaisar ^a  

^a CENTRAL UNIVERSITY OF RAJASTHAN   (India)

^b PANJAB UNIVERSITY   (India)

^c PANJAB UNIVERSITY   (India)

Author keywords

Bioavailability; Cytotoxicity; Drug delivery; Glycine; MDA MB 231 cells; Nanoparticles; Protein binding

Indexed keywords

GLYCINE; METHOTREXATE; NANOCARRIER; POLYGLACTIN; ANTINEOPLASTIC AGENT; DRUG CARRIER; LACTIC ACID; MICELLE; NANOPARTICLE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; POLYMER;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD PH; CONFOCAL LASER SCANNING MICROSCOPY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG PROTEIN BINDING; DRUG RELEASE; DRUG TRANSPORT; ELIMINATION HALF-LIFE; IC50; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; INTRACELLULAR TRANSPORT; NANOFABRICATION; NONHUMAN; PARTICLE SIZE; PHARMACOKINETIC PARAMETERS; POLYMERIZATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SURFACE CHARGE; WISTAR RAT; ZETA POTENTIAL; ANIMAL; BIOAVAILABILITY; CHEMISTRY; HALF LIFE TIME; HUMAN; MICELLE; PROCEDURES; SOLUBILITY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL AVAILABILITY; CELL LINE, TUMOR; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; GLYCINE; HALF-LIFE; HUMANS; LACTIC ACID; METHOTREXATE; MICELLES; NANOPARTICLES; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, WISTAR; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 85009732726     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2017.01.021     Document Type: Article

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