Enhanced Brain Delivery of Dimethyl Fumarate Employing Tocopherol-Acetate-Based Nanolipidic Carriers: Evidence from Pharmacokinetic, Biodistribution, and Cellular Uptake Studies

ACS Chemical Neuroscience

Volumn 8, Issue 4, 2017, Pages 860-865

  Kumar, Pramod ^a   Sharma, Gajanand ^b   Kumar, Rajendra ^c   Malik, Ruchi ^a   Singh, Bhupinder ^b,c   Katare, O P ^b   Raza, Kaisar ^a  

^a CENTRAL UNIVERSITY OF RAJASTHAN   (India)

^b PANJAB UNIVERSITY   (India)

^c PANJAB UNIVERSITY   (India)

Author keywords

Caco 2; confocal laser scanning microscopy; drug delivery; NLCs; SH SY5Y; SLNs; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; FUMARIC ACID DIMETHYL ESTER; NANOCARRIER; DRUG CARRIER; IMMUNOSUPPRESSIVE AGENT; LIPID; NANOMATERIAL;

AREA UNDER THE CURVE; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DISPERSITY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG TOLERANCE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; MAXIMUM PLASMA CONCENTRATION; MULTIPLE SCLEROSIS; PARTICLE SIZE; PERMEABILITY; PRIORITY JOURNAL; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; ANIMAL; BLOOD BRAIN BARRIER; BRAIN; CACO-2 CELL LINE; CAPILLARY PERMEABILITY; CHEMISTRY; CONFOCAL MICROSCOPY; DRUG EFFECTS; NERVE CELL; PROCEDURES; RAT; TISSUE DISTRIBUTION; WISTAR RAT;

ALPHA-TOCOPHEROL; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CACO-2 CELLS; CAPILLARY PERMEABILITY; DIMETHYL FUMARATE; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LIPIDS; MICROSCOPY, CONFOCAL; NANOSTRUCTURES; NEURONS; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 85018192914     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.6b00428     Document Type: Article

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