Elevated preoperative neutrophil-to-lymphocytes ratio predicts poor prognosis after esophagectomy in T1 esophageal cancer

International Journal of Clinical Oncology

Volumn 22, Issue 3, 2017, Pages 469-475

  Nakamura, Kenichi ^a   Yoshida, Naoya ^a   Baba, Yoshifumi ^a   Kosumi, Keisuke ^a   Uchihara, Tomoyuki ^a   Kiyozumi, Yuki ^a   Ohuchi, Mayuko ^a   Ishimoto, Takatsugu ^a   Iwatsuki, Masaaki ^a   Sakamoto, Yasuo ^a   Watanabe, Masayuki ^b   Baba, Hideo ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b CANCER INSTITUTE HOSPITAL   (Japan)

Author keywords

Neutrophil to lymphocyte ratio; Poor prognosis; Preoperative NLR; T1 esophageal cancer

Indexed keywords

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; DISEASE FREE SURVIVAL; ESOPHAGUS CANCER; ESOPHAGUS RESECTION; FEMALE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL LYMPHOCYTE RATIO; OVERALL SURVIVAL; PREDICTIVE VALUE; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEX DIFFERENCE; TUMOR INVASION; VASCULAR TUMOR; CLINICAL TRIAL; ESOPHAGEAL NEOPLASMS; KAPLAN MEIER METHOD; LYMPHOCYTE; LYMPHOCYTE COUNT; MIDDLE AGED; MORTALITY; NEUTROPHIL; PATHOLOGY; PREOPERATIVE PERIOD; PROGNOSIS; TREATMENT OUTCOME;

AGED; DISEASE-FREE SURVIVAL; ESOPHAGEAL NEOPLASMS; ESOPHAGECTOMY; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LYMPHOCYTE COUNT; LYMPHOCYTES; MALE; MIDDLE AGED; NEUTROPHILS; PREOPERATIVE PERIOD; PROGNOSIS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 85009727186     PISSN: 13419625     EISSN: 14377772     Source Type: Journal    
DOI: 10.1007/s10147-017-1090-5     Document Type: Article

References (47)

1. Enzinger PC, Mayer RJ (2003) Esophageal cancer. N Engl J Med 349(23):2241–2252
2. Allum WH, Stenning SP, Bancewicz J et al (2009) Long-term results of a randomized trial of surgery with or without preoperative chemotherapy in esophageal cancer. J Clin Oncol 27(30):5062–5067
3. Rizk NP, Ishwaran H, Rice TW et al (2010) Optimum lymphadenectomy for esophageal cancer. Ann Surg 251(1):46–50
4. Thallinger CM, Raderer M, Hejna M (2011) Esophageal cancer: a critical evaluation of systemic second-line therapy. J Clin Oncol 29(35):4709–4714
5. Dubecz A, Kern M, Solymosi N et al (2015) Predictors of lymph node metastasis in surgically resected T1 esophageal cancer. Ann Thorac Surg 99(6):1879–1885 (discussion 1886)
6. Baba Y, Murata A, Watanabe M et al (2014) Clinical implications of the LINE-1 methylation levels in patients with gastrointestinal cancer. Surg Today 44(10):1807–1816
7. Morita M, Otsu H, Kawano H et al (2014) Gender differences in prognosis after esophagectomy for esophageal cancer. Surg Today 44(3):505–512
8. Nakamura M, Iwahashi M, Nakamori M et al (2014) New prognostic score for the survival of patients with esophageal squamous cell carcinoma. Surg Today 44(5):875–883
9. Arima K, Okabe H, Hashimoto D et al (2016) The diagnostic role of the neutrophil-to-lymphocyte ratio in predicting pancreatic ductal adenocarcinoma in patients with pancreatic diseases. Int J Clin Oncol 21(5):940–945
10. Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow? Lancet 357(9255):539–545
11. Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420(6917):860–867
12. Proctor MJ, Morrison DS, Talwar D et al (2011) A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study. Eur J Cancer 47(17):2633–2641
13. Proctor MJ, Talwar D, Balmar SM et al (2010) The relationship between the presence and site of cancer, an inflammation-based prognostic score and biochemical parameters. Initial results of the Glasgow Inflammation Outcome Study. Br J Cancer 103(6):870–876
14. Gomez D, Morris-Stiff G, Toogood GJ et al (2008) Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma. J Surg Oncol 97(6):513–518
15. Zahorec R (2001) Ratio of neutrophil to lymphocyte counts—rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 102(1):5–14
16. Paramanathan A, Saxena A, Morris DL (2014) A systematic review and meta-analysis on the impact of pre-operative neutrophil lymphocyte ratio on long term outcomes after curative intent resection of solid tumours. Surg Oncol 23(1):31–39
17. Mano Y, Shirabe K, Yamashita Y et al (2013) Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival after hepatectomy for hepatocellular carcinoma: a retrospective analysis. Ann Surg 258(2):301–305
18. Kishi Y, Kopetz S, Chun YS et al (2009) Blood neutrophil-to-lymphocyte ratio predicts survival in patients with colorectal liver metastases treated with systemic chemotherapy. Ann Surg Oncol 16(3):614–622
19. Sugiura T, Uesaka K, Kanemoto H et al (2013) Elevated preoperative neutrophil-to-lymphocyte ratio as a predictor of survival after gastroenterostomy in patients with advanced pancreatic adenocarcinoma. Ann Surg Oncol 20(13):4330–4337
20. Zhang X, Zhang W, Feng LJ (2014) Prognostic significance of neutrophil lymphocyte ratio in patients with gastric cancer: a meta-analysis. PLoS ONE 9(11):e111906
21. Kosumi K, Baba Y, Ishimoto T et al (2016) Neutrophil/lymphocyte ratio predicts the prognosis in esophageal squamous cell carcinoma patients. Surg Today 46(4):405–413
22. Sharaiha RZ, Halazun KJ, Mirza F et al (2011) Elevated preoperative neutrophil:lymphocyte ratio as a predictor of postoperative disease recurrence in esophageal cancer. Ann Surg Oncol 18(12):3362–3369
23. Shimada H, Takiguchi N, Kainuma O et al (2010) High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer. Gastric Cancer 13(3):170–176
24. Rice TW, Blackstone EH, Rusch VW (2010) 7th edition of the AJCC cancer staging manual: esophagus and esophagogastric junction. Ann Surg Oncol 17(7):1721–1724
25. McShane LM, Altman DG, Sauerbrei W et al (2005) Reporting recommendations for tumor marker prognostic studies (REMARK). J Natl Cancer Inst 97(16):1180–1184
26. Kodama M, Kakegawa T (1998) Treatment of superficial cancer of the esophagus: a summary of responses to a questionnaire on superficial cancer of the esophagus in Japan. Surgery 123(4):432–439
27. Tanaka T, Matono S, Mori N et al (2014) T1 squamous cell carcinoma of the esophagus: long-term outcomes and prognostic factors after esophagectomy. Ann Surg Oncol 21(3):932–938
28. Schmidt H, Suciu S, Punt CJ et al (2007) Pretreatment levels of peripheral neutrophils and leukocytes as independent predictors of overall survival in patients with American Joint Committee on Cancer Stage IV Melanoma: results of the EORTC 18951 Biochemotherapy Trial. J Clin Oncol 25(12):1562–1569
29. Donskov F, Bennedsgaard KM, Hokland M et al (2004) Leukocyte orchestration in blood and tumour tissue following interleukin-2 based immunotherapy in metastatic renal cell carcinoma. Cancer Immunol Immunother 53(8):729–739
30. Teramukai S, Kitano T, Kishida Y et al (2009) Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: an analysis of Japan Multinational Trial Organisation LC00-03. Eur J Cancer 45(11):1950–1958
31. Riesco A (1970) Five-year cancer cure: relation to total amount of peripheral lymphocytes and neutrophils. Cancer 25(1):135–140
32. Atzpodien J, Royston P, Wandert T et al (2003) Metastatic renal carcinoma comprehensive prognostic system. Br J Cancer 88(3):348–353
33. Negrier S, Escudier B, Gomez F et al (2002) Prognostic factors of survival and rapid progression in 782 patients with metastatic renal carcinomas treated by cytokines: a report from the Groupe Francais d’Immunotherapie. Ann Oncol 13(9):1460–1468
34. Kitayama J, Yasuda K, Kawai K et al (2010) Circulating lymphocyte number has a positive association with tumor response in neoadjuvant chemoradiotherapy for advanced rectal cancer. Radiat Oncol 5:47
35. Clark EJ, Connor S, Taylor MA et al (2007) Preoperative lymphocyte count as a prognostic factor in resected pancreatic ductal adenocarcinoma. HPB (Oxford) 9(6):456–460
36. Suzuki S, Toyabe S, Moroda T et al (1997) Circadian rhythm of leucocytes and lymphocytes subsets and its possible correlation with the function of the autonomic nervous system. Clin Exp Immunol 110(3):500–508
37. Wang S, Zhang Z, Fang F et al (2011) The neutrophil/lymphocyte ratio is an independent prognostic indicator in patients with bone metastasis. Oncol Lett 2(4):735–740
38. Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140(6):883–899
39. Webb NJ, Myers CR, Watson CJ et al (1998) Activated human neutrophils express vascular endothelial growth factor (VEGF). Cytokine 10(4):254–257
40. Jablonska E, Puzewska W, Grabowska Z et al (2005) VEGF, IL-18 and NO production by neutrophils and their serum levels in patients with oral cavity cancer. Cytokine 30(3):93–99
41. Ardi VC, Kupriyanova TA, Deryugina EI et al (2007) Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis. Proc Natl Acad Sci USA 104(51):20262–20267
42. Petrie HT, Klassen LW, Kay HD (1985) Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes. J Immunol 134(1):230–234
43. el-Hag A, Clark RA (1987) Immunosuppression by activated human neutrophils. Dependence on the myeloperoxidase system. J Immunol 139(7):2406–2413
44. Shau HY, Kim A (1988) Suppression of lymphokine-activated killer induction by neutrophils. J Immunol 141(12):4395–4402
45. Kay HD, Smith DL (1983) Regulation of human lymphocyte-mediated natural killer (NK) cell activity. I. Inhibition in vitro by peripheral blood granulocytes. J Immunol 130(1):475–483
46. McMillan DC (2009) Systemic inflammation, nutritional status and survival in patients with cancer. Curr Opin Clin Nutr Metab Care 12(3):223–226
47. Dou X, Wang RB, Yan HJ et al (2013) Circulating lymphocytes as predictors of sensitivity to preoperative chemoradiotherapy in rectal cancer cases. Asian Pac J Cancer Prev 14(6):3881–3885