Early life peripheral lipopolysaccharide challenge reprograms catecholaminergic neurons

Scientific Reports

Volumn 7, Issue , 2017, Pages

  Ong, Lin Kooi ^a   Fuller, Erin A ^a   Sominsky, Luba ^a,b   Hodgson, Deborah M ^a   Dunkley, Peter R ^a   Dickson, Phillip W ^a  

^a HUNTER MEDICAL RESEARCH INSTITUTE   (Australia)

^b RMIT UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN BINDING PROTEIN; AIF1 PROTEIN, RAT; CALCIUM BINDING PROTEIN; CATECHOLAMINE; GLIAL FIBRILLARY ACIDIC PROTEIN; LIPOPOLYSACCHARIDE; TYROSINE 3 MONOOXYGENASE;

ANIMAL; DRUG EFFECT; LOCUS CERULEUS; METABOLISM; NERVE CELL; NEWBORN; PHOSPHORYLATION; SUBSTANTIA NIGRA; VENTRAL TEGMENTUM; WISTAR RAT;

ANIMALS; ANIMALS, NEWBORN; CALCIUM-BINDING PROTEINS; CATECHOLAMINES; GLIAL FIBRILLARY ACIDIC PROTEIN; LIPOPOLYSACCHARIDES; LOCUS COERULEUS; MICROFILAMENT PROTEINS; NEURONS; PHOSPHORYLATION; RATS, WISTAR; SUBSTANTIA NIGRA; TYROSINE 3-MONOOXYGENASE; VENTRAL TEGMENTAL AREA;

EID: 85009083356     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep40475     Document Type: Article

References (34)

1. Schwarz, J. M. & Bilbo, S. D. The Immune System and the Developing Brain. Colloquium Series on The Developing Brain 2, 1-128, doi: 10.4199/C00045ED1V01Y201110DBR004 (2011).
2. Walker, F. R., March, J. & Hodgson, D. M. Endotoxin exposure in early life alters the development of anxiety-like behaviour in the Fischer 344 rat. Behav Brain Res 154, 63-69, doi: 10.1016/j.bbr.2004.01.019 (2004).
3. Walker, A. K., Hiles, S. A., Sominsky, L., McLaughlin, E. A. & Hodgson, D. M. Neonatal lipopolysaccharide exposure impairs sexual development and reproductive success in the Wistar rat. Brain Behav Immun 25, 674-684, doi: 10.1016/j.bbi.2011.01.004 (2011).
4. Hodgson, D. M., Knott, B. & Walker, F. R. Neonatal endotoxin exposure influences HPA responsivity and impairs tumor immunity in Fischer 344 rats in adulthood. Pediatr Res 50, 750-755, doi: 10.1203/00006450-200112000-00020 (2001).
5. Shanks, N., Larocque, S. & Meaney, M. J. Neonatal endotoxin exposure alters the development of the hypothalamic-pituitaryadrenal axis: early illness and later responsivity to stress. J Neurosci 15, 376-384 (1995).
6. Shanks, N. et al. Early-life exposure to endotoxin alters hypothalamic-pituitary-adrenal function and predisposition to inflammation. Proc Natl Acad Sci USA 97, 5645-5650, doi: 10.1073/pnas.090571897 (2000).
7. Sominsky, L. et al. Functional programming of the autonomic nervous system by early life immune exposure: implications for anxiety. PLoS One 8, e57700, doi: 10.1371/journal.pone.0057700 (2013).
8. Karrow, N. A. Activation of the hypothalamic-pituitary-adrenal axis and autonomic nervous system during inflammation and altered programming of the neuroendocrine-immune axis during fetal and neonatal development: lessons learned from the model inflammagen, lipopolysaccharide. Brain Behav Immun 20, 144-158, doi: 10.1016/j.bbi.2005.05.003 (2006).
9. Dickson, P. W. & Briggs, G. D. Tyrosine hydroxylase: regulation by feedback inhibition and phosphorylation. Advances in pharmacology 68, 13-21, doi: 10.1016/B978-0-12-411512-5.00002-6 (2013).
10. Dunkley, P. R., Bobrovskaya, L., Graham, M. E., Nagy-Felsobuki, E. I. & Dickson, P. W. Tyrosine hydroxylase phosphorylation: regulation and consequences. Journal of Neurochemistry 91, 1025-1043 (2004).
11. Ong, L. K., Sominsky, L., Dickson, P. W., Hodgson, D. M. & Dunkley, P. R. The sustained phase of tyrosine hydroxylase activation in vivo. Neurochem Res 37, 1938-1943, doi: 10.1007/s11064-012-0812-3 (2012).
12. Sominsky, L. et al. Increased microglial activation in the rat brain following neonatal exposure to a bacterial mimetic. Behav Brain Res 226, 351-356, doi: 10.1016/j.bbr.2011.08.038 (2012).
13. Dunn, A. J. Endotoxin-induced activation of cerebral catecholamine and serotonin metabolism: comparison with interleukin-1. J Pharmacol Exp Ther 261, 964-969 (1992).
14. Eng, L. F., Ghirnikar, R. S. & Lee, Y. L. Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem Res 25, 1439-1451 (2000).
15. Imai, Y. & Kohsaka, S. Intracellular signaling in M-CSF-induced microglia activation: role of Iba1. Glia 40, 164-174, doi: 10.1002/ glia.10149 (2002).
16. Cai, Z. et al. Neonatal systemic exposure to lipopolysaccharide enhances susceptibility of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later life. Dev Neurosci 35, 155-171, doi: 10.1159/000346156 (2013).
17. Qin, L. et al. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 55, 453-462, doi: 10.1002/ glia.20467 (2007).
18. Sarkar, C., Basu, B., Chakroborty, D., Dasgupta, P. S. & Basu, S. The immunoregulatory role of dopamine: an update. Brain Behav Immun 24, 525-528, doi: 10.1016/j.bbi.2009.10.015 (2010).
19. Bilbo, S. D. & Schwarz, J. M. Early-life programming of later-life brain and behavior: a critical role for the immune system. Front Behav Neurosci 3, 14, doi: 10.3389/neuro.08.014.2009 (2009).
20. Walker, F. R., Nilsson, M. & Jones, K. Acute and chronic stress-induced disturbances of microglial plasticity, phenotype and function. Curr Drug Targets 14, 1262-1276 (2013).
21. Zavitsanou, K. et al. Neonatal lipopolysaccharide treatment has long term effects on monoaminergic and cannabinoid receptors in the rat. Synapse, doi: 10.1002/syn.21640 (2013).
22. Damanhuri, H. A. et al. Tyrosine hydroxylase phosphorylation in catecholaminergic brain regions: a marker of activation following acute hypotension and glucoprivation. PLoS One 7, e50535, doi: 10.1371/journal.pone.0050535 (2012).
23. Ong, L. K. et al. Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla. J Neurochem 128, 547-560, doi: 10.1111/jnc.12482 (2014).
24. Salvatore, M. F. ser31 Tyrosine hydroxylase phosphorylation parallels differences in dopamine recovery in nigrostriatal pathway following 6-OHDA lesion. J Neurochem 129, 548-558, doi: 10.1111/jnc.12652 (2014).
25. Salvatore, M. F. & Pruett, B. S. Dichotomy of tyrosine hydroxylase and dopamine regulation between somatodendritic and terminal field areas of nigrostriatal and mesoaccumbens pathways. PLoS One 7, e29867, doi: 10.1371/journal.pone.0029867 (2012).
26. Salvatore, M. F., Pruett, B. S., Spann, S. L. & Dempsey, C. Aging reveals a role for nigral tyrosine hydroxylase ser31 phosphorylation in locomotor activity generation. PLoS One 4, e8466, doi: 10.1371/journal.pone.0008466 (2009).
27. Daubner, S. C., Le, T. & Wang, S. Tyrosine hydroxylase and regulation of dopamine synthesis. Arch Biochem Biophys 508, 1-12, doi: 10.1016/j.abb.2010.12.017 (2011).
28. Sofroniew, M. V. & Vinters, H. V. Astrocytes: biology and pathology. Acta Neuropathol 119, 7-35, doi: 10.1007/s00401-009-0619-8 (2010).
29. Ong, L. K. et al. The effect of social defeat on tyrosine hydroxylase phosphorylation in the rat brain and adrenal gland. Neurochem Res 36, 27-33, doi: 10.1007/s11064-010-0255-7 (2011).
30. Ong, L. K. et al. The effects of footshock and immobilization stress on tyrosine hydroxylase phosphorylation in the rat locus coeruleus and adrenal gland. Neuroscience 192, 20-27, doi: 10.1016/j.neuroscience.2011.06.087 (2011).
31. Hebert, M. A., Serova, L. I. & Sabban, E. L. Single and repeated immobilization stress differentially trigger induction and phosphorylation of several transcription factors and mitogen-activated protein kinases in the rat locus coeruleus. J Neurochem 95, 484-498, doi: 10.1111/j.1471-4159.2005.03386.x (2005).
32. Sara, S. J. The locus coeruleus and noradrenergic modulation of cognition. Nat Rev Neurosci 10, 211-223, doi: 10.1038/nrn2573 (2009).
33. Pavlov, V. A. & Tracey, K. J. Neural regulators of innate immune responses and inflammation. Cell Mol Life Sci 61, 2322-2331, doi: 10.1007/s00018-004-4102-3 (2004).
34. Gordon, S. L., Bobrovskaya, L., Dunkley, P. R. & Dickson, P. W. Differential regulation of human tyrosine hydroxylase isoforms 1 and 2 in situ: Isoform 2 is not phosphorylated at Ser35. Biochimica et biophysica acta 1793, 1860-1867, doi: 10.1016/j.bbamcr.2009.10.001 (2009).