MicroRNA profiling reveals a role for MicroRNA-218-5p in the pathogenesis of chronic obstructive pulmonary disease

American Journal of Respiratory and Critical Care Medicine

Volumn 195, Issue 1, 2017, Pages 43-56

  Conickx, Griet ^a   Mestdagh, Pieter ^a   Cobos, Francisco Avila ^a   Verhamme, Fien M ^a   Maes, Tania ^a   Vanaudenaerde, Bart M ^b   Seys, Leen J M ^a   Lahousse, Lies ^a   Kim, Richard Y ^c   Hsu, Alan C ^c   Wark, Peter A ^c,d   Hansbro, Philip M ^c   Joos, Guy F ^a   Vandesompele, Jo ^a   Bracke, Ken R ^a   Brusselle, Guy G ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITY OF NEWCASTLE   (Australia)

^d JOHN HUNTER HOSPITAL   (Australia)

Author keywords

Chronic obstructive pulmonary disease; Lung; microRNA; microRNA 218

Indexed keywords

CIGARETTE SMOKE; CORTICOSTEROID; MESSENGER RNA; MICRORNA; MICRORNA 218 5P; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; MIRN218 MICRORNA, HUMAN;

ADULT; AGED; AIRFLOW; AIRWAY OBSTRUCTION; ANIMAL MODEL; ARTICLE; BRONCHUS BIOPSY; BRONCHUS MUCOSA; CELLULAR DISTRIBUTION; CHRONIC OBSTRUCTIVE LUNG DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DOWN REGULATION; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE SET ENRICHMENT ANALYSIS; GENETIC ANALYSIS; HIGH THROUGHPUT SCREENING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LUNG; LUNG CANCER; LUNG PARENCHYMA; LUNG RESECTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MICROARRAY; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; SMOKING; ANIMAL; BRONCHUS; CASE CONTROL STUDY; DNA MICROARRAY; GENETICS; METABOLISM; PHYSIOLOGY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY MUCOSA;

ADULT; AGED; ANIMALS; BRONCHI; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION PROFILING; HUMANS; LUNG; MALE; MICE; MICRORNAS; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY MUCOSA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 85008694230     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201506-1182OC     Document Type: Article

References (42)

1. Hogg JC, Timens W. The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol 2009;4:435-459.
2. Sin DD, Anthonisen NR, Soriano JB, Agusti AG. Mortality in COPD: role of comorbidities. Eur Respir J 2006;28:1245-1257.
3. Mannino DM, Buist AS. Global burden of COPD: risk factors, prevalence, and future trends. Lancet 2007;370:765-773.
4. Ning W, Li CJ, Kaminski N, Feghali-Bostwick CA, Alber SM, Di YP, Otterbein SL, Song R, Hayashi S, Zhou Z, et al. Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc Natl Acad Sci USA 2004; 101:14895-14900.
5. Wang IM, Stepaniants S, Boie Y, Mortimer JR, Kennedy B, Elliott M, Hayashi S, Loy L, Coulter S, Cervino S, et al. Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer. Am J Respir Crit Care Med 2008;177:402-411.
6. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116:281-297.
7. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009;136:215-233.
8. Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009;19: 92-105.
9. Van Pottelberge GR, Mestdagh P, Bracke KR, Thas O, van Durme YMTA, Joos GF, Vandesompele J, Brusselle GG. MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2011;183: 898-906.
10. Schembri F, Sridhar S, Perdomo C, Gustafson AM, Zhang X, Ergun A, Lu J, Liu G, Zhang X, Bowers J, et al. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci USA 2009;106: 2319-2324.
11. Ezzie ME, Crawford M, Cho JH, Orellana R, Zhang S, Gelinas R, Batte K, Yu L, Nuovo G, Galas D, et al. Gene expression networks in COPD: microRNA and mRNA regulation. Thorax 2012;67:122-131.
12. Conickx G, Bracke KR, Mestdagh P, Joos GF, Vandesompele J, Brusselle GG. Expression of microRNA-218 is reduced in cigarette smoke-exposed mice and in patients with chronic obstructive pulmonary disease [abstract]. Am J Respir Crit Care Med 2014;189: A5576.
13. D'hulst AI, Vermaelen KY, Brusselle GG, Joos GF, Pauwels RA. Time course of cigarette smoke-induced pulmonary inflammation in mice. Eur Respir J 2005;26:204-213.
14. Verhamme FM, Bracke KR, Amatngalim GD, Verleden GM, Van Pottelberge GR, Hiemstra PS, Joos GF, Brusselle GG. Role of activin-A in cigarette smoke-induced inflammation and COPD. Eur Respir J 2014;43:1028-1041.
15. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005; 102:15545-15550.
16. Mestdagh P, Feys T, Bernard N, Guenther S, Chen C, Speleman F, Vandesompele J. High-throughput stem-loop RT-qPCR miRNA expression profiling using minute amounts of input RNA. Nucleic Acids Res 2008;36:e143.
17. Wang G, Wang R, Strulovici-Barel Y, Salit J, Staudt MR, Ahmed J, Tilley AE, Yee-Levin J, Hollmann C, Harvey BG, et al. Persistence of smoking-induced dysregulation of miRNA expression in the small airway epithelium despite smoking cessation. PLoS One 2015;10: e0120824.
18. Molina-Pinelo S, Pastor MD, Suarez R, Romero-Romero B, Gonzalez De la Peña M, Salinas A, García-Carbonero R, De Miguel MJ, Rodríguez-Panadero F, Carnero A, et al. MicroRNA clusters: dysregulation in lung adenocarcinoma and COPD. EurRespirJ 2014; 43:1740-1749.
19. Mestdagh P, Lefever S, Pattyn F, Ridzon D, Fredlund E, Fieuw A, Ongenaert M, Vermeulen J, De Paepe A, Wong L, et al. The microRNA body map: dissecting microRNA function through integrative genomics. Nucleic Acids Res 2011;39:e136.
20. Demedts IK, Bracke KR, Van Pottelberge G, Testelmans D, Verleden GM, Vermassen FE, Joos GF, Brusselle GG. Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007;175:998-1005.
21. Nadigel J, Audusseau S, Baglole CJ, Eidelman DH, Hamid Q. IL-8 production in response to cigarette smoke is decreased in epithelial cells from COPD patients. Pulm Pharmacol Ther 2013;26:596-602.
22. Zhang X, Zheng H, Zhang H, Ma W, Wang F, Liu C, He S. Increased interleukin (IL)-8 and decreased IL-17 production in chronic obstructive pulmonary disease (COPD) provoked by cigarette smoke. Cytokine 2011;56:717-725.
23. Traves SL, Culpitt SV, Russell RE, Barnes PJ, Donnelly LE. Increased levels of the chemokines GROalpha and MCP-1 in sputum samples from patients with COPD. Thorax 2002;57:590-595.
24. Davidson MR, Larsen JE, Yang IA, Hayward NK, Clarke BE, Duhig EE, Passmore LH, Bowman RV, Fong KM. MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma. PLoS One 2010;5: e12560.
25. Baskerville S, Bartel DP. Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA 2005;11:241-247.
26. Izzotti A, Calin GA, Arrigo P, Steele VE, Croce CM, De Flora S. Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke. FASEB J 2009;23:806-812.
27. Izzotti A, Calin GA, Steele VE, Croce CM, De Flora S. Relationships of microRNA expression in mouse lung with age and exposure to cigarette smoke and light. FASEB J 2009;23:3243-3250.
28. Barnes PJ. The cytokine network in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2009;41:631-638.
29. Wang H, Morse HC III. IRF8 regulates myeloid and B lymphoid lineage diversification. Immunol Res 2009;43:109-117.
30. Tamura T, Kurotaki D, Koizumi S. Regulation of myelopoiesis by the transcription factor IRF8. Int J Hematol 2015;101:342-351.
31. Hausser J, Zavolan M. Identification and consequences of miRNA-target interactions: beyond repression of gene expression. Nat Rev Genet 2014;15:599-612.
32. Osella M, Bosia C, Cora D, Caselle M. The role of incoherent microRNA-mediated feedforward loops in noise buffering. PLOS Comput Biol 2011;7:e1001101.
33. Pilewski JM, Liu L, Henry AC, Knauer AV, Feghali-Bostwick CA. Insulin like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition. Am J Pathol 2005;166:399-407.
34. Veraldi KL, Gibson BT, Yasuoka H, Myerburg MM, Kelly EA, Balzar S, Jarjour NN, Pilewski JM, Wenzel SE, Feghali-Bostwick CA. Role of insulin-like growth factor binding protein-3 in allergic airway remodeling. Am J Respir Crit Care Med 2009;180:611-617.
35. Schnapp LM, Donohoe S, Chen J, Sunde DA, Kelly PM, Ruzinski J, Martin T, Goodlett DR. Mining the acute respiratory distress syndrome proteome: identification of the insulin-like growth factor (IGF)/IGF-binding protein-3 pathway in acute lung injury. Am J Pathol 2006;169:86-95.
36. Halappanavar S, Russell M, Stampfli MR, Williams A, Yauk CL. Induction of the interleukin 6/signal transducer and activator of transcription pathway in the lungs of mice sub-chronically exposed to mainstream tobacco smoke. BMC Med Genomics 2009;2:56.
37. Kang CB, Hong Y, Dhe-Paganon S, Yoon HS. FKBP family proteins: immunophilins with versatile biological functions. Neurosignals 2008; 16:318-325.
38. Nath PR, Isakov N. Insights into peptidyl-prolyl cis-trans isomerase structure and function in immunocytes. Immunol Lett 2015;163: 120-131.
39. Kucharska A, Rushworth LK, Staples C, Morrice NA, Keyse SM. Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK. Cell Signal 2009;21:1794-1805.
40. Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, et al. A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. Am J Respir Crit Care Med 2013;187: 933-942.
41. Mestdagh P, Hartmann N, Baeriswyl L, Andreasen D, Bernard N, Chen C, Cheo D, D'Andrade P, DeMayo M, Dennis L, et al. Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study. Nat Methods 2014;11:809-815.
42. Wang J, Li Z, Ge Q, Wu W, Zhu Q, Luo J, Chen L. Characterization of microRNA transcriptome in tumor, adjacent, and normal tissues of lung squamous cell carcinoma. J Thorac Cardiovasc Surg 2015;149:1404-14.e4.