Randomized Evidence for Reduction of Perioperative Mortality: An Updated Consensus Process

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 31, Issue 2, 2017, Pages 719-730

  Landoni, Giovanni ^a,b   Pisano, Antonio ^c   Lomivorotov, Vladimir ^d   Alvaro, Gabriele ^e   Hajjar, Ludhmila ^f   Paternoster, Gianluca ^g   Nigro Neto, Caetano ^h   Latronico, Nicola ⁱ   Fominskiy, Evgeny ^a,d   Pasin, Laura ^a   Finco, Gabriele ^j   Lobreglio, Rosetta ^k   Azzolini, Maria Luisa ^a   Buscaglia, Giuseppe ^l   Castella, Alberto ^a   Comis, Marco ^m   Conte, Adele ^c   Conte, Massimiliano ⁿ   Corradi, Francesco ^o   Dal Checco, Erika ^p   De Vuono, Giovanni ^e   Ganzaroli, Marco ^m   Garofalo, Eugenio ^e   Gazivoda, Gordana ^q   Lembo, Rosalba ^a   Marianello, Daniele ^r   Baiardo Redaelli, Martina ^a   Monaco, Fabrizio ^a   Tarzia, Valentina ^a   Mucchetti, Marta ^a   Belletti, Alessandro ^a   Mura, Paolo ^j   Musu, Mario ^k   Pala, Giovanni ^s   Paltenghi, Massimiliano ⁱ   Pasyuga, Vadim ^t   Piras, Desiderio ^j   Riefolo, Claudio ^a   Roasio, Agostino ^u   Ruggeri, Laura ^a   Santini, Francesco ^l   Székely, Andrea ^v   Verniero, Luigi ^c   Vezzani, Antonella ^w   Zangrillo, Alberto ^a,b   Bellomo, Rinaldo ^x   more..

^a SAN RAFFAELE HOSPITAL   (Italy)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^c MONALDI HOSPITAL   (Italy)

^d MESHALKIN NATIONAL MEDICAL RESEARCH CENTER   (Russian Federation)

^e Azienda Ospedaliera Universitaria Mater Domini   (Italy)

^f UNIVERSITY OF SÃO PAULO   (Brazil)

^g SAN CARLO HOSPITAL   (Italy)

^h INSTITUTO DANTE PAZZANESE DE CARDIOLOGIA   (Brazil)

ⁱ SPEDALI CIVILI   (Italy)

^j DEPARTMENT OF RADIOLOGY   (Italy)

^k UNIVERSITY OF TURIN   (Italy)

^l UNIVERSITY OF GENOA   (Italy)

^m MAURIZIANO HOSPITAL   (Italy)

ⁿ MATER DEI HOSPITAL   (Italy)

^o GALLIERA HOSPITAL   (Italy)

^p UNIVERSITY OF BOLOGNA   (Italy)

^q Institute of Cardiovascular Disease Dedinje   (Serbia)

^r UNIVERSITY OF SIENA   (Italy)

^s SS Annunziata Hospital   (Italy)

^t Federal Centre for Cardiac Surgery   (Russian Federation)

^u Department of Medical Oncology   (Italy)

^v SEMMELWEIS UNIVERSITY   (Hungary)

^w UNIVERSITY HOSPITAL OF PARMA   (Italy)

^x AUSTIN HOSPITAL   (Australia)

more..

Author keywords

anesthesia; consensus; intensive care; mortality; perioperative care

Indexed keywords

APROTININ; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; LEVOSIMENDAN; TRANEXAMIC ACID; VOLATILE AGENT;

ANESTHESIA INDUCTION; CLINICAL PRACTICE; CONSENSUS; CONSERVATIVE TREATMENT; ERYTHROCYTE TRANSFUSION; EVIDENCE BASED PRACTICE; GASTROINTESTINAL TRACT; GLYCEMIC CONTROL; HEALTH SURVEY; HEMODYNAMIC PARAMETERS; HUMAN; INSULIN TREATMENT; INTRAAORTIC BALLOON PUMP; ISCHEMIC PRECONDITIONING; META ANALYSIS (TOPIC); MORTALITY RATE; NONINVASIVE VENTILATION; PERIOPERATIVE PERIOD; PRACTICE GUIDELINE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SURGICAL MORTALITY; SYSTEMATIC REVIEW; WEB BROWSER; MORTALITY; ORGANIZATION; POSTOPERATIVE COMPLICATION; PROCEDURES;

CONGRESSES AS TOPIC; CONSENSUS; HUMANS; PERIOPERATIVE CARE; POSTOPERATIVE COMPLICATIONS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 85008689675     PISSN: 10530770     EISSN: 15328422     Source Type: Journal    
DOI: 10.1053/j.jvca.2016.07.017     Document Type: Review

References (74)

1. 1 Pearse, R.M., Moreno, R.P., Bauer, P., et al. European Surgical Outcomes Study (EuSOS) group for the trials groups of the European Society of Intensive Care Medicine and the European Society of Anaesthesiology: Mortality after surgery in Europe: A 7 day cohort study. Lancet 380 (2012), 1059–1065.
2. 2 Devereaux, P.J., Xavier, D., Pogue, J., et al. Characteristics and short-term prognosis of perioperative myocardial infarction in patients undergoing noncardiac surgery: A cohort study. Ann Intern Med 154 (2011), 523–528.
3. 3 Weiser, T.G., Regenbogen, S.E., Thompson, K.D., et al. An estimation of the global volume of surgery: A modelling strategy based on available data. Lancet 372 (2008), 139–144.
4. 4 Landoni, G., Augoustides, J.G., Guarracino, F., et al. Mortality reduction in cardiac anaesthesia and intensive care: Results of the first International Consensus Conference. Acta Anaesthesiol Scand 55 (2011), 259–266.
5. 5 Landoni, G., Rodseth, R.N., Santini, F., et al. Randomised evidence for reduction of perioperative mortality. J Cardiothorac Vasc Anesth 26 (2012), 764–772.
6. 6 Landoni, G., Bove, T., Székely, A., et al. Reducing mortality in acute kidney injury patients: Systematic review and international web-based survey. J Cardiothorac Vasc Anesth 27 (2013), 1384–1398.
7. 7 Landoni, G., Comis, M., Conte, M., et al. Mortality in multicenter critical care trials: An analysis of interventions with a significant effect. Crit Care Med 43 (2015), 1559–1568.
8. 8 Pisano, A., Landoni, G., Lomivorotov, V., et al. Worldwide opinion on multicenter randomized interventions showing mortality reduction in critically ill patients: A democracy-based medicine approach. J Cardiothorac Vasc Anesth 43 (2015), 1559–1568.
9. 9 Van, Es. J.C., Lawrence, D.P., Morgan, G.W., et al. Don't know responses in environmental surveys. J Environ Educ 27 (1996), 13–18.
10. 10 Cecconi, M., Corredor, C., Arulkumaran, N., et al. Clinical review: Goal-directed therapy-what is the evidence in surgical patients? The effect on different risk groups. Crit Care, 17, 2013, 209.
11. 11 Gurgel, S.T., do Nascimento, P. Jr, Maintaining tissue perfusion in high-risk surgical patients: A systematic review of randomised clinical trials. Anesth Analg 112 (2011), 1384–1391.
12. 12 Hamilton, M.A., Cecconi, M., Rhodes, A., A systematic review and meta-analysis on the use of preemptive haemodynamic intervention to improve postoperative outcomes in moderate and high-risk surgical patients. Anesth Analg 112 (2011), 1392–1402.
13. 13 Brienza, N., Giglio, M.T., Marucci, M., et al. Does perioperative hemodynamic optimization protect renal function in surgical patients? A meta-analytic study. Crit Care Med 37 (2009), 2079–2090.
14. 14 Poeze, M., Greve, J.W., Ramsay, G., Meta-analysis of hemodynamic optimization: Relationship to methodological quality. Crit Care 9 (2005), R771–R779.
15. 15 Giakoumidakis, K., Eltheni, R., Patelarou, E., et al. Effects of intensive glycemic control on outcomes of cardiac surgery. Heart Lung 42 (2013), 146–151.
16. 16 Haga, K.K., McClymont, K.L., Clarke, S., et al. The effect of tight glycaemic control, during and after cardiac surgery, on patient mortality and morbidity: A systematic review and meta-analysis. J Cardiothorac Surg, 6, 2011, 3.
17. 17 Van den Berghe, G., Wouters, P., Weekers, F., et al. Intensive insulin therapy in critically ill patients. N Engl J Med 345 (2011), 1359–1367.
18. 18 Zhu, G.F., Wang, D.J., Liu, S., et al. Efficacy and safety of non invasive positive pressure ventilation in the treatment of acute respiratory failure after cardiac surgery. Chin Med J 126 (2013), 4463–4469.
19. 19 Auriant, I., Jallot, A., Hervé, P., et al. Non invasive ventilation reduces mortality in acute respiratory failure following lung resection. Am J Respir Crit Care Med 164 (2001), 1231–1235.
20. 20 Antonelli, M., Conti, G., Bufi, M., et al. Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: A randomized trial. JAMA 283 (2000), 235–241.
21. 21 Harrison, R.W., Hasselblad, V., Mehta, R.H., et al. Effect of levosimendan on survival and adverse events after cardiac surgery: A meta-analysis. J Cardiothorac Vasc Anesth 27 (2013), 1224–1232.
22. 22 Landoni, G., Biondi-Zoccai, G., Greco, M., et al. Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomised controlled studies. Crit Care Med 40 (2012), 634–646.
23. 23 Maharaj, R., Metaxa, V., Levosimendan and mortality after coronary revascularization: A meta-analysis of randomized controlled trials. Crit Care, 15, 2011, R140.
24. 24 Landoni, G., Mizzi, A., Biondi-Zoccai, G., et al. Reducing mortality in cardiac surgery with levosimendan: A meta-analysis of randomised controlled trials. J Cardiothorac Vasc Anesth 24 (2010), 51–57.
25. 25 Levin, R.L., Degrange, M.A., Porcile, R., et al. The calcium sensitizer levosimendan gives superior results to dobutamine in postoperative low cardiac output syndrome. Rev Esp Cardiol 61 (2008), 471–479.
26. 26 Bilgin, Y.M., Van de Watering, L.M., Eijsman, L., et al. Double-blind, randomised controlled trial on the effect of leukocyte-depleted erythrocyte transfusions in cardiac valve surgery. Circulation 109 (2004), 2755–2760.
27. 27 Van de Watering, L.M., Hermans, J., Houbiers, J.G., et al. Beneficial effects of leukocyte depletion of transfused blood on postoperative complications in patients undergoing cardiac surgery: A randomised clinical trial. Circulation 97 (1998), 562–568.
28. 28 Zangrillo, A., Pappalardo, F., Dossi, R., et al. Preoperative intra-aortic balloon pump to reduce mortality in coronary artery bypass graft: A meta-analysis of randomized controlled trials. Crit Care, 19, 2015, 10.
29. 29 Sá, M.P., Ferraz, P.E., Escobar, R.R., et al. Prophylactic intra-aortic balloon pump in high-risk patients undergoing coronary artery bypass surgery: A meta-analysis of randomised controlled trials. Coron Artery Dis 23 (2012), 480–486.
30. 30 Theologou, T., Bashir, M., Rengarajan, A., et al. Preoperative intra aortic balloon pumps in patients undergoing coronary artery bypass grafting. Cochrane Database Syst Rev, 19, 2011, CD004472.
31. 31 Qiu, Z., Chen, X., Xu, M., et al. Evaluation of preoperative intra-aortic balloon pump in coronary patients with severe left ventricular dysfunction undergoing OPCAB surgery: Early and mid-term outcomes. J Cardiothorac Surg, 4, 2009, 39.
32. 32 Dyub, A.M., Whitlock, R.P., Abouzahr, L.L., et al. Preoperative intra-aortic balloon pump in patients undergoing coronary bypass surgery: A systematic review and meta-analysis. J Card Surg 23 (2008), 79–86.
33. 33 Landoni, G., Greco, T., Biondi-Zoccai, G., et al. Anaesthetic drugs and survival: A Bayesian network meta-analysis of randomised trials in cardiac surgery. Br J Anaesth 111 (2013), 886–896.
34. 34 Landoni, G., Biondi-Zoccai, G.G., Zangrillo, A., et al. Desflurane and sevoflurane in cardiac surgery: A meta-analysis of randomised clinical trials. J Cardiothorac Vasc Anesth 21 (2007), 502–511.
35. 35 Ker, K., Edwards, P., Perel, P., et al. Effect of tranexamic acid on surgical bleeding: Systematic review and cumulative meta-analysis. BMJ, 344, 2012, e3054.
36. 36 Guay, J., Choi, P.T., Suresh, S., et al. Neuraxial anesthesia for the prevention of postoperative mortality and major morbidity: An overview of Cochrane systematic reviews. Anesth Analg 119 (2014), 716–725.
37. 37 Guay, J., Choi, P., Suresh, S., et al. Neuraxial blockade for the prevention of postoperative mortality and major morbidity: An overview of Cochrane systematic reviews. Cochrane Database Syst Rev, 1, 2014, CD010108.
38. 38 Pöpping, D.M., Elia, N., Van Aken, H.K., et al. Impact of epidural analgesia on mortality and morbidity after surgery: Systematic review and meta-analysis of randomised controlled trials. Ann Surg 259 (2014), 1056–1067.
39. 39 Rodgers, A., Walker, N., Schug, S., et al. Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: Results from overview of randomised trials. BMJ, 321, 2000, 1493.
40. 40 Urwin, S.C., Parker, M.J., Griffiths, R., General versus regional anaesthesia for hip fracture surgery: A meta-analysis of randomized trials. Br J Anaesth 84 (2000), 450–455.
41. 41 Thielmann, M., Kottenberg, E., Kleinbongard, P., et al. Cardioprotective and prognostic effects of remote ischaemic preconditioning in patients undergoing coronary artery bypass surgery: A single-centre randomised, double-blind, controlled trial. Lancet 382 (2013), 597–604.
42. 42 Nathens, A.B., Marshall, J.C., Selective decontamination of the digestive tract in surgical patients: A systematic review of the evidence. Arch Surg 134 (1999), 170–176.
43. 43 Wijeysundera, D.N., Duncan, D., Nkonde-Price, C., et al. Perioperative beta blockade in noncardiac surgery: A systematic review for the 2014 ACC/AHA Guideline on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 130 (2014), 2246–2264.
44. 44 Wijeysundera, D.N., Duncan, D., Nkonde-Price, C., et al. Perioperative beta blockade in noncardiac surgery: A systematic review for the 2014 ACC/AHA Guideline on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 64 (2014), 2406–2425.
45. 45 Blessberger, H., Kammler, J., Domanovits, H., et al. Perioperative beta-blockers for preventing surgery-related mortality and morbidity. Cochrane Database Syst Rev, 9, 2014, CD004476.
46. 46 Devereaux, P.J., Yang, H., Yusuf, S., et al. Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): A randomised controlled trial. Lancet 371 (2008), 1839–1847.
47. 47 Bouri, S., Shun-Shin, M.J., Cole, G.D., et al. Meta-analysis of secure randomised controlled trials of β-blockade to prevent perioperative death in non-cardiac surgery. Heart 100 (2014), 456–464.
48. 48 Fergusson, D.A., Hébert, P.C., Mazer, C.D., et al. A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med 358 (2008), 2319–2331.
49. 49 De Waal, B.A., Buise, M.P., Van Zundert, A.A., Perioperative statin therapy in patients at high risk for cardiovascular morbidity undergoing surgery: A review. Br J Anaesth 114 (2015), 44–52.
50. 50 Kobashigawa, J.A., Moriguchi, J.D., Laks, H., et al. Ten-year follow-up of a randomised trial of pravastatin in heart transplant patients. J Heart Lung Transplant 24 (2005), 1736–1740.
51. 51 Schouten, O., Boersma, E., Hoeks, S.E., et al. Fluvastatin and perioperative events in patients undergoing vascular surgery. N Engl J Med 361 (2009), 980–989.
52. 52 Zheng, Z., Jayaram, R., Jiang, L., et al. Perioperative rosuvastatin in cardiac surgery. N Engl J Med 374 (2016), 1744–1753.
53. 53 Billings, F.T. 4th, Hendricks, P.A., Schildcrout, J.S., et al. High-dose perioperative atorvastatin and acute kidney injury following cardiac surgery: A randomized clinical trial. JAMA 315 (2016), 877–888.
54. 54 Greco, M., Zangrillo, A., Mucchetti, M., et al. Democracy-based consensus in medicine. J Cardiothorac Vasc Anesth 29 (2015), 506–509.
55. 55 Klompas, M., Speck, K., Howell, M.D., et al. Reappraisal of routine oral care with chlorhexidine gluconate for patients receiving mechanical ventilation: Systematic review and meta-analysis. JAMA Intern Med 174 (2014), 751–761.
56. 56 Price, H.I., Agnew, M.D., Gamble, J.M., Comparative cardiovascular morbidity and mortality in patients taking different insulin regimens for type 2 diabetes: A systematic review. BMJ Open, 5, 2015, e006341.
57. 57 Brar, M.S., Brar, S.S., Dixon, E., Perioperative supplemental oxygen in colorectal patients: A meta-analysis. J Surg Res 166 (2011), 227–235.
58. 58 Meyhoff, C.S., Jorgensen, L.N., Wetterslev, J., et al. Increased long-term mortality after a high perioperative inspiratory oxygen fraction during abdominal surgery: Follow-up of a randomised clinical trial. Anesth Analg 115 (2012), 849–854.
59. 59 Pisano, A., Perioperative supplemental oxygen to reduce surgical site infection: Too easy to be true. J Trauma Acute Care Surg, 76, 2014, 1332.
60. 60 Pisano, A., Capasso, A., Perioperative supplemental oxygen to reduce perioperative mortality. Landoni, G., Ruggeri, L., Zangrillo, A., (eds.) Reducing mortality In the perioperative period, 2014, Springer, Cham, Switzerland, 77–83.
61. 61 Finfer, S., Chittock, D.R., Su, S.Y., et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 360 (2009), 1283–1297.
62. 62 Kristensen, S.D., Knuuti, J., Saraste, A., et al. 2014 ESC/ESA Guidelines on non-cardiac surgery: Cardiovascular assessment and management: The Joint Task Force on non-cardiac surgery: Cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA). Eur Heart J 35 (2014), 2383–2431.
63. 63 Fominskiy, E., Putzu, A., Monaco, F., et al. Liberal transfusion strategy improves survival in perioperative but not in critically ill patients. A meta-analysis of randomised trials. Br J Anaesth 115 (2015), 511–519.
64. 64 Murphy, G.J., Pike, K., Rogers, C.A., Liberal or restrictive transfusion after cardiac surgery. N Engl J Med, 372, 2015, 997–1008.
65. 65 Uhlig, C., Bluth, T., Schwarz, K., et al. Effects of volatile anesthetics on mortality and postoperative pulmonary and other complications in patients undergoing surgery: A systematic review and meta-analysis. Anesthesiology 124 (2016), 1230–1245.
66. 66 Giglio M, Manca F, Dalfino L, et al: Perioperative haemodynamic goal-directed therapy and mortality: Systematic review and meta-analysis with meta regression. Minerva Anestesiol [epub ahead of print].
67. 67 Pilarczyk, K., Boening, A., Jakob, H., et al. Preoperative intra-aortic counterpulsation in high-risk patients undergoing cardiac surgery: A meta-analysis of randomized controlled trials. Eur J Cardiothorac Surg 49 (2016), 5–17.
68. 68 Hausenloy, D.J., Candilio, L., Evans, R., et al. Remote ischemic preconditioning and outcomes of cardiac surgery. N Engl J Med 373 (2015), 1408–1417.
69. 69 Meybohm, P., Bein, B., Brosteanu, O., et al. A multicenter trial of remote ischaemic preconditioning for heart surgery. N Engl J Med 373 (2015), 1397–1407.
70. 70 Vincent, J.L., We should abandon randomized controlled trials in the intensive care unit. Crit Care Med 38 (2010), S534–S538.
71. 71 Toller, W., Heringlake, M., Guarracino, F., et al. Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion. Int J Cardiol 184 (2015), 323–336.
72. 72 Zangrillo, A., Alvaro, G., Pisano, A., et al. A randomized controlled trial of levosimendan to reduce mortality in high-risk cardiac surgery patients (CHEETAH): Rationale and design. Am Heart J 177 (2016), 66–73.
73. 73 Myles, P.S., Smith, J., Knight, J., et al. Aspirin and Tranexamic Acid for Coronary Artery Surgery (ATACAS) Trial: Rationale and design. Am Heart J 155 (2008), 224–230.
74. 74 Landoni, G., Ruggeri, L., Zangrillo, A., Reducing mortality in the perioperative period. 2014, Springer, Cham, Switzerland.