Remote ischemic preconditioning and outcomes of cardiac surgery

New England Journal of Medicine

Volumn 373, Issue 15, 2015, Pages 1408-1417

  Hausenloy, Derek J ^a,b,i,j   Candilio, Luciano ^a   Evans, Richard ^c   Ariti, Cono ^d   Jenkins, David P ^h   Kolvekar, Shyam ^b   Knight, Rosemary ^c   Kunst, Gudrun ^e   Laing, Christopher ^f   Nicholas, Jennifer ^c   Pepper, John ^g   Robertson, Steven ^c   Xenou, Maria ^a   Clayton, Tim ^c   Yellon, Derek M ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^d London   (United Kingdom)

^e KING S COLLEGE HOSPITAL   (United Kingdom)

^f ROYAL FREE HOSPITAL   (United Kingdom)

^g ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^h PAPWORTH HOSPITAL   (United Kingdom)

ⁱ DEPARTMENT OF CARDIOLOGY   (Singapore)

^j NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

more..

Author keywords

[No Author keywords available]

Indexed keywords

INOTROPIC AGENT; TROPONIN T; TROPONIN;

ACUTE KIDNEY FAILURE; ADULT; AGED; ANESTHESIA INDUCTION; ARM; ARTICLE; BLOOD PRESSURE CUFF; CARDIOPLEGIA; CARDIOVASCULAR MORTALITY; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; FEMALE; HEART INFARCTION; HEART MUSCLE INJURY; HEART MUSCLE REVASCULARIZATION; HOSPITALIZATION; HUMAN; INCIDENCE; INTENSIVE CARE UNIT; ISCHEMIA; MAJOR CLINICAL STUDY; MALE; MEDICAL PROCEDURES; MULTICENTER STUDY; OUTCOME ASSESSMENT; PERIOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REMOTE ISCHEMIC PRECONDITIONING; REPERFUSION; SURGICAL RISK; UNITED KINGDOM; ADVERSE EFFECTS; BLOOD; CARDIOVASCULAR DISEASES; CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; ELECTIVE SURGERY; HEART VALVE; ISCHEMIC PRECONDITIONING; LENGTH OF STAY; MIDDLE AGED; MORTALITY; POSTOPERATIVE COMPLICATIONS; PROCEDURES; PROSPECTIVE STUDY; QUALITY OF LIFE; SURGERY; TREATMENT FAILURE; VASCULARIZATION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CARDIOVASCULAR DISEASES; CORONARY ARTERY BYPASS; DOUBLE-BLIND METHOD; ELECTIVE SURGICAL PROCEDURES; FEMALE; HEART VALVES; HUMANS; ISCHEMIA; ISCHEMIC PRECONDITIONING; LENGTH OF STAY; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; QUALITY OF LIFE; TREATMENT FAILURE; TROPONIN; UPPER EXTREMITY;

EID: 84943567211     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1413534     Document Type: Article

References (30)

1. Ferguson TB Jr, Hammill BG, Peterson ED, DeLong ER, Grover FL. A decade of change-risk profiles and outcomes for isolated coronary artery bypass grafting procedures, 1990-1999: A report from the STS National Database Committee and the Duke Clinical Research Institute. Ann Thorac Surg 2002; 73: 480-9.
2. Thorsteinsson K, Fonager K, Mérie C, et al. Age-dependent trends in postoperative mortality and preoperative comorbidity in isolated coronary artery bypass surgery: A nationwide study. Eur J Cardiothorac Surg 2015 February 19 (Epub ahead of print).
3. Przyklenk K, Bauer B, Ovize M, Kloner RA, Whittaker P. Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation 1993; 87: 893-9.
4. Hausenloy DJ, Yellon DM. Remote ischaemic preconditioning: underlying mechanisms and clinical application. Cardiovasc Res 2008; 79: 377-86.
5. Sivaraman V, Pickard JM, Hausenloy DJ. Remote ischaemic conditioning: cardiac protection from afar. Anaesthesia 2015; 70: 732-48.
6. Heusch G, Bøtker HE, Przyklenk K, Redington A, Yellon D. Remote ischemic conditioning. J Am Coll Cardiol 2015; 65: 177-95.
7. Kharbanda RK, Mortensen UM, White PA, et al. Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation 2002; 106: 2881-3.
8. Hausenloy DJ, Mwamure PK, Venugopal V, et al. Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: A randomised controlled trial. Lancet 2007; 370: 575-9.
9. Venugopal V, Hausenloy DJ, Ludman A, et al. Remote ischaemic preconditioning reduces myocardial injury in patients undergoing cardiac surgery with coldblood cardioplegia: A randomised controlled trial. Heart 2009; 95: 1567-71.
10. Thielmann M, Kottenberg E, Boengler K, et al. Remote ischemic preconditioning reduces myocardial injury after coronary artery bypass surgery with crystalloid cardioplegic arrest. Basic Res Cardiol 2010; 105: 657-64.
11. Hausenloy DJ, Candilio L, Laing C, et al. Effect of Remote Ischemic Preconditioning on Clinical Outcomes in Patients Undergoing Coronary Artery Bypass Graft Surgery (ERICCA): rationale and study design of a multi-centre randomized double-blinded controlled clinical trial. Clin Res Cardiol 2012; 101: 339-48.
12. Kellum JA, Lameire N. Diagnosis, evaluation, and management of acute kidney injury: A KDIGO summary. Crit Care 2013; 17: 204.
13. Ko WJ, Lin CY, Chen RJ, Wang SS, Lin FY, Chen YS. Extracorporeal membrane oxygenation support for adult postcardiotomy cardiogenic shock. Ann Thorac Surg 2002; 73: 538-45.
14. Lee MS, Kapoor N, Jamal F, et al. Comparison of coronary artery bypass surgery with percutaneous coronary intervention with drug-eluting stents for unprotected left main coronary artery disease. J Am Coll Cardiol 2006; 47: 864-70.
15. Serruys PW, Morice MC, Kappetein AP, et al. Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. N Engl J Med 2009; 360: 961-72.
16. Candilio L, Malik A, Ariti C, et al. Effect of remote ischaemic preconditioning on clinical outcomes in patients undergoing cardiac bypass surgery: A randomised controlled clinical trial. Heart 2015; 101: 185-92.
17. Thielmann M, Kottenberg E, Kleinbongard P, et al. Cardioprotective and prognostic effects of remote ischaemic preconditioning in patients undergoing coronary artery bypass surgery: A singlecentre randomised, double-blind, controlled trial. Lancet 2013; 382: 597-604.
18. McCrindle BW, Clarizia NA, Khaikin S, et al. Remote ischemic preconditioning in children undergoing cardiac surgery with cardiopulmonary bypass: A singlecenter double-blinded randomized trial. J Am Heart Assoc 2014; 3(4): e000964.
19. Hong DM, Lee EH, Kim HJ, et al. Does remote ischaemic preconditioning with postconditioning improve clinical outcomes of patients undergoing cardiac surgery? Remote Ischaemic Preconditioning with Postconditioning Outcome Trial. Eur Heart J 2014; 35: 176-83.
20. Rahman IA, Mascaro JG, Steeds RP, et al. Remote ischemic preconditioning in human coronary artery bypass surgery: from promise to disappointment? Circulation 2010; 122: Suppl: S53-S59.
21. Karuppasamy P, Chaubey S, Dew T, et al. Remote intermittent ischemia before coronary artery bypass graft surgery: A strategy to reduce injury and inflammation? Basic Res Cardiol 2011; 106: 511-9.
22. Kottenberg E, Thielmann M, Bergmann L, et al. Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol-A clinical trial. Acta Anaesthesiol Scand 2012; 56: 30-8.
23. Kottenberg E, Musiolik J, Thielmann M, Jakob H, Peters J, Heusch G. Interference of propofol with signal transducer and activator of transcription 5 activation and cardioprotection by remote ischemic preconditioning during coronary artery bypass grafting. J Thorac Cardiovasc Surg 2014; 147: 376-82.
24. Bautin AE, Galagudza MM, Datsenko SV, et al. Effects of remote ischemic preconditioning on perioperative period in elective aortic valve replacement. Anesteziol Reanimatol 2014; 3: 11-7. (In Russian.)
25. Heusch G. Cardioprotection: chances and challenges of its translation to the clinic. Lancet 2013; 381: 166-75.
26. Lucchinetti E, Bestmann L, Feng J, et al. Remote ischemic preconditioning applied during isoflurane inhalation provides no benefit to the myocardium of patients undergoing on-pump coronary artery bypass graft surgery: lack of synergy or evidence of antagonism in cardioprotection? Anesthesiology 2012; 116: 296-310.
27. D'Ascenzo F, Cavallero E, Moretti C, et al. Remote ischaemic preconditioning in coronary artery bypass surgery: A metaanalysis. Heart 2012; 98: 1267-71.
28. Remote Preconditioning Trialists' Group. Remote preconditioning and major clinical complications following adult cardiovascular surgery: systematic review and meta-analysis. Int J Cardiol 2014; 176: 20-31.
29. D'Ascenzo F, Moretti C, Omedè P, et al. Cardiac remote ischaemic preconditioning reduces periprocedural myocardial infarction for patients undergoing percutaneous coronary interventions: A meta-analysis of randomised clinical trials. EuroIntervention 2014; 9: 1463-71.
30. Zhang B, Zhou J, Li H, Zhou M, Chen A, Zhao Q. Remote ischemic preconditioning does not improve the clinical outcomes in patients undergoing coronary artery bypass grafting: A meta-analysis of randomized controlled trials. Int J Cardiol 2014; 172(1): e36-e38.